EA200500006A1 - Лекарственное средство для лечения нейродегенеративных заболеваний - Google Patents

Лекарственное средство для лечения нейродегенеративных заболеваний

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Publication number
EA200500006A1
EA200500006A1 EA200500006A EA200500006A EA200500006A1 EA 200500006 A1 EA200500006 A1 EA 200500006A1 EA 200500006 A EA200500006 A EA 200500006A EA 200500006 A EA200500006 A EA 200500006A EA 200500006 A1 EA200500006 A1 EA 200500006A1
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EA
Eurasian Patent Office
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group
formula
same meaning
conh
represented
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EA200500006A
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EA011707B1 (ru
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Сусуму Муто
Акико Итай
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Инститьют Оф Медисинал Молекьюлар Дизайн. Инк.
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Publication of EA200500006A1 publication Critical patent/EA200500006A1/ru
Publication of EA011707B1 publication Critical patent/EA011707B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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Abstract

Лекарственное средство для профилактики и/или терапевтического лечения нейродегенеративного заболевания, такого как болезнь Альцгеймера или тому подобное, которое содержит в качестве активного ингредиента вещество, выбранное из группы, состоящей из соединения, представленного общей формулой (I), и его фармакологически приемлемой соли, и его гидрата, и его сольватагде A представляет собой атом водорода или ацетильную группу, E представляет собой 2,5-дизамещенную или 3,5-дизамещенную фенильную группу или моноциклическую или конденсированную полициклическую гетероарильную группу, которая может быть замещенной, при условии, что исключено соединение, у которого указанная гетероарильная группа является (1) конденсированной полициклической гетероарильной группой, у которой кольцо, которое непосредственно связано с группой -CONH- в формуле (I), является бензольным кольцом, (2) незамещенной тиазол-2-ильной группой или (3) незамещенной бензотиазол-2-ильной группой, кольцо Z представляет собой арен, который может иметь один или несколько заместителей в дополнение к группе, представленной формулой -O-A, где A имеет такое же значение, как указано выше, и группе, представленной формулой -CONH-E, где E имеет такое же значение, как указано выше, или гетероарен, который может иметь один или несколько заместителей в дополнение к группе, представленной формулой -O-A, где A имеет такое же значение, как указано выше, и группе, представленной формулой -CONH-E, где E имеет такое же значение, как указано выше.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200500006A 2002-06-11 2003-06-05 Лекарственное средство для лечения нейродегенеративных заболеваний EA011707B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002169640 2002-06-11
PCT/JP2003/007128 WO2003103657A1 (ja) 2002-06-11 2003-06-05 神経変性疾患治療剤

Publications (2)

Publication Number Publication Date
EA200500006A1 true EA200500006A1 (ru) 2005-08-25
EA011707B1 EA011707B1 (ru) 2009-04-28

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TW200402290A (en) 2004-02-16
TWI280127B (en) 2007-05-01
US20080234233A1 (en) 2008-09-25
CN1658858A (zh) 2005-08-24
EP1555018A4 (en) 2009-01-07
CA2488979A1 (en) 2003-12-18
AU2003242124A1 (en) 2003-12-22
US20060035944A1 (en) 2006-02-16
CN100490793C (zh) 2009-05-27
EP1555018A1 (en) 2005-07-20
JP4635130B2 (ja) 2011-02-16
JPWO2003103657A1 (ja) 2005-10-06
WO2003103657A1 (ja) 2003-12-18
EA011707B1 (ru) 2009-04-28

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