FR2442836A1 - 1,2,4,5-tetra-alkyl-4-arylpiperidines, leur preparation et leur utilisation therapeutique - Google Patents
1,2,4,5-tetra-alkyl-4-arylpiperidines, leur preparation et leur utilisation therapeutiqueInfo
- Publication number
- FR2442836A1 FR2442836A1 FR7928977A FR7928977A FR2442836A1 FR 2442836 A1 FR2442836 A1 FR 2442836A1 FR 7928977 A FR7928977 A FR 7928977A FR 7928977 A FR7928977 A FR 7928977A FR 2442836 A1 FR2442836 A1 FR 2442836A1
- Authority
- FR
- France
- Prior art keywords
- arylpiperidines
- tetra
- alkyl
- preparation
- therapeutic use
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
L'invention concerne des 4-arylpipéridines 1,2,4,5-tétrasubstituées de formule :
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/965,137 US4284635A (en) | 1978-11-29 | 1978-11-29 | Analgesic 1,2,4,5-tetra-alkyl-4-arylpiperidines |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2442836A1 true FR2442836A1 (fr) | 1980-06-27 |
FR2442836B1 FR2442836B1 (fr) | 1983-07-29 |
Family
ID=25509504
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7928977A Granted FR2442836A1 (fr) | 1978-11-29 | 1979-11-23 | 1,2,4,5-tetra-alkyl-4-arylpiperidines, leur preparation et leur utilisation therapeutique |
FR8010755A Granted FR2453154A1 (fr) | 1978-11-29 | 1980-05-13 | Sels de tetrahydropyridinium, utiles comme intermediaires de synthese |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8010755A Granted FR2453154A1 (fr) | 1978-11-29 | 1980-05-13 | Sels de tetrahydropyridinium, utiles comme intermediaires de synthese |
Country Status (26)
Country | Link |
---|---|
US (1) | US4284635A (fr) |
EP (1) | EP0013078A3 (fr) |
JP (1) | JPS5573657A (fr) |
KR (1) | KR830001214A (fr) |
AR (1) | AR224138A1 (fr) |
AT (1) | ATA750879A (fr) |
AU (1) | AU529136B2 (fr) |
BE (1) | BE880220A (fr) |
CA (1) | CA1121357A (fr) |
DD (1) | DD147537A5 (fr) |
DK (1) | DK504979A (fr) |
EG (1) | EG14137A (fr) |
ES (2) | ES486425A0 (fr) |
FI (1) | FI793663A (fr) |
FR (2) | FR2442836A1 (fr) |
GB (1) | GB2038812B (fr) |
GR (1) | GR72292B (fr) |
HU (1) | HU178532B (fr) |
IL (1) | IL58793A0 (fr) |
IT (1) | IT1126406B (fr) |
LU (1) | LU81923A1 (fr) |
PH (1) | PH15420A (fr) |
PL (1) | PL123672B1 (fr) |
PT (1) | PT70486A (fr) |
SU (1) | SU967275A3 (fr) |
ZA (1) | ZA796336B (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5212183A (en) * | 1981-11-14 | 1993-05-18 | Basf Aktiengesellschaft | 4-(p-tert.-butylphenyl)-3-methylpiperidines substituted at the nitrogen, their quaternary salts and their use as fungicides |
US4485109A (en) * | 1982-05-07 | 1984-11-27 | E. I. Du Pont De Nemours And Company | 4-Aryl-4-piperidinecarbinols |
US4581456A (en) * | 1983-09-21 | 1986-04-08 | Eli Lilly And Company | Processes for preparing picenadol precursors and novel intermediates thereof |
ZW10287A1 (en) * | 1986-07-15 | 1988-01-13 | Hoffmann La Roche | Tetrahydronaphthaline and indane derivatives |
EP0299549A3 (fr) * | 1987-07-09 | 1989-02-08 | Duphar International Research B.V | 3,5-Dialkyl-3-phényl-pipéridines avec une activité antagoniste des opiates |
CA1337418C (fr) * | 1988-03-28 | 1995-10-24 | Engelbert Ciganek | 4-aryl-4piperidine(ou pyrrolidine ou hexahydroazepine) cardinols et leurs analogues heterocycliques |
US5136040A (en) * | 1991-02-26 | 1992-08-04 | Eli Lilly And Company | Preparation of substituted tetrahydropyridines |
US5250542A (en) * | 1991-03-29 | 1993-10-05 | Eli Lilly And Company | Peripherally selective piperidine carboxylate opioid antagonists |
US5270328A (en) * | 1991-03-29 | 1993-12-14 | Eli Lilly And Company | Peripherally selective piperidine opioid antagonists |
US5159081A (en) * | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
GB9912410D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912411D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912413D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912415D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912416D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
GB9912417D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2956058A (en) * | 1957-08-19 | 1960-10-11 | Lilly Co Eli | Novel substituted piperidines and pyrrolidines |
US3080372A (en) * | 1960-03-25 | 1963-03-05 | Res Lab Dr C Janssen | 1-aroylalkyl-4-arylpiperidine derivatives |
US3574219A (en) * | 1967-09-27 | 1971-04-06 | Tanabe Seiyaku Co | 1-(beta-hydroxyphenethyl)-2,3-dimethyl-3-(3-hydroxyphenyl)-piperidine |
FR2224457A1 (fr) * | 1973-04-05 | 1974-10-31 | Ciba Geigy Ag | |
US4115400A (en) * | 1976-05-27 | 1978-09-19 | Eli Lilly And Company | 1-Azoniabicyclo[3.1.0]hexanes |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2892842A (en) * | 1959-06-30 | Their preparation | ||
US3043845A (en) * | 1958-12-29 | 1962-07-10 | Abbott Lab | Phenylmethylpiperidine derivatives |
NL123743C (fr) * | 1963-09-18 | |||
US3936468A (en) * | 1969-10-27 | 1976-02-03 | Sumitomo Chemical Company, Ltd. | Phenylbutanol derivatives |
AR206937A1 (es) * | 1974-09-06 | 1976-08-31 | Lilly Co Eli | Procedimiento para preparar compuestos de 1-sustituido-4-alquil-4-fenil-piperidina |
ZA777356B (en) * | 1976-12-17 | 1979-01-31 | Rohm & Haas | Arthropod repellents |
-
1978
- 1978-11-29 US US05/965,137 patent/US4284635A/en not_active Expired - Lifetime
-
1979
- 1979-11-22 CA CA000340379A patent/CA1121357A/fr not_active Expired
- 1979-11-22 ZA ZA00796336A patent/ZA796336B/xx unknown
- 1979-11-22 GB GB7940422A patent/GB2038812B/en not_active Expired
- 1979-11-22 PT PT70486A patent/PT70486A/pt unknown
- 1979-11-22 AU AU53100/79A patent/AU529136B2/en not_active Expired - Fee Related
- 1979-11-22 FI FI793663A patent/FI793663A/fi not_active Application Discontinuation
- 1979-11-22 EP EP79302674A patent/EP0013078A3/fr not_active Ceased
- 1979-11-23 BE BE1/9621A patent/BE880220A/fr unknown
- 1979-11-23 IL IL58793A patent/IL58793A0/xx unknown
- 1979-11-23 PH PH23322A patent/PH15420A/en unknown
- 1979-11-23 FR FR7928977A patent/FR2442836A1/fr active Granted
- 1979-11-26 PL PL1979219885A patent/PL123672B1/pl unknown
- 1979-11-26 JP JP15349279A patent/JPS5573657A/ja active Pending
- 1979-11-26 LU LU81923A patent/LU81923A1/fr unknown
- 1979-11-27 AT AT0750879A patent/ATA750879A/de not_active Application Discontinuation
- 1979-11-27 AR AR279039A patent/AR224138A1/es active
- 1979-11-27 IT IT27614/79A patent/IT1126406B/it active
- 1979-11-27 GR GR60608A patent/GR72292B/el unknown
- 1979-11-27 EG EG708/79A patent/EG14137A/xx active
- 1979-11-27 HU HU79EI892A patent/HU178532B/hu unknown
- 1979-11-28 KR KR1019790004179A patent/KR830001214A/ko unknown
- 1979-11-28 DK DK504979A patent/DK504979A/da unknown
- 1979-11-28 SU SU792847573A patent/SU967275A3/ru active
- 1979-11-28 ES ES486425A patent/ES486425A0/es active Granted
- 1979-11-29 DD DD79217246A patent/DD147537A5/de unknown
-
1980
- 1980-05-13 FR FR8010755A patent/FR2453154A1/fr active Granted
- 1980-07-31 ES ES493915A patent/ES8200664A1/es not_active Expired
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2956058A (en) * | 1957-08-19 | 1960-10-11 | Lilly Co Eli | Novel substituted piperidines and pyrrolidines |
US3080372A (en) * | 1960-03-25 | 1963-03-05 | Res Lab Dr C Janssen | 1-aroylalkyl-4-arylpiperidine derivatives |
US3574219A (en) * | 1967-09-27 | 1971-04-06 | Tanabe Seiyaku Co | 1-(beta-hydroxyphenethyl)-2,3-dimethyl-3-(3-hydroxyphenyl)-piperidine |
FR2224457A1 (fr) * | 1973-04-05 | 1974-10-31 | Ciba Geigy Ag | |
US4115400A (en) * | 1976-05-27 | 1978-09-19 | Eli Lilly And Company | 1-Azoniabicyclo[3.1.0]hexanes |
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ER | Errata listed in the french official journal (bopi) |
Free format text: 31/80 |
|
ST | Notification of lapse |