FR2853546B1 - Nouvelle composition pharmaceutique contenant la cyclosporine a - Google Patents

Nouvelle composition pharmaceutique contenant la cyclosporine a

Info

Publication number
FR2853546B1
FR2853546B1 FR0403163A FR0403163A FR2853546B1 FR 2853546 B1 FR2853546 B1 FR 2853546B1 FR 0403163 A FR0403163 A FR 0403163A FR 0403163 A FR0403163 A FR 0403163A FR 2853546 B1 FR2853546 B1 FR 2853546B1
Authority
FR
France
Prior art keywords
pharmaceutical composition
composition containing
novel pharmaceutical
containing cyclosporin
cyclosporin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0403163A
Other languages
English (en)
Other versions
FR2853546A1 (fr
Inventor
Michael Ambuhl
Barbara Luckel
Firedrich Richter
Barbara Haberlin
Armin Meinzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27269231&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2853546(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9804742.6A external-priority patent/GB9804742D0/en
Priority claimed from GBGB9805104.8A external-priority patent/GB9805104D0/en
Priority claimed from GBGB9805199.8A external-priority patent/GB9805199D0/en
Application filed by Novartis AG filed Critical Novartis AG
Publication of FR2853546A1 publication Critical patent/FR2853546A1/fr
Application granted granted Critical
Publication of FR2853546B1 publication Critical patent/FR2853546B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FR0403163A 1998-03-06 2004-03-26 Nouvelle composition pharmaceutique contenant la cyclosporine a Expired - Fee Related FR2853546B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9804742.6A GB9804742D0 (en) 1998-03-06 1998-03-06 Organic compounds
GBGB9805104.8A GB9805104D0 (en) 1998-03-10 1998-03-10 Organic compounds
GBGB9805199.8A GB9805199D0 (en) 1998-03-11 1998-03-11 Organic compounds

Publications (2)

Publication Number Publication Date
FR2853546A1 FR2853546A1 (fr) 2004-10-15
FR2853546B1 true FR2853546B1 (fr) 2006-04-07

Family

ID=27269231

Family Applications (4)

Application Number Title Priority Date Filing Date
FR9902748A Expired - Fee Related FR2775596B1 (fr) 1998-03-06 1999-03-04 Nouvelles compositions pharmaceutiques
FR0013782A Expired - Fee Related FR2800277B1 (fr) 1998-03-06 2000-10-25 Compositions pharmaceutiques comprenant une substance active difficilement soluble et un milieu vehiculeur
FR0403163A Expired - Fee Related FR2853546B1 (fr) 1998-03-06 2004-03-26 Nouvelle composition pharmaceutique contenant la cyclosporine a
FR0600097A Withdrawn FR2881956A1 (fr) 1998-03-06 2006-01-05 Nouvelle composition pharmaceutique contenant la cycloporine a

Family Applications Before (2)

Application Number Title Priority Date Filing Date
FR9902748A Expired - Fee Related FR2775596B1 (fr) 1998-03-06 1999-03-04 Nouvelles compositions pharmaceutiques
FR0013782A Expired - Fee Related FR2800277B1 (fr) 1998-03-06 2000-10-25 Compositions pharmaceutiques comprenant une substance active difficilement soluble et un milieu vehiculeur

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR0600097A Withdrawn FR2881956A1 (fr) 1998-03-06 2006-01-05 Nouvelle composition pharmaceutique contenant la cycloporine a

Country Status (30)

Country Link
EP (2) EP1059913B1 (fr)
JP (2) JP2002505271A (fr)
KR (1) KR100443306B1 (fr)
CN (1) CN1195495C (fr)
AR (1) AR015729A1 (fr)
AT (1) ATE277599T1 (fr)
AU (1) AU749217B2 (fr)
BE (3) BE1012400A5 (fr)
BR (1) BR9908597A (fr)
CA (1) CA2322845C (fr)
CO (1) CO4930289A1 (fr)
CZ (1) CZ301967B6 (fr)
DE (2) DE69920668T2 (fr)
ES (1) ES2228014T3 (fr)
FR (4) FR2775596B1 (fr)
GB (1) GB2350791B (fr)
HK (2) HK1034038A1 (fr)
HU (1) HUP0101080A3 (fr)
ID (1) ID25908A (fr)
IL (2) IL138248A0 (fr)
IT (1) IT1313550B1 (fr)
MY (1) MY129274A (fr)
NO (1) NO331800B1 (fr)
NZ (1) NZ506644A (fr)
PE (1) PE20000324A1 (fr)
PT (1) PT1059913E (fr)
SK (1) SK285139B6 (fr)
TR (1) TR200002586T2 (fr)
TW (3) TWI257870B (fr)
WO (1) WO1999044584A1 (fr)

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KR100602725B1 (ko) * 1998-12-11 2006-07-20 파마솔루션스, 인코포레이티드 물에서 불충분하게 용해되는 약제를 위한 자가-유화용조성물
AU769429C (en) * 1998-12-30 2004-10-28 Dexcel Limited Dispersible concentrate for the delivery of cyclosporin
US6294192B1 (en) * 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US20070032853A1 (en) 2002-03-27 2007-02-08 Hossainy Syed F 40-O-(2-hydroxy)ethyl-rapamycin coated stent
GB2362573A (en) * 2000-05-25 2001-11-28 Cipla Ltd Cyclosporin formulation
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WO2001032143A1 (fr) * 1999-11-02 2001-05-10 Cipla Ltd. Composition pharmaceutique pour administer des substances actives sur le plan pharmaceutique insolubles dans l'eau et procede de preparation afferent
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US6960563B2 (en) 2001-08-31 2005-11-01 Morton Grove Pharmaceuticals, Inc. Spontaneous emulsions containing cyclosporine
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US8802116B2 (en) 2003-02-27 2014-08-12 Novasel Australia Pty. Ltd. Poloxamer emulsion preparations
KR20040084240A (ko) * 2003-03-27 2004-10-06 (주) 코스메디 고형지질나노입자, 이를 함유하는 활성성분 전달용약학조성물 및 이의 제조방법
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KR20070069172A (ko) * 2004-10-29 2007-07-02 노파르티스 아게 자발적 분산성 약제학적 조성물
PL1885342T3 (pl) 2005-03-21 2016-10-31 Inhibitor krystalizacji i jego zastosowanie w kapsułkach żelatynowych
CN101032620B (zh) * 2007-03-08 2010-05-19 上海凯昭医药科技有限公司 一种环孢素自乳化制剂及其制备方法
US20090130198A1 (en) * 2007-11-21 2009-05-21 Innopharmax Inc. Pharmaceutical composition with enhanced bioavailability
BRPI0909185A2 (pt) 2008-03-20 2015-08-25 Virun Inc Derivado de vitamina e e seus usos
DK2548456T3 (en) 2008-03-20 2015-09-28 Virun Inc Emulsions including (comprising) a PEG derivative of tocopherol
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
JP5567909B2 (ja) * 2010-06-17 2014-08-06 東洋カプセル株式会社 タクロリムス含有カプセル剤
WO2011162802A1 (fr) 2010-06-21 2011-12-29 Virun, Inc. Compositions contenant des composés non polaires
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
JO3337B1 (ar) 2010-12-13 2019-03-13 Debiopharm Sa تركيبات صيدلية تشمل أليسبوريفير
JP5717034B2 (ja) * 2012-08-27 2015-05-13 丸和バイオケミカル株式会社 マクロライド系化合物を含有する土壌線虫防除用薬剤
KR101458466B1 (ko) * 2013-06-24 2014-11-07 한국화학연구원 면역억제제가 봉입된 마이셀을 함유하는 경구제
WO2016033556A1 (fr) 2014-08-28 2016-03-03 Lipocine Inc. Esters de (17-β)-hydroxy-4-androstène-3-one biodisponibles à l'état solide
WO2016033549A2 (fr) 2014-08-28 2016-03-03 Lipocine Inc. Compositions de (17-ss)-3-oxoandrost-4-èn-17-yl tridécanoate et leurs procédés de préparation et d'utilisation
US11260018B2 (en) 2015-09-17 2022-03-01 Jrx Biotechnology, Inc. Approaches for improving skin hydration and moisturization
CA3078723A1 (fr) 2016-11-28 2018-05-31 Nachiappan Chidambaram Traitement oral a base d'undecanoate de testosterone
RS64239B1 (sr) * 2018-11-26 2023-06-30 Hepion Pharmaceuticals Inc Farmaceutske formulacije analoga ciklosporina
WO2024014959A2 (fr) * 2022-07-15 2024-01-18 Seranovo Holding B.V. Formulations générant des micelles avec une hydrophobicité améliorée
WO2024014958A2 (fr) * 2022-07-15 2024-01-18 Seranovo Holding B.V. Plate-forme de formulation de lides
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Also Published As

Publication number Publication date
ITMI990452A1 (it) 2000-09-05
TR200002586T2 (tr) 2000-11-21
KR100443306B1 (ko) 2004-08-09
IL138248A0 (en) 2001-10-31
DE69920668D1 (de) 2004-11-04
HK1034038A1 (en) 2001-10-12
NZ506644A (en) 2004-02-27
CO4930289A1 (es) 2000-06-27
MY129274A (en) 2007-03-30
FR2775596B1 (fr) 2004-12-24
AU749217B2 (en) 2002-06-20
HUP0101080A2 (hu) 2001-08-28
HK1033277A1 (en) 2001-08-24
CA2322845A1 (fr) 1999-09-10
BE1013648A5 (fr) 2002-05-07
GB0021495D0 (en) 2000-10-18
JP2004189753A (ja) 2004-07-08
FR2775596A1 (fr) 1999-09-10
DE69920668T2 (de) 2005-10-06
GB2350791B (en) 2003-04-02
KR20010041657A (ko) 2001-05-25
BR9908597A (pt) 2000-11-14
EP1059913B1 (fr) 2004-09-29
TWI257870B (en) 2006-07-11
CA2322845C (fr) 2009-12-08
NO331800B1 (no) 2012-04-02
PE20000324A1 (es) 2000-04-13
FR2800277A1 (fr) 2001-05-04
WO1999044584A1 (fr) 1999-09-10
ES2228014T3 (es) 2005-04-01
GB2350791A (en) 2000-12-13
TWI236912B (en) 2005-08-01
DE19983012T1 (de) 2001-02-01
CN1195495C (zh) 2005-04-06
IT1313550B1 (it) 2002-09-09
TWI248368B (en) 2006-02-01
PT1059913E (pt) 2005-01-31
SK13192000A3 (sk) 2001-02-12
CZ20003222A3 (cs) 2000-12-13
FR2881956A1 (fr) 2006-08-18
FR2853546A1 (fr) 2004-10-15
IL138248A (en) 2006-06-11
FR2800277B1 (fr) 2004-06-25
CZ301967B6 (cs) 2010-08-18
ID25908A (id) 2000-11-09
BE1013423A5 (fr) 2002-01-15
AU2836199A (en) 1999-09-20
HUP0101080A3 (en) 2001-12-28
EP1059913A1 (fr) 2000-12-20
NO20004299D0 (no) 2000-08-29
ATE277599T1 (de) 2004-10-15
BE1012400A5 (fr) 2000-10-03
JP2002505271A (ja) 2002-02-19
AR015729A1 (es) 2001-05-16
CN1292684A (zh) 2001-04-25
NO20004299L (no) 2000-08-29
EP1354582A3 (fr) 2004-06-09
EP1354582A2 (fr) 2003-10-22
SK285139B6 (sk) 2006-07-07
TW200422057A (en) 2004-11-01

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