FR2886938B1 - EXTRUSION PROCESS FOR MAKING SOLID DISPERSIONS OF PHARMACEUTICAL ACTIVE INGREDIENTS IN A POLYMERIC MATRIX - Google Patents

EXTRUSION PROCESS FOR MAKING SOLID DISPERSIONS OF PHARMACEUTICAL ACTIVE INGREDIENTS IN A POLYMERIC MATRIX

Info

Publication number
FR2886938B1
FR2886938B1 FR0551577A FR0551577A FR2886938B1 FR 2886938 B1 FR2886938 B1 FR 2886938B1 FR 0551577 A FR0551577 A FR 0551577A FR 0551577 A FR0551577 A FR 0551577A FR 2886938 B1 FR2886938 B1 FR 2886938B1
Authority
FR
France
Prior art keywords
active ingredients
extrusion process
polymeric matrix
pharmaceutical active
solid dispersions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0551577A
Other languages
French (fr)
Other versions
FR2886938A1 (en
Inventor
Jacques Fages
Martial Sauceau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Association pour la Recherche et le Developpement des Methodes et Processus Industriels
Original Assignee
Association pour la Recherche et le Developpement des Methodes et Processus Industriels
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Association pour la Recherche et le Developpement des Methodes et Processus Industriels filed Critical Association pour la Recherche et le Developpement des Methodes et Processus Industriels
Priority to FR0551577A priority Critical patent/FR2886938B1/en
Priority to EP06763648A priority patent/EP1888676A2/en
Priority to PCT/EP2006/063110 priority patent/WO2006131570A2/en
Publication of FR2886938A1 publication Critical patent/FR2886938A1/en
Application granted granted Critical
Publication of FR2886938B1 publication Critical patent/FR2886938B1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/04—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent
    • C08J9/12—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent
    • C08J9/122—Hydrogen, oxygen, CO2, nitrogen or noble gases
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2201/00—Foams characterised by the foaming process
    • C08J2201/02—Foams characterised by the foaming process characterised by mechanical pre- or post-treatments
    • C08J2201/03—Extrusion of the foamable blend
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2203/00—Foams characterized by the expanding agent
    • C08J2203/08—Supercritical fluid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
FR0551577A 2005-06-10 2005-06-10 EXTRUSION PROCESS FOR MAKING SOLID DISPERSIONS OF PHARMACEUTICAL ACTIVE INGREDIENTS IN A POLYMERIC MATRIX Expired - Fee Related FR2886938B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR0551577A FR2886938B1 (en) 2005-06-10 2005-06-10 EXTRUSION PROCESS FOR MAKING SOLID DISPERSIONS OF PHARMACEUTICAL ACTIVE INGREDIENTS IN A POLYMERIC MATRIX
EP06763648A EP1888676A2 (en) 2005-06-10 2006-06-12 Method for producing a composite material comprising active substance solid dispersions in a polymer matrix
PCT/EP2006/063110 WO2006131570A2 (en) 2005-06-10 2006-06-12 Method for producing an active substance-containing composite material

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0551577A FR2886938B1 (en) 2005-06-10 2005-06-10 EXTRUSION PROCESS FOR MAKING SOLID DISPERSIONS OF PHARMACEUTICAL ACTIVE INGREDIENTS IN A POLYMERIC MATRIX

Publications (2)

Publication Number Publication Date
FR2886938A1 FR2886938A1 (en) 2006-12-15
FR2886938B1 true FR2886938B1 (en) 2008-04-18

Family

ID=36008403

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0551577A Expired - Fee Related FR2886938B1 (en) 2005-06-10 2005-06-10 EXTRUSION PROCESS FOR MAKING SOLID DISPERSIONS OF PHARMACEUTICAL ACTIVE INGREDIENTS IN A POLYMERIC MATRIX

Country Status (3)

Country Link
EP (1) EP1888676A2 (en)
FR (1) FR2886938B1 (en)
WO (1) WO2006131570A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1968553A2 (en) * 2005-11-09 2008-09-17 Novartis AG Process for making pharmaceutical compositions with a transient plasticizer
CN102443970A (en) * 2011-10-28 2012-05-09 中原工学院 Method for preparing polysulfonate microporous fibre non-woven fabric
FR2989916B1 (en) * 2012-04-27 2014-04-11 Arkema France PROCESS FOR THE PRODUCTION OF THERMOPLASTIC POLYMER PARTICLES BASED ON POLYAMIDE BASED ON SUPERCRITICAL CO2
EP2815879A3 (en) 2014-09-02 2015-04-29 Mondi Consumer Packaging Technologies GmbH Polyethylene coextrusion film
HUE030040T2 (en) 2014-09-02 2017-04-28 Mondi Consumer Packaging Tech Gmbh Plastic multilayer film
GB2565831A (en) * 2017-04-25 2019-02-27 Windsor Hamilton Stephen Apparatus for depolymerisation of waste plastics

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5082608A (en) * 1990-06-14 1992-01-21 Owens-Illinois Plastic Products Inc. Polystyrene foam sheet manufacture
US5866053A (en) * 1993-11-04 1999-02-02 Massachusetts Institute Of Technology Method for providing continuous processing of microcellular and supermicrocellular foamed materials
DE19635676A1 (en) * 1996-09-03 1998-03-05 Basf Ag Solid foamed active ingredient preparations
US6403663B1 (en) * 1999-09-20 2002-06-11 North Carolina State University Method of making foamed materials using surfactants and carbon dioxide
TW520383B (en) * 2001-08-03 2003-02-11 Ind Tech Res Inst Method of making porous biodegradable polymers
WO2005023215A2 (en) * 2003-09-10 2005-03-17 Janssen Pharmaceutica N.V. Particles shaped as platelets

Also Published As

Publication number Publication date
FR2886938A1 (en) 2006-12-15
EP1888676A2 (en) 2008-02-20
WO2006131570A2 (en) 2006-12-14
WO2006131570A3 (en) 2007-06-07

Similar Documents

Publication Publication Date Title
FR2886938B1 (en) EXTRUSION PROCESS FOR MAKING SOLID DISPERSIONS OF PHARMACEUTICAL ACTIVE INGREDIENTS IN A POLYMERIC MATRIX
EP2054036A4 (en) Solid nanoparticle formulation of water insoluble pharmaceutical substances with reduced ostwald ripening
IL191604A (en) Pharmaceutical compositions for sustained release containing mixtures of polymers and active agents poorly soluble in water and a process for their preparation
BRPI0807285A2 (en) "COMPOSITION, METHOD FOR PREPARING PHARMACEUTICAL COMPOSITION, UNIT FORM OF DOSAGE, METHOD FOR ADMINISTRATING A BIOLOGICAL ACTIVE AGENT NEEDING THE AGENT, METHOD FOR INCREASING BIODISPONABILITY FOR PREPARING AN AGENT OF COMPOSITION"
FR2902653B1 (en) COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, COSMETIC PROCESSING METHOD EMPLOYING SAID COMPOSITION, POLYCONDENSATE AND PREPARATION METHOD
PL2091514T3 (en) Water insoluble polymer matrix for drug delivery
BRPI0914902A2 (en) pharmaceutical composition and method for treating parkinson's disease
FR2909205B1 (en) METHOD FOR DESIGNATION OF AN OBJECT IN AN IMAGE
WO2008144061A3 (en) Novel combinations comprising a phosphodiesterase-5 inhibitor and their use
FR2920275B1 (en) METHOD FOR INJECTING A TREATMENT SUBSTANCE IN EGGS AND CORRESPONDING INJECTION HEAD
IL197871A0 (en) Pharmaceutical solid dosage forms comprising compounds micro-embedded in ionic water-insoluble polymers
FR2901172B1 (en) METHOD FOR COLD LOADING AN ASSET IN A MATRIX POLYMER
FR2936889B1 (en) METHOD FOR REPLACING A SET OF POINTS IN IMAGES
CL2007002376A1 (en) COMPOUNDS DERIVED FROM REPLACED PIRROL; PREPARATION PROCESS; PHARMACEUTICAL COMPOSITION; AND USE IN BACTERIAL DISEASES.
FR2940051B1 (en) MULTI-COMPONENT ANTI-TRANSPIRANT AGENT COMPRISING TWO COMPONENTS CAPABLE OF COOPERATING AND METHOD FOR TREATING HUMAN TRANSPIRATION IN TWO STEPS
WO2008124081A3 (en) Rapid dissolution of combination products
IL195648A0 (en) Pharmaceutical compositions containing erythropoietin for mobilizing mononuclear cells in peripheral blood for treating ischemic diseases
FR2939795B1 (en) PROCESS FOR PREPARING ACTIVE ESTERS
ATE542525T1 (en) IMPROVED PHARMACEUTICAL COMPOSITION COMPRISING A PYRROLIDONE ANTICONVULSANT AND METHOD FOR THE PRODUCTION THEREOF
FR2912648B1 (en) POLYMER PARTICLE DISPERSION, COMPOSITION COMPRISING THE SAME, AND COSMETIC PROCESSING METHOD
FR2934780B1 (en) PHARMACEUTICAL COMPOSITION IN THE FORM OF PELLETS AND PROCESS FOR PRODUCING SUCH A PHARMACEUTICAL COMPOSITION.
FR2927539B1 (en) PROCESS FOR PREPARING A PHARMACEUTICAL FORMULATION OF CONTRAST AGENTS.
FR2892016B1 (en) METHOD AND DEVICE FOR DISTRIBUTING DRUG PILLS IN A DETERMINED TIME RANGE.
FR2936129B1 (en) PRODUCT COMPRISING DIAMIDES, PROCESS FOR PREPARATION AND USES
PL379569A1 (en) Production method of pharmaceutical composition containing active substance ziprasidone or its pharmaceutically admitted salt, increasing solubility and bio-availability of this drug, pharmaceutical composition and application of hydrophilic auxiliary subs

Legal Events

Date Code Title Description
PLFP Fee payment

Year of fee payment: 12

PLFP Fee payment

Year of fee payment: 13

PLFP Fee payment

Year of fee payment: 14

PLFP Fee payment

Year of fee payment: 15

ST Notification of lapse

Effective date: 20210206