FR2882928A1 - Cosmetic composition, useful to regenerate, restructure and stimulate derma, comprises palmitoyl-3-pentapeptide in combination with Centella asiatica extract - Google Patents
Cosmetic composition, useful to regenerate, restructure and stimulate derma, comprises palmitoyl-3-pentapeptide in combination with Centella asiatica extract Download PDFInfo
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- FR2882928A1 FR2882928A1 FR0502352A FR0502352A FR2882928A1 FR 2882928 A1 FR2882928 A1 FR 2882928A1 FR 0502352 A FR0502352 A FR 0502352A FR 0502352 A FR0502352 A FR 0502352A FR 2882928 A1 FR2882928 A1 FR 2882928A1
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- centella asiatica
- pentapeptide
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- whey protein
- palmitoyl pentapeptide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
Description
La présente invention a pour objet de nouvelles compositionsThe present invention relates to new compositions
régénératrices, restructurantes et stimulantes du derme, utilisables pour luter contre le vieillissement cutané, les cicatrices et autres phénomènes dégénérants et destructurants. regenerative, restructuring and stimulating the dermis, used to fight against skin aging, scars and other degenerating and destructuring phenomena.
Pour agir efficacement contre ces phénomènes, les actifs utilisés en cosmétique doivent avoir des effets conjugués et notamment un effet régénérant, un effet restructurant et un effet stimulant grâce à une action immédiate en surface. To act effectively against these phenomena, the active ingredients used in cosmetics must have combined effects and in particular a regenerating effect, a restructuring effect and a stimulating effect thanks to an immediate action on the surface.
Les actifs actuellement utilisés pour lutter contre le vieillissement ont fréquemment des effets secondaires irritants qui freinent leur utilisation potentielle notamment dans les produits solaires que ceux-ci soient destinés à une application pendant l'exposition ou après l'exposition pour apaiser et réparer et dans les cosmétiques destinés aux peaux fragiles et irritatives. The active ingredients currently used to fight against aging frequently have irritating side effects which slow down their potential use, especially in solar products, which are intended for application during exposure or after exposure to soothe and repair and in the cosmetics for fragile and irritated skin.
Or, le demandeur a constaté que l'on parvenait à atteindre ces objectifs de réparation sans irritation en utilisant en association un peptide, le palmitoyl pentapeptide-3 (dénomination INCI), qui résulte de la réaction de l'acide palmitique et d'un peptide synthétique comprenant des restes Lysine, Thréonine et Sérine, commercialisé sous la marque Matrixyl par la société Sederma, et des extraits de la plante dénommée Centella asiatica (dénomination INCI), par exemple l'extrait commercialisé par la société Cognis sous la marque Herbalia Centella . However, the Applicant has found that it is possible to achieve these repair objectives without irritation by using in combination a peptide, palmitoyl pentapeptide-3 (INCI name), which results from the reaction of palmitic acid and a synthetic peptide comprising residues Lysine, Threonine and Serine, sold under the tradename Matrixyl by Sederma, and extracts of the plant called Centella asiatica (INCI name), for example the extract sold by Cognis under the trademark Herbalia Centella .
Le palmitoyl pentapeptide-3 est un actif, qui permet la réparation de la matrice et de la jonction dermo-épidermique et aboutit au comblement de rides, il permet également de favoriser l'expression des gènes de la cicatrisation. Son action promotrice de la synthèse de collagène I et III et de fibronectine a été démontrée in vitro et ex vivo sur expiant de peau humaine en comparaison de la vitamine C. La stimulation de la synthèse de collagène IV sur fibroblastes âgés et la synthèse de glycosaminoglycannes sur fibroblastes ont également été mises en évidence. . Palmitoyl pentapeptide-3 is an active ingredient, which allows the repair of the matrix and the dermal-epidermal junction and leads to the filling of wrinkles, it also helps to promote the expression of genes for healing. Its promoting action on the synthesis of collagen I and III and fibronectin has been demonstrated in vitro and ex vivo on human skin explant in comparison with vitamin C. The stimulation of collagen IV synthesis on aged fibroblasts and the synthesis of glycosaminoglycans on fibroblasts have also been highlighted. .
Centella asiatica est connue en Asie pour l'activité de certains de ses extraits, notamment en cicatrisation par activation de la biosynthèse du collagène et de l'élastine, et dans le traitement des ulcères variqueux et insuffisances veineuses,. L'administration se fait par voie orale ou topique. Centella asiatica is known in Asia for the activity of some of its extracts, particularly in healing by activation of the biosynthesis of collagen and elastin, and in the treatment of varicose ulcers and venous insufficiency. Administration is oral or topical.
L'association de ces deux actifs permet d'atteindre des résultats jamais atteints et surtout d'obtenir une véritable action de réparation et de prévention du vieillissement cutané, notamment sur les zones les plus exposées du visage et du corps. The combination of these two assets allows to achieve results never achieved and especially to obtain a real action of repair and prevention of skin aging, especially in the most exposed areas of the face and body.
Il est également possible d'améliorer encore les effets en combinant avec le palmitoyl pentapeptide-3, et/ou avec l'association palmitoyl pentapeptide-3 et Centella asiatica, un autre peptide dénommé Whey Protein (dénomination INCI), qui est un polypeptide obtenu à partir de la partie liquide du lait après séparation du caillé, commercialisé par exemple par la société Milei GmbH sous la marque Milveta-WPC . It is also possible to further improve the effects by combining with palmitoyl pentapeptide-3, and / or with the combination palmitoyl pentapeptide-3 and Centella asiatica, another peptide called Whey Protein (INCI name), which is a polypeptide obtained from the liquid part of the milk after separation of the curd, marketed for example by the company Milei GmbH under the trademark Milveta-WPC.
La présente invention concerne ainsi des compositions cosmétiques pour la régénération, la restructuration et la stimulation du derme, comprenant le palmitoyl pentapeptide-3 associé à un extrait de Centella asiatica. The present invention thus relates to cosmetic compositions for the regeneration, restructuring and stimulation of the dermis, comprising palmitoyl pentapeptide-3 combined with an extract of Centella asiatica.
Elle concerne également des compositions selon l'invention caractérisées en ce qu'elles contiennent en outre le peptide de lait, Whey Protein. It also relates to compositions according to the invention characterized in that they additionally contain the milk peptide, Whey Protein.
Bien entendu des compositions sont caractérisées en ce que le ou les produits actifs sont associés à une base cosmétique. Naturally, compositions are characterized in that the active product or products are associated with a cosmetic base.
Plus précisément les compositions selon l'invention sont, caractérisées en ce qu'elles contiennent de 0,01 à 10 % de Centella asiatica, 10-8 à 10- 2 % de palmitoyl pentapeptide-3, et 0 à 0,1 % de Whey Protein. More specifically, the compositions according to the invention are characterized in that they contain from 0.01 to 10% of Centella asiatica, 10-8 to 10-2% of palmitoyl pentapeptide-3, and 0 to 0.1% of Whey Protein.
Dans une forme de réalisation elles sont caractérisées en ce qu'elles contiennent: 0,5 à 3 % de Centella asiatica 10-8 à 10-5 % palmitoyl pentapeptide-3 5 0,01 à 0,1 % de Whey Protein Dans une forme de réalisation des compositions selon l'invention, l'extrait de Centella asiatica est un extrait glycolique de la partie antérieure de la plante. In one embodiment, they are characterized in that they contain: 0.5 to 3% Centella asiatica 10-8 to 10-5% palmitoyl pentapeptide-3 0.01 to 0.1% Whey Protein In a As an embodiment of the compositions according to the invention, the Centella asiatica extract is a glycolic extract from the anterior part of the plant.
L'invention concerne également l'utilisation du palmitoyl pentapeptide-3 associé à un extrait de Centella asiatica, pour la formulation de compositions cosmétiques destinées à la réparation tissulaire cutanée. The invention also relates to the use of palmitoyl pentapeptide-3 combined with an extract of Centella asiatica, for the formulation of cosmetic compositions intended for cutaneous tissue repair.
Elle concerne également l'utilisation ci-dessus citée en association avec l'utilisation du peptide de lait, Whey Protein Elle concerne plus particulièrement l'utilisation des ces actifs dans des proportions pondérales de 0,01 à 10 % de Centella asiatica, 10-8 à 10"2 % de palmitoyl pentapeptide-3 et 0 à 0,1 % de Whey Protein. It also relates to the use mentioned above in association with the use of the milk peptide, Whey Protein It relates more particularly to the use of these active ingredients in proportions by weight of 0.01 to 10% Centella asiatica, 10- 8 to 10 -2% palmitoyl pentapeptide-3 and 0 to 0.1% Whey Protein.
Ou dans une forme de réalisation dans les proportions pondérales de: 0,5 à 3 % de Centella asiatica 10-8 à 10-5 % palmitoyl pentapeptide-3 0,01 à 0,1 % de Whey Protein II a pu être mis en évidence que, non seulement les associations décrites préalablement, assuraient un renforcement et une potentialisation des constituants de l'association, mais que l'on obtenait en outre une remarquable régulation de leur activité et une facilité de maîtrise des réparations tissulaires sans effets secondaires nocifs. Or in one embodiment in the weight proportions of: 0.5 to 3% Centella asiatica 10-8 to 10-5% palmitoyl pentapeptide-3 0.01 to 0.1% Whey Protein II could be evidence that not only the associations previously described, provided a strengthening and potentiation of the constituents of the association, but that we also obtained a remarkable regulation of their activity and ease of control of tissue repairs without harmful side effects.
Les compositions selon l'invention comprennent un milieu cosmétiquement, diététiquement ou pharmaceutiquement acceptable, c'est-à-dire compatible avec la peau, les muqueuses, les cheveux et le cuir chevelu ou l'organisme en général. Elles peuvent se présenter sous toutes les formes galéniques appropriées pour une application topique, notamment sous forme de solution aqueuse, hydroalcoolique, organique ou huileuse, de suspension ou de dispersion dans des solvants ou des corps gras, de type lotion ou sérum; sous forme de dispersion vésiculaire; sous forme d'émulsion E/H, H/E ou multiple telle qu'une crème ou un lait; sous forme de pommade, de gel, de bâtonnet solide, de produits anhydres pâteux ou solides; sous forme de mousse notamment aérosol ou de spray ou sous une forme galénique comme les gélules, capsules ou comprimés adaptée pour une utilisation en diététique. The compositions according to the invention comprise a cosmetically, dietetically or pharmaceutically acceptable medium, that is to say compatible with the skin, the mucous membranes, the hair and the scalp or the body in general. They may be in any suitable dosage form for topical application, especially in the form of an aqueous solution, hydroalcoholic, organic or oily, suspension or dispersion in solvents or fats, lotion or serum type; as a vesicular dispersion; in the form of W / O, O / W or multiple emulsion such as cream or milk; in the form of ointment, gel, solid stick, anhydrous pasty or solid products; in the form of foam, especially aerosol or spray or in a dosage form such as capsules, capsules or tablets adapted for use in dietetics.
Le milieu physiologiquement acceptable dans lequel les composés peuvent être employés, ainsi que ses constituants, leur quantité, la forme galénique de la composition et son mode de préparation, peuvent être choisis par l'homme du métier sur la base de ses connaissances générales en fonction du type de composition recherchée et l'incorporation des actifs, dans les compositions, est réalisée par tous procédés classiquement utilisés par l'homme de l'art. The physiologically acceptable medium in which the compounds may be employed, as well as its constituents, their quantity, the galenic form of the composition and its method of preparation, may be chosen by those skilled in the art on the basis of their general knowledge in function the type of composition sought and the incorporation of the active ingredients in the compositions is carried out by any method conventionally used by those skilled in the art.
Notamment, la composition peut comprendre tout corps gras usuellement utilisé dans le domaine d'application envisagé. On peut notamment citer les corps gras siliconés tels que les huiles, les gommes et les cires de silicone, ainsi que les corps gras non siliconés tels que les huiles et les cires d'origine végétale, minérale, animale et/ou synthétique. Les huiles peuvent éventuellement être volatiles ou non volatiles. On peut encore citer les hydrocarbures, les esters et les éthers de synthèse, les alcools gras et les acides gras. La composition peut également comprendre un milieu aqueux, un milieu hydro-alcoolique contenant un alcool tel que l'éthanol ou l'isopropanol, ou un milieu organique comprenant des solvants organiques usuels tels que des alcools en C1_6, notamment l'éthanol et l'isopropanol, des glycols tels que le propylène glycol, des cétones. In particular, the composition may comprise any fatty substance usually used in the intended field of application. Mention may in particular be made of silicone fatty substances such as oils, gums and silicone waxes, as well as non-silicone fatty substances such as oils and waxes of vegetable, mineral, animal and / or synthetic origin. The oils may optionally be volatile or non-volatile. Mention may also be made of hydrocarbons, esters and synthetic ethers, fatty alcohols and fatty acids. The composition may also comprise an aqueous medium, an alcohol-alcoholic medium containing an alcohol such as ethanol or isopropanol, or an organic medium comprising common organic solvents such as C1-C6 alcohols, in particular ethanol and ethyl alcohol. isopropanol, glycols such as propylene glycol, ketones.
La composition peut comprendre au moins un émulsionnant classique, choisi parmi les émulsionnants amphotères, anioniques, cationiques ou non ioniques, utilisés seuls ou en mélange. The composition may comprise at least one conventional emulsifier chosen from amphoteric, anionic, cationic or nonionic emulsifiers, used alone or as a mixture.
Elle peut également comprendre les adjuvants habituels dans le domaine considéré, tels que les épaississants ou gélifiants hydrophiles ou lipophiles, les additifs hydrophiles ou lipophiles, les actifs notamment cosmétiques, les conservateurs, les antioxydants, les parfums, les charges, les pigments, les filtres UV, les absorbeurs d'odeur, les colorants, les hydratants (glycérine), des vitamines, des acides gras essentiels, des polymères liposolubles notamment hydrocarbonés, les opacifiants, les stabilisants, les séquestrants, les conditionneurs, les agents propulseurs. It may also comprise the usual adjuvants in the field under consideration, such as hydrophilic or lipophilic thickeners or gelling agents, hydrophilic or lipophilic additives, especially cosmetic actives, preservatives, antioxidants, perfumes, fillers, pigments, filters. UV, odor absorbers, dyes, moisturizers (glycerine), vitamins, essential fatty acids, liposoluble polymers including hydrocarbon, opacifiers, stabilizers, sequestering agents, conditioners, propellants.
Bien entendu l'homme du métier veillera à choisir ce ou ces éventuels adjuvants complémentaires et/ou leur quantité de manière telle que les propriétés de la composition selon l'invention ne soient pas, ou substantiellement pas, altérées par l'adjonction envisagée. Of course, those skilled in the art will take care to choose this or these optional additional adjuvants and / or their quantity in such a way that the properties of the composition according to the invention are not, or not substantially, impaired by the addition envisaged.
Les actifs utilisés dans le cadre de la présente invention présentant donc une activité régénératice et réparatrice remarquables, ceux-ci trouvent une application toute particulière dans des compositions pouvant se présenter: - sous la forme d'un produit de soin dermatologique ou cosmétique de la peau du visage, du corps y compris le cuir chevelu, des lèvres, tel qu'une base de soin pour les lèvres, une base fixante à appliquer sur un rouge à lèvres classique, une composition de protection solaire ou de bronzage artificiel; un produit déodorant; une composition de soin (de jour, de nuit, anti-rides, hydratante, etc.) pour le visage, mais également. The active agents used in the context of the present invention thus having a remarkable regenerative and restorative activity, these find a very particular application in compositions which may be: in the form of a dermatological or cosmetic skin care product facial, body including scalp, lips, such as a lip care base, a fixing base to be applied to a conventional lipstick, a sunscreen or artificial tanning composition; a deodorant product; a care composition (day, night, anti-wrinkle, moisturizing, etc.) for the face, but also.
- sous la forme d'une composition désodorisante; d'un gel ou lotion aprèsrasage; d'une crème dépilatoire, d'une composition pharmaceutique, d'une composition solide telle qu'un savon ou un pain de nettoyage, d'une composition pour aérosol comprenant également un agent propulseur sous pression, d'une composition pour soins capillaires, d'une composition à usage bucco-dentaire, d'une composition à usage alimentaire ou complément alimentaire ou diététique ou de patch pouvant être appliqués sur les zones de peau à traiter. in the form of a deodorizing composition; a gel or lotion after shaving; a depilatory cream, a pharmaceutical composition, a solid composition such as a soap or a cleaning roll, an aerosol composition also comprising a pressurized propellant, a hair care composition, a composition for oral use, a composition for food or dietary or dietary supplement or patch that can be applied to the skin areas to be treated.
La présente invention est illustrée dans les exemples suivants, qui ne sont pas limitatifs. The present invention is illustrated in the following examples, which are not limiting.
- Huile minérale 2,00% - palmitoyl pentapeptide-3 0.1 10' % -Extrait de Centella Asiatica 1% - Triglycéride caprylique/caprique 4,00% -S- téarate d'octyle 3,00% - Isoamyl-p-Méthoxycinnamate 5,00% -Benzophénone-3 1,00% Parfum 0,30% - Diisostéarate de polyglycéryl-3 3, 00 % - PEG-20 Laurate de glycéryle 1,00% - Carbomer 0,4% - Propylène glycol 2,00% - Phénoxyéthanol 0,50% - Méthyl-paraben 0,25% - Propyl-paraben 0,10% - Gomme de xanthane 0,30% - Triéthanolamine 0,85% Exemple 1: huile solaire 20 30 - Acide phénylbenzimidazole-sulfonique 2,5% - Eau qsp Exemple 2: crème de soin palmitoyl pentapeptide-3 0.1 10-6 % -Extrait de Centella Asiatica 0,3 % Whey protein 0,02 % - phosphate d'hydroxypropyl amidon 7. 5 % - Extrait de racine deDioscorea villosa 2.0 % - isoflavone aglycone de soja 2.0 % Alkyl Benzoate en C12-C15 10.0 % -glycérine 3.0 % - Phenonip 0.5 % - eau déminéralisée qsp 100% - Mineral oil 2.00% - palmitoyl pentapeptide-3 0.1 10% - Centella Asiatica extract 1% - Caprylic / capric triglyceride 4.00% -S-octyl tetar 3.00% - Isoamyl-p-methoxycinnamate 5 , 00% -Benzophenone-3 1.00% Perfume 0.30% - Polyglyceryl-3 Diisostearate 3.00% - PEG-20 Glyceryl Laurate 1.00% - Carbomer 0.4% - Propylene Glycol 2.00% - Phenoxyethanol 0.50% - Methyl paraben 0.25% - Propyl paraben 0.10% - Xanthan gum 0.30% - Triethanolamine 0.85% Example 1: Solar oil 20 30 - Phenylbenzimidazolesulfonic acid 2, 5% - Water qs Example 2: palmitoyl pentapeptide-3 care cream 0.1 10-6% -Extract Centella Asiatica 0.3% Whey protein 0.02% -hydroxypropyl starch phosphate 7. 5% -Dioscorea root extract villosa 2.0% - isoflavone soy aglycone 2.0% C12-C15 alkyl benzoate 10.0% -glycerine 3.0% - Phenonip 0.5% - demineralised water qs 100%
Exemple 3: lotionExample 3: lotion
- palmitoyl pentapeptide-3 0.5 10"6 % - Extrait de Centella Asiatica 0,3 % - Whey protein 0,01 % - glycérine 2.0 0/0 - alcool éthylique 2.0 % Cétrimide BP 0.1 % - butanol oxyéthyléné (260E) oxypropyléné (260P), huile de ricin hydrogénée oxyéthylénée (40 0E) dans l'eau1.0 % - eau déminéralisée qsp 100% - palmitoyl pentapeptide-3 0.5 10 "6% - Centella Asiatica extract 0.3% - Whey protein 0.01% - glycerin 2.0 0/0 - ethyl alcohol 2.0% Cetrimide BP 0.1% - oxyethylenated butanol (260E) oxypropylene (260P ), hydrogenated castor oil oxyethylenated (40 0E) in water1.0% - demineralised water qs 100%
Exemple 4: GelExample 4: Gel
- palmitoyl pentapeptide-3 0.5 10-6 % - Extrait de Centella Asiatica 0,1 0/0 - Whey protein 0,02 % - Glycérine 2.0 % - Xylitol 3.0 % -Cétrimide BP 0.4 - Sulfate de Mg 0.05 % - Prunus dulcis 7.0 % -Isopropyl palmitate 3.0 % - Salcare 91 1 0/0 - Eau déminéralisée qsp 100% La préparation de ces compositions se fait par tous moyens adéquats classiques bien connus dans le domaine cosmétique ou pharmaceutique. - palmitoyl pentapeptide-3 0.5 10-6% - Centella Asiatica Extract 0.1 0/0 - Whey Protein 0.02% - Glycerin 2.0% - Xylitol 3.0% - Cetrimide BP 0.4 - Mg Sulfate 0.05% - Prunus dulcis 7.0 % -Isopropyl palmitate 3.0% - Salcare 91 1 0/0 - Demineralized water qs 100% The preparation of these compositions is by any suitable conventional means well known in the cosmetic or pharmaceutical field.
Claims (8)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0502352A FR2882928A1 (en) | 2005-03-09 | 2005-03-09 | Cosmetic composition, useful to regenerate, restructure and stimulate derma, comprises palmitoyl-3-pentapeptide in combination with Centella asiatica extract |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0502352A FR2882928A1 (en) | 2005-03-09 | 2005-03-09 | Cosmetic composition, useful to regenerate, restructure and stimulate derma, comprises palmitoyl-3-pentapeptide in combination with Centella asiatica extract |
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| Publication Number | Publication Date |
|---|---|
| FR2882928A1 true FR2882928A1 (en) | 2006-09-15 |
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| FR0502352A Pending FR2882928A1 (en) | 2005-03-09 | 2005-03-09 | Cosmetic composition, useful to regenerate, restructure and stimulate derma, comprises palmitoyl-3-pentapeptide in combination with Centella asiatica extract |
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Cited By (1)
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| FR2914857A1 (en) * | 2007-04-12 | 2008-10-17 | Dermathologiques D Uriage Soc | Cosmetic/dermatological composition, useful to fight against epidermis inflammation on the skin, mucous membranes or integuments, comprises asiaticoside and/or phytosphingosine in combination or in mixture with excipients or vehicles |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2914857A1 (en) * | 2007-04-12 | 2008-10-17 | Dermathologiques D Uriage Soc | Cosmetic/dermatological composition, useful to fight against epidermis inflammation on the skin, mucous membranes or integuments, comprises asiaticoside and/or phytosphingosine in combination or in mixture with excipients or vehicles |
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