FR2666226A1 - Composition for protecting the skin - Google Patents
Composition for protecting the skin Download PDFInfo
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- FR2666226A1 FR2666226A1 FR9010840A FR9010840A FR2666226A1 FR 2666226 A1 FR2666226 A1 FR 2666226A1 FR 9010840 A FR9010840 A FR 9010840A FR 9010840 A FR9010840 A FR 9010840A FR 2666226 A1 FR2666226 A1 FR 2666226A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/447—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof containing sulfur
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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Abstract
Description
NOUVELLES COMPOSITIONS PROTECTRICES DE LA PEAU
La présente invention a pour objet de nouvelles compositions protectrices de la peau, destinées à limiter les facteurs de dégradation tissulaire notamment exogènes. Elle concerne également le procédé de préparation de tels produits.NEW PROTECTIVE SKIN COMPOSITIONS
The subject of the present invention is new protective compositions for the skin, intended to limit the factors of tissue degradation, in particular exogenous. It also relates to the process for the preparation of such products.
En ce qui concerne les causes exogènes, elle vise en particulier l'élimination des effets photobiologiqes nocifs en limitant l'énergie lumineuse incidente par réduction de la quantité de photons admis à atteindre la peau par unité de surface, et en modifiant leur bande spectrale, étant bien entendu que doit être prise en compte la totalité du spectre de rayonnement lumineux incident (spectre infra-rouge, visible et ultra-violet). With regard to exogenous causes, it aims in particular to eliminate harmful photobiological effects by limiting the incident light energy by reducing the quantity of photons admitted to reach the skin per unit area, and by modifying their spectral band, it being understood that the entire spectrum of incident light radiation must be taken into account (infrared, visible and ultra-violet spectrum).
L'invention concerne vise également la réduction des facteurs anormaux endogènes et en particulier celle de l'élastase, ainsi que les déviations dûes à l'âge qui se traduisent notamment par des déstructurations progressives.The invention also relates to the reduction of endogenous abnormal factors and in particular that of elastase, as well as the deviations due to age which are manifested in particular by progressive destructuring.
L'art antérieur connaît d'innombrables compositions tentant d'assurer une protection aussi complète que possible de la peau contre les radiations, mais, jusqu'à présent, toutes les solutions sont loin de conduire à une efficacité satisfaisante, et on observe toujours, en dépit des progrès réalisés et des précautions prises, des désordres parfois graves et trop souvent irréversibles; que ce soit par la prévention, c'est-à-dire en filtrant ou en réfléchissant les rayonnements, ou par le traitement intervenant postérieurement et trop souvent trop tard, les résultats restent décevants dans la plupart des cas. Numerous compositions have been known in the prior art which attempt to ensure as complete protection as possible of the skin against radiation, but, until now, all the solutions are far from leading to satisfactory effectiveness, and we always observe, despite the progress made and the precautions taken, sometimes serious and too often irreversible disorders; whether by prevention, that is to say by filtering or reflecting radiation, or by treatment intervening later and too often too late, the results remain disappointing in most cases.
I1 convient de rappeler que les effets des rayonnements lumineux, auxquels on se limitera ici, c'est-à-dire l'action des photons, se traduit notamment par divers effets sur la peau:
a) Ils provoquent, comme la plupart des autres
agressions, la formation de radicaux libres aux effets
destructeurs;
b) Ils favorisent l'action de l'élastase et donc la
destruction de la couche-d'élastine;
c) Ils provoquent des désordres au niveau vasculaire se
traduisant par érythème, oedèmes, etc.,...;
d) Ils activent, en cas de rayonnements intenses,
certains gènes dans la partie germinative de l'épiderme
(mélanocytes et dans une certaine mesure kératinocytes),
ce qui peut se traduire par de nombreux phénomènes ou
désordres dépendant essentiellement de l'efficacitérdu
système de défense de l'organisme considéré.It should be recalled that the effects of light radiation, to which we will limit ourselves here, that is to say the action of photons, is reflected in particular by various effects on the skin:
a) They cause, like most of the others
attacks, the formation of free radicals
destructive;
b) They promote the action of elastase and therefore the
destruction of the elastin layer;
c) They cause disorders at the vascular level
translating by erythema, edemas, etc., ...;
d) They activate, in the event of intense radiation,
certain genes in the germinal part of the epidermis
(melanocytes and to some extent keratinocytes),
which can result in many phenomena or
disorders essentially dependent on the efficiency of the
defense system of the organism considered.
I1 est donc essentiel, si l'on veut assurer une protection aussi complète que possible, de tenir compte des points qui viennent d'être soulignés et de résoudre les problèmes soulevés par ces phénomènes sous l'action des photons, et notamment du rayonnement solaire. It is therefore essential, if we want to ensure as complete protection as possible, to take into account the points which have just been highlighted and to solve the problems raised by these phenomena under the action of photons, and in particular solar radiation. .
Or, il s'avère que la filtration par les filtres dits"chimiques" est toujours insuffisante et qu'en conséquence, si on limite certains désordres, on est loin de les éliminer, notamment dans le cas de sujets sensibles tels que ceux à faible système de défenses naturelles, par exemple, les sujets du photype I, ce qui correspond sensiblement au type celte à cheveux roux et à carnation laiteuse, ne bronzant pratiquement jamais et restant très sujet aux coups de soleil, aux éphélides et aux érythèmes). Le recours à des écrans ou filtres dits"physiques" forme un bouclier plus sûr mais présente des inconvénients sur lesquels on reviendra ci-après. However, it turns out that filtration by so-called "chemical" filters is still insufficient and that consequently, if we limit certain disorders, we are far from eliminating them, especially in the case of sensitive subjects such as those with low natural defense system, for example, subjects of photype I, which corresponds appreciably to the Celtic type with red hair and milky complexion, practically never tanning and remaining very subject to sunburn, ephelids and erythemas). The use of so-called "physical" screens or filters forms a safer shield but has drawbacks which will be discussed below.
L'expérience a montré que l'on pouvait parvenir, grâce à certaines associations de composants spécifiques, choisis et dosés conformément à l'invention, à des résultats que 1' on n'avait pas atteints jusqu'à présent par l'emploi, désormais classique, d'agents filtrants ou réfléchissants associés à divers autres agents de protection. Experience has shown that it is possible, thanks to certain combinations of specific components, chosen and dosed in accordance with the invention, to results which have hitherto not been achieved by use, now classic, of filtering or reflecting agents associated with various other protective agents.
On a également remarqué que, jusqu'à présent, grâce à des filtres, on avait cherché à atténuer, voire occulter les rayonnements dans certaines gammes, surtout d'ultra-violet, connues pour particulièrement nocives sans se préoccuper du fait que des réactions photochimiques ou des transformations photobiologiques se produisaient avec des rayonnements s'étendant sur la quasi totalité du spectre lumineux, y compris dans la zone du visible et de l'infra-rouge, et que pour assurer une protection efficace, surtout des sujets à peau sensible bu à certaines zones de peau sensibles, il importait d'assurer une protection plus étendue dans la gamme des longueurs d'ondes. We have also noticed that, up to now, thanks to filters, we have sought to attenuate or even obscure the radiation in certain ranges, especially ultraviolet, known to be particularly harmful without worrying about the fact that photochemical reactions or photobiological transformations occurred with radiation extending over almost the entire light spectrum, including in the visible and infrared region, and only to provide effective protection, especially of subjects with sensitive skin drunk for certain sensitive skin areas, it was important to provide more protection in the wavelength range.
On rappellera qu'en vertu de la loi de Planck, l'énergie des photons est proportionnelle à leur fréquence et par conséquent inversement proportionnelle à leur longueur d'onde, et que donc, si l'on prend en considération les fréquences basses (longueurs d'ondes les plus longues et donc à énergie la moins forte selon Planck), c'est-à-dire essentiellement l'ultra-violet, il est, a fortiori, plus que souhaitable de ne pas omettre les fréquences qui correspondent à des niveaux d'énergie plus élévés, c'est-à-dire les fréquences moyennes du spectre visible (longueurs d'ondes moyennes) et les plus élevées de l'infra-rouge(longueurs d'ondes les plus courtes). It will be recalled that under Planck's law, the energy of photons is proportional to their frequency and therefore inversely proportional to their wavelength, and that therefore, if we take into account low frequencies (lengths longest waves and therefore with the least energy according to Planck), that is to say essentially the ultraviolet, it is, a fortiori, more than desirable not to omit the frequencies which correspond to higher energy levels, i.e. the average frequencies of the visible spectrum (medium wavelengths) and the highest of the infrared (shortest wavelengths).
On rappellera également que, dans l'ordre des fréquences et des énergies décroissantes et donc des longueurs d'ondes croissantes, les infra-rouges lointains sont dans la gamme de fréquences du spectre lumineux au-delà de 1.500 nm, les infrarouges proches entre 700 et 1.500 nm, le visible entre 380 et 700 nm, les ultra-violets A entre 315 et 380 nm, les,ultra- violets B entre 280 et 315 nm, et les ultra-violets C entre 190 et 280 nm.It will also be recalled that, in the order of decreasing frequencies and energies and therefore increasing wavelengths, the far infrared are in the frequency range of the light spectrum beyond 1,500 nm, the near infrared between 700 and 1,500 nm, the visible between 380 and 700 nm, the ultraviolet A between 315 and 380 nm, the ultraviolet B between 280 and 315 nm, and the ultraviolet C between 190 and 280 nm.
Or, l'expérience a montré qu'une telle protection élargie, combinée à une action antiélastase et à une action antiradicalaire ou anti-radicaux libres menées dans des conditions adéquates, dépassait très largement en résultats les compositions antérieures les plus performantes. However, experience has shown that such extended protection, combined with an anti-elastase action and with an anti-free radical or anti-free radical action carried out under adequate conditions, greatly exceeds the results of the most effective previous compositions.
I1 est évident que la protection maximale pourrait être aisément obtenue par des éléments extérieurs comme le vêtements, ce qui sort du domaine cosméto-dermatologique, mais, par exemple, par des applications topiques d'écrans ou filtres"physiques à haute teneur en particules opaques formant, au moins théoriquement, un écran parfait à tout rayonnement lumineux, ce qui nécessite une haute densité particulaire, une parfaite homogénéïté de répartition et, dans toute la mesure nécessaire, une épaisseur suffisante, mais cela conduit à des applications inesthétiques se traduisant le plus souvent par une couleur uniforme et généralement blanche, d'autant plus inacceptable que la plupart des sujets intéressés cherchent justement l'effet de coloration opposé. It is obvious that maximum protection could be easily obtained by external elements such as clothing, which is outside the cosmeto-dermatological field, but, for example, by topical applications of screens or filters "physical with a high content of opaque particles. forming, at least theoretically, a perfect screen with any light radiation, which requires a high particle density, a perfect homogeneity of distribution and, to the extent necessary, a sufficient thickness, but this leads to unsightly applications resulting most often by a uniform and generally white color, all the more unacceptable as most of the interested parties precisely seek the opposite coloring effect.
L'utilisation d'écrans ou autres filtres"physiques", par opposition aux filtres"chimiques", est donc essentiellement limitée par des considérations non techniques, mais le plus généralement esthétiques, et, dans certains cas également, par des aspects législatifs et réglementaires. The use of "physical" screens or other filters, as opposed to "chemical" filters, is therefore essentially limited by non-technical, but more generally aesthetic considerations, and, in some cases also, by legislative and regulatory aspects. .
Comme cela a été également mentionné ci-dessus, l'invention cherche à s'opposer aux facteurs endogènes de dégradation de la peau qui se présentent essentiellement et finalement sous la forme de radicaux libres et d'élastase. As has also been mentioned above, the invention seeks to oppose endogenous factors of degradation of the skin which are essentially and ultimately in the form of free radicals and elastase.
L'un des buts de la présente invention est donc de parvenir à des compositions qui n'altèrent pas l'apparence de la peau ou éventuellement l'améliorent, tout en assurant la protection maximale recherchée vis-à-vis des facteurs exogènes ou endogènes les plus marquants, et en restant dans les limites du cadre des autorisations légales et réglementaires. One of the aims of the present invention is therefore to achieve compositions which do not alter the appearance of the skin or possibly improve it, while ensuring the maximum protection sought with respect to exogenous or endogenous factors the most significant, and remaining within the limits of legal and regulatory authorizations.
La présente invention a donc pour objet de nouvelles compositions protectrices de la peau,comprenant l'association d'un système filtrant dans l'étendue du spectre des fréquences photoniques, combiné avec au moins un composant antiradicalaire, à savoir l'alpha-tocophérol ou l'un de ses dérivés, notamment l'un de ses esters, et au moins un composant antiélastasique. A subject of the present invention is therefore novel compositions for protecting the skin, comprising the combination of a filtering system over the entire spectrum of photonic frequencies, combined with at least one anti-radical component, namely alpha-tocopherol or one of its derivatives, in particular one of its esters, and at least one antielastatic component.
Selon un mode de réalisation préféré de l'invention, on utilisera comme composants du système filtrant au moins un écran ou filtre"physique", l'oxyde de titane, les microperles, par exemple de polyméthacrylate de méthyle et le mica, étant entendu que l'on peut utiliser également dans le cadre de la présente invention, d'autres substances telles que le talc, le kaolin, ou d'autres oxydes de préférence de couleur claire, pour éviter l'absorption d'énergie photonique. On peutégalement utiliser au moins un filtre"chimique". According to a preferred embodiment of the invention, as components of the filtering system, at least one "physical" screen or filter will be used, titanium oxide, microbeads, for example polymethyl methacrylate and mica, it being understood that one can also use in the context of the present invention, other substances such as talc, kaolin, or other oxides preferably of light color, to avoid the absorption of photonic energy. It is also possible to use at least one "chemical" filter.
En ce qui concerne les constituants antiradicalaires, il convient de souligner, en particulier, le recours à la vitamine
E qui constitue un élément important dans les combinaisons conformes à la présente invention: l'alpha-tocophérol et certains de ses dérivés comme l'acétate ou le linoléate, présentent des propriétés particulièrement importantes dans le domaine cosméto-dermatologique.La vitamine E présente essentiellement les propriété suivantes:
- elle est tout d'abord un antioxydant et, de ce fait,
empêche les peroxydations, notamment des lipides, réduit
les désordres dûs aux ultra-violets et, en particulier,
agit à l'encontre de la formation des radicaux libres,
(favorisée notamment par les ultra-violets A et B);
- elle empêche la formation de nitrosamine aux effets
cancérigènes, ainsi que de prostaglandines, notamment à
partir de l'acide arachidonique, et les inflammations et
érythèmes qu'elles entraînent;
- elle réduit l'activité défavorable de l'ornithine
décarboxylase, mais protège celle de la superoxyde
dismutase et son action antiradicalaire;
- elle hydrate et adoucit la peau, la protège, aide à
la réparation tissulaire et à la cicatrisation, et
présente des propriétés anti-inflammatoires;;
- elle favorise la formation in vivo d'autres molécules
de vitamine E, et protège la vitamine A.With regard to the anti-free radical components, it should be emphasized, in particular, the use of vitamin
E which constitutes an important element in the combinations in accordance with the present invention: alpha-tocopherol and certain of its derivatives such as acetate or linoleate, have particularly important properties in the cosmeto-dermatological field. Vitamin E has essentially the following properties:
- it is first of all an antioxidant and, therefore,
prevents peroxidation, especially of lipids, reduces
disorders due to ultraviolet rays and, in particular,
acts against the formation of free radicals,
(favored in particular by ultraviolet A and B);
- it prevents the formation of nitrosamine with the effects
carcinogens, as well as prostaglandins, especially
from arachidonic acid, and inflammation and
the erythema they cause;
- it reduces the unfavorable activity of ornithine
decarboxylase, but protects that of the superoxide
dismutase and its anti-radical action;
- it hydrates and softens the skin, protects it, helps
tissue repair and scarring, and
has anti-inflammatory properties;
- it promotes the in vivo formation of other molecules
of vitamin E, and protects vitamin A.
L'expérience a montré que, conformément à la présente invention, les associations proposées potentialisaient l'action de l'alpha-tocophérol et en étendaient le champ d'action à l'encontre des photons et des désordres qu'ils peuvent entraîner. Experience has shown that, in accordance with the present invention, the proposed combinations potentiate the action of alpha-tocopherol and extend its field of action against photons and the disorders they may cause.
On peut également utiliser d'autres constituants antiradicalaires tels que l'acétylcystéine qui amène les radicaux libres à être évacués par la microcirculation sanguine. It is also possible to use other anti-radical constituents such as acetylcysteine which causes the free radicals to be evacuated by the blood microcirculation.
En ce qui concerne les composants antiélastasiques, selon un mode de réalisation préféré de l'invention, on fait appel aux composés flavoniques et à la juglone que l'on trouve dans de nombreux végétaux, ce qui permet d'utiliser des extraits ou huiles essentielles, comme par exemple de- noyer, de mûrier ou de millepertuis, qui présentent souvent l'avantage d'exercer pàr ailleurs une action antiradicalaire, comme c'est le cas pour la vitamine P dont les effets peuvent être éventuellement renforcés par synergie avec la vitamine C par ailleurs antioxydante. As regards the antielastatic components, according to a preferred embodiment of the invention, use is made of the flavonic compounds and the juglone which are found in many plants, which makes it possible to use extracts or essential oils. , such as walnut, mulberry or St. John's wort, which often have the advantage of exerting an anti-free radical action elsewhere, as is the case for vitamin P, the effects of which can be possibly reinforced by synergy with also antioxidant vitamin C.
Selon un mode de réalisation préféré de la présente invention, on peut associer aux écrans ou filtres "physiques" des filtres"chimiques", tels que, de préférence, les benzophénones et/ou le dibenzoylméthane et ses dérivés dont le spectre d'action est relativement large, mais on peut également faire appel aux benzimidazoles,aux cinnamates,aux salicylates, ainsi qu'au benzylidène-camphre et à l'acide paraminobenzoïque et à leurs dérivés. According to a preferred embodiment of the present invention, it is possible to combine with "physical" screens or filters "chemical" filters, such as, preferably, benzophenones and / or dibenzoylmethane and its derivatives whose spectrum of action is relatively broad, but it is also possible to use benzimidazoles, cinnamates, salicylates, as well as benzylidene-camphor and paraminobenzoic acid and their derivatives.
Les compositions conformes à l'invention peuvent également contenir divers agents et notamment des agents antiinflammatoires. The compositions according to the invention can also contain various agents and in particular anti-inflammatory agents.
L'invention concerne également le procédé pour la fabrication de telles compositions consistant à sélectionner filtres et écrans s'étendant dans l'étendue du spectre des fréquences photoniques, à les doser de façon à opposer aux photons un filtrage physique et notamment optique qui limite la largeur des bandes de fréquences passantes et l'énergie passante, ce qui dépend notamment des filtres ou écrans choisis et de la densité superficielle de répartition des particules, elle-même fonction de la concentration de ces particules dans la composition utilisée. The invention also relates to the method for the manufacture of such compositions consisting in selecting filters and screens extending over the extent of the spectrum of photonic frequencies, in dosing them so as to oppose photons physical and in particular optical filtering which limits the width of the pass frequency bands and the pass energy, which depends in particular on the filters or screens chosen and on the surface density of distribution of the particles, itself a function of the concentration of these particles in the composition used.
Pour mieux faire comprendre les caractéristiques techniques et les avantages de la présente invention, on va en décrire des exemples de réalisation étant bien entendu que ceux-ci ne sont pas limitatifs quant à leur mode de mise en oeuvre et aux applications qu'on peut en faire. To better understand the technical characteristics and advantages of the present invention, we will describe embodiments thereof, it being understood that these are not limiting as to their mode of implementation and to the applications that can be made of them. to do.
Exemple 1: CREME D'INDUCTION DE MELANOGENESE
On se base sur la composition suivante:
Phase huileuse % en masse microperles de polyméthacrylate de méthyle 1,50 filtre"phys." oxyde de titane 1,50 filtre"phys." mica 2,00 filtre"phys." alpha-tocophérol (vitamine E) 0,50 antiradic.Example 1: MELANOGENESIS INDUCTION CREAM
We use the following composition:
Oily phase% by mass polymethyl methacrylate microbeads 1.50 "phys." Filter titanium oxide 1.50 "phys." filter 2.00 mica "phys." filter alpha-tocopherol (vitamin E) 0.50 antiradic.
extrait de feuilles de noyer, brou de noix et millepertuis (juglone et fla- antiradic.et voniques) 0,50 antiélastase huiles végétales 2,10 huile de vaseline 19,20 cire minérale 3,00 myristate d'isopropyle 6,00 ester glycérique de vitamine F 0,20 palmitate de vitamine A 0,10 parfum 0,75
Complexe gras concentrat de feuilles de murier 0,50 antiradic.extract of walnut leaves, walnut husk and St. John's wort (juglone and fla- antiradic. and vonic) 0.50 antielastase vegetable oils 2.10 vaseline oil 19.20 mineral wax 3.00 isopropyl myristate 6.00 glycerol ester of vitamin F 0.20 palmitate of vitamin A 0.10 perfume 0.75
Oily complex concentrate of mulberry leaves 0.50 antiradic.
antiélastase vaseline blanche 35,00 lanoline 27,00
Base bronzante eau déminéralisée 0,10 soude 0,01 complexe bronzant 0,04
On prépare la phase grasse par les moyens classiques sous agitation moyenne à 380 C; on prépare le complexe gras également de façon classique par fusion et mélange, puis on l'émulsionne avec la phase grasse; enfin, en laissant la température retomber vers 250C, on y incorpore après l'avoir filtrée la base bronzante jusquà homogénéïsation, puis on poursuit le mélange sous agitation modérée. On obtient ainsi une composition présentant l'aspect d'un crème assurant une excellente protection antiphotons dans toute la largeur du spectre, grâce aux filtres et écrans, protection considérablement renforcée par la combinaison avec les composants antiradicalaires et antiélastases.On notera que la présence dans cette composition d'un complexe dit"bronzant" permet, malgré la protection très efficace d'initier, sans risques, la mélanogénèse.white petrolatum antielastase 35.00 lanolin 27.00
Demineralized water tanning base 0.10 soda 0.01 tanning complex 0.04
The fatty phase is prepared by conventional means with average stirring at 380 C; the fatty complex is also prepared in a conventional manner by melting and mixing, then it is emulsified with the fatty phase; finally, letting the temperature drop to around 250C, after incorporating it, incorporate the tanning base until homogenization, then continue mixing with moderate stirring. A composition is thus obtained having the appearance of a cream providing excellent protection against photons across the spectrum, thanks to filters and screens, protection considerably reinforced by the combination with the anti-free radical and anti-elastase components. It will be noted that the presence in this composition of a complex called "bronzing" allows, despite the very effective protection to initiate, without risk, melanogenesis.
Exemple 2: LAIT DE HAUTE PROTECTION
On part de la composition suivante:
Phase grasse % en masse microperles de polyméthacrylate de méthyle 1,50 filtre"phys." oxyde de titane 1,50 filtre"phys." mica 1,50 filtre"phys." méthoxycinnamate d'octyle 0,50 filtre"chim." 3-(méthyl-4-benzylidéne)-camphre 0,50 filtre"chim." hydroxy-2-méthoxy-4-benzophénone 0,50 filtre"chim." alphatocophérol (vitamine E) 0,50 antiradic.Example 2: HIGH PROTECTION MILK
We start from the following composition:
Fat phase% by mass polymethyl methacrylate microbeads 1.50 "phys." Filter titanium oxide 1.50 "phys." filter 1.50 mica "phys." filter octyl methoxycinnamate 0.50 filter "chem." 3- (methyl-4-benzylidene) -camphor 0.50 filter "chem." hydroxy-2-methoxy-4-benzophenone 0.50 filter "chem." alphatocopherol (vitamin E) 0.50 antiradic.
extrait de feuilles de noyer, brou de noix et millepertuis (juglone et fla- antiradic.et voniques) 0,50 antiélastase acétylcystéine 0,50 antiradic.extract of walnut leaves, walnut husk and St. John's wort (juglone and fla- antiradic. and vonic) 0.50 antielastase acetylcysteine 0.50 antiradic.
octyl-2-dodécanol 4,50 acide stéarique + oléate de sorbitan 1,50 huile de vaseline fluide 6,00 huile végétale 1,10 myristate d'isopropyle 3,00 palmitate de vitamine A 0,10 ester glycérique de vitamine F 0,30 parfum 0,40
Phase aqueuse bio-flavonoïdes naturels (vitamine P) 0,05 antiélastase palmitate de vitamine C 0,05 antiradical.octyl-2-dodecanol 4.50 stearic acid + sorbitan oleate 1.50 liquid vaseline oil 6.00 vegetable oil 1.10 isopropyl myristate 3.00 vitamin A palmitate 0.10 glycerol ester of vitamin F 0, 30 perfume 0.40
Natural bio-flavonoids aqueous phase (vitamin P) 0.05 antielastase palmitate vitamin C 0.05 anti-radical.
eau déminéralisée 66,00 glycérine 2,00 sulfate de magnésium 0,65 soude 0,13
L-tyrosine 0,30 alcool benzylique + méthylchloroisothiazolinone + méthylisothiazolinone 0,15 l,l'-méthylène-bis(3-[3-(hydroxy- méthyl ) -2, 4-dioxo-5-imidazolidinyl] y- urée 0,20 acide citrique 0,05
On prépare la phase aqueuse sous agitation faible à 380C; on réalise la phase grasse sous agitation moyenne à température ambiante, puis on émulsionne l'ensemble en laissant refroidir vers 300C. On obtient un lait hautement protecteur contre les photons.et leurs divers effets, et ceci sur toute la largeur du spectre allant des ultra-violets aux infra-rouges.demineralized water 66.00 glycerin 2.00 magnesium sulfate 0.65 soda 0.13
L-tyrosine 0.30 benzyl alcohol + methylchloroisothiazolinone + methylisothiazolinone 0.15 l, l'-methylene-bis (3- [3- (hydroxy-methyl) -2, 4-dioxo-5-imidazolidinyl] y-urea 0, 20 citric acid 0.05
The aqueous phase is prepared with gentle stirring at 380C; the fatty phase is carried out with medium stirring at room temperature, then the whole is emulsified while allowing to cool to around 300C. A highly protective milk is obtained against photons. And their various effects, and this across the entire spectrum, from ultra-violet to infrared.
Exemple 3 CREME CONTRE LES INTOLERANCES AUX PHOTONS
On part de la composition suivante:
Phase grasse % en masse oxyde de titane 2,50 filtre"phys." mica 5,00 filtre"phys." microperles de polyméthacrylate de méthyle 1,50 filtre"phys." méthoxycinnamate d'éthyle 2,00 filtre"chim." hydroxy-2-méthoxy-4-benzophénone 2,50 filtre"chim." 3-(méthyl-4-benzylidène)-camphre 2,50 filtre"chim." extrait de feuilles de noyer, brou de noix et millepertuis (juglone et fla- antiradic.et voniques) 0,50 antiélastase acétylcystéine 0,50 antiradic.EXAMPLE 3 CREAM AGAINST PHOTO INTOLERANCES
We start from the following composition:
Fat phase% by mass of titanium oxide 2.50 "phys." Filter mica 5.00 filter "phys." Polymethylmethacrylate microbeads 1.50 "phys." filter ethyl methoxycinnamate 2.00 "chem." filter hydroxy-2-methoxy-4-benzophenone 2.50 "chem." filter 3- (methyl-4-benzylidene) -chamber 2.50 "chem." Filter extract of walnut leaves, walnut husk and St. John's wort (juglone and fla- antiradic. and vonic) 0.50 antielastase acetylcysteine 0.50 antiradic.
alphatocophérol (vitamine E) 0,50 antiradic.alphatocopherol (vitamin E) 0.50 antiradic.
octyl-2-dodécanol 7,00 huile végétale 1,00 monostéarate de sorbitan 2,00 trioléate de sorbitan 2,00 stéarate de glycéryle 2,50 vaseline blanche 4,00 myristate de myristyle 4,00 stéarine 5,00 triglycérides caprylique + caprique 1,00 palmitate de vitamine A 0,30 ester glycérique de vitamine F 0,10 parfum 0,20
Phase aqueuse eau déminéralisée 48,59 bioflavonoïdes naturels (vitamine P) 0,10 antiélastase
et antiradic.octyl-2-dodecanol 7.00 vegetable oil 1.00 sorbitan monostearate 2.00 sorbitan trioleate 2.00 glyceryl stearate 2.50 white petrolatum 4.00 myristyl myristate 4.00 stearin 5.00 caprylic triglycerides + capric 1.00 vitamin A palmitate 0.30 glycerol ester of vitamin F 0.10 perfume 0.20
Aqueous phase demineralized water 48.59 natural bioflavonoids (vitamin P) 0.10 antielastase
and antiradic.
palmitate de vitamine C 0,10 allantoïne 0,10 triéthanolamine à 99% 0,21 chloro-5-méthyl-2-isothiazoline-4-one-3 + méthyl-2-isothiazoline-4-one-3 + chlorure de magnésium 0,10 1,1' -méthylène-bis3-[ 3-(hydroxy- méthyl)-2,4-dioxo-5-imidazolidinyl])- urée 0,20 propylèneglycol 3,00 acide 18béta-glycyrrhétinique 1,00
On prépare la phase aqueuse à chaud sous agitation lente et sous vide léger, en mélangeant à part propylèneglycol et acide 18béta-glycyrrhétinique; on prépare la phase grasse à 750C sous agitation moyenne et on y ajoute sous vide la phase aqueuse en émulsionnant; on laisse-la température baisser à 400C et on ajoute le propylène glycol et l'acide 18bétaglycyrrhétinique sous agitation modérée en laissant refroidir jusqu'à l'ambiante; on obtient ainsi une crême très protectrice contre les photons de la gamme la plus large, présentant de plus de bonnes propriétés antiinflammatoires.vitamin C palmitate 0.10 allantoin 0.10 99% triethanolamine 0.21 chloro-5-methyl-2-isothiazoline-4-one-3 + methyl-2-isothiazoline-4-one-3 + magnesium chloride 0 , 10 1,1 '-methylene-bis3- [3- (hydroxy-methyl) -2,4-dioxo-5-imidazolidinyl]) - urea 0.20 propylene glycol 3.00 18beta-glycyrrhetinic acid 1.00
The aqueous phase is prepared hot with slow stirring and under slight vacuum, by mixing separately propylene glycol and 18beta-glycyrrhetinic acid; the fatty phase is prepared at 750C with medium stirring and the aqueous phase is added thereto under vacuum while emulsifying; the temperature is allowed to drop to 400C and the propylene glycol and 18betaglycyrrhetinic acid are added with moderate stirring while allowing to cool to ambient; a very protective cream is thus obtained against photons of the widest range, having more good anti-inflammatory properties.
Exemple 4: CREME REPARATRICE
On se base sur la composition suivante:
Phase grasse % en masse oxyde de titane 1,25 filtre"phys." mica 1,50 filtre"phys." microperles de polyméthacrylate de méthyle 0,25 filtre"phys." méthoxycinnamate d'octyle 0,50 filtre"chim." 3-(méthyl-4-benzylidène)-camphre 0,50 filtre"chim." alpha-tocophérol (vitamine E) 0,50 antiradic.Example 4: REPAIRING CREAM
We use the following composition:
Fat phase% by mass titanium oxide 1.25 "phys." Filter 1.50 mica "phys." filter 0.25 polymethyl methacrylate microbeads "phys." filter octyl methoxycinnamate 0.50 filter "chem." 3- (methyl-4-benzylidene) -camphor 0.50 filter "chem." alpha-tocopherol (vitamin E) 0.50 antiradic.
extrait de feuilles de noyer, brou de noix et millepertuis (juglone et fla- antiradic.et voniques) 0,50 antiélastase huile végétale 1,50 huile de vaseline 10,00 cire d'abeille blanche 2,00 myristate d'isopropyle 2,00 stéarate de glycéryle 4,50 monostéarate de polyéthylène 2,50 octyl-2-dodécanol 5,00 palmitate de cétyle 1,00 alcool cétylique 2,00 hexadiméthylsiloxane 0,50 complexe réparateur 7,50 palmitate de vitamine A 0,10 ester glycérique de vitamine F 0,30 parfum 0,40
Phase aqueuse eau déminéralisée 48,40 bioflavonoïdes naturels (vitamine P) 0,10 antiélastase
et antiradic. extract of walnut leaves, walnut husk and St. John's wort (juglone and fla- antiradic. and vonic) 0.50 antielastase vegetable oil 1.50 petroleum jelly oil 10.00 white beeswax 2.00 isopropyl myristate 2, 00 glyceryl stearate 4.50 polyethylene monostearate 2.50 octyl-2-dodecanol 5.00 cetyl palmitate 1.00 cetyl alcohol 2.00 hexadimethylsiloxane 0.50 repair complex 7.50 vitamin A palmitate 0.10 glycerol ester vitamin F 0.30 perfume 0.40
Aqueous phase demineralized water 48.40 natural bioflavonoids (vitamin P) 0.10 antielastase
and antiradic.
palmitate de vitamine C 0,10 antiradic.0.10 antiradic vitamin C palmitate.
N-acétyl-L-tyrosine 1,10 complexe inducteur de mélanogénèse 3,05 triéthanolamine à 99% 1,70 alcool benzylique + méthylchloroisothiazolinone + méthylisothiazolinone 0,15 1,1'-méthylène-bis{3-[3-(hydroxy- méthyl)-2,4-dioxo-5-imidazolidinyl])- urée 0,20
On réalise la phase aqueuse à 800 sous agitation faible; on réalise la phase grasse à 750C sous agitation très lente, à l'exception du complexe réparateur; on émulsionne l'ensemble sous vide en laissant refroidir jusqu'à 390, température à laquelle on ajoute le complexe réparateur; on homogénéïse sous agitation moyenne, en laissant la température revenir à l'ambiante. On obtient ainsi une crème à la fois protectrice et réparatrice convenant aux peaux abimées et permettant néanmoins aux sujets de s'exposer raisonnablement, par exemple, au rayonnement solaire.N-acetyl-L-tyrosine 1.10 melanogenesis-inducing complex 3.05 99% triethanolamine 1.70 benzyl alcohol + methylchloroisothiazolinone + methylisothiazolinone 0.15 1,1'-methylene-bis {3- [3- (hydroxy- methyl) -2,4-dioxo-5-imidazolidinyl]) - urea 0.20
The aqueous phase is carried out at 800 with gentle stirring; the fatty phase is carried out at 750C with very slow stirring, with the exception of the repair complex; the whole is emulsified under vacuum, allowing to cool to 390, the temperature at which the repair complex is added; it is homogenized with moderate stirring, leaving the temperature to return to ambient. A cream is thus obtained which is both protective and repairing, suitable for damaged skin and nevertheless allowing the subjects to be reasonably exposed, for example, to solar radiation.
Les produits résultants ont fait l'objet des tests suivants:
Tests sur l'ornithine décarboxylase et le dialdéhyde.de malonyle
Ils ont été menés sur la partie dorsale de souris tondues de huit semaines. Un quart d'heure après application, elles ont été soumises au rayonnement solaire pendant une journée. On a constaté 18 heures plus tard, une absence de désordre et une réduction de plus de la-moitié de I'activité de l'ornithine décarboxylase et du dialdéhyde de malonyle avec tous les produits des exemples ci-dessus.The resulting products were subjected to the following tests:
Ornithine decarboxylase and dialdehyde.de malonyl tests
They were conducted on the dorsal side of eight-week-old clipped mice. A quarter of an hour after application, they were subjected to solar radiation for one day. 18 hours later, an absence of disorder and a reduction of more than half of the activity of ornithine decarboxylase and of malonyl dialdehyde were observed with all the products of the above examples.
Tests sur les érythèmes et la superoxyde dismutase
Ils ont été menés sur la partie dorsale épilée de cobayes.Erythema and superoxide dismutase tests
They were conducted on the shaved dorsal part of guinea pigs.
Après application des divers produits ci-dessus définis aux exemples donnés, on a exposé les cobayes pendant une heure au rayonnement solaire et l'on n'a pu constater dans tous les cas après 24 et 48 heures, qu'une rougeur modérée, voire négligeable. Par ailleurs, on a compté par surfaces de 4 mm le nombre de cellules présentant les désordres typiques résultant de la présence de radicaux libres. Leur nombre s'est révélé négligeable, même pour des energies photoniques anormalement élevées. Par ailleurs, On a constaté une réduction très importante de l'activité de la superoxyde dismutase. After application of the various products defined above to the examples given, the guinea pigs were exposed for one hour to solar radiation and, in all cases after 24 and 48 hours, only moderate redness, or even negligible. In addition, the number of cells with typical disorders resulting from the presence of free radicals was counted in 4 mm areas. Their number has been found to be negligible, even for abnormally high photonic energies. Furthermore, a very significant reduction in the activity of superoxide dismutase has been observed.
Claims (8)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9010840A FR2666226B1 (en) | 1990-08-30 | 1990-08-30 | PROTECTIVE SKIN COMPOSITION. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9010840A FR2666226B1 (en) | 1990-08-30 | 1990-08-30 | PROTECTIVE SKIN COMPOSITION. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2666226A1 true FR2666226A1 (en) | 1992-03-06 |
| FR2666226B1 FR2666226B1 (en) | 1994-10-28 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR9010840A Expired - Fee Related FR2666226B1 (en) | 1990-08-30 | 1990-08-30 | PROTECTIVE SKIN COMPOSITION. |
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| FR2688136A1 (en) * | 1992-03-03 | 1993-09-10 | Oreal | COSMETIC COMPOSITION CONTAINING MELANIC PIGMENTS IN ASSOCIATION WITH CERTAIN TOCOPHEROLS, AND METHOD FOR PROTECTING THE SKIN, HAIR, MUCOSA AND COSMETIC COMPOSITIONS. |
| WO1994004128A2 (en) * | 1992-08-26 | 1994-03-03 | Beiersdorf Ag | Use of radical catchers as immunomodulating agents in cosmetic and dermatological compositions |
| WO1994004129A3 (en) * | 1992-08-26 | 1994-05-26 | Beiersdorf Ag | Cosmetic and dermatological sunscreen compositions containing thiols and/or thiol derivates |
| EP0607642A1 (en) * | 1993-01-19 | 1994-07-27 | PERRICONE, Nicholas V., Dr. | Compositions for topical application to the skin for treatment and/or prevention of radiation-induced skin damage |
| FR2708851A1 (en) * | 1993-08-12 | 1995-02-17 | Oreal | Cosmetic composition comprising the combination of a nanopigment of metal oxides and an antioxidant, and use thereof for protecting the skin and the hair |
| FR2710839A1 (en) * | 1993-10-08 | 1995-04-14 | Rocher Yves Biolog Vegetale | Cosmetic composition and aesthetic treatment method opposing aging of the skin. |
| FR2719468A1 (en) * | 1994-05-05 | 1995-11-10 | Oreal | Cosmetic compositions based on certain bioflavonoids and uses in particular in the hair field. |
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| WO1996019099A2 (en) * | 1995-08-25 | 1996-06-27 | Lvmh Recherche | Use of vitamin c or derivatives or analogues thereof for promoting skin elastin synthesis |
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| WO1997047279A1 (en) * | 1996-06-12 | 1997-12-18 | Johnson & Johnson Consumer Products, Inc. | Photoprotective lipophilic antioxidant compounds |
| WO1998013020A1 (en) * | 1996-09-27 | 1998-04-02 | Unilever Plc | Skin care compositions containing combinations of compounds for mimicking the effect on skin of retinoic acid |
| FR2765104A1 (en) * | 1997-06-26 | 1998-12-31 | Jean Noel Thorel | Cosmetic sun screen preparations |
| GR970100233A (en) * | 1997-06-09 | 1999-02-26 | Use of organic, anti-oxidant substances for the protection of the lungs, the skin and the eyes from free radicals | |
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| EP0953337A1 (en) * | 1998-04-10 | 1999-11-03 | Ioannis Papadakos | Preparation of sun protection oil |
| EP0995428A2 (en) * | 1998-08-29 | 2000-04-26 | Beiersdorf Aktiengesellschaft | Skin care composition contaning retionoids |
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| WO1994004129A3 (en) * | 1992-08-26 | 1994-05-26 | Beiersdorf Ag | Cosmetic and dermatological sunscreen compositions containing thiols and/or thiol derivates |
| WO1994004128A3 (en) * | 1992-08-26 | 1994-07-07 | Beiersdorf Ag | Use of radical catchers as immunomodulating agents in cosmetic and dermatological compositions |
| DE4228455A1 (en) * | 1992-08-26 | 1994-09-15 | Beiersdorf Ag | Cosmetic and dermatological sunscreen formulations containing thiols and / or thiol derivatives |
| EP0607642A1 (en) * | 1993-01-19 | 1994-07-27 | PERRICONE, Nicholas V., Dr. | Compositions for topical application to the skin for treatment and/or prevention of radiation-induced skin damage |
| FR2708851A1 (en) * | 1993-08-12 | 1995-02-17 | Oreal | Cosmetic composition comprising the combination of a nanopigment of metal oxides and an antioxidant, and use thereof for protecting the skin and the hair |
| FR2710839A1 (en) * | 1993-10-08 | 1995-04-14 | Rocher Yves Biolog Vegetale | Cosmetic composition and aesthetic treatment method opposing aging of the skin. |
| EP0684040A2 (en) * | 1994-04-25 | 1995-11-29 | Unilever Plc | Skin treatment composition |
| EP0684040A3 (en) * | 1994-04-25 | 1995-12-13 | Unilever Plc | Skin treatment composition |
| US5660818A (en) * | 1994-05-05 | 1997-08-26 | L'oreal | Bioflavonoids as agents for protecting the physical and/or cosmetic properties of keratinous superficial body growths |
| FR2719468A1 (en) * | 1994-05-05 | 1995-11-10 | Oreal | Cosmetic compositions based on certain bioflavonoids and uses in particular in the hair field. |
| EP0681827A1 (en) * | 1994-05-05 | 1995-11-15 | L'oreal | Use of bioflavonoids as keratineous phaners protection agent |
| EP0754446A3 (en) * | 1995-07-20 | 2007-04-04 | L'oreal | Use of an antioxydant and/or antiradical in a sunscreening cosmetic or dermatologic composition |
| EP0754446A2 (en) * | 1995-07-20 | 1997-01-22 | L'oreal | Use of an antioxydant and/or antiradical in a sunscreening cosmetic or dermatologic composition |
| FR2736826A1 (en) * | 1995-07-20 | 1997-01-24 | Oreal | FILTERING COMPOSITION FOR COSMETIC OR DERMATOLOGICAL USE |
| WO1996019099A3 (en) * | 1995-08-25 | 1997-04-10 | Lvmh Rech | Use of vitamin c or derivatives or analogues thereof for promoting skin elastin synthesis |
| WO1996019099A2 (en) * | 1995-08-25 | 1996-06-27 | Lvmh Recherche | Use of vitamin c or derivatives or analogues thereof for promoting skin elastin synthesis |
| GB2308811A (en) * | 1995-08-25 | 1997-07-09 | Lvmh Rech | Use of vitamin C or derivatives or analogues thereof for promoting skin elastic synthesis |
| FR2737971A1 (en) * | 1995-08-25 | 1997-02-28 | Lvmh Rech | USE OF VITAMIN C OR ITS DERIVATIVES OR ANALOGUES TO STIMULATE THE SYNTHESIS OF SKIN ELASTIN |
| US5801192A (en) * | 1995-08-25 | 1998-09-01 | Lvmh Recherche | Use of vitamin C or derivatives or analogues thereof promoting skin elastin synthesis |
| BE1009858A5 (en) * | 1995-08-25 | 1997-10-07 | Lvmh Rech | Use of vitamin c or derivatives or similar to stimulate the synthesis of skin elastin. |
| GB2308811B (en) * | 1995-08-25 | 2000-04-05 | Lvmh Rech | Use of vitamin C or derivatives or analogues thereof for promoting skin elastin synthesis |
| ES2129013A1 (en) * | 1995-08-25 | 1999-05-16 | Lvmh Rech | Use of vitamin c or derivatives or analogues thereof for promoting skin elastin synthesis |
| FR2746008A1 (en) * | 1996-03-14 | 1997-09-19 | Thorel Jean Noel | Compositions containing vitamin C and protease inhibitor |
| FR2746316A1 (en) * | 1996-03-19 | 1997-09-26 | Guerlain | NEW COSMETOLOGICAL OR DERMATOLOGICAL COMPOSITIONS |
| WO1996028008A3 (en) * | 1996-03-19 | 1997-03-13 | Guerlain S A | Novel cosmetic or dermatological compositions for controlling skin ageing |
| WO1996028008A2 (en) * | 1996-03-19 | 1996-09-19 | Guerlain S.A. | Novel cosmetic or dermatological compositions for controlling skin ageing |
| WO1997047279A1 (en) * | 1996-06-12 | 1997-12-18 | Johnson & Johnson Consumer Products, Inc. | Photoprotective lipophilic antioxidant compounds |
| WO1998013020A1 (en) * | 1996-09-27 | 1998-04-02 | Unilever Plc | Skin care compositions containing combinations of compounds for mimicking the effect on skin of retinoic acid |
| CN1105554C (en) * | 1996-09-27 | 2003-04-16 | 尤尼利弗公司 | Skin care compositions containing combinations of compounds for mimicking effect on skin of retinoic acid |
| GR970100233A (en) * | 1997-06-09 | 1999-02-26 | Use of organic, anti-oxidant substances for the protection of the lungs, the skin and the eyes from free radicals | |
| FR2765104A1 (en) * | 1997-06-26 | 1998-12-31 | Jean Noel Thorel | Cosmetic sun screen preparations |
| FR2776188A1 (en) * | 1998-03-20 | 1999-09-24 | Fabre Pierre Dermo Cosmetique | Glycylglycine oleamide to combat the effects of skin aging |
| WO1999048470A1 (en) * | 1998-03-20 | 1999-09-30 | Pierre Fabre Dermo-Cosmetique | Glycylglycine oleamide in dermo-cosmetology |
| EP0953337A1 (en) * | 1998-04-10 | 1999-11-03 | Ioannis Papadakos | Preparation of sun protection oil |
| EP0995428A3 (en) * | 1998-08-29 | 2000-06-14 | Beiersdorf Aktiengesellschaft | Skin care composition contaning retionoids |
| EP0995428A2 (en) * | 1998-08-29 | 2000-04-26 | Beiersdorf Aktiengesellschaft | Skin care composition contaning retionoids |
| WO2000074641A1 (en) * | 1999-06-04 | 2000-12-14 | Beiersdorf Ag | Use of ascorbic acid and one or more flavone derivatives and/or flavan derivatives, especially flavonoids, for producing cosmetic or dermatological preparations used to prevent or sooth sunburns |
| EP1057475A1 (en) * | 1999-06-04 | 2000-12-06 | Beiersdorf AG | Use of ascorbic acid and one or more flavone derivatives and/or flavanone derivatives particularly flavonoids for the preparation of cosmetic or dermatological compositions for preventing or relieving of sunburns |
| WO2001030313A1 (en) * | 1999-10-22 | 2001-05-03 | Unilever Plc | Cosmetic compositions containing mulberry extract and retinoids |
| US6261566B1 (en) | 1999-10-22 | 2001-07-17 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Cosmetic compositions containing mulberry extract and retinoids |
| EP1297821A1 (en) * | 2001-10-01 | 2003-04-02 | Hive of Beauty (Europe) BVBA | Skin treatment compositions |
| WO2003028693A1 (en) * | 2001-10-01 | 2003-04-10 | Hive Of Beauty (Europe) Bvba | Skin treatment compositions |
| JP2016094454A (en) * | 2008-08-12 | 2016-05-26 | イーエルシー マネージメント エルエルシー | Composite particles having antioxidant-based protective system, and topical compositions comprising the same |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2666226B1 (en) | 1994-10-28 |
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