BRPI0910689A2 - processo de síntese de rna por via química - Google Patents
processo de síntese de rna por via químicaInfo
- Publication number
- BRPI0910689A2 BRPI0910689A2 BRPI0910689A BRPI0910689A BRPI0910689A2 BR PI0910689 A2 BRPI0910689 A2 BR PI0910689A2 BR PI0910689 A BRPI0910689 A BR PI0910689A BR PI0910689 A BRPI0910689 A BR PI0910689A BR PI0910689 A2 BRPI0910689 A2 BR PI0910689A2
- Authority
- BR
- Brazil
- Prior art keywords
- synthesis process
- rna synthesis
- process chemically
- chemically
- rna
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0802928A FR2931824B1 (fr) | 2008-05-29 | 2008-05-29 | Procede de synthese d'arn par voie chimique. |
PCT/FR2009/000624 WO2009144418A1 (fr) | 2008-05-29 | 2009-05-28 | Procede de synthese d'arn par voie chimique |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0910689A2 true BRPI0910689A2 (pt) | 2016-11-01 |
Family
ID=39712442
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0910689A BRPI0910689A2 (pt) | 2008-05-29 | 2009-04-28 | processo de síntese de rna por via química |
Country Status (7)
Country | Link |
---|---|
US (1) | US8536318B2 (pt) |
EP (1) | EP2303905B1 (pt) |
JP (1) | JP5689054B2 (pt) |
BR (1) | BRPI0910689A2 (pt) |
CA (1) | CA2726260C (pt) |
FR (1) | FR2931824B1 (pt) |
WO (1) | WO2009144418A1 (pt) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011028218A1 (en) | 2009-09-02 | 2011-03-10 | Alnylam Pharmaceuticals, Inc. | Process for triphosphate oligonucleotide synthesis |
WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
DK3590949T3 (da) | 2010-10-01 | 2022-07-11 | Modernatx Inc | Ribonukleinsyrer indeholdende n1-methyl-pseudouracil og anvendelse heraf |
US8710200B2 (en) | 2011-03-31 | 2014-04-29 | Moderna Therapeutics, Inc. | Engineered nucleic acids encoding a modified erythropoietin and their expression |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
RU2648950C2 (ru) | 2011-10-03 | 2018-04-02 | Модерна Терапьютикс, Инк. | Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение |
US20130156849A1 (en) | 2011-12-16 | 2013-06-20 | modeRNA Therapeutics | Modified nucleoside, nucleotide, and nucleic acid compositions |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US9303079B2 (en) | 2012-04-02 | 2016-04-05 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
WO2013151667A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides |
JP5757641B2 (ja) | 2012-07-25 | 2015-07-29 | 国立大学法人高知大学 | Rna合成用モノマー、その製造方法、およびrnaの製造方法 |
RS63237B1 (sr) | 2012-11-26 | 2022-06-30 | Modernatx Inc | Terminalno modifikovana rnk |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
PL221806B1 (pl) * | 2013-03-21 | 2016-05-31 | Inst Chemii Bioorg Polskiej Akademii Nauk | Sposób wprowadzania acetalowych i acetaloestrowych grup ochronnych oraz związki do realizacji tego sposobu |
US20160194625A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
KR20160067219A (ko) | 2013-10-03 | 2016-06-13 | 모더나 세라퓨틱스, 인코포레이티드 | 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드 |
EP3542802A1 (en) | 2013-11-01 | 2019-09-25 | CureVac AG | Modified rna with decreased immunostimulatory properties |
CA2925021A1 (en) | 2013-11-01 | 2015-05-07 | Curevac Ag | Modified rna with decreased immunostimulatory properties |
JP2017524357A (ja) | 2014-07-16 | 2017-08-31 | モデルナティエックス インコーポレイテッドModernaTX,Inc. | キメラポリヌクレオチド |
WO2023097308A1 (en) * | 2021-11-29 | 2023-06-01 | Hongene Biotech Corporation | Synthesis of 2' acetyl-ester protected nucleosides |
CN114685572B (zh) * | 2022-06-02 | 2022-08-30 | 上海百力格生物技术有限公司 | 用于mgb核酸探针合成的氧化剂组合物及探针的合成方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4458066A (en) * | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
EP1386925A1 (en) * | 2002-07-31 | 2004-02-04 | Girindus AG | Method for preparing oligonucleotides |
CN100484949C (zh) * | 2005-07-18 | 2009-05-06 | 张必良 | 用于rna寡核苷酸合成中的核苷亚磷酰胺及其合成方法 |
-
2008
- 2008-05-29 FR FR0802928A patent/FR2931824B1/fr not_active Expired - Fee Related
-
2009
- 2009-04-28 BR BRPI0910689A patent/BRPI0910689A2/pt not_active IP Right Cessation
- 2009-05-28 US US12/995,001 patent/US8536318B2/en active Active
- 2009-05-28 JP JP2011511053A patent/JP5689054B2/ja active Active
- 2009-05-28 EP EP09754068A patent/EP2303905B1/fr active Active
- 2009-05-28 WO PCT/FR2009/000624 patent/WO2009144418A1/fr active Application Filing
- 2009-05-28 CA CA2726260A patent/CA2726260C/fr active Active
Also Published As
Publication number | Publication date |
---|---|
CA2726260C (fr) | 2017-04-04 |
EP2303905A1 (fr) | 2011-04-06 |
WO2009144418A1 (fr) | 2009-12-03 |
US8536318B2 (en) | 2013-09-17 |
FR2931824A1 (fr) | 2009-12-04 |
US20110275793A1 (en) | 2011-11-10 |
FR2931824B1 (fr) | 2014-11-28 |
CA2726260A1 (fr) | 2009-12-03 |
EP2303905B1 (fr) | 2012-11-28 |
JP2011521930A (ja) | 2011-07-28 |
JP5689054B2 (ja) | 2015-03-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application fees: application dismissed [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |