FR2896159B1 - Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline. - Google Patents
Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline.Info
- Publication number
- FR2896159B1 FR2896159B1 FR0600344A FR0600344A FR2896159B1 FR 2896159 B1 FR2896159 B1 FR 2896159B1 FR 0600344 A FR0600344 A FR 0600344A FR 0600344 A FR0600344 A FR 0600344A FR 2896159 B1 FR2896159 B1 FR 2896159B1
- Authority
- FR
- France
- Prior art keywords
- combination
- triazine derivatives
- sensitizing agents
- insulin sensitizing
- insulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Priority Applications (24)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0600344A FR2896159B1 (fr) | 2006-01-13 | 2006-01-13 | Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline. |
AU2006334734A AU2006334734B2 (en) | 2006-01-13 | 2006-12-18 | Combination of triazine derivatives and insulin sensitisers |
KR1020147002582A KR20140033498A (ko) | 2006-01-13 | 2006-12-18 | 트리아진 유도체 및 인슐린 감작제의 조합물 |
KR20087019624A KR101482685B1 (ko) | 2006-01-13 | 2006-12-18 | 트리아진 유도체 및 인슐린 감작제의 조합물 |
CNA2006800509443A CN101355933A (zh) | 2006-01-13 | 2006-12-18 | 三嗪衍生物与胰岛素增敏剂的组合 |
SI200630793T SI1971330T1 (sl) | 2006-01-13 | 2006-12-18 | Kombinacija derivatov triazina in insulinskih senzibilizatorjev |
CA2640897A CA2640897C (fr) | 2006-01-13 | 2006-12-18 | Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline |
DE602006016014T DE602006016014D1 (de) | 2006-01-13 | 2006-12-18 | Kombination aus triazinderivaten und insulin-sensibilisatoren |
EA200801676A EA015576B1 (ru) | 2006-01-13 | 2006-12-18 | Комбинация производных триазина и сенсибилизаторов инсулина |
EP06829706A EP1971330B1 (fr) | 2006-01-13 | 2006-12-18 | Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline |
AT06829706T ATE476179T1 (de) | 2006-01-13 | 2006-12-18 | Kombination aus triazinderivaten und insulin- sensibilisatoren |
PCT/EP2006/012185 WO2007079917A2 (fr) | 2006-01-13 | 2006-12-18 | Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline |
PT06829706T PT1971330E (pt) | 2006-01-13 | 2006-12-18 | Associação de derivados de triazina e sensibilizadores de insulina |
DK06829706.8T DK1971330T3 (da) | 2006-01-13 | 2006-12-18 | Kombination af triazinderivater og insulin-sensibilisatorer |
BRPI0620985A BRPI0620985B8 (pt) | 2006-01-13 | 2006-12-18 | composição farmacêutica, e usos de derivados de triazina e sensibilizadores de insulina |
ES06829706T ES2347177T3 (es) | 2006-01-13 | 2006-12-18 | Combinacion de derivados de triazina y sensibilizadores de insulina. |
US12/160,664 US8791115B2 (en) | 2006-01-13 | 2006-12-18 | Combination of triazine derivatives and insulin sensitisers |
PL06829706T PL1971330T3 (pl) | 2006-01-13 | 2006-12-18 | Połączenie pochodnych triazyny ze środkami zwiększającymi wrażliwość na insulinę |
JP2008549783A JP5249782B2 (ja) | 2006-01-13 | 2006-12-18 | トリアジン誘導体およびインスリン増感剤の組合せ |
ARP070100138A AR059032A1 (es) | 2006-01-13 | 2007-01-12 | Combinacion de derivados de triazina y sensibilizadores de insulina |
IL192558A IL192558A (en) | 2006-01-13 | 2008-07-01 | A medicinal product and kit containing a combination of triazine derivatives and insulin sensitizers and its uses |
ZA200806947A ZA200806947B (en) | 2006-01-13 | 2008-08-12 | Combination of triazine derivatives and insulin sensitisers |
CY20101100840T CY1110789T1 (el) | 2006-01-13 | 2010-09-16 | Συνδυασμος παραγωγων τριαζινης και ευαισθητοποιητων ινσουλινης |
US14/063,530 US20140050786A1 (en) | 2006-01-13 | 2013-10-25 | Combination of triazine derivatives and insulin sensitisers |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0600344A FR2896159B1 (fr) | 2006-01-13 | 2006-01-13 | Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline. |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2896159A1 FR2896159A1 (fr) | 2007-07-20 |
FR2896159B1 true FR2896159B1 (fr) | 2008-09-12 |
Family
ID=36654309
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR0600344A Expired - Fee Related FR2896159B1 (fr) | 2006-01-13 | 2006-01-13 | Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline. |
Country Status (22)
Country | Link |
---|---|
US (2) | US8791115B2 (fr) |
EP (1) | EP1971330B1 (fr) |
JP (1) | JP5249782B2 (fr) |
KR (2) | KR101482685B1 (fr) |
CN (1) | CN101355933A (fr) |
AR (1) | AR059032A1 (fr) |
AT (1) | ATE476179T1 (fr) |
AU (1) | AU2006334734B2 (fr) |
BR (1) | BRPI0620985B8 (fr) |
CA (1) | CA2640897C (fr) |
CY (1) | CY1110789T1 (fr) |
DE (1) | DE602006016014D1 (fr) |
DK (1) | DK1971330T3 (fr) |
EA (1) | EA015576B1 (fr) |
ES (1) | ES2347177T3 (fr) |
FR (1) | FR2896159B1 (fr) |
IL (1) | IL192558A (fr) |
PL (1) | PL1971330T3 (fr) |
PT (1) | PT1971330E (fr) |
SI (1) | SI1971330T1 (fr) |
WO (1) | WO2007079917A2 (fr) |
ZA (1) | ZA200806947B (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2896159B1 (fr) * | 2006-01-13 | 2008-09-12 | Merck Sante Soc Par Actions Si | Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline. |
BRPI0922650A2 (pt) | 2008-12-12 | 2017-07-11 | Poxel | Composto, composição farmacêutica, uso de pelo menos um composto, métodos para tratar doenças, para diagnosticar nefropatia diabética, e para triar compostos, e, uso de sinaptopodina |
EP2355829B1 (fr) | 2008-12-12 | 2014-12-31 | Poxel S.A.S. | Combinaison de l'insuline avec des dérivés de la triazine et son utilisation dans le traitement du diabète |
FR2948026B1 (fr) * | 2009-07-17 | 2011-12-02 | Merck Sante Sas | Derives amines de dihydro-1,3,5-triazine |
FR2948027A1 (fr) * | 2009-07-17 | 2011-01-21 | Merck Sante Sas | Derives amines de dihydro-1,3,5-triazine pour leur utilisation dans le traitement des maladies associees a une ischemie et/ou une reperfusion |
TWI436768B (zh) * | 2010-06-09 | 2014-05-11 | Poxel | 第2型糖尿病之治療 |
KR20120011667A (ko) * | 2010-07-29 | 2012-02-08 | 광주과학기술원 | 당뇨병 치료제의 스크리닝 방법 |
KR101271218B1 (ko) * | 2012-12-07 | 2013-06-07 | 광주과학기술원 | 당뇨병 치료제의 스크리닝 방법 |
US11617754B2 (en) | 2017-10-02 | 2023-04-04 | Poxel Sa | Methods of treating heart failure with preserved ejection fraction |
EP3801542B1 (fr) | 2018-06-06 | 2022-08-10 | Poxel SA | Méthodes de traitement de sujets atteints de diabète avec une maladie rénale chronique |
MX2020013567A (es) | 2018-06-14 | 2021-05-27 | Poxel | Tableta recubierta con pelicula que comprende un derivado de triazina para su uso en el tratamiento de la diabetes. |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6288095B1 (en) * | 1987-09-04 | 2001-09-11 | Beecham Group P.L.C. | Compounds |
US5885980A (en) * | 1996-06-25 | 1999-03-23 | Enrique G. Gutierrez | Composition and method for treating diabetes |
US6011049A (en) | 1997-02-19 | 2000-01-04 | Warner-Lambert Company | Combinations for diabetes |
TWI302149B (en) | 1999-09-22 | 2008-10-21 | Bristol Myers Squibb Co | Substituted acid derivatives useful as antiodiabetic and antiobesity agents and method |
MY125516A (en) | 1999-11-16 | 2006-08-30 | Smithkline Beecham Plc | Novel composition based on thiazolidinedione and metformin and use |
FR2804113B1 (fr) * | 2000-01-26 | 2004-06-18 | Lipha | Derives animes de dihydro-1,3,5-triazine et leurs applications en therapeutique |
AU2001257456B2 (en) * | 2000-05-01 | 2006-02-09 | Aeropharm Technology, Inc. | A core formulation |
FR2853650B1 (fr) * | 2003-04-10 | 2006-07-07 | Merck Sante Sas | Procede de dedoublement d'amines utiles pour le traitement de desordres associes au syndrome d'insulino-resistance |
EA010422B1 (ru) * | 2003-08-01 | 2008-08-29 | Янссен Фармацевтика Н.В. | Замещённые индол-о-глюкозиды |
FR2863484B1 (fr) * | 2003-12-11 | 2007-04-13 | Oreal | Utilisation de composes capables d'agir sur la voie metabolique controlee par la dopachrome tautomerase trp-2 comme agent protecteur des melanocytes du follicule pileux et applications |
EP1841414A1 (fr) * | 2003-12-31 | 2007-10-10 | Alpharma, Inc. | Preparations de rosiglitazone et de metformine |
FR2896159B1 (fr) * | 2006-01-13 | 2008-09-12 | Merck Sante Soc Par Actions Si | Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline. |
-
2006
- 2006-01-13 FR FR0600344A patent/FR2896159B1/fr not_active Expired - Fee Related
- 2006-12-18 AU AU2006334734A patent/AU2006334734B2/en not_active Ceased
- 2006-12-18 AT AT06829706T patent/ATE476179T1/de active
- 2006-12-18 JP JP2008549783A patent/JP5249782B2/ja active Active
- 2006-12-18 CN CNA2006800509443A patent/CN101355933A/zh active Pending
- 2006-12-18 EP EP06829706A patent/EP1971330B1/fr active Active
- 2006-12-18 US US12/160,664 patent/US8791115B2/en active Active
- 2006-12-18 CA CA2640897A patent/CA2640897C/fr not_active Expired - Fee Related
- 2006-12-18 KR KR20087019624A patent/KR101482685B1/ko active IP Right Grant
- 2006-12-18 SI SI200630793T patent/SI1971330T1/sl unknown
- 2006-12-18 KR KR1020147002582A patent/KR20140033498A/ko not_active Application Discontinuation
- 2006-12-18 EA EA200801676A patent/EA015576B1/ru not_active IP Right Cessation
- 2006-12-18 WO PCT/EP2006/012185 patent/WO2007079917A2/fr active Application Filing
- 2006-12-18 DE DE602006016014T patent/DE602006016014D1/de active Active
- 2006-12-18 PL PL06829706T patent/PL1971330T3/pl unknown
- 2006-12-18 BR BRPI0620985A patent/BRPI0620985B8/pt not_active IP Right Cessation
- 2006-12-18 PT PT06829706T patent/PT1971330E/pt unknown
- 2006-12-18 ES ES06829706T patent/ES2347177T3/es active Active
- 2006-12-18 DK DK06829706.8T patent/DK1971330T3/da active
-
2007
- 2007-01-12 AR ARP070100138A patent/AR059032A1/es unknown
-
2008
- 2008-07-01 IL IL192558A patent/IL192558A/en active IP Right Grant
- 2008-08-12 ZA ZA200806947A patent/ZA200806947B/xx unknown
-
2010
- 2010-09-16 CY CY20101100840T patent/CY1110789T1/el unknown
-
2013
- 2013-10-25 US US14/063,530 patent/US20140050786A1/en not_active Abandoned
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |
Effective date: 20140930 |