FR2896415A1 - Topical parasiticide composition, useful to treat, eliminate or prevent infestation of ectoparasites e.g. human louse, comprises alcohol, dark tobacco leaves and wild thyme zaatar - Google Patents
Topical parasiticide composition, useful to treat, eliminate or prevent infestation of ectoparasites e.g. human louse, comprises alcohol, dark tobacco leaves and wild thyme zaatar Download PDFInfo
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- FR2896415A1 FR2896415A1 FR0600624A FR0600624A FR2896415A1 FR 2896415 A1 FR2896415 A1 FR 2896415A1 FR 0600624 A FR0600624 A FR 0600624A FR 0600624 A FR0600624 A FR 0600624A FR 2896415 A1 FR2896415 A1 FR 2896415A1
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- zaatar
- alcohol
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- tobacco leaves
- maceration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
-1- Composition topique parasiticide pour traiter, éliminer, ou prévenir-1- Parasiticidal topical composition for treating, eliminating, or preventing
l'infestation d'ectoparasites tel que le pou humain, son procédé de préparation et d'application. the infestation of ectoparasites such as the human lung, its process of preparation and application.
L'invention concerne une composition à usage externe destinée d'une part à traiter l'infestation d'ectoparasites, tels que les poux (pediculus capitis, pediculus humanus et pthiris pubic) et tiques, en éradiquant les individus adultes ainsi que leurs oeufs, et, d'autre part, à prévenir durablement une nouvelle infestation. L'invention concerne également le procédé de préparation de cette composition et son application en vue du traitement de l'être infesté. The invention relates to a composition for external use intended on the one hand to treat the infestation of ectoparasites, such as lice (pediculus capitis, pediculus humanus and pthiris pubic) and ticks, by eradicating adult individuals and their eggs, and, on the other hand, to permanently prevent a new infestation. The invention also relates to the method of preparation of this composition and its application for the treatment of the infested being.
Les ectoparasites tels que les poux humains de la tête représentent un problème persistant à travers le monde, et touchent plusieurs millions d'individus chaque année, et notamment les enfants. Parce qu'ils se nourrissent de sang, ces parasites sont à l'origine de diverses lésions de la peau, créent des démangeaisons, et véhiculent des maladies en transmettant notamment des bactéries nocives. En outre, les poux peuvent être source de difficultés sociales, l'individu infesté et plus particulièrement l'enfant étant souvent mis à l'écart de ses camarades. Ectoparasites such as head lice are a persistent problem around the world, affecting millions of people every year, including children. Because they feed on blood, these parasites cause various skin lesions, create itching, and carry diseases including transmitting harmful bacteria. In addition, lice can be a source of social hardship, with the infested individual, and especially the child, often left out of school.
A ce jour, un grand nombre de produits anti-poux ou autres parasiticides sont proposés sur le marché mais peu sont véritablement efficaces et beaucoup présentent à long terme des inconvénients divers. Quand ces produits ont une activité avérée, cette activité est bien souvent limitée aux individus parasites adultes, de sorte qu'une nouvelle infestation se déclare lorsque les oeufs éclosent. Les oeufs ou lentes sont en effet particulièrement difficiles à atteindre, étant véritablement cimentés à la base du poil ou du cheveux par une sorte de colle naturelle (glycoprotéine), et enveloppés dans une pellicule limitant la pénétration du parasiticide et donc son efficacité. L'action mécanique avec par exemple un peigne à poux permet d'enlever bon nombre de parasites adultes mais est inefficace sur les oeufs. To date, a large number of anti-lice products or other parasiticides are on the market but few are truly effective and many have long-term disadvantages. When these products have a proven activity, this activity is often limited to adult parasitic individuals, so that a new infestation occurs when the eggs hatch. Eggs or nits are indeed particularly difficult to reach, being actually cemented at the base of the hair or hair by a kind of natural glue (glycoprotein), and wrapped in a film limiting the penetration of the parasiticide and therefore its effectiveness. The mechanical action with such a rag comb can remove many adult parasites but is ineffective on eggs.
Cette efficacité partielle nécessite donc, dans la plupart des cas, des applications répétées de produit traitant, à intervalles réguliers, afin d'éliminer les -2- parasites à chaque nouvelle éclosion. Outre les contraintes liées à la répétition du traitement créant notamment des irritations de la peau et des difficultés d'observance, le renouvellement des générations de parasites aboutit à des résistances de ceux-ci au produit utilisé pour le traitement, le rendant inactif à long terme et requérant son changement. This partial efficacy therefore requires, in most cases, repeated applications of product treating, at regular intervals, in order to eliminate the parasites during each new hatching. In addition to the constraints related to the repetition of the treatment creating in particular irritations of the skin and difficulties of observance, the renewal of the generations of parasites leads to resistances of these to the product used for the treatment, rendering it inactive in the long term and requesting his change.
La présente invention propose de remédier à ces inconvénients grâce à une composition topique permettant d'éliminer en une seule fois, ou dans des cas d'infestation extrême ou de grande résistance, en deux applications, simultanément ectoparasites adultes et oeufs par exemple mais de façon non limitative, du cuir chevelu ou des poils chez l'humain, ou des poils chez les animaux à fourrure ou simple pelage (chiens, chats, lapins, etc). Cette composition présente également une action répulsive, de sorte qu'une nouvelle infestation par des individus exogènes peut être prévenue. Elle est réalisée avec notamment des produits naturels, ne présente aucune nocivité ni toxicité pour l'être infesté, et est donc bien tolérée par celui-ci. The present invention proposes to overcome these disadvantages with a topical composition to eliminate in one go, or in cases of extreme infestation or high resistance, in two applications, simultaneously adult ectoparasites and eggs for example but non-limiting, scalp or hairs in humans, or hairs in animals with fur or simple coat (dogs, cats, rabbits, etc.). This composition also has a repellent action, so that a new infestation by exogenous individuals can be prevented. It is made with particular natural products, has no harmfulness or toxicity to be infested, and is well tolerated by it.
Réalisée sous forme liquide, elle présente les avantages d'une facilité d'application et d'une bonne pénétration dans la chevelure ou le pelage, jusqu'à 20 atteindre les oeufs souvent accrochés à la racine des cheveux ou des poils. Made in liquid form, it has the advantages of ease of application and good penetration into the hair or coat, until reaching the eggs often attached to the hairline or hair.
Des études ont été menées auprès de nombreux enfants, population facilement et régulièrement infestée par les poux, véritable fléau pour les écoliers. Ces essais ont été effectués avec l'autorisation des parents et en 25 accord avec les directeurs d'établissements scolaires et de crèches. Dans 89% des cas, une seule application de la composition selon l'invention pendant une durée d'une vingtaine de minutes environ a suffit pour éliminer poux et lentes des têtes infestées. Une observation sur plusieurs jours a permis de constater qu'aucune nouvelle infestation n'était déclarée. 30 Très peu d'enfants, même parmi ceux ayant une chevelure épaisse et très fournie, ont eu besoin d'une seconde application. Studies have been conducted with many children, easily and regularly infested with lice, a real scourge for schoolchildren. These tests were carried out with the parents' permission and in agreement with the directors of schools and nurseries. In 89% of cases, a single application of the composition according to the invention for a period of about twenty minutes is enough to eliminate lice and nits infested heads. One observation over several days revealed that no new infestation was reported. Very few children, even those with thick, well-stocked hair, needed a second application.
Aucun trouble tel que irritations, brûlures, etc, après application de la composition n'a été relevé. No disorder such as irritation, burns, etc., after application of the composition was noted.
Des expériences similaires ont été menées chez les chiens et les chats et ont abouti à la même constatation : la composition selon l'invention est efficace sur les poux et lentes de ces espèces animales. On peut donc s'attendre à des résultats positifs pour tout animal à fourrure ou simple pelage infesté par des ectoparasites. Similar experiments have been conducted in dogs and cats and have reached the same conclusion: the composition according to the invention is effective on the lice and slow of these animal species. Positive results can therefore be expected for any fur or fur animal infested with ectoparasites.
Selon l'invention, la composition parasiticide est obtenue par macération d'un mélange essentiellement composé d'alcool, de tabac brun naturel et de thyms sauvage zaatar (thym d'origine orientale). According to the invention, the parasiticidal composition is obtained by maceration of a mixture consisting essentially of alcohol, natural brown tobacco and zaatar wild thyme (thyme of oriental origin).
De manière avantageuse quoique nullement limitative, ladite composition est 15 constituée d'une macération de : - alcool tel que alcool à brûler : de l'ordre de 60% - feuilles de tabac naturel brun : de l'ordre de 25% racines et branches de thym sauvage zaatar : de l'ordre de 8% - tiges et fleurs dudit thym : de l'ordre de 5% 20 - fleurs d'oranger amer ou un concentré de ces fleurs : de l'ordre de 2% Advantageously, although in no way limiting, said composition consists of a maceration of: alcohol such as alcohol to be burned: of the order of 60% brown natural tobacco leaves: of the order of 25% roots and branches zaatar wild thyme: about 8% - stems and flowers of the thyme: about 5% 20 - bitter orange flowers or a concentrate of these flowers: about 2%
La fleur d'oranger n'est pas indispensable pour l'élaboration de cette composition mais sa présence en renforce l'efficacité : l'amertume de cette fleur contribue au caractère répulsif de la composition vis-à- vis du parasite, tandis que 25 son parfum est apprécié de l'individu soigné. Orange blossom is not essential for the development of this composition but its presence enhances its effectiveness: the bitterness of this flower contributes to the repellency of the composition with respect to the parasite, while its scent is appreciated by the neat individual.
Feuilles de tabac et alcool sont mélangés dans tout récipient approprié et sont laissés macérer pendant 5 à 7 jours, selon la température ambiante, jusqu'à obtention d'un liquide de couleur très noire. Dès le troisième jour de macération, racines et branches de zaatar sont incorporées au mélange puis, au cinquième-sixième jour, on ajoute les tiges et les fleurs de cette plante. 30 5 -4- Pour finir, la fleur d'oranger ou son concentré est ajouté. Pendant cette période de macération, un brassage de la préparation est effectué à intervalles réguliers, par exemple une fois par jour. Lorsque la macération est terminée, la préparation est pressée et filtrée finement. Le liquide obtenu constitue la composition parasiticide selon l'invention. Tobacco leaves and alcohol are mixed in any suitable container and are allowed to macerate for 5 to 7 days, depending on the ambient temperature, until a very black colored liquid is obtained. On the third day of maceration, roots and branches of zaatar are incorporated into the mixture and, on the fifth-sixth day, the stems and flowers of this plant are added. Finally, the orange blossom or its concentrate is added. During this period of maceration, a stirring of the preparation is carried out at regular intervals, for example once a day. When the maceration is complete, the preparation is pressed and finely filtered. The resulting liquid constitutes the parasiticidal composition according to the invention.
Elle peut être conditionnée dans tout contenant approprié (flacon, bouteille, 10 vaporisateur, etc). It can be packaged in any suitable container (bottle, bottle, spray bottle, etc.).
La composition selon l'invention est appliquée pure sur la zone à traiter, en prenant soin de bien la répartir sur ladite zone et, dans le cas d'une chevelure ou d'un pelage épais, de bien la faire pénétrer jusqu'à la racine des poils et des 15 cheveux. Aucun bonnet de protection n'est nécessaire. The composition according to the invention is applied pure to the area to be treated, taking care to distribute it well on said zone and, in the case of a thick hair or coat, to make it penetrate to the root of hair and hair. No protective cap is needed.
Un temps de repos de 20 à 30 minutes est souhaitable pour une action optimale. Un temps supplémentaire est inutile. A rest period of 20 to 30 minutes is desirable for optimal action. Extra time is useless.
20 Enfin, la zone traitée doit être lavée et rincée à l'eau additionnée de savon ou de shampooing ordinaire. Finally, the treated area should be washed and rinsed with water supplemented with soap or ordinary shampoo.
En de rares cas de résistance, une seconde application peut être effectuée, environ une semaine après la première. 25 La réalisation de la composition selon l'invention est simple à mettre en oeuvre et ne comporte que des ingrédients d'obtention facile et peu onéreux. Ainsi, la composition parasiticide peut être commercialisée à un faible coût. Elle présente également l'avantage d'être réalisée et utilisée dans le respect de 30 l'environnement. In rare cases of resistance, a second application can be made, about a week after the first. The production of the composition according to the invention is simple to implement and comprises only easy and inexpensive ingredients. Thus, the parasiticidal composition can be marketed at a low cost. It also has the advantage of being made and used in respect of the environment.
Le traitement est efficace en une seule application, voire dans de rares cas en deux applications, de sorte qu'il n'y a ni contraintes d'observance, ni de résistances développées par les parasites. 15 The treatment is effective in a single application, or even in rare cases in two applications, so that there are no constraints of compliance or resistances developed by the parasites. 15
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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FR0600624A FR2896415B1 (en) | 2006-01-24 | 2006-01-24 | TOPICAL PARASITICIDE COMPOSITION FOR TREATING, ELIMINATING, OR PREVENTING THE INFESTATION OF ECTOPARASITES, SUCH AS THE HUMAN POU, ITS PREPARATION AND APPLICATION METHOD |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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FR0600624A FR2896415B1 (en) | 2006-01-24 | 2006-01-24 | TOPICAL PARASITICIDE COMPOSITION FOR TREATING, ELIMINATING, OR PREVENTING THE INFESTATION OF ECTOPARASITES, SUCH AS THE HUMAN POU, ITS PREPARATION AND APPLICATION METHOD |
Publications (2)
Publication Number | Publication Date |
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FR2896415A1 true FR2896415A1 (en) | 2007-07-27 |
FR2896415B1 FR2896415B1 (en) | 2008-05-23 |
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FR0600624A Expired - Fee Related FR2896415B1 (en) | 2006-01-24 | 2006-01-24 | TOPICAL PARASITICIDE COMPOSITION FOR TREATING, ELIMINATING, OR PREVENTING THE INFESTATION OF ECTOPARASITES, SUCH AS THE HUMAN POU, ITS PREPARATION AND APPLICATION METHOD |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2446672A (en) * | 2007-02-14 | 2008-08-20 | Cotrex Llc | Tobacco extraction methods and formulations |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2424024A1 (en) * | 1978-04-26 | 1979-11-23 | Roman Aguilera Mercedes | PROCESS FOR THE PREPARATION OF A HAIR LOTION ACTING AGAINST HAIR LOSS AS WELL AS A HAIR LOTION OBTAINED BY THIS PROCESS |
WO2000000213A1 (en) * | 1998-06-30 | 2000-01-06 | Arbor Vida Natural Products | Compositions and methods for killing or repelling insects |
WO2000064265A2 (en) * | 1999-04-23 | 2000-11-02 | John Alfred Wilkinson | Insecticidal compositions |
-
2006
- 2006-01-24 FR FR0600624A patent/FR2896415B1/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2424024A1 (en) * | 1978-04-26 | 1979-11-23 | Roman Aguilera Mercedes | PROCESS FOR THE PREPARATION OF A HAIR LOTION ACTING AGAINST HAIR LOSS AS WELL AS A HAIR LOTION OBTAINED BY THIS PROCESS |
WO2000000213A1 (en) * | 1998-06-30 | 2000-01-06 | Arbor Vida Natural Products | Compositions and methods for killing or repelling insects |
WO2000064265A2 (en) * | 1999-04-23 | 2000-11-02 | John Alfred Wilkinson | Insecticidal compositions |
Non-Patent Citations (7)
Title |
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BURKHART CRAIG G ET AL: "Use of topical nicotine for treatment of Pediculus humanus capitis (Anaplura: Pediculidae)", JOURNAL OF MEDICAL ENTOMOLOGY, vol. 37, no. 1, January 2000 (2000-01-01), pages 170 - 171, XP009073061, ISSN: 0022-2585 * |
CROSSAN LIZ: "Experience based treatment of head lice.", BMJ (CLINICAL RESEARCH ED.) 18 MAY 2002, vol. 324, no. 7347, 18 May 2002 (2002-05-18), pages 1220, XP002401593, ISSN: 1468-5833 * |
FLAMINI GUIDO ET AL: "Composition of the essential oil of leaves, galls, and ripe and unripe fruits of jordanian Pistacia palaestina Boiss.", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 52, no. 3, 11 February 2004 (2004-02-11), pages 572 - 576, XP002401128, ISSN: 0021-8561 * |
HOUMANI ET AL: "The essential oil composition of Algerian Zaatar: Origanum spp. and Thymus spp", MEDICINAL & AROMATIC PLANTS ABSTRACTS, NATIONAL INSTITUTE OF SCIENCE COMMUNICATION AND INFORMATION, IN, vol. 25, no. 2, April 2003 (2003-04-01), XP018015997, ISSN: 0250-4367 * |
LAHLOU ET AL: "The potential effectiveness of essential oils in the control of human head lice in Morocco", MEDICINAL & AROMATIC PLANTS ABSTRACTS, NATIONAL INSTITUTE OF SCIENCE COMMUNICATION AND INFORMATION, IN, vol. 24, no. 2, April 2002 (2002-04-01), XP018014817, ISSN: 0250-4367 * |
REGNAULT-ROGER C ET AL: "INSECTIDAL EFFECT OF ESSENTIAL OILS FROM MEDITERRANEAN PLANTS UPON ACANTHOSCELIDES OBTECTUS SAY (COLEOPTERA, BRUCHIDAE), A PEST OF KIDNEY BEAN (PHASEOLUS VULGARIS L.)", JOURNAL OF CHEMICAL ECOLOGY, PLENUM PUBLISHING CORPORATION, US, vol. 19, no. 6, 1993, pages 1233 - 1244, XP000940842, ISSN: 0098-0331 * |
VEAL ET AL: "The potential effectiveness of essential oils as a treatment for headlice, Pediculus humanus capitis", COMPLEMENTARY THERAPIES IN NURSING AND MIDWIFERY, CHURCHILL LIVINGSTONE, vol. 2, no. 4, August 1996 (1996-08-01), pages 97 - 101, XP005472058, ISSN: 1353-6117 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2446672A (en) * | 2007-02-14 | 2008-08-20 | Cotrex Llc | Tobacco extraction methods and formulations |
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FR2896415B1 (en) | 2008-05-23 |
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