FR2854634A1 - Nouveaux derives de thiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux derives de thiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2854634A1
FR2854634A1 FR0305448A FR0305448A FR2854634A1 FR 2854634 A1 FR2854634 A1 FR 2854634A1 FR 0305448 A FR0305448 A FR 0305448A FR 0305448 A FR0305448 A FR 0305448A FR 2854634 A1 FR2854634 A1 FR 2854634A1
Authority
FR
France
Prior art keywords
diamondf
branched
linear
novel
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR0305448A
Other languages
English (en)
Other versions
FR2854634B1 (fr
Inventor
Emmanuel Graindorge
Pierre Francotte
Stephane Boverie
Tullio Pascal De
Bernard Pirotte
Pierre Lestage
Laurence Danober
Pierre Renard
Daniel Henri Caignard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Priority to FR0305448A priority Critical patent/FR2854634B1/fr
Priority to UAA200511454A priority patent/UA80046C2/uk
Priority to MYPI20041647A priority patent/MY136694A/en
Priority to GEAP20049092A priority patent/GEP20084318B/en
Priority to EP04742632A priority patent/EP1620441A1/fr
Priority to US10/555,743 priority patent/US7476668B2/en
Priority to CNB200480014886XA priority patent/CN100363368C/zh
Priority to CA2524377A priority patent/CA2524377C/fr
Priority to ZA200508660A priority patent/ZA200508660B/en
Priority to BRPI0410002-6A priority patent/BRPI0410002A/pt
Priority to PCT/FR2004/001070 priority patent/WO2004099217A1/fr
Priority to MXPA05011823A priority patent/MXPA05011823A/es
Priority to ARP040101515A priority patent/AR044245A1/es
Priority to KR1020057020817A priority patent/KR100741235B1/ko
Priority to NZ543214A priority patent/NZ543214A/en
Priority to AU2004236005A priority patent/AU2004236005B2/en
Priority to EA200501696A priority patent/EA009240B1/ru
Priority to JP2006505830A priority patent/JP4461139B2/ja
Publication of FR2854634A1 publication Critical patent/FR2854634A1/fr
Application granted granted Critical
Publication of FR2854634B1 publication Critical patent/FR2854634B1/fr
Priority to MA28567A priority patent/MA27732A1/fr
Priority to NO20055695A priority patent/NO20055695L/no
Priority to HK06108870A priority patent/HK1088327A1/xx
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Composés de formule (I) :dans laquelle :&diamondf; A représente un groupement thiényle, furyle, pyrrolyle, oxathiole, thiazole, isothiazole, oxazole ou imidazole,&diamondf; R1 représente un atome d'hydrogène ou un groupement alkyle (C1-C6) linéaire ou ramifié, éventuellement substitué par un ou plusieurs atomes d'halogène,&diamondf; R2 représente un atome d'hydrogène ou un groupement alkyle (C1-C6) linéaire ou ramifié, éventuellement substitué par un ou plusieurs atomes d'halogène,&diamondf;R3 représente un atome d'hydrogène ou un groupement choisi parmi alkyle (C1-C6) linéaire ou ramifié, CONHR' ou SO2NHR' dans lesquels R' représente un groupement alkyle (C1-C6) linéaire ou ramifié,leurs énantiomères, diastéréoisomères ainsi que leurs sels d'addition à un acide ou à une base pharmaceutiquement acceptable.Médicaments.
FR0305448A 2003-05-05 2003-05-05 Nouveaux derives de thiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related FR2854634B1 (fr)

Priority Applications (21)

Application Number Priority Date Filing Date Title
FR0305448A FR2854634B1 (fr) 2003-05-05 2003-05-05 Nouveaux derives de thiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
UAA200511454A UA80046C2 (en) 2003-05-05 2004-04-05 Thiadiazine compounds, method for obtaning thereof and pharmaceutical composition containing them
MYPI20041647A MY136694A (en) 2003-05-05 2004-04-30 New thiadiazine compounds, a process for their preparation and pharmaceutical compositions containing them
NZ543214A NZ543214A (en) 2003-05-05 2004-05-04 New thiadiazine compounds, a process for their preparation and pharmaceutical compositions containing them
US10/555,743 US7476668B2 (en) 2003-05-05 2004-05-04 Thiadiazine derivatives and use thereof as positive AMPA receptor modulators
CNB200480014886XA CN100363368C (zh) 2003-05-05 2004-05-04 噻二嗪衍生物及其用作正ampa受体调节剂的用途
CA2524377A CA2524377C (fr) 2003-05-05 2004-05-04 Nouveaux derives de thiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ZA200508660A ZA200508660B (en) 2003-05-05 2004-05-04 Thiadiazine derivatives and use thereof as positive AMPA receptor modulators
BRPI0410002-6A BRPI0410002A (pt) 2003-05-05 2004-05-04 derivados de tiadiazina e sua utilização como modeladores positivos dos receptores ampa
PCT/FR2004/001070 WO2004099217A1 (fr) 2003-05-05 2004-05-04 Derives de thiadiazine et leur utilisation comme modulateurs positifs des recepteurs ampa
GEAP20049092A GEP20084318B (en) 2003-05-05 2004-05-04 Thiadiazine derivatives and use thereof as positive ampa receptor modulators
ARP040101515A AR044245A1 (es) 2003-05-05 2004-05-04 Derivados de tiadiazina su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
KR1020057020817A KR100741235B1 (ko) 2003-05-05 2004-05-04 티아디아진 유도체 및 양성 ａｍｐａ 수용체조절인자로서의 이들의 용도
EP04742632A EP1620441A1 (fr) 2003-05-05 2004-05-04 Derives de thiadiazine et leur utilisation comme modulateurs positifs des recepteurs ampa
AU2004236005A AU2004236005B2 (en) 2003-05-05 2004-05-04 Thiadiazine derivatives and use thereof as positive AMPA receptor modulators
EA200501696A EA009240B1 (ru) 2003-05-05 2004-05-04 Новые соединения тиадиазина, способ их получения и фармацевтические композиции, которые их содержат
JP2006505830A JP4461139B2 (ja) 2003-05-05 2004-05-04 チアジアジン誘導体及びポジティブａｍｐａ受容体モジュレーターとしてのそれらの使用
MXPA05011823A MXPA05011823A (es) 2003-05-05 2004-05-04 Derivados de tiadiazina y su uso como moduladores positivos de los receptores ampa.
MA28567A MA27732A1 (fr) 2003-05-05 2005-10-21 Nouveaux derives de thiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
NO20055695A NO20055695L (no) 2003-05-05 2005-12-01 Tiadiazinforbindelser og anvendelse derav som positive AMPA-reseptormodulatorer
HK06108870A HK1088327A1 (en) 2003-05-05 2006-08-10 Thiadiazine derivatives and use thereof as positive ampa receptor modulator

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0305448A FR2854634B1 (fr) 2003-05-05 2003-05-05 Nouveaux derives de thiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2854634A1 true FR2854634A1 (fr) 2004-11-12
FR2854634B1 FR2854634B1 (fr) 2005-07-08

Family

ID=33306157

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0305448A Expired - Fee Related FR2854634B1 (fr) 2003-05-05 2003-05-05 Nouveaux derives de thiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (21)

Country Link
US (1) US7476668B2 (fr)
EP (1) EP1620441A1 (fr)
JP (1) JP4461139B2 (fr)
KR (1) KR100741235B1 (fr)
CN (1) CN100363368C (fr)
AR (1) AR044245A1 (fr)
AU (1) AU2004236005B2 (fr)
BR (1) BRPI0410002A (fr)
CA (1) CA2524377C (fr)
EA (1) EA009240B1 (fr)
FR (1) FR2854634B1 (fr)
GE (1) GEP20084318B (fr)
HK (1) HK1088327A1 (fr)
MA (1) MA27732A1 (fr)
MX (1) MXPA05011823A (fr)
MY (1) MY136694A (fr)
NO (1) NO20055695L (fr)
NZ (1) NZ543214A (fr)
UA (1) UA80046C2 (fr)
WO (1) WO2004099217A1 (fr)
ZA (1) ZA200508660B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE463249T1 (de) 2004-08-25 2010-04-15 Essentialis Inc Pharmazeutische formulierungen von kalium-atp- kanalöffnern und deren verwendungen
DK1968601T3 (da) * 2006-01-05 2012-02-06 Essentialis Inc Salte af kalium-ATP-kanalåbnere og anvendelser heraf
WO2010054336A2 (fr) * 2008-11-10 2010-05-14 The Regents Of The University Of California Utilisations thérapeutiques de modulateurs du récepteur ampa pour le traitement d'un dysfonctionnement moteur
HUE049460T2 (hu) 2010-08-10 2020-09-28 Takeda Pharmaceuticals Co Heterociklusos vegyület és annak alkalmazása ampa receptor pozitív allosztérikus modulátorként
JP5901365B2 (ja) * 2012-03-12 2016-04-06 株式会社トクヤマ イミダート化合物の製造方法
CA2915405A1 (fr) 2013-06-13 2014-12-18 Veroscience Llc Compositions et methodes pour le traitement des troubles metaboliques
RU2705595C2 (ru) 2015-07-06 2019-11-11 Паблик Юниверсити Корпорейшн Йокогама Сити Юниверсити Новое соединение, специфически связывающееся с рецептором ampa
JP6241974B1 (ja) 2017-01-11 2017-12-06 公立大学法人横浜市立大学 霊長類生体の脳内ａｍｐａ受容体のイメージング方法、プログラム、及びスクリーニング方法
US10680583B1 (en) * 2019-02-26 2020-06-09 Xilinx, Inc. Control circuit for and method of controlling an operation of an integrated circuit device

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998012185A1 (fr) * 1996-09-17 1998-03-26 The Regents Of The University Of California Derives de benzothiadiazide et leur utilisation en tant que modulateurs positifs allosteriques du recepteur ampa
WO1999003861A1 (fr) * 1997-07-16 1999-01-28 Novo Nordisk A/S Derives de 1,2,4-thiadiazine fusionnee, leur preparation et utilisation
WO1999042456A2 (fr) * 1998-02-18 1999-08-26 Neurosearch A/S Nouveaux composes et leur utilisation comme modulateurs positifs du recepteur ampa
FR2801587A1 (fr) * 1999-11-30 2001-06-01 Adir Nouveaux derives de benzothiadiazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3733409A (en) * 1969-05-20 1973-05-15 Schering Corp Method of treating hypertension using thieno (1,2,4) thiadiazines

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998012185A1 (fr) * 1996-09-17 1998-03-26 The Regents Of The University Of California Derives de benzothiadiazide et leur utilisation en tant que modulateurs positifs allosteriques du recepteur ampa
WO1999003861A1 (fr) * 1997-07-16 1999-01-28 Novo Nordisk A/S Derives de 1,2,4-thiadiazine fusionnee, leur preparation et utilisation
WO1999042456A2 (fr) * 1998-02-18 1999-08-26 Neurosearch A/S Nouveaux composes et leur utilisation comme modulateurs positifs du recepteur ampa
FR2801587A1 (fr) * 1999-11-30 2001-06-01 Adir Nouveaux derives de benzothiadiazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
MXPA05011823A (es) 2006-05-25
KR100741235B1 (ko) 2007-07-19
NZ543214A (en) 2009-02-28
UA80046C2 (en) 2007-08-10
AR044245A1 (es) 2005-09-07
JP2006525292A (ja) 2006-11-09
GEP20084318B (en) 2008-03-10
NO20055695L (no) 2005-12-01
CN100363368C (zh) 2008-01-23
KR20060006830A (ko) 2006-01-19
AU2004236005B2 (en) 2010-01-21
HK1088327A1 (en) 2006-11-03
AU2004236005A1 (en) 2004-11-18
EA200501696A1 (ru) 2006-06-30
CN1798750A (zh) 2006-07-05
JP4461139B2 (ja) 2010-05-12
CA2524377C (fr) 2010-08-24
BRPI0410002A (pt) 2006-04-25
MY136694A (en) 2008-11-28
ZA200508660B (en) 2007-01-31
US20070004709A1 (en) 2007-01-04
MA27732A1 (fr) 2006-01-02
EA009240B1 (ru) 2007-12-28
US7476668B2 (en) 2009-01-13
FR2854634B1 (fr) 2005-07-08
CA2524377A1 (fr) 2004-11-18
WO2004099217A1 (fr) 2004-11-18
EP1620441A1 (fr) 2006-02-01

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Effective date: 20130131