FR2457868A1 - Derives de l'imidazobenzodiazepine, leur preparation et leurs utilisations therapeutiques - Google Patents

Derives de l'imidazobenzodiazepine, leur preparation et leurs utilisations therapeutiques

Info

Publication number
FR2457868A1
FR2457868A1 FR8011691A FR8011691A FR2457868A1 FR 2457868 A1 FR2457868 A1 FR 2457868A1 FR 8011691 A FR8011691 A FR 8011691A FR 8011691 A FR8011691 A FR 8011691A FR 2457868 A1 FR2457868 A1 FR 2457868A1
Authority
FR
France
Prior art keywords
preparation
therapeutic uses
imidazobenzodiazepine
derivatives
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8011691A
Other languages
English (en)
Other versions
FR2457868B1 (fr
Inventor
Armin Walser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2457868A1 publication Critical patent/FR2457868A1/fr
Application granted granted Critical
Publication of FR2457868B1 publication Critical patent/FR2457868B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

DERIVES DE L'IMIDAZOBENZODIAZEPINE, LEUR PREPARATION ET LEURS UTILISATIONS THERAPEUTIQUES. CES COMPOSES REPONDENT A LA FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE X REPRESENTE L'HYDROGENE, UN HALOGENE, UN GROUPE NITRO OU TRIFLUOROMETHYLE, Y REPRESENTE L'HYDROGENE, UN HALOGENE OU UN GROUPE TRIFLUOROMETHYLE, R REPRESENTE L'HYDROGENE, UN GROUPE ALKYLE INFERIEUR OU ARYLE, R REPRESENTE UN GROUPE AMINO DISUBSTITUE ET N EST EGAL A 0 OU 1, ET LEURS SELS FORMES PAR ADDITION AVEC DES ACIDES ACCEPTABLES POUR L'USAGE PHARMACEUTIQUE. CES COMPOSES ONT DES PROPRIETES SEDATIVES, ANXIOLYTIQUES, RELAXANTES ET ANTICONVULSIVES EXPLOITABLES EN THERAPEUTIQUE.
FR8011691A 1979-05-29 1980-05-27 Derives de l'imidazobenzodiazepine, leur preparation et leurs utilisations therapeutiques Granted FR2457868A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/043,417 US4226768A (en) 1979-05-29 1979-05-29 Process for the preparation of imidazobenzodiazepines

Publications (2)

Publication Number Publication Date
FR2457868A1 true FR2457868A1 (fr) 1980-12-26
FR2457868B1 FR2457868B1 (fr) 1985-04-05

Family

ID=21927076

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8011691A Granted FR2457868A1 (fr) 1979-05-29 1980-05-27 Derives de l'imidazobenzodiazepine, leur preparation et leurs utilisations therapeutiques

Country Status (7)

Country Link
US (1) US4226768A (fr)
JP (1) JPS55160778A (fr)
CH (1) CH644380A5 (fr)
DE (1) DE3020267A1 (fr)
FR (1) FR2457868A1 (fr)
GB (1) GB2052493B (fr)
IT (1) IT1131195B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4390471A (en) * 1978-05-15 1983-06-28 Hoffmann-La Roche Inc. Imidazodiazepines and processes therefor
JP2696342B2 (ja) * 1988-06-27 1998-01-14 日本曹達株式会社 アミジン誘導体、その製造方法及び殺ダニ剤・農園芸用殺菌剤
US5574028A (en) * 1994-10-31 1996-11-12 Eli Lilly And Company Method for treating anxiety
DE19824673A1 (de) * 1998-05-26 1999-12-02 Schering Ag Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
JP7023876B2 (ja) 2016-03-18 2022-02-22 ユーダブリューエム・リサーチ・ファウンデーション，インコーポレーテッド α５含有ＧＡＢＡＡ受容体アゴニストによる神経変性および神経精神障害における認知症状および気分症状の処置
US11447495B2 (en) 2016-08-16 2022-09-20 Uwm Research Foundation, Inc. Substituted benzo[f]imidazo[1,5-a][1,4]diazepines as GABA(a) receptor modulators

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2342736A1 (fr) * 1975-08-07 1977-09-30 Hoffmann La Roche Nouveaux derives de diazepine
FR2383183A1 (fr) * 1977-03-11 1978-10-06 Hoffmann La Roche Derives de benzodiazepine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA755418B (en) * 1974-09-11 1977-06-29 Hoffmann La Roche Diazepine derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2342736A1 (fr) * 1975-08-07 1977-09-30 Hoffmann La Roche Nouveaux derives de diazepine
FR2383183A1 (fr) * 1977-03-11 1978-10-06 Hoffmann La Roche Derives de benzodiazepine

Also Published As

Publication number Publication date
IT8022396A0 (it) 1980-05-29
IT1131195B (it) 1986-06-18
DE3020267A1 (de) 1980-12-11
US4226768A (en) 1980-10-07
GB2052493B (en) 1983-06-08
FR2457868B1 (fr) 1985-04-05
CH644380A5 (de) 1984-07-31
DE3020267C2 (fr) 1989-06-22
GB2052493A (en) 1981-01-28
JPS55160778A (en) 1980-12-13

Similar Documents

Publication Publication Date Title
NO802352L (no) Fremgangsmaate for fremstilling av terapeutisk aktive imidazolderivater.
ATE8874T1 (de) Therapeutisch nuetzliche 1-alkyl-2-amino-tetralin- derivate.
YU42397A (sh) Korišćenje raloksifena za pripremu leka
FR2457868A1 (fr) Derives de l'imidazobenzodiazepine, leur preparation et leurs utilisations therapeutiques
FR2358406A1 (fr) Derives d'acides 5-aroyl-1,2-dihydro-3h-pyrrolo (1,2-a)pyrrole-1-carboxyliques, leur obtention et leur application a titre de medicament
ATE55248T1 (de) Arzneimittelkombination.
FR2631827B1 (fr) Nouveaux derives d'(hetero)aryl-5 tetrazole, leur procede de preparation et leur application en therapeutique
ES2109216T3 (es) Un procedimiento para la preparacion de una composicion farmaceutica con actividad relajante muscular de accion central.
ATE90673T1 (de) Antifolat-mittel.
KR960703912A (ko) 중추신경계 활성을 갖는 헤테로사이클 아민(heterocyclic amines having central nervous system activity)
PT77666A (fr) Procede de preparation de nouveaux derives de la nitrosouree
SE7606424L (sv) Substituerade bensamider
ZA876625B (en) Benzhydryloxyethylpiperidine derivatives,process for their preparation and pharmaceutical compositions in which they are present
NO794316L (no) Fremgangsmaate for fremstilling av terapeutisk aktive 1,4-oksazepin-derivater
IL101506A0 (en) Use of 2-iminothiazolidin-4-one derivatives as novel pharmaceutical active ingredients
FR2410640A1 (fr) Derives de phenoxyalcanolamines, leur preparation et leurs utilisations therapeutiques
ES8609207A1 (es) Procedimiento para la preparacion de derivados de feniletilamina.
FR2408589A1 (fr) Nouvelles 13,14-bisdeshydroprostaglandines, leur procede de preparation et leurs applications therapeutiques
BE1002099A3 (fr) Nouvelles quinazolinones tetracycliques, leur preparation et leur utilisation comme medicaments.
ES477257A1 (es) Un procedimiento para preprarar derivados de isoquinoleina.
ES2036539T3 (es) Un procedimiento para preparar derivados de ergolina.
FR2455598A1 (fr) Nouveaux derives 5- (2- ((2,3-dihydro-1,4-benzodioxanne-2-ylmethyl)- amino)-1- hydroxyethyl)-2-hydroxybenzoiques, utiles notamment comme agents bloquants des recepteurs adrenergiques a et b, et leur procede de preparation
FR2603282A1 (fr) Derives d'isoquinoleine
FR2405236A1 (fr) Acides 5, 6, 7-trimethoxy-naphtalene et hydronaphtalene-(2)-carboxyliques et derives, leur preparation et leur application a titre de medicament
ATE283834T1 (de) Phenantrenderivate mit medizinischer anwendung sowie dessen herstellungsverfahren

Legal Events

Date Code Title Description
ST Notification of lapse