FR2446823A1 - Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique - Google Patents
Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutiqueInfo
- Publication number
- FR2446823A1 FR2446823A1 FR7900971A FR7900971A FR2446823A1 FR 2446823 A1 FR2446823 A1 FR 2446823A1 FR 7900971 A FR7900971 A FR 7900971A FR 7900971 A FR7900971 A FR 7900971A FR 2446823 A1 FR2446823 A1 FR 2446823A1
- Authority
- FR
- France
- Prior art keywords
- methoxy
- amino
- bromophenyl
- thenyl
- pyrimidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (31)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7900971A FR2446823A1 (fr) | 1979-01-16 | 1979-01-16 | Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique |
FR7931656A FR2476088A2 (fr) | 1979-01-16 | 1979-12-26 | Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique |
SE8000068A SE444941B (sv) | 1979-01-16 | 1980-01-04 | Derivat av nor-tropan och farmaceutisk komposition derav |
GR60908A GR66499B (de) | 1979-01-16 | 1980-01-05 | |
US06/110,067 US4471120A (en) | 1979-01-16 | 1980-01-07 | Nor-tropane derivatives |
IT19071/80A IT1148801B (it) | 1979-01-16 | 1980-01-08 | Derivati del nor-tropano, loro procedimento di preparazione e loro applicazione terapeutica |
CH111/80A CH647520A5 (fr) | 1979-01-16 | 1980-01-08 | Derives du nortropane, leur procede de preparation et composition pharmaceutique les contenant. |
CA343,219A CA1130286A (en) | 1979-01-16 | 1980-01-08 | Derivates of nor-tropane, a process for preparing same and their application in therapeutics |
ZA00800160A ZA80160B (en) | 1979-01-16 | 1980-01-10 | Novel nor-tropane derivatives,a process for preparing same and their application in therapeutics |
GB8028343A GB2055374B (en) | 1979-01-16 | 1980-01-11 | -amino-3 nor-tropane derivatives |
GB8001037A GB2042522B (en) | 1979-01-16 | 1980-01-11 | Nor-tropane derivatives a process for preparing same and their application in therapeutics |
BE0/198955A BE881134A (fr) | 1979-01-16 | 1980-01-14 | Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique |
LU82083A LU82083A1 (fr) | 1979-01-16 | 1980-01-14 | Nouveaux derives du nor-tropane,leur procede de preparation et leur application en therapeutique |
ES487721A ES487721A1 (es) | 1979-01-16 | 1980-01-15 | Procedimiento de preparacion de nuevos derivados del nor- tropano |
MX10153780U MX6529E (es) | 1979-01-16 | 1980-01-15 | Procedimiento para preparar derivados del nor-tropano |
AU54610/80A AU542537B2 (en) | 1979-01-16 | 1980-01-15 | Nor-tropane derivatives |
DE3049963A DE3049963C2 (de) | 1979-01-16 | 1980-01-16 | 3-ß-Amino-nortropan-Derivate und Verfahren zu ihrer Herstellung |
JP55003433A JPS6059915B2 (ja) | 1979-01-16 | 1980-01-16 | 新規なノル−トロパン誘導体、その製法及び用途 |
NL8000277A NL8000277A (nl) | 1979-01-16 | 1980-01-16 | Nieuwe nor-tropaanverbindingen alsmede werkwijze ter bereiding en therapeutische toepassing van deze verbindingen. |
DE19803001328 DE3001328A1 (de) | 1979-01-16 | 1980-01-16 | Neue nortropan-derivate, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittel |
SE8005674A SE431984B (sv) | 1979-01-16 | 1980-08-12 | Derivat av 3-beta-amiro-nortropan som mellanprodukter for framstellning av nortropanderivat |
CH622080A CH646969A5 (fr) | 1979-01-16 | 1980-08-18 | Derives du beta-amino-3 nor-tropane. |
US06/186,100 US4424358A (en) | 1979-01-16 | 1980-09-11 | β-3-Amino nor-tropane compounds |
IT8024713A IT1235424B (it) | 1979-01-16 | 1980-09-17 | Derivati del beta-3-ammino-nortropano |
NL8005774A NL8005774A (nl) | 1979-01-16 | 1980-10-20 | Nieuwe 3-beta-amino-nor-tropaanverbindingen. |
US06/254,684 US4329466A (en) | 1979-01-16 | 1981-04-16 | Certain nor-tropan-8-amine-3-aryl or heteroaryl derivatives |
US06/254,683 US4321378A (en) | 1979-01-16 | 1981-04-16 | 8-(5-Pyrimidinecarboxamide)nor-tropane derivatives |
JP6772381A JPS56164187A (en) | 1979-01-16 | 1981-05-07 | Novel beta-amino-3-nor tropane derivative |
US06/399,392 US4536580A (en) | 1979-01-16 | 1982-07-19 | 4-Amino-5-bromo-2-methoxy-N-[8-(benzyl)]-8-azabicyclo[3.2.1]-3-YL-benzamide or a pharmacologically acceptable acid addition salt thereof |
CA000409952A CA1160227A (en) | 1979-01-16 | 1982-08-23 | DERIVATIVES OF .beta.-3-AMINO-N-NOR-TROPANES |
JP58122438A JPS5976084A (ja) | 1979-01-16 | 1983-07-07 | 新規なノル−トロパン誘導体、その製法及び用途 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7900971A FR2446823A1 (fr) | 1979-01-16 | 1979-01-16 | Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2446823A1 true FR2446823A1 (fr) | 1980-08-14 |
FR2446823B1 FR2446823B1 (de) | 1983-10-21 |
Family
ID=9220797
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7900971A Granted FR2446823A1 (fr) | 1979-01-16 | 1979-01-16 | Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique |
Country Status (3)
Country | Link |
---|---|
JP (3) | JPS6059915B2 (de) |
FR (1) | FR2446823A1 (de) |
ZA (1) | ZA80160B (de) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0067615A1 (de) * | 1981-06-17 | 1982-12-22 | Beecham Group Plc | Alkylthioderivate von Azabicyclobenzamiden, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
EP0068700A1 (de) * | 1981-06-29 | 1983-01-05 | Beecham Group Plc | Azabicycloalkylbenzamide, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
EP0069481A1 (de) * | 1981-06-17 | 1983-01-12 | Beecham Group Plc | Azabicycloalkylbenzamide, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
EP0069482A1 (de) * | 1981-06-29 | 1983-01-12 | Beecham Group Plc | Azabicycloalkylbenzamide, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
EP0081054A2 (de) * | 1978-12-30 | 1983-06-15 | Beecham Group Plc | Azabicyclo-Alkyl-Derivate |
WO2009126806A2 (en) | 2008-04-11 | 2009-10-15 | Janssen Pharmaceutica Nv | Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene a4 hydrolase |
WO2010132599A1 (en) | 2009-05-14 | 2010-11-18 | Janssen Pharmaceutica Nv | Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene a4 hydrolase |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2493848B2 (fr) * | 1980-11-07 | 1986-05-16 | Delalande Sa | Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1162129A (fr) * | 1954-10-20 | 1958-09-09 | Sandoz Ag | Dérivés amidés du tropane et leur préparation |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5592384A (en) * | 1978-12-30 | 1980-07-12 | Beecham Group Ltd | Compound having pharmacological activity |
JPH01112779A (ja) * | 1987-10-27 | 1989-05-01 | Oki Electric Ind Co Ltd | 定電圧ダイオード及びその製造方法 |
-
1979
- 1979-01-16 FR FR7900971A patent/FR2446823A1/fr active Granted
-
1980
- 1980-01-10 ZA ZA00800160A patent/ZA80160B/xx unknown
- 1980-01-16 JP JP55003433A patent/JPS6059915B2/ja not_active Expired
-
1981
- 1981-05-07 JP JP6772381A patent/JPS56164187A/ja active Pending
-
1983
- 1983-07-07 JP JP58122438A patent/JPS5976084A/ja active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1162129A (fr) * | 1954-10-20 | 1958-09-09 | Sandoz Ag | Dérivés amidés du tropane et leur préparation |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0081054A3 (en) * | 1978-12-30 | 1983-08-24 | Beecham Group Plc | Azabicyclo alkyl derivatives |
EP0081054A2 (de) * | 1978-12-30 | 1983-06-15 | Beecham Group Plc | Azabicyclo-Alkyl-Derivate |
US4499099A (en) * | 1981-06-17 | 1985-02-12 | Beecham Group P.L.C. | Nortropane and granatane type compounds useful in treating psychosis |
EP0069481A1 (de) * | 1981-06-17 | 1983-01-12 | Beecham Group Plc | Azabicycloalkylbenzamide, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
EP0067615A1 (de) * | 1981-06-17 | 1982-12-22 | Beecham Group Plc | Alkylthioderivate von Azabicyclobenzamiden, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
US4459300A (en) * | 1981-06-29 | 1984-07-10 | Beecham Group P.L.C. | Pharmaceutically active aza-bicyclo benzamide derivatives |
EP0069482A1 (de) * | 1981-06-29 | 1983-01-12 | Beecham Group Plc | Azabicycloalkylbenzamide, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
EP0068700A1 (de) * | 1981-06-29 | 1983-01-05 | Beecham Group Plc | Azabicycloalkylbenzamide, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
WO2009126806A2 (en) | 2008-04-11 | 2009-10-15 | Janssen Pharmaceutica Nv | Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene a4 hydrolase |
US7939527B2 (en) | 2008-04-11 | 2011-05-10 | Janssen Pharmaceutica Nv | Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase |
EP2336125A1 (de) | 2008-04-11 | 2011-06-22 | Janssen Pharmaceutica N.V. | Thiazolopyridin-2-yloxy-phenyl- und Thiazolopyrazin-2-yloxy-phenyl-amine als Modulatoren von Leukotrien-A4-hydrolase |
US8357684B2 (en) | 2008-04-11 | 2013-01-22 | Janssen Pharmaceutica Nv | Thyazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase |
WO2010132599A1 (en) | 2009-05-14 | 2010-11-18 | Janssen Pharmaceutica Nv | Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene a4 hydrolase |
US8399465B2 (en) | 2009-05-14 | 2013-03-19 | Janssen Pharmaceutica Nv | Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene A4 hydrolase |
Also Published As
Publication number | Publication date |
---|---|
JPS5976084A (ja) | 1984-04-28 |
JPS56164187A (en) | 1981-12-17 |
ZA80160B (en) | 1981-01-28 |
FR2446823B1 (de) | 1983-10-21 |
JPS6059915B2 (ja) | 1985-12-27 |
JPS55108871A (en) | 1980-08-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property |