FR2455609A1 - 24-24-difluoro-25-hydroxycholecalciferol - Google Patents

24-24-difluoro-25-hydroxycholecalciferol

Info

Publication number
FR2455609A1
FR2455609A1 FR8018944A FR8018944A FR2455609A1 FR 2455609 A1 FR2455609 A1 FR 2455609A1 FR 8018944 A FR8018944 A FR 8018944A FR 8018944 A FR8018944 A FR 8018944A FR 2455609 A1 FR2455609 A1 FR 2455609A1
Authority
FR
France
Prior art keywords
difluoro
bopi
formula
design
hydroxycholecalciferol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8018944A
Other languages
English (en)
Other versions
FR2455609B1 (fr
Inventor
Hector F De Luca
Nobuo Ikekawa
Yoko Tanaka
Yoshiro Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of FR2455609A1 publication Critical patent/FR2455609A1/fr
Application granted granted Critical
Publication of FR2455609B1 publication Critical patent/FR2455609B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

24,24-DIFLUORO-25-HYDROXYCHLOLECALCIFEROL. DERIVE DE LA VITAMINE D AYANT LA FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE AC DESIGNE UN RADICAL ACETYLE ET Q UN RADICAL DIFLUORO-CHOLESTEROL SUBSTITUE AYANT LA FORMULE: (CF DESSIN DANS BOPI) CE COMPOSE, UTILE DANS LA PREVENTION DU RACHITISME, PERMET D'ENTRETENIR PLUS LONGTEMPS, LORS DE SON APPLICATION, DES CONCENTRATIONS TISSULAIRES ELEVEES.
FR8018944A 1979-03-05 1980-09-02 24-24-difluoro-25-hydroxycholecalciferol Granted FR2455609A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/017,168 US4196133A (en) 1979-03-05 1979-03-05 24,24-Difluoro-25-hydroxycholecalciferol

Publications (2)

Publication Number Publication Date
FR2455609A1 true FR2455609A1 (fr) 1980-11-28
FR2455609B1 FR2455609B1 (fr) 1983-07-01

Family

ID=21781101

Family Applications (2)

Application Number Title Priority Date Filing Date
FR8004852A Expired FR2450814B1 (fr) 1979-03-05 1980-03-04 24,24-difluoro-25-hydroxycholecalciferol et composition pharmaceutique renfermant ce produit
FR8018944A Granted FR2455609A1 (fr) 1979-03-05 1980-09-02 24-24-difluoro-25-hydroxycholecalciferol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR8004852A Expired FR2450814B1 (fr) 1979-03-05 1980-03-04 24,24-difluoro-25-hydroxycholecalciferol et composition pharmaceutique renfermant ce produit

Country Status (16)

Country Link
US (1) US4196133A (fr)
JP (2) JPS6310946B2 (fr)
AU (1) AU532388B2 (fr)
BE (1) BE882036A (fr)
CA (1) CA1157049A (fr)
CH (2) CH653018A5 (fr)
DK (3) DK156635C (fr)
FR (2) FR2450814B1 (fr)
GB (1) GB2044770B (fr)
IE (1) IE49532B1 (fr)
IL (1) IL58525A (fr)
IT (1) IT1151077B (fr)
NL (1) NL7920160A (fr)
NZ (1) NZ191899A (fr)
SE (1) SE8007427L (fr)
WO (1) WO1980001915A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284577A (en) * 1979-02-16 1981-08-18 Sachiko Yamada Novel vitamin D3 derivative and process for preparing the same
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol
US4254045A (en) * 1980-04-21 1981-03-03 Wisconsin Alumni Research Foundation 1α-Hydroxy-2β-fluorocholecalciferol
US4307025A (en) * 1981-02-17 1981-12-22 Wisconsin Alumni Research Foundation 1α, 25-dihydroxy-2β-fluorovitamin D3
US4428946A (en) * 1982-07-26 1984-01-31 Wisconsin Alumni Research Foundation Method of preventing milk fever in dairy cattle
US4500460A (en) * 1983-08-18 1985-02-19 Wisconsin Alumni Research Foundation 23,23-Difluoro-25-hydroxy-vitamin D3 and process for preparing same
US4564474A (en) * 1983-08-18 1986-01-14 Wisconsin Alumni Research Foundation 23,23-Difluoro-25-hydroxy-vitamin D3 and process for preparing same
IT1175607B (it) * 1983-08-18 1987-07-15 Wisconsin Alumni Res Found 23,23-difluoro-25-idrossi-e 1 alfa, 25-diidrossi-vitamina d3
ATE45347T1 (de) * 1985-05-30 1989-08-15 Taisho Pharmaceutical Co Ltd Vitamin d3-derivate.
IL139241A0 (en) 1998-05-13 2001-11-25 Novo Nordisk As Meiosis regulating compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2453151A1 (fr) * 1979-02-16 1980-10-31 Yamada Sachiko Derives de la vitamine d3, leur procede de preparation et leur application en therapeutique

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993675A (en) * 1975-02-24 1976-11-23 Hoffmann-La Roche Inc. Process for the preparation of 1α,25-dihydroxycholecalciferol
US4069321A (en) * 1975-10-14 1978-01-17 Merck & Co., Inc. Blocked cholecalciferol and dihydrotachysterol 3 derivatives
US4028349A (en) * 1976-03-08 1977-06-07 Hoffmann-La Roche Inc. Syntheses of 24R,25- and 24S,25-dihydroxycholesterol 24,25-ketals and alkanoyl derivatives thereof
JPS595432B2 (ja) * 1976-11-09 1984-02-04 凸版印刷株式会社 容器の製造方法
US4188345A (en) * 1978-07-26 1980-02-12 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2453151A1 (fr) * 1979-02-16 1980-10-31 Yamada Sachiko Derives de la vitamine d3, leur procede de preparation et leur application en therapeutique

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/79 *

Also Published As

Publication number Publication date
JPH0142944B2 (fr) 1989-09-18
IT1151077B (it) 1986-12-17
AU5580980A (en) 1980-09-11
GB2044770A (en) 1980-10-22
IE800420L (en) 1980-09-05
DK446482A (da) 1982-10-08
DK156635B (da) 1989-09-18
CH654015A5 (de) 1986-01-31
IT8020326A0 (it) 1980-03-03
DK156726B (da) 1989-09-25
AU532388B2 (en) 1983-09-29
IL58525A0 (en) 1980-01-31
NL7920160A (nl) 1980-12-31
DK425183A (da) 1983-09-19
JPS56500064A (fr) 1981-01-22
DK425183D0 (da) 1983-09-19
BE882036A (fr) 1980-07-01
NZ191899A (en) 1984-11-09
WO1980001915A1 (fr) 1980-09-18
DK156644B (da) 1989-09-18
DK156644C (da) 1990-02-12
FR2450814B1 (fr) 1986-04-11
CH653018A5 (de) 1985-12-13
SE8007427L (sv) 1980-10-22
GB2044770B (en) 1983-05-11
IL58525A (en) 1983-02-23
DK467780A (da) 1980-11-04
DK156726C (da) 1990-03-05
DK156635C (da) 1990-02-12
CA1157049A (fr) 1983-11-15
FR2455609B1 (fr) 1983-07-01
US4196133A (en) 1980-04-01
JPS63183559A (ja) 1988-07-28
IE49532B1 (en) 1985-10-16
FR2450814A1 (fr) 1980-10-03
JPS6310946B2 (fr) 1988-03-10

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Legal Events

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