FR2939045B1 - PHARMACEUTICAL AND NUTRITIONAL COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING COLON INFLAMMATION AND METABOLIC ENDOTOXEMIA - Google Patents
PHARMACEUTICAL AND NUTRITIONAL COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING COLON INFLAMMATION AND METABOLIC ENDOTOXEMIAInfo
- Publication number
- FR2939045B1 FR2939045B1 FR0806785A FR0806785A FR2939045B1 FR 2939045 B1 FR2939045 B1 FR 2939045B1 FR 0806785 A FR0806785 A FR 0806785A FR 0806785 A FR0806785 A FR 0806785A FR 2939045 B1 FR2939045 B1 FR 2939045B1
- Authority
- FR
- France
- Prior art keywords
- compositions
- pharmaceutical
- inflammation
- preventing
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 208000037487 Endotoxemia Diseases 0.000 title abstract 2
- 230000002503 metabolic effect Effects 0.000 title abstract 2
- 206010009887 colitis Diseases 0.000 title 1
- 235000016709 nutrition Nutrition 0.000 title 1
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 229930091371 Fructose Natural products 0.000 abstract 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 abstract 1
- 239000005715 Fructose Substances 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010033307 Overweight Diseases 0.000 abstract 1
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 abstract 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 235000006708 antioxidants Nutrition 0.000 abstract 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 abstract 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000008951 colonic inflammation Effects 0.000 abstract 1
- 235000013325 dietary fiber Nutrition 0.000 abstract 1
- 235000015872 dietary supplement Nutrition 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002066 eicosanoids Chemical class 0.000 abstract 1
- 239000002158 endotoxin Substances 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000004609 intestinal homeostasis Effects 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000419 plant extract Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 150000008442 polyphenolic compounds Chemical class 0.000 abstract 1
- 235000013824 polyphenols Nutrition 0.000 abstract 1
- 230000000770 proinflammatory effect Effects 0.000 abstract 1
- 235000021283 resveratrol Nutrition 0.000 abstract 1
- 229940016667 resveratrol Drugs 0.000 abstract 1
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical class OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/52—Juglandaceae (Walnut family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
La présente invention concerne des compositions pharmaceutiques ou des compléments alimentaires dotées de propriétés anti-inflammatoires qui comprennent des polyphénols antioxydants capables de freiner l'expression de cytokines pro-inflammatoires induites par les endotoxines bactériennes et de s'opposer à la formation des eicosanoïdes médiateurs de l'inflammation. Ces compositions sont utiles pour traiter l'inflammation colique et l'endotoxémie métabolique responsables de surpoids et de l'obésité. En particulier, l'invention concerne des compositions pour administration orale fondées sur l'association d'une part d'extraits végétaux anti-inflammatoires riches en flavono-lignanes, en dérivés de l'acide caféique, en resvératrol, et d'autre part de fibres alimentaires, polymères de fructose ou de xylose, à effet bifodogène et permettant de restaurer l'homéostasie intestinale.The present invention relates to pharmaceutical compositions or food supplements with anti-inflammatory properties which comprise antioxidant polyphenols capable of inhibiting the expression of pro-inflammatory cytokines induced by bacterial endotoxins and of opposing the formation of eicosanoids mediators. inflammation. These compositions are useful for treating colonic inflammation and metabolic endotoxemia responsible for overweight and obesity. In particular, the invention relates to compositions for oral administration based on the combination on the one hand of anti-inflammatory plant extracts rich in flavono-lignans, in caffeic acid derivatives, in resveratrol, and on the other hand dietary fibers, polymers of fructose or xylose, with a bifodogenic effect and making it possible to restore intestinal homeostasis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0806785A FR2939045B1 (en) | 2008-12-02 | 2008-12-02 | PHARMACEUTICAL AND NUTRITIONAL COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING COLON INFLAMMATION AND METABOLIC ENDOTOXEMIA |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0806785A FR2939045B1 (en) | 2008-12-02 | 2008-12-02 | PHARMACEUTICAL AND NUTRITIONAL COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING COLON INFLAMMATION AND METABOLIC ENDOTOXEMIA |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2939045A1 FR2939045A1 (en) | 2010-06-04 |
| FR2939045B1 true FR2939045B1 (en) | 2010-12-31 |
Family
ID=40897364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR0806785A Active FR2939045B1 (en) | 2008-12-02 | 2008-12-02 | PHARMACEUTICAL AND NUTRITIONAL COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING COLON INFLAMMATION AND METABOLIC ENDOTOXEMIA |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2939045B1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3094612B1 (en) * | 2019-04-05 | 2022-08-19 | Laboratoires Iphym | Composition comprising a green coffee extract and a Superoxide dismutase (SOD) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE391509T1 (en) * | 2000-12-18 | 2008-04-15 | Probio Health | PROBIOTIC COMPOUNDS DERIVED FROM LACTOBACILLUS CASEI KE01 STRAIN |
| CA2549509C (en) * | 2003-12-18 | 2014-07-22 | Nestec S.A. | Composition for improving skin, hair and coat health containing flavanones |
| WO2005085287A1 (en) * | 2004-03-03 | 2005-09-15 | En-N-Tech, Inc. | Treatments for contaminant reduction in lactoferrin preparations and lactoferrin-containing compositions |
| EP2233127B1 (en) * | 2004-03-17 | 2020-05-27 | Stada Arzneimittel Ag | Use of antioxidants for the preparation of pharmaceutical or cosmetic compositions for protecting the skin from damages by infrared-radiations |
| US20070065396A1 (en) * | 2005-09-21 | 2007-03-22 | Tracie Martyn International, Llc | Topical macqui berry formulation |
| WO2008143182A1 (en) * | 2007-05-17 | 2008-11-27 | Kaneka Corporation | Composition containing licorice-derived polyphenol |
-
2008
- 2008-12-02 FR FR0806785A patent/FR2939045B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| FR2939045A1 (en) | 2010-06-04 |
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