FR2847165A1 - Topical cosmetic or pharmaceutical compositions, containing nisin as non-irritating preservative having broad antimicrobial spectrum, also effective against greasy skin and acne - Google Patents
Topical cosmetic or pharmaceutical compositions, containing nisin as non-irritating preservative having broad antimicrobial spectrum, also effective against greasy skin and acne Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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Abstract
Description
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La présente invention a trait à l'utilisation de la Nisine, comme matière première utilisable dans des compositions cosmétiques, pharmaceutiques ou dermatologiques à usage topique, en tant qu'agent conservateur et plus particulièrement dans des compositions destinées à une application topique pour peaux grasses ou pour peaux sensibles. The present invention relates to the use of Nisin as a raw material for use in cosmetic, pharmaceutical or dermatological compositions for topical use, as a preservative and more particularly in compositions intended for topical application for oily or oily skin. for sensitive skin.
Il est courant d'introduire dans les compositions à usage topique, des conservateurs chimiques destinés à lutter contre le développement des microorganismes dans ces compositions. Il faut notamment protéger les compositions contre les micro-organismes susceptibles de se développer à l'intérieur de la composition et également contre ceux que l'utilisateur pourrait y introduire en la manipulant, en particulier lors de la préhension avec les doigts de produits conditionnés en pot. It is common to introduce into the compositions for topical use, chemical preservatives for combating the development of microorganisms in these compositions. In particular, it is necessary to protect the compositions against the microorganisms that can develop inside the composition and also against those that the user could introduce by manipulating it, in particular during the gripping with the fingers of products packaged in pot.
Des conservateurs chimiques couramment utilisés sont notamment les parabènes ou les composés libérateurs de formol, le trichlosan, la chorhexidine et ses sels, l'acide undecylenique et ses sels, l'octopirox, le phenoxyéthanol, l'hexamidine iséthionate, les dérivés de kétoconazole et tous les conservateurs faisant partie de la liste autorisée par la Communauté Européenne, listés au journal officiel. Commonly used chemical preservatives include parabens or formalin-releasing compounds, trichlosan, chorhexidine and its salts, undecylenic acid and its salts, octopirox, phenoxyethanol, hexamidine isethionate, ketoconazole derivatives and all the curators on the list authorized by the European Community, listed in the official journal.
Ces conservateurs présentent toutefois l'inconvénient de causer des irritations, en particulier sur les peaux sensibles, lorsqu'ils sont présents à des taux relativement importants. Comme autres conservateurs connus, on peut citer les hydroxyacides organiques. Mais ces composés peuvent également générer des irritations du fait de leur effet desquamant sur la peau. These preservatives, however, have the disadvantage of causing irritation, especially on sensitive skin, when they are present at relatively high rates. Other known preservatives include organic hydroxy acids. But these compounds can also cause irritation because of their desquamating effect on the skin.
Il subsiste donc le besoin d'agents conservateurs, notamment d'agents antimicrobiens, ayant une action au moins aussi efficace que les composés de l'art antérieur, mais n'en présentant pas les inconvénients. There therefore remains the need for preservatives, especially antimicrobial agents, having an action at least as effective as the compounds of the prior art, but without the disadvantages.
La Nisine, polypeptide contenant de la lanthinonine, est un peptide produit par le lactococcus lactis et utilisé comme conservateur dans le domaine de l'alimentation est connu pour avoir un large spectre d'activité antibactérienne. Nisin, a polypeptide containing lanthinonin, is a peptide produced by lactococcus lactis and used as a preservative in the field of diet is known to have a broad spectrum of antibacterial activity.
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La Nisine présente également une bonne solubilité et compatibilité avec les milieux couramment utilisés en cosmétique, les milieux aqueux notamment. Nisin also has good solubility and compatibility with the media commonly used in cosmetics, in particular aqueous media.
La Nisine répond à la formule générale 1 ci-dessous représentée : [CAS. 1414-45-5]
Abu = a-aminobutyric acid
Dha = dehydroalanine
Dhb = dehydrobutyrine
Sa masse moléculaire élevée (3400 Da) permet de réduire la risque de passage de la barrière transcutanée
La présente invention concerne l'utilisation de la Nisine, en tant qu'agent conservateur, seule ou en association avec d'autres conservateurs, dans des compositions cosmétiques et/ou pharmaceutiques à usage topique. Abu = a-aminobutyric acid
Dha = dehydroalanine
Dhb = dehydrobutyrine
Its high molecular weight (3400 Da) reduces the risk of transcutaneous barrier
The present invention relates to the use of Nisin, as a preservative, alone or in combination with other preservatives, in cosmetic and / or pharmaceutical compositions for topical use.
Elle concerne également une composition cosmétique ou pharmaceutique à usage topique, caractérisée en ce qu'elle comprend en tant qu'agent conservateur seul ou en association avec d'autres conservateurs dans un milieu physiologiquement acceptable, la Nisine. It also relates to a cosmetic or pharmaceutical composition for topical use, characterized in that it comprises as preservative alone or in combination with other preservatives in a physiologically acceptable medium, Nisin.
Elle concerne plus particulièrement une composition cosmétique ou pharmaceutique à usage topique, comprenant entre 0,0000001 à 10 % en poids de It relates more particularly to a cosmetic or pharmaceutical composition for topical use, comprising between 0.0000001 to 10% by weight of
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Nisine, de préférence entre 0,0001 et 5 % en poids de Nisine, par rapport au poids total de la composition. Nisin, preferably between 0.0001 and 5% by weight of Nisine, relative to the total weight of the composition.
Dans un mode préférentiel de réalisation, les compositions cosmétiques ou pharmaceutiques, selon l'invention, comprennent entre 0,001 et 0,1 % en poids de Nisine par rapport au poids total de la composition. In a preferred embodiment, the cosmetic or pharmaceutical compositions according to the invention comprise between 0.001 and 0.1% by weight of Nisine relative to the total weight of the composition.
On a constaté que, de manière surprenante et inattendue, la Nisine présentait de bonnes propriétés anti-microbiennes pour la conservation des formulations cosmétiques comme les émulsions, les lotions, que cela soit vis-à-vis des bactéries, des levures ou des champignons/moisissures, sans affecter les propriétés physiques desdites formulations. De par leur spectre anti-microbien, la Nisine peut donc être employée, notamment dans les compositions cosmétiques, comme agent antimicrobien, notamment comme agent anti-bactérien, comme agent anti-levure et/ou comme agent anti fongique seul ou en association avec d'autres conservateurs. It has been found that, surprisingly and unexpectedly, Nisin has good antimicrobial properties for the preservation of cosmetic formulations such as emulsions, lotions, whether against bacteria, yeasts or fungi. mold, without affecting the physical properties of said formulations. By their anti-microbial spectrum, Nisin can therefore be used, especially in cosmetic compositions, as an antimicrobial agent, especially as an anti-bacterial agent, as an anti-yeast agent and / or as an anti fungal agent alone or in combination with other preservatives.
De manière surprenante et inattendue, l'utilisation de la Nisine comme conservateur dans des compositions cosmétiques et/ou pharmaceutiques permet de potentialiser les effets d'autres actifs et de renforcer leur action. Surprisingly and unexpectedly, the use of Nisin as a preservative in cosmetic and / or pharmaceutical compositions makes it possible to potentiate the effects of other active ingredients and to enhance their action.
L'invention concerne également des compositions cosmétiques et/ou pharmaceutiques à action cicatrisante, comprenant de la Nisine et en association avec des oligonucléotides ou nucléotides, et plus particulièrement la diguanosine tetraphosphate. The invention also relates to cosmetic and / or pharmaceutical compositions with healing action, comprising Nisin and in combination with oligonucleotides or nucleotides, and more particularly diguanosine tetraphosphate.
Dans les compositions destinées au traitement des peaux grasses et acnéiques, on note une diminution de la quantité de sébum et une diminution de l'apparition de boutons. In compositions for the treatment of oily and acne skin, there is a decrease in the amount of sebum and a decrease in the appearance of pimples.
Les compositions présentent ainsi une activité antiséborréhique, améliorée du fait de la présence de Nisine. The compositions thus have an antiseborrhetic activity, improved because of the presence of Nisin.
L'invention concerne également des compositions cosmétiques destinées au traitement des peaux grasses et acnéiques comprenant de la Nisine. The invention also relates to cosmetic compositions for the treatment of oily and acne skin comprising Nisin.
Elle concerne plus particulièrement des compositions cosmétiques destinées au traitement des peaux grasses et acnéiques comprenant de 0,000001 à 10 % en poids de Nisine par rapport au poids total de la composition, de préférence de 0,0001 à 5 % et plus particulièrement de 0,001 à 0,1 % en poids de Nisine par rapport au poids total de la composition. It relates more particularly to cosmetic compositions intended for the treatment of oily and acneic skin comprising from 0.000001 to 10% by weight of Nisin relative to the total weight of the composition, preferably from 0.0001 to 5% and more particularly from 0.001 to 0.1% by weight of Nisine relative to the total weight of the composition.
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De manière avantageuse, la tolérance des produits topiques ainsi fabriqués est grandement améliorée. En effet l'un des inconvénients majeur des produits actifs sur les micro-organismes responsables de l'acné est la mauvaise tolérance cutanée. Advantageously, the tolerance of the topical products thus manufactured is greatly improved. Indeed, one of the major drawbacks of the active products on the micro-organisms responsible for acne is poor skin tolerance.
Il se trouve que dans le cadre de l'invention, les produits sont efficaces sans être irritants pour la muqueuse cutanée. It is found that in the context of the invention, the products are effective without being irritating to the cutaneous mucosa.
Les compositions comprenant la Nisine également comprennent un milieu cosmétiquement ou pharmaceutiquement acceptable, c'est-à-dire compatible avec la peau, les muqueuses, les cheveux et le cuir chevelu. Elles peuvent se présenter sous toutes les formes galéniques appropriées pour une application topique, notamment sous forme de solution aqueuse, hydroalcoolique, organique ou huileuse; de suspension ou de dispersion dans des solvants ou des corps gras, de type lotion ou sérum ; forme de dispersion vésiculaire; sous forme d'émulsion E/H, HIE ou multiple telle qu'une crème ou un lait; sous forme de pommade, de gel, de bâtonnet solide, de produits anhydres pâteux ou solides, de mousse notamment aérosol ou de spray. Compositions comprising Nisin also comprise a cosmetically or pharmaceutically acceptable medium, that is to say compatible with the skin, the mucous membranes, the hair and the scalp. They may be in any of the galenic forms suitable for topical application, especially in the form of aqueous, hydroalcoholic, organic or oily solution; suspension or dispersion in solvents or fatty substances, of lotion or serum type; vesicular dispersion form; in the form of W / O, HIE or multiple emulsion such as cream or milk; in the form of ointment, gel, solid stick, anhydrous pasty or solid products, foam, especially aerosol or spray.
Le milieu physiologiquement acceptable dans lequel la Nisine peut être employée, ainsi que ses constituants, leur quantité, la forme galénique de la composition et son mode de préparation, peuvent être choisis par l'homme du métier sur la base de ses connaissances générales en fonction du type de composition recherchée. The physiologically acceptable medium in which Nisin may be employed, as well as its constituents, their amount, the dosage form of the composition and its method of preparation, may be selected by one skilled in the art on the basis of his general knowledge in function the type of composition sought.
Notamment, la composition peut comprendre tout corps gras usuellement utilisé dans le domaine d'application envisagé. On peut notamment citer les corps gras siliconés tels que les huiles, les gommes et les cires de silicone, ainsi que les corps gras non siliconés tels que les huiles et les cires d'origine végétale, minérale, animale et/ou synthétique. Les huiles peuvent éventuellement être volatiles ou non volatiles. On peut encore citer les hydrocarbures, les esters et les éthers de synthèse, les alcools gras et les acides gras. La composition peut également comprendre un milieu aqueux, un milieu hydro-alcoolique contenant un alcool tel que l'éthanol ou l'isopropanol, ou un milieu organique comprenant des solvants organiques usuels tels que des alcools en C1-C6, notamment l'éthanol et l'isopropanol, des glycols tels que le propylène glycol, des cétones. In particular, the composition may comprise any fatty substance usually used in the intended field of application. Mention may in particular be made of silicone fatty substances such as oils, gums and silicone waxes, as well as non-silicone fatty substances such as oils and waxes of vegetable, mineral, animal and / or synthetic origin. The oils may optionally be volatile or non-volatile. Mention may also be made of hydrocarbons, esters and synthetic ethers, fatty alcohols and fatty acids. The composition may also comprise an aqueous medium, an alcohol-alcoholic medium containing an alcohol such as ethanol or isopropanol, or an organic medium comprising usual organic solvents such as C 1 -C 6 alcohols, in particular ethanol and isopropanol, glycols such as propylene glycol, ketones.
La composition peut comprendre au moins un émulsionnant classique, choisi parmi les émulsionnants amphotères, anioniques, cationiques ou non ioniques, utilisés seuls ou en mélange. The composition may comprise at least one conventional emulsifier chosen from amphoteric, anionic, cationic or nonionic emulsifiers, used alone or as a mixture.
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Elle peut également comprendre les adjuvants habituels dans le domaine considéré, tels que les épaississants ou gélifiants hydrophiles ou lipophiles, les additifs hydrophiles ou lipophiles, les actifs notamment cosmétiques, les conservateurs, les antioxydants, les parfums, les charges, les pigments, les filtres UV, les absorbeurs d'odeur, les colorants, les hydratants (glycérine), des vitamines, des acides gras essentiels, des polymères liposolubles notamment hydrocarbonés, les opacifiants, les stabilisants, les séquestrants, les conditionneurs, les agents propulseurs. It may also comprise the usual adjuvants in the field under consideration, such as hydrophilic or lipophilic thickeners or gelling agents, hydrophilic or lipophilic additives, especially cosmetic actives, preservatives, antioxidants, perfumes, fillers, pigments, filters. UV, odor absorbers, dyes, moisturizers (glycerine), vitamins, essential fatty acids, liposoluble polymers including hydrocarbon, opacifiers, stabilizers, sequestering agents, conditioners, propellants.
Bien entendu l'homme du métier veillera à choisir ce ou ces éventuels adjuvants complémentaires et/ou leur quantité de manière telle que les propriétés avantageuses de la composition selon l'invention ne soient pas, ou substantiellement pas, altérées par l'adjonction envisagée. Of course the skilled care to select this or these optional additional adjuvants and / or their amount so that the advantageous properties of the composition according to the invention are not, or not substantially impaired by the addition envisaged.
La Nisine présente une activité anti-microbienne, notamment une activité anti- bactérienne et anti-fongique, remarquable, elle trouve donc une application toute particulière dans des compositions pouvant se présenter : - sous la forme d'un produit de maquillage de la peau du visage, du corps ou des lèvres, tel qu'un fond de teint, un fard à joues ou à paupières, un stick anti- cernes, un stick camouflant, un eye-liner, un mascara, un rouge à lèvres, un vernis à ongles, un soin des ongles, - sous la forme d'un produit de soin dermatologique ou cosmétique de la peau du visage, du corps y compris le cuir chevelu, des lèvres, tel qu'une base de soin pour les lèvres, une base fixante à appliquer sur un rouge à lèvres classique, une composition de protection solaire ou de bronzage artificiel ; produit déodorant ; composition de soin (de jour, de nuit, anti-rides, hydratante, etc. ) pour le visage; une composition matifiante pour le visage ; un gel ou une crème de nettoyage ou de démaquillage; un lait corporel de protection ou de soin; un lait purifiant, - sous la forme d'une composition désodorisante ; d'ungel ou lotion après- rasage; d'une crème dépilatoire, - sous la forme d'une composition pharmaceutique, - sous la forme d'une composition solide telle qu'un savon - sous la forme d'une composition pour aérosol comprenant également un agent propulseur sous pression, - sous la forme d'une composition pour soins capillaires, et notamment un shampooing, une lotion de mise en plis, une lotion traitante, une crème ou un gel coiffant, une composition de teinture (notamment d'oxydation) éventuellement sous Nisin has anti-microbial activity, especially antibacterial and anti-fungal activity, remarkable, it therefore finds a very particular application in compositions that can be: - in the form of a makeup product of the skin of the face, body or lips, such as a foundation, a blush or eyeshadow, a concealer, a camouflaging stick, an eyeliner, a mascara, a lipstick, a nail varnish nails, nail care, - in the form of a dermatological or cosmetic care product for the skin of the face, the body including the scalp, lips, such as a base for care of the lips, a base fixative for applying to a conventional lipstick, a sunscreen or artificial tanning composition; deodorant product; care composition (day, night, anti-wrinkle, moisturizing, etc.) for the face; a mattifying composition for the face; a gel or a cream for cleaning or removing make-up; body milk for protection or care; a purifying milk, in the form of a deodorizing composition; ungel or aftershave; a depilatory cream, - in the form of a pharmaceutical composition, - in the form of a solid composition such as a soap - in the form of an aerosol composition also comprising a propellant under pressure, - under the form of a composition for hair care, and in particular a shampoo, a setting lotion, a treatment lotion, a cream or a styling gel, a dyeing composition (in particular oxidation) possibly under
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forme de shampooing colorant, de lotion restructurante pour cheveux, une composition pour permanente, une lotion ou un gel antichute, un shampooing antiparasitaire ; une lotion ou un shampooing antipelliculaire; un shampooing traitant notamment anti-séborrhéique, - sous la forme d'une composition à usage bucco-dentaire, par exemple une pâte dentifrice. dye shampoo form, restructuring hair lotion, permanent composition, anti-fall lotion or gel, pest control shampoo; an anti-dandruff lotion or shampoo; a shampoo including anti-seborrheic treating, - in the form of a composition for oral use, for example a toothpaste.
Des tests de conservations ont été réalisés, ces tests appelés challenge tests, où les produits sont contaminés volontairement par des inoculum calibrés, sont destinés à vérifier l'efficacité du système de conservation. Conservation tests have been carried out, these tests called challenge tests, where products are voluntarily contaminated by calibrated inoculum, are intended to verify the effectiveness of the conservation system.
Lorsque les compositions testées comprennent de la Nisine, celle-ci a été incorporée à raison de 0,005 % en poids par rapport au poids total de la composition. When the compositions tested comprise Nisin, it was incorporated at a rate of 0.005% by weight relative to the total weight of the composition.
Crème A : Base 1 et conservateurs 1
Crème B : Base 1 et conservateurs 1 + nisine
Crème C : Base 1 et nisine
Crème D : Base 2 et conservateurs 2
Crème E : Base 2 et conservateurs 2 + nisine
Crème F : Base 2 et nisine
Cream B: Base 1 and preservatives 1 + nisin
Cream C: Base 1 and Nisin
Cream D: Base 2 and preservatives 2
Cream E: Base 2 and preservatives 2 + nisin
Cream F: Base 2 and Nisin
<tb>
<tb> Bactéries <SEP> Levures <SEP> Moisissures
<tb> CrèmeA <SEP> 14 <SEP> 21 <SEP> > <SEP> 28
<tb> Crème <SEP> B <SEP> 7 <SEP> 21 <SEP> > <SEP> 28
<tb> Crème <SEP> C <SEP> > <SEP> 28 <SEP> > <SEP> 28j <SEP> > <SEP> 28
<tb> Crème <SEP> D <SEP> 7 <SEP> 28j <SEP> > <SEP> 28 <SEP> J
<tb> Crème <SEP> E <SEP> 1 <SEP> 14 <SEP> 21
<tb> Crème <SEP> F <SEP> 3j <SEP> 21j <SEP> 21 <SEP> j
<tb> <Tb>
<tb> Bacteria <SEP> Yeasts <SEP> Molds
<tb> CreamA <SEP> 14 <SEP> 21 <SEP>><SEP> 28
<tb> Cream <SEP> B <SEP> 7 <SEP> 21 <SEP>><SEP> 28
<tb> Cream <SEP> C <SEP>><SEP> 28 <SEP>><SEP> 28d <SEP>><SEP> 28
<tb> Cream <SEP> D <SEP> 7 <SEP> 28d <SEP>><SEP> 28 <SEP> J
<tb> Cream <SEP> E <SEP> 1 <SEP> 14 <SEP> 21
<tb> Cream <SEP> F <SEP> 3d <SEP> 21d <SEP> 21 <SEP> j
<Tb>
On note un allongement significatif du temps nécessaire à la disparition des colonies correspondant aux différents microorganismes contenus dans les inoculums utilisés. There is a significant increase in the time required for the disappearance of the colonies corresponding to the various microorganisms contained in the inocula used.
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La présente invention est illustrée plus en détails dans les exemples suivants. The present invention is further illustrated in the following examples.
Exemple 1 : crème de soin - Tristéarate de sorbitane 1 - Nisine.............................................................................. 0.00015% - Homopolymère carboxyvinylique ................................... 0,4% - Gomme de xanthane ...................................................... 0,5% - Copolymère diméthacrylate d'éthylèneglycol/méthacrylate de lauryle ........................ 1% - Cyclopentadiméthylsiloxane ........................................... 6% - Glycérine......................................................................... 3% - Emulsionnant.................................................................. 4% - Parfum qsp - Eau déminéralisée .......................................................... qsp 100% Exemple 2 : lotion - Nisine.............................................................................. 0.0002% - Glycérine......................................................................... 2% - Alcool éthylique............................................................... 2% - Cétrimide BP................................................................... 0.4% - Butanol oxyéthyléné (260E) oxypropyléné (260P), huile de ricin hydrogénée oxyéthylénée (40 OE) dans l'eau ....................................................................... 1% - Eau déminéralisée .......................................................... qsp 100% Exemple 3 : Crème de traitement des peaux grasses - Nisine.............................................................................. 0.0004% - Glycérine......................................................................... 2% - Cétrimide BP................................................................... 0. 4% - Sulfate de Zinc................................................................ 0.05% - Gluconate de Zinc.......................................................... 0.1 % - Vitamine B6 .................................................................... 0.01% - Diguanosine Tetraphosphate.......................................... 0.0001%
- Salcare 91 .................................................................... 1 /o - Eau déminéralisée.......................................................... qsp 100%Example 1: Care Cream - Sorbitan Tristearate 1 - Nisine ..................................... ......................................... 0.00015% - Carboxylic homopolymer .... ............................... 0,4% - Xanthan gum ........... ........................................... 0,5% - Dimethacrylate Copolymer ethylene glycol / lauryl methacrylate ....................... 1% - Cyclopentadimethylsiloxane ............... ............................ 6% - Glycerin .................. .................................................. ..... 3% - Emulsifier ......................................... ......................... 4% - Perfume qsp - Demineralized water ................. ......................................... qs 100% Example 2: lotion - Nisin .................................................. ............................ 0.0002% - Glycerin .................. .................................................. ..... 2% - Ethyl alcohol ............... ................................................ 2% - Cetimide BP ............................................... .................... 0.4% - Butylated oxyethylenated (260E) oxypropylene (260P), hydrogenated castor oil oxyethylenated (40 EO) in water .... .................................................. ................. 1% - Demineralized water ............................ .............................. qs 100% Example 3: Cream for the treatment of oily skin - Nisin ...... .................................................. ...................... 0.0004% - Glycerine ........................ ................................................. 2 % - Cetimide BP .............................................. ..................... 0. 4% - Zinc Sulfate ..................... ........................................... 0.05% - Zinc Gluconate. .................................................. ....... 0.1% - Vitamin B6 ...................................... ............................ .. 0.01% - Diguanosine Tetraphosphate .......................................... 0.0001 %
- Salcare 91 ............................................... ..................... 1 / o - Demineralized water ....................... ................................... qs 100%
Claims (6)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0214774A FR2847165A1 (en) | 2002-11-15 | 2002-11-15 | Topical cosmetic or pharmaceutical compositions, containing nisin as non-irritating preservative having broad antimicrobial spectrum, also effective against greasy skin and acne |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0214774A FR2847165A1 (en) | 2002-11-15 | 2002-11-15 | Topical cosmetic or pharmaceutical compositions, containing nisin as non-irritating preservative having broad antimicrobial spectrum, also effective against greasy skin and acne |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2847165A1 true FR2847165A1 (en) | 2004-05-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR0214774A Withdrawn FR2847165A1 (en) | 2002-11-15 | 2002-11-15 | Topical cosmetic or pharmaceutical compositions, containing nisin as non-irritating preservative having broad antimicrobial spectrum, also effective against greasy skin and acne |
Country Status (1)
| Country | Link |
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| FR (1) | FR2847165A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2954140A1 (en) * | 2009-12-17 | 2011-06-24 | Oreal | COSMETIC OR DERMATOLOGICAL COMPOSITIONS BASED ON BACTERIOCINS AND PREBIOTICS |
| PL424179A1 (en) * | 2018-01-03 | 2019-07-15 | Prof. Cosmetica Spółka Z Ograniczoną Odpowiedzialnością | Emulsion preservation system and cosmetic gels containing the anti-oxidative complex of active components and nisin peptide |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991007164A1 (en) * | 1989-11-16 | 1991-05-30 | Beiersdorf Ag | Cosmetic deodorants |
| EP0466244A1 (en) * | 1990-07-13 | 1992-01-15 | Unilever N.V. | Compositions having antibacterial properties and use of such compositions in suppressing growth of microorganisms, eg. Listeria bacteria |
| EP0545911A2 (en) * | 1988-06-22 | 1993-06-09 | Applied Microbiology, Inc. | Lanthionine-containing bacteriocin compositions for use as bactericides |
| DE4229707A1 (en) * | 1992-09-05 | 1994-03-10 | Beiersdorf Ag | Germicide drug combinations |
| US5945111A (en) * | 1992-11-18 | 1999-08-31 | Unilever Patent Holdings B.V. | Method for applying a cosmetic agent by electrostatic spraying |
| US5981473A (en) * | 1996-09-13 | 1999-11-09 | Clemson University | Composition and method for treating acne |
| KR20000038940A (en) * | 1998-12-10 | 2000-07-05 | 성재갑 | Composition containing nisin and salix bark extract for oral hygiene improvement |
| DE19962881A1 (en) * | 1999-12-24 | 2001-06-28 | Henkel Kgaa | Water-based antiperspirant composition comprises at least two water-soluble polysaccharides, a water-soluble astringent and a wax |
-
2002
- 2002-11-15 FR FR0214774A patent/FR2847165A1/en not_active Withdrawn
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0545911A2 (en) * | 1988-06-22 | 1993-06-09 | Applied Microbiology, Inc. | Lanthionine-containing bacteriocin compositions for use as bactericides |
| WO1991007164A1 (en) * | 1989-11-16 | 1991-05-30 | Beiersdorf Ag | Cosmetic deodorants |
| EP0466244A1 (en) * | 1990-07-13 | 1992-01-15 | Unilever N.V. | Compositions having antibacterial properties and use of such compositions in suppressing growth of microorganisms, eg. Listeria bacteria |
| DE4229707A1 (en) * | 1992-09-05 | 1994-03-10 | Beiersdorf Ag | Germicide drug combinations |
| US5945111A (en) * | 1992-11-18 | 1999-08-31 | Unilever Patent Holdings B.V. | Method for applying a cosmetic agent by electrostatic spraying |
| US5981473A (en) * | 1996-09-13 | 1999-11-09 | Clemson University | Composition and method for treating acne |
| KR20000038940A (en) * | 1998-12-10 | 2000-07-05 | 성재갑 | Composition containing nisin and salix bark extract for oral hygiene improvement |
| DE19962881A1 (en) * | 1999-12-24 | 2001-06-28 | Henkel Kgaa | Water-based antiperspirant composition comprises at least two water-soluble polysaccharides, a water-soluble astringent and a wax |
Non-Patent Citations (4)
| Title |
|---|
| C. VALENTA & AL.: "Nisin, ein potentielles Konservierungsmittel in topischen Zubereitungen", PHARMAZIE, vol. 51, no. 2, 1996, pages 119 - 122, XP001153371 * |
| DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KIM, MUN MU ET AL: "Composition containing nisin and Salix bark extract for oral hygiene improvement", XP002248032, retrieved from STN Database accession no. 136:156228 * |
| J.A. WENNINGER, R.C. CANTERBERY, G.N. MCEWEN: "International Cosmetic Ingredient Dictionary and Handbook", 2000, THE COSMETIC, TOILETRY AND FRAGRANCE ASSOCIATION, XP002248031 * |
| VALENTA, CLAUDIA ET AL: "Chitosan-EDTA conjugate: a novel polymer for topical gels", JOURNAL OF PHARMACY AND PHARMACOLOGY (1998), 50(5), 445-452, XP009013808 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2954140A1 (en) * | 2009-12-17 | 2011-06-24 | Oreal | COSMETIC OR DERMATOLOGICAL COMPOSITIONS BASED ON BACTERIOCINS AND PREBIOTICS |
| WO2011073437A3 (en) * | 2009-12-17 | 2012-08-23 | L'oreal | Bacteriocin- and prebiotic-based cosmetic or dermatological compositions |
| PL424179A1 (en) * | 2018-01-03 | 2019-07-15 | Prof. Cosmetica Spółka Z Ograniczoną Odpowiedzialnością | Emulsion preservation system and cosmetic gels containing the anti-oxidative complex of active components and nisin peptide |
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| CL | Concession to grant licences | ||
| AU | Other action affecting the ownership or exploitation of an industrial property right | ||
| ST | Notification of lapse |
Effective date: 20080930 |