FR2620028B2 - Procede de preparation de microcristaux comportant a titre de substance active, notamment de l'amphotericine b, microcristaux obtenus et composition pharmaceutique en comprenant - Google Patents

Procede de preparation de microcristaux comportant a titre de substance active, notamment de l'amphotericine b, microcristaux obtenus et composition pharmaceutique en comprenant

Info

Publication number
FR2620028B2
FR2620028B2 FR8712424A FR8712424A FR2620028B2 FR 2620028 B2 FR2620028 B2 FR 2620028B2 FR 8712424 A FR8712424 A FR 8712424A FR 8712424 A FR8712424 A FR 8712424A FR 2620028 B2 FR2620028 B2 FR 2620028B2
Authority
FR
France
Prior art keywords
microcrystals
preparation
pharmaceutical composition
active substance
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR8712424A
Other languages
English (en)
Other versions
FR2620028A2 (fr
Inventor
Roger Baurain
Andre Trouet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ire Celltarg SA
Original Assignee
Ire Celltarg SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8617116A external-priority patent/FR2607719B1/fr
Application filed by Ire Celltarg SA filed Critical Ire Celltarg SA
Priority to FR8712424A priority Critical patent/FR2620028B2/fr
Priority to CA000553232A priority patent/CA1338736C/fr
Priority to DE3751258T priority patent/DE3751258T2/de
Priority to AT87402747T priority patent/ATE121301T1/de
Priority to ES87402747T priority patent/ES2070827T3/es
Priority to EP87402747A priority patent/EP0270460B1/fr
Priority to JP62307342A priority patent/JP2852421B2/ja
Publication of FR2620028A2 publication Critical patent/FR2620028A2/fr
Priority to US07/364,481 priority patent/US4973465A/en
Priority to MX9203411A priority patent/MX9203411A/es
Publication of FR2620028B2 publication Critical patent/FR2620028B2/fr
Application granted granted Critical
Priority to HK98106755A priority patent/HK1007502A1/xx
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
FR8712424A 1986-12-05 1987-09-08 Procede de preparation de microcristaux comportant a titre de substance active, notamment de l'amphotericine b, microcristaux obtenus et composition pharmaceutique en comprenant Expired - Lifetime FR2620028B2 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR8712424A FR2620028B2 (fr) 1986-12-05 1987-09-08 Procede de preparation de microcristaux comportant a titre de substance active, notamment de l'amphotericine b, microcristaux obtenus et composition pharmaceutique en comprenant
CA000553232A CA1338736C (fr) 1986-12-05 1987-12-01 Microcristaux comportant une substance active presentant une affinite pour les phospholipides, et au moins un phospholipide, procede de preparation
DE3751258T DE3751258T2 (de) 1986-12-05 1987-12-03 Mikrokristalle, die eine aktive Substanz mit phospholipidischer Affinität enthalten und mindestens ein Phospholipid, Verfahren zur Herstellung.
AT87402747T ATE121301T1 (de) 1986-12-05 1987-12-03 Mikrokristalle, die eine aktive substanz mit phospholipidischer affinität enthalten und mindestens ein phospholipid, verfahren zur herstellung.
ES87402747T ES2070827T3 (es) 1986-12-05 1987-12-03 Microcristales que contienen una sustancia activa que presenta afinidad por los fosfolipidos y al menos un fosfolipido, procedimiento de preparacion.
EP87402747A EP0270460B1 (fr) 1986-12-05 1987-12-03 Microcristaux comportant une substance active présentant une affinité pour les phospholipides et au moins un phospholipide, procédé de préparation
JP62307342A JP2852421B2 (ja) 1986-12-05 1987-12-04 燐脂質類に対し、そして少くとも一種類の燐脂質に対して親和性を有する活性物質から成る微結晶、並びにその製造方法及びこの微結晶を含有する薬剤組成物
US07/364,481 US4973465A (en) 1986-12-05 1989-06-08 Microcrystals comprising an active substance having an affinity for phospholipids, and at least one phospholipid, process of preparation
MX9203411A MX9203411A (es) 1986-12-05 1992-06-25 Microcristales que comprenden una substancia activa que tiene una afinidad por los fosfolipidos y por lo menos un fosfolipido, proceso de preparacion
HK98106755A HK1007502A1 (en) 1986-12-05 1998-06-25 Microcrystals containing an active substance with a phospholipid affinity and at least one phospholipid preparation process

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8617116A FR2607719B1 (fr) 1986-12-05 1986-12-05 Microcristaux comportant a titre de substance active des ginkgolides et compositions pharmaceutiques les contenant
FR8712424A FR2620028B2 (fr) 1986-12-05 1987-09-08 Procede de preparation de microcristaux comportant a titre de substance active, notamment de l'amphotericine b, microcristaux obtenus et composition pharmaceutique en comprenant

Publications (2)

Publication Number Publication Date
FR2620028A2 FR2620028A2 (fr) 1989-03-10
FR2620028B2 true FR2620028B2 (fr) 1994-02-25

Family

ID=26225626

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8712424A Expired - Lifetime FR2620028B2 (fr) 1986-12-05 1987-09-08 Procede de preparation de microcristaux comportant a titre de substance active, notamment de l'amphotericine b, microcristaux obtenus et composition pharmaceutique en comprenant

Country Status (1)

Country Link
FR (1) FR2620028B2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616334A (en) * 1987-03-05 1997-04-01 The Liposome Company, Inc. Low toxicity drug-lipid systems
US6406713B1 (en) 1987-03-05 2002-06-18 The Liposome Company, Inc. Methods of preparing low-toxicity drug-lipid complexes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663167A (en) * 1984-04-16 1987-05-05 The Board Of Regents Of The University Of Texas System Composition and method for treatment of disseminated fungal infections in mammals
US4766046A (en) * 1985-09-27 1988-08-23 Liposome Technology, Inc. Stabilized liposome/amphotericin composition and method
SE462894B (sv) * 1985-10-28 1990-09-17 Biogram Ab Mikrokapslar, foerfarande foer framstaellning daerav samt anvaendning
IE60901B1 (en) * 1986-08-21 1994-08-24 Vestar Inc Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics

Also Published As

Publication number Publication date
FR2620028A2 (fr) 1989-03-10

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CD Change of name or company name
TP Transmission of property