FR2908133B1 - Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux - Google Patents
Nouveaux analogues de nucleotides comme molecules precurseurs d'antivirauxInfo
- Publication number
- FR2908133B1 FR2908133B1 FR0609749A FR0609749A FR2908133B1 FR 2908133 B1 FR2908133 B1 FR 2908133B1 FR 0609749 A FR0609749 A FR 0609749A FR 0609749 A FR0609749 A FR 0609749A FR 2908133 B1 FR2908133 B1 FR 2908133B1
- Authority
- FR
- France
- Prior art keywords
- nucleotide analogues
- precursor molecules
- novel nucleotide
- antiviral
- antiviral precursor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000000840 anti-viral effect Effects 0.000 title 1
- 239000002773 nucleotide Substances 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0609749A FR2908133B1 (fr) | 2006-11-08 | 2006-11-08 | Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux |
US12/514,285 US8884011B2 (en) | 2006-11-08 | 2007-11-08 | Nucleotide analogues as precursor molecules for antivirals |
EP20070859278 EP2086990A2 (fr) | 2006-11-08 | 2007-11-08 | Analogues de nucléotides innovants en tant que molécules précurseurs d'antiviraux |
CA2669450A CA2669450C (fr) | 2006-11-08 | 2007-11-08 | Analogues de nucleotides innovants en tant que molecules precurseurs d'antiviraux |
JP2009535833A JP5584865B2 (ja) | 2006-11-08 | 2007-11-08 | 抗ウイルス薬のための前駆体分子としての新規なヌクレオチド類似体 |
PCT/IB2007/004233 WO2008056264A2 (fr) | 2006-11-08 | 2007-11-08 | Analogues de nucléotides innovants en tant que molécules précurseurs d'antiviraux |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0609749A FR2908133B1 (fr) | 2006-11-08 | 2006-11-08 | Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2908133A1 FR2908133A1 (fr) | 2008-05-09 |
FR2908133B1 true FR2908133B1 (fr) | 2012-12-14 |
Family
ID=38018742
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR0609749A Expired - Fee Related FR2908133B1 (fr) | 2006-11-08 | 2006-11-08 | Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux |
Country Status (6)
Country | Link |
---|---|
US (1) | US8884011B2 (fr) |
EP (1) | EP2086990A2 (fr) |
JP (1) | JP5584865B2 (fr) |
CA (1) | CA2669450C (fr) |
FR (1) | FR2908133B1 (fr) |
WO (1) | WO2008056264A2 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2559788B1 (fr) * | 2010-04-16 | 2015-10-14 | National University Corporation Okayama University | Procédé de production directe d'un dérivé de phosphine à partir d'un dérivé d'oxyde de phosphine |
EP3578563B1 (fr) | 2011-12-22 | 2021-04-14 | Geron Corporation | Analogues de guanine en tant que substrats de télomérase et d'agents affecteurs de longueur de télomère |
CN107312039B (zh) | 2012-08-30 | 2019-06-25 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药的制备方法 |
CN104710424B (zh) * | 2013-12-11 | 2017-03-01 | 河南师范大学 | (r)‑(+)‑9‑(2‑羟丙基)腺嘌呤的制备方法 |
CN104725423A (zh) * | 2013-12-18 | 2015-06-24 | 山东新时代药业有限公司 | 一种富马酸替诺福韦二吡呋酯的合成方法 |
CN105541910A (zh) * | 2015-12-21 | 2016-05-04 | 山东金城医药化工股份有限公司 | 对甲苯磺酰氧甲基膦酸二乙酯的合成方法 |
CN107021985A (zh) * | 2017-05-08 | 2017-08-08 | 四川理工学院 | 药物中间体r‑9‑[2‑(二乙氧基膦酰甲氧基)丙基]腺嘌呤的合成方法 |
EP3730503A4 (fr) * | 2017-12-21 | 2021-05-05 | Shenzhen TargetRx, Inc. | Inhibiteur nucléosidique de la transcriptase inverse antiviral |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS263951B1 (en) * | 1985-04-25 | 1989-05-12 | Antonin Holy | 9-(phosponylmethoxyalkyl)adenines and method of their preparation |
CS263952B1 (en) * | 1985-04-25 | 1989-05-12 | Holy Antonin | Remedy with antiviral effect |
CS264222B1 (en) * | 1986-07-18 | 1989-06-13 | Holy Antonin | N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them |
US4935427A (en) | 1987-12-31 | 1990-06-19 | The United States Of America As Represented By The Department Of Health And Human Services | Pyrimidine and purine 1,2-butadiene-4-ols as anti-retroviral agents |
US5072032A (en) | 1989-06-21 | 1991-12-10 | Mckenna Charles E | Preparation and use of thiophosphonates and thio-analogues of phosphonoformic acid |
ATE167679T1 (de) | 1990-09-14 | 1998-07-15 | Acad Of Science Czech Republic | Wirkstoffvorläufer von phosphonaten |
CA2120743C (fr) | 1991-10-11 | 2005-03-08 | John C. Martin | Derives acycliques purine et pyrimidine de type alkenyl et alkynyl avec un substitut phosphonomethoxyalkyl et ayant une activite antivirale |
WO2003002580A1 (fr) * | 2001-06-29 | 2003-01-09 | Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic | Nouveaux composes et methodes therapeutiques |
CN1523028A (zh) * | 2003-02-18 | 2004-08-25 | 田镇华 | 一种新型的膦酸酯-核苷酸化合物 |
SI1644389T1 (sl) * | 2003-06-16 | 2011-06-30 | Acad Of Science Czech Republic | Pirimidinske spojine s fosfonatnimi skupinami kot antivirusni nukleotidni analogi |
CN1634943A (zh) * | 2004-11-05 | 2005-07-06 | 中国医学科学院医药生物技术研究所 | 一组非环核苷酸类似物及其合成方法和在抗病毒中的应用 |
AU2006239677A1 (en) * | 2005-04-25 | 2006-11-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Use of compounds to enhance processivity of telomerase |
CN100396689C (zh) * | 2006-03-07 | 2008-06-25 | 中国医学科学院医药生物技术研究所 | 一组具有抑制hiv-1/hbv病毒复制活性的替诺福韦单酯化合物 |
-
2006
- 2006-11-08 FR FR0609749A patent/FR2908133B1/fr not_active Expired - Fee Related
-
2007
- 2007-11-08 WO PCT/IB2007/004233 patent/WO2008056264A2/fr active Application Filing
- 2007-11-08 CA CA2669450A patent/CA2669450C/fr not_active Expired - Fee Related
- 2007-11-08 US US12/514,285 patent/US8884011B2/en not_active Expired - Fee Related
- 2007-11-08 EP EP20070859278 patent/EP2086990A2/fr not_active Withdrawn
- 2007-11-08 JP JP2009535833A patent/JP5584865B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2669450C (fr) | 2016-02-09 |
JP2010510965A (ja) | 2010-04-08 |
WO2008056264A2 (fr) | 2008-05-15 |
WO2008056264A3 (fr) | 2008-10-30 |
US20100099869A1 (en) | 2010-04-22 |
CA2669450A1 (fr) | 2008-05-15 |
JP5584865B2 (ja) | 2014-09-10 |
EP2086990A2 (fr) | 2009-08-12 |
FR2908133A1 (fr) | 2008-05-09 |
US8884011B2 (en) | 2014-11-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TQ | Partial transmission of property |
Owner name: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (, FR Effective date: 20131002 Owner name: KU LEUVEN RESEARCH & DEVELOPMENT, BE Effective date: 20131002 Owner name: UNIVERSITE D'AIX-MARSEILLE, FR Effective date: 20131002 |
|
PLFP | Fee payment |
Year of fee payment: 10 |
|
ST | Notification of lapse |
Effective date: 20170731 |