FR2453860A1 - Nouveaux derives d'isoquinoleine, procede et composes intermediaires pour leur preparation et application comme medicaments exercant une activite sur le systeme nerveux central - Google Patents

Nouveaux derives d'isoquinoleine, procede et composes intermediaires pour leur preparation et application comme medicaments exercant une activite sur le systeme nerveux central

Info

Publication number
FR2453860A1
FR2453860A1 FR7912963A FR7912963A FR2453860A1 FR 2453860 A1 FR2453860 A1 FR 2453860A1 FR 7912963 A FR7912963 A FR 7912963A FR 7912963 A FR7912963 A FR 7912963A FR 2453860 A1 FR2453860 A1 FR 2453860A1
Authority
FR
France
Prior art keywords
nervous system
central nervous
preparation
application
drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7912963A
Other languages
English (en)
Other versions
FR2453860B1 (fr
Inventor
David Christopher Horwell
David Edward Tupper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lilly Industries Ltd
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of FR2453860A1 publication Critical patent/FR2453860A1/fr
Application granted granted Critical
Publication of FR2453860B1 publication Critical patent/FR2453860B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'INVENTION CONCERNE DE NOUVEAUX DERIVES D'ISOQUINOLEINE, PROCEDE POUR LEUR PREPARATION ET APPLICATION COMME MEDICAMENTS EXERCANT UNE ACTIVITE SUR LE SYSTEME NERVEUX CENTRAL. LES COMPOSES D'ISOQUINOLEINE DE L'INVENTION REPONDENT A LA FORMULE SUIVANTE: (CF DESSIN DANS BOPI) OU A-B -CH-NR- OU -NR-CH-; RH, ALKYLE, CYCLOALKYLE, CYCLOALKYLALKYLE, BENZYLE, ALCENYLE OU ALCANOYLE; RH, ALKYLE; CYCLOALKYLE OU BENZYLE; R ET RH OU LIAISON CHIMIQUE ET XH OU HAL. LES COMPOSES DE L'INVENTION SONT UTILISES COMME MEDICAMENTS AGISSANT SUR LE SYSTEME NERVEUX CENTRAL.
FR7912963A 1978-05-23 1979-05-22 Nouveaux derives d'isoquinoleine, procede et composes intermediaires pour leur preparation et application comme medicaments exercant une activite sur le systeme nerveux central Granted FR2453860A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2135578 1978-05-23
GB7912970 1979-04-12

Publications (2)

Publication Number Publication Date
FR2453860A1 true FR2453860A1 (fr) 1980-11-07
FR2453860B1 FR2453860B1 (fr) 1982-02-19

Family

ID=26255289

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7912963A Granted FR2453860A1 (fr) 1978-05-23 1979-05-22 Nouveaux derives d'isoquinoleine, procede et composes intermediaires pour leur preparation et application comme medicaments exercant une activite sur le systeme nerveux central

Country Status (24)

Country Link
US (3) US4245095A (fr)
EP (1) EP0005646B1 (fr)
AR (1) AR223177A1 (fr)
AU (1) AU525554B2 (fr)
BG (1) BG30326A3 (fr)
CA (1) CA1118423A (fr)
CH (1) CH641802A5 (fr)
DD (1) DD143776A5 (fr)
DE (1) DE2962784D1 (fr)
DK (1) DK209279A (fr)
EG (1) EG14314A (fr)
ES (1) ES480849A1 (fr)
FI (1) FI64595C (fr)
FR (1) FR2453860A1 (fr)
GB (1) GB2031409B (fr)
HU (1) HU180494B (fr)
IL (1) IL57344A (fr)
MX (1) MX5565E (fr)
NZ (1) NZ190513A (fr)
PL (1) PL121298B1 (fr)
PT (1) PT69645A (fr)
RO (1) RO77552A (fr)
SU (1) SU1072808A3 (fr)
YU (1) YU120079A (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3207775A1 (de) * 1981-03-13 1982-09-23 Sandoz-Patent-GmbH, 7850 Lörrach Verfahren zur herstellung von mutterkornalkaloiden
DE3402392A1 (de) 1984-01-25 1985-08-01 Sandoz-Patent-GmbH, 7850 Lörrach Neue ergolinderivate, deren herstellung und deren verwendung
GB8419278D0 (en) * 1984-07-27 1984-08-30 Lilly Industries Ltd Pharmaceutical compounds
DE4033496A1 (de) * 1990-10-20 1992-04-23 Sandoz Ag Neue ergolinderivate, ihre herstellung und verwendung

Also Published As

Publication number Publication date
FI64595B (fi) 1983-08-31
FI64595C (fi) 1983-12-12
US4245095A (en) 1981-01-13
AU4728879A (en) 1979-11-29
DD143776A5 (de) 1980-09-10
IL57344A (en) 1982-05-31
EG14314A (en) 1983-12-31
EP0005646A1 (fr) 1979-11-28
FR2453860B1 (fr) 1982-02-19
IL57344A0 (en) 1979-09-30
ES480849A1 (es) 1980-02-01
USRE31194E (en) 1983-03-29
RO77552A (fr) 1982-02-01
AR223177A1 (es) 1981-07-31
PL215772A1 (fr) 1980-07-14
DE2962784D1 (en) 1982-07-01
GB2031409B (en) 1982-12-08
CH641802A5 (fr) 1984-03-15
NZ190513A (en) 1982-03-30
DK209279A (da) 1979-11-24
PL121298B1 (en) 1982-04-30
HU180494B (en) 1983-03-28
MX5565E (es) 1983-10-14
BG30326A3 (en) 1981-05-15
FI791615A (fi) 1979-11-24
AU525554B2 (en) 1982-11-11
US4277480A (en) 1981-07-07
EP0005646B1 (fr) 1982-05-12
SU1072808A3 (ru) 1984-02-07
CA1118423A (fr) 1982-02-16
YU120079A (en) 1983-06-30
PT69645A (en) 1979-06-01
GB2031409A (en) 1980-04-23

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Legal Events

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