FR2639350B1 - Radical nitroxyde, son procede de fabrication et son application en magnetometrie - Google Patents

Radical nitroxyde, son procede de fabrication et son application en magnetometrie

Info

Publication number
FR2639350B1
FR2639350B1 FR8815107A FR8815107A FR2639350B1 FR 2639350 B1 FR2639350 B1 FR 2639350B1 FR 8815107 A FR8815107 A FR 8815107A FR 8815107 A FR8815107 A FR 8815107A FR 2639350 B1 FR2639350 B1 FR 2639350B1
Authority
FR
France
Prior art keywords
magnetometry
application
manufacturing process
radical nitroxide
nitroxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR8815107A
Other languages
English (en)
Other versions
FR2639350A1 (fr
Inventor
Yves Berchadsky
Nelly Kernevez
Francois Le Moigne
Anne Mercier
Liliane Secourgeon
Paul Tordo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat a lEnergie Atomique CEA filed Critical Commissariat a lEnergie Atomique CEA
Priority to FR8815107A priority Critical patent/FR2639350B1/fr
Priority to GB8924622A priority patent/GB2225015B/en
Priority to US07/433,597 priority patent/US5006663A/en
Publication of FR2639350A1 publication Critical patent/FR2639350A1/fr
Application granted granted Critical
Publication of FR2639350B1 publication Critical patent/FR2639350B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
FR8815107A 1988-11-21 1988-11-21 Radical nitroxyde, son procede de fabrication et son application en magnetometrie Expired - Lifetime FR2639350B1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR8815107A FR2639350B1 (fr) 1988-11-21 1988-11-21 Radical nitroxyde, son procede de fabrication et son application en magnetometrie
GB8924622A GB2225015B (en) 1988-11-21 1989-11-01 Nitroxide radical,its production process and its use in magnetometry
US07/433,597 US5006663A (en) 1988-11-21 1989-11-08 Phosphorus-containing cyclic nitroxide free radicals

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8815107A FR2639350B1 (fr) 1988-11-21 1988-11-21 Radical nitroxyde, son procede de fabrication et son application en magnetometrie

Publications (2)

Publication Number Publication Date
FR2639350A1 FR2639350A1 (fr) 1990-05-25
FR2639350B1 true FR2639350B1 (fr) 1990-12-21

Family

ID=9372036

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8815107A Expired - Lifetime FR2639350B1 (fr) 1988-11-21 1988-11-21 Radical nitroxyde, son procede de fabrication et son application en magnetometrie

Country Status (3)

Country Link
US (1) US5006663A (fr)
FR (1) FR2639350B1 (fr)
GB (1) GB2225015B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2688594B1 (fr) * 1992-03-13 1994-04-29 Commissariat Energie Atomique Materiau organique utilisable dans un magnetometre et sonde pour magnetometre a resonance paramagnetique electronique (rpe) utilisant ce materiau.
US5264204A (en) * 1992-04-30 1993-11-23 Mallinckrodt Medical, Inc. Hydrophilic free radicals for magnetic resonance imaging
FR2707990B1 (fr) * 1993-07-20 1995-10-20 Centre Nat Rech Scient Nouvelles nitrones utilisables pour le piégeage des radicaux libres.
AU8051894A (en) * 1993-10-25 1995-05-22 Oklahoma Medical Research Foundation Novel phosphorus-containing spin-trap compositions
US5622687A (en) * 1994-11-15 1997-04-22 Molecular Biosystems, Inc. Calixarene conjugates useful as MRI and CT diagnostic imaging agents
FR2730240A1 (fr) 1995-02-07 1996-08-09 Atochem Elf Sa Stabilisation d'un polymere par un radical libre stable
FR2776293B1 (fr) 1998-03-18 2002-10-04 Centre Nat Rech Scient Nouveaux aminophosphonates et utilisation d'aminophosphonates comme marqueurs de ph et rmn du 31p
JP2002519311A (ja) * 1998-06-26 2002-07-02 ジョージタウン・ユニバーシティ・メディカル・センター 細胞死を誘発するための組成物と方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4920974B1 (fr) * 1970-06-01 1974-05-29
GB1325775A (en) * 1970-06-10 1973-08-08 Ciba Geigy Uk Ltd Phosphorus-containing piperidine derivatives and their use as stabilisers for polymerica material
CA1001232A (en) * 1973-11-30 1976-12-07 Ivan Hrvoic Nuclear dynamic polarization magnetometer
US4105432A (en) * 1977-07-18 1978-08-08 Monsanto Company Cyclized derivatives of N-(2-hydroxyalkyl)-N-phosphonomethylglycine compounds
FR2546518B1 (fr) * 1980-10-09 1986-08-01 Commissariat Energie Atomique Radicaux nitroxydes et leur procede de fabrication, application a la magnetometrie et a la gyrometrie

Also Published As

Publication number Publication date
US5006663A (en) 1991-04-09
GB8924622D0 (en) 1989-12-20
GB2225015B (en) 1992-07-15
FR2639350A1 (fr) 1990-05-25
GB2225015A (en) 1990-05-23

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Legal Events

Date Code Title Description
CL Concession to grant licences
ST Notification of lapse