FI871087A0 - Menetelmä terapeuttisesti aktiivisten 1,2,3,4-tetrahydro-3-karbamoyyli-2-tiokso/okso-5-pyrimidiinikarboksyylihappojohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti aktiivisten 1,2,3,4-tetrahydro-3-karbamoyyli-2-tiokso/okso-5-pyrimidiinikarboksyylihappojohdannaisten valmistamiseksi

Info

Publication number: FI871087A0
Authority: FI; Finland
Prior art keywords: thioxo; carbamoyl; tetrahydro; oxo; preparation
Prior art date: 1986-03-14

Application number

FI871087A

Other languages

English (en)

Swedish (sv)

Other versions

FI96683B (fi

FI871087A (fi

FI96683C (fi

Inventor

Karnail Singh Atwal

George Charles Rovnyak

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-03-14

Filing date

1987-03-12

Publication date

1987-03-12

1987-02-09 Priority claimed from US07/008,037 external-priority patent/US4855301A/en

1987-03-12 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1987-03-12 Publication of FI871087A0 publication Critical patent/FI871087A0/fi

1987-09-15 Publication of FI871087A publication Critical patent/FI871087A/fi

1996-04-30 Publication of FI96683B publication Critical patent/FI96683B/fi

1996-08-12 Application granted granted Critical

1996-08-12 Publication of FI96683C publication Critical patent/FI96683C/fi

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

FI871087A 1986-03-14 1987-03-12 Menetelmä terapeuttisesti aktiivisten 1,2,3,4-tetrahydro-3-karbamoyyli-2-tiokso/okso-5-pyrimidiinikarboksyylihappojohdannaisten valmistamiseksi FI96683C (fi)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US83976786A	1986-03-14	1986-03-14
US83976786		1986-03-14
US91734986A	1986-10-09	1986-10-09
US91734986		1986-10-09
US07/008,037 US4855301A (en)	1986-10-09	1987-02-09	1,2,3,4-Tetrahydro-6-substituted-4-aryl(or heterocyclo)-3-((substituted amino)carbonyl)-2-thioxo (or oxo)-5-pyrimidinecarboxylic acids and esters
US803787		1987-02-09

Publications (4)

Publication Number	Publication Date
FI871087A0 true FI871087A0 (fi)	1987-03-12
FI871087A FI871087A (fi)	1987-09-15
FI96683B FI96683B (fi)	1996-04-30
FI96683C FI96683C (fi)	1996-08-12

Family

ID=27358497

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI871087A FI96683C (fi)	1986-03-14	1987-03-12	Menetelmä terapeuttisesti aktiivisten 1,2,3,4-tetrahydro-3-karbamoyyli-2-tiokso/okso-5-pyrimidiinikarboksyylihappojohdannaisten valmistamiseksi

Country Status (17)

Country	Link
EP (1)	EP0237347B1 (fi)
JP (1)	JPH0819113B2 (fi)
KR (1)	KR900005014B1 (fi)
CA (1)	CA1337655C (fi)
DE (1)	DE3770661D1 (fi)
DK (1)	DK169031B1 (fi)
ES (1)	ES2039234T3 (fi)
FI (1)	FI96683C (fi)
GR (1)	GR3002715T3 (fi)
HU (1)	HU206091B (fi)
IE (1)	IE60114B1 (fi)
IL (1)	IL81800A0 (fi)
NO (1)	NO871044L (fi)
PH (1)	PH27052A (fi)
PL (1)	PL153727B1 (fi)
PT (1)	PT84479B (fi)
SU (1)	SU1713437A3 (fi)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS62267272A (ja) *	1986-05-15	1987-11-19	Sanwa Kagaku Kenkyusho Co Ltd	新規なジヒドロピリミジン化合物及びその塩、これらの製法並びに該化合物を有効成分とする循環器系作用剤
US4847379A (en) *	1987-11-30	1989-07-11	E. R. Squibb & Sons, Inc.	3,6-dihydro-1,5(2H)-pyrimidinecarboxylic acid esters
SK60097A3 (en)	1994-11-16	1998-01-14	Synaptic Pharma Corp	Dihydropyrimidines, pharmaceutical composition containing same and use thereof
US6268369B1 (en)	1994-11-16	2001-07-31	Synaptic Pharmaceutical Corporation	5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
US6228861B1 (en)	1995-11-16	2001-05-08	Synaptic Pharmaceutical Corporation	Dihydropyrimidines and uses thereof
AU714287B2 (en) *	1995-11-16	1999-12-23	Merck & Co., Inc.	Dihydropyrimidines and uses thereof
US6172066B1 (en)	1996-05-16	2001-01-09	Synaptic Pharmaceutical Corporation	Dihydropyrimidines and uses thereof
US6245773B1 (en)	1996-05-16	2001-06-12	Synaptic Pharmaceutical Corporation	5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
CA2277965A1 (en) *	1997-02-04	1998-08-06	Marc A. Bruce	Dihydropyrimidone derivatives as npy antagonists
US6680323B2 (en)	1998-12-23	2004-01-20	Synaptic Pharmaceutical Corporation	Dihydropyrimidines and uses thereof
US6274585B1 (en)	1998-12-23	2001-08-14	Synaptic Pharmaceutical Corporation	Dihydropyrimidines and uses thereof
EP1193259A4 (en) *	1999-06-23	2003-01-29	Ajinomoto Kk	dihydropyrimidine
US6720324B2 (en)	2000-07-05	2004-04-13	Synaptic Pharmaceutical Corporation	Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof
AU2003270562B2 (en)	2002-09-12	2010-09-16	Diakron Pharmaceuticals, Inc.	Calcium channel blockers
WO2005007124A2 (en)	2003-07-23	2005-01-27	Bristol-Myers Squibb Company	Substituted dihydropyrimidine inhibitors of calcium channel function
US7166603B2 (en)	2003-07-23	2007-01-23	Bristol-Myers Squibb Co.	Dihydropyrimidone inhibitors of calcium channel function

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60214778A (ja) *	1984-03-08	1985-10-28	Suntory Ltd	Ν置換３，４−ジヒドロピリミジン誘導体ならびにその製造法および用途
HUT42077A (en) *	1985-06-03	1987-06-29	Squibb & Sons Inc	Process for producing diesters of 2-tioxo- or 2-oxo-pyrimidine-1,5-dicarboxylic acid and 1-acyl-pyrimidine-5-carboxylic acids and esters
US4675321A (en) *	1986-02-07	1987-06-23	Merck & Co., Inc.	Substituted pyrimidines useful as calcium channel blockers
NZ219299A (en) *	1986-03-14	1989-01-06	Squibb & Sons Inc	Pyrimidine derivatives

1987
- 1987-03-05 IL IL81800A patent/IL81800A0/xx not_active IP Right Cessation
- 1987-03-06 PH PH34991A patent/PH27052A/en unknown
- 1987-03-11 JP JP62057890A patent/JPH0819113B2/ja not_active Expired - Lifetime
- 1987-03-11 IE IE63387A patent/IE60114B1/en not_active IP Right Cessation
- 1987-03-12 EP EP87302130A patent/EP0237347B1/en not_active Expired - Lifetime
- 1987-03-12 ES ES198787302130T patent/ES2039234T3/es not_active Expired - Lifetime
- 1987-03-12 FI FI871087A patent/FI96683C/fi not_active IP Right Cessation
- 1987-03-12 DE DE8787302130T patent/DE3770661D1/de not_active Expired - Fee Related
- 1987-03-13 SU SU874202205A patent/SU1713437A3/ru active
- 1987-03-13 NO NO871044A patent/NO871044L/no unknown
- 1987-03-13 DK DK131887A patent/DK169031B1/da not_active IP Right Cessation
- 1987-03-13 KR KR1019870002239A patent/KR900005014B1/ko not_active IP Right Cessation
- 1987-03-13 PT PT84479A patent/PT84479B/pt not_active IP Right Cessation
- 1987-03-13 PL PL1987264629A patent/PL153727B1/pl unknown
- 1987-03-13 HU HU871127A patent/HU206091B/hu not_active IP Right Cessation
- 1987-03-16 CA CA000532125A patent/CA1337655C/en not_active Expired - Fee Related
1991
- 1991-09-12 GR GR91401319T patent/GR3002715T3/el unknown

Also Published As

Publication number	Publication date
HU206091B (en)	1992-08-28
EP0237347B1 (en)	1991-06-12
NO871044L (no)	1987-09-15
JPH0819113B2 (ja)	1996-02-28
KR900005014B1 (ko)	1990-07-16
HUT43832A (en)	1987-12-28
EP0237347A3 (en)	1988-11-02
PL153727B1 (en)	1991-05-31
DK131887A (da)	1987-09-15
PT84479A (en)	1987-04-01
SU1713437A3 (ru)	1992-02-15
DK169031B1 (da)	1994-08-01
KR870008856A (ko)	1987-10-21
IE60114B1 (en)	1994-06-01
GR3002715T3 (en)	1993-01-25
JPS62265271A (ja)	1987-11-18
NO871044D0 (no)	1987-03-13
CA1337655C (en)	1995-11-28
DE3770661D1 (de)	1991-07-18
IE870633L (en)	1987-09-14
FI96683B (fi)	1996-04-30
DK131887D0 (da)	1987-03-13
PL264629A1 (en)	1988-07-21
PH27052A (en)	1993-02-01
FI871087A (fi)	1987-09-15
IL81800A0 (en)	1987-10-20
FI96683C (fi)	1996-08-12
EP0237347A2 (en)	1987-09-16
PT84479B (pt)	1990-08-31
ES2039234T3 (es)	1993-09-16

Legal Events

Date	Code	Title	Description
1996-04-01	BB	Publication of examined application
1997-10-16	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: E.R. SQUIBB & SONS, INC.

Publication	Publication Date	Title
FI91152B (fi)	1994-02-15	Menetelmä terapeuttisesti aktiivisten bentsimidatsolijohdannaisten valmistamiseksi
FI96861C (fi)	1996-09-10	Menetelmä terapeuttisesti aktiivisten substituoitujen indolyylipyrrolijohdannaisten valmistamiseksi
FI890282A0 (fi)	1989-01-19	Menetelmä terapeuttisesti käyttökelpoisten 23,24-didehydro-25-hydroksikalsiferolijohdannaisten valmistamiseksi
PT87754A (pt)	1988-07-01	Process for the preparation of new amino acid derivatives
FI94340C (fi)	1995-08-25	Menetelmä farmakologisesti vaikuttavien 1,5-diaryyli-3-(w-substituoitu-alempi-alkyyli)-pyratsolien valmistamiseksi
NO179584C (no)	1996-11-06	Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-acylaminotiazoler
NO863061L (no)	1987-02-02	Fremgangsmaate for fremstilling av fysiologisk aktive fenoksyeddiksyrederivater.
NO178619C (no)	1996-05-02	Analogifremgangsmåte for fremstilling av terapeutisk aktive di-t-butylfenoler
NO871295D0 (no)	1987-03-27	Fremgangsmaate for fremstilling av terapeutisk aktive aminosyrederivater.
FI871087A (fi)	1987-09-15	Menetelmä terapeuttisesti aktiivisten 1,2,3,4-tetrahydro-3-karbamoyyli-2-tiokso/okso-5-pyrimidiinikarboksyylihappojohdannaisten valmistamiseksi
FI96601C (fi)	1996-07-25	Menetelmä terapeuttisesti aktiivisten tetratsolijohdannaisten valmistamiseksi
PT87153A (pt)	1988-05-01	Process for the preparation of acid ribofuranuronic derivatives
NO176273C (no)	1995-03-08	Analogifremgangsmåte for fremstilling av aktive substituerte benzamider
FI93444B (fi)	1994-12-30	Menetelmä terapeuttisesti aktiivisten dihydropyridiinijohdannaisten valmistamiseksi
FI880467A0 (fi)	1988-02-02	Menetelmä terapeuttisesti käyttökelpoisten substituoitujen 3,4-dihydro-2H-bentsopyraanien valmistamiseksi
NO870049D0 (no)	1987-01-06	Fremgangsmaate for fremstilling av terapeutisk aktive aminosyrederivater.
FI873350A (fi)	1988-02-05	Menetelmä terapeuttisesti käyttökelpoisten 1,4-dihydropyridiinijohdannaisten valmistamiseksi
NO174203C (no)	1994-04-06	Analogifremgangsmåte for fremstilling av terapeutisk aktive
FI900145A0 (fi)	1990-01-11	Menetelmä farmaseuttisesti käyttökelpoisten 1,1-diokso-kefem-4-karbotiolihappojohdannaisten valmistamiseksi
FI93216C (fi)	1995-03-10	Analogiamenetelmä terapeuttisesti käyttökelpoisten 1,3-dioksaanialkeenihappojohdannaisten valmistamiseksi
NO164243C (no)	1990-09-19	Analogifremgangsmaate for fremstilling av nye terapeutisk aktive 16,17-acetalsubstituerte pregnan-21-oinsyrederivater
FI893121A0 (fi)	1989-06-27	Menetelmä farmakologisesti aktiivisten 6,21-dimetyyli-19-norprogesteronijohdannaisten valmistamiseksi
NO171499C (no)	1993-03-24	Analogifremgangsmaate for fremstilling av terapeutisk aktive 5,6-dihydro-4h-cyklo-penta(b)tiofen-6-karboksylsyre-derivater
NO166322C (no)	1991-07-03	Analogifremgangsmaate for fremstilling av terapeutisk aktive nitroapovincaminsyrederivater.
FI89595B (fi)	1993-07-15	Foerfarande foer framstaellning av terapeutiskt aktiva 2-(tioalkylamino)etyl-1H-imidazolderivat