FR2440949A1 - Nouveaux 4-hydroxy-4h-2,3-dihydrobenzopyranne-4-carboximidates, utiles comme intermediaires chimiques - Google Patents

Nouveaux 4-hydroxy-4h-2,3-dihydrobenzopyranne-4-carboximidates, utiles comme intermediaires chimiques

Info

Publication number
FR2440949A1
FR2440949A1 FR8002697A FR8002697A FR2440949A1 FR 2440949 A1 FR2440949 A1 FR 2440949A1 FR 8002697 A FR8002697 A FR 8002697A FR 8002697 A FR8002697 A FR 8002697A FR 2440949 A1 FR2440949 A1 FR 2440949A1
Authority
FR
France
Prior art keywords
atoms
carbon
bromo
phenyl
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8002697A
Other languages
English (en)
Other versions
FR2440949B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of FR2440949A1 publication Critical patent/FR2440949A1/fr
Application granted granted Critical
Publication of FR2440949B1 publication Critical patent/FR2440949B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Moulding By Coating Moulds (AREA)
  • Dental Preparations (AREA)
  • Photosensitive Polymer And Photoresist Processing (AREA)

Abstract

LA PRESENTE INVENTION CONCERNE DE NOUVEAUX COMPOSES CHIMIQUES UTILES DANS LA SYNTHESE DE SPIRO-OXAZOLIDINE-DIONES. CES COMPOSES ONT COMME FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE X EST UN ATOME D'OXYGENE OU DE SOUFRE; N EST EGAL A 1 OU 2; R, R ET R REPRESENTENT CHACUN UN ATOME D'HYDROGENE OU UN RADICAL CHLORO, BROMO, FLUORO, ALKYLE AYANT 1 A 3 ATOMES DE CARBONE, PHENYLE OU PHENYLE MONOSUBSTITUE DONT LE SUBSTITUANT EST UN RADICAL CHLORO, BROMO, FLUORO, HYDROXYLE, ALKYLE AYANT 1 A 3 ATOMES DE CARBONE OU ALKOXY AYANT 1 A 3 ATOMES DE CARBONE ET R EST UN GROUPE ALKYLE AYANT 1 A 4 ATOMES DE CARBONE, BENZYLE OU BENZYLE MONOSUBSTITUE, DONT LE SUBSTITUANT EST UN RADICAL CHLORO, BROMO, FLUORO, HYDROXY, ALKYLE AYANT 1 A 3 ATOMES DE CARBONE OU ALKOXY AYANT 1 A 3 ATOMES DE CARBONE.
FR8002697A 1978-08-21 1980-02-07 Nouveaux 4-hydroxy-4h-2,3-dihydrobenzopyranne-4-carboximidates, utiles comme intermediaires chimiques Granted FR2440949A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/935,199 US4200642A (en) 1978-08-21 1978-08-21 Spiro-oxazolidindiones

Publications (2)

Publication Number Publication Date
FR2440949A1 true FR2440949A1 (fr) 1980-06-06
FR2440949B1 FR2440949B1 (fr) 1981-06-12

Family

ID=25466700

Family Applications (3)

Application Number Title Priority Date Filing Date
FR7920969A Granted FR2442851A1 (fr) 1978-08-21 1979-08-20 Nouvelles spiro(4 h-2,3-dihydrovenzopyranne(4,5')oxazolidine)-2',4'-diones et medicament en contenant
FR8002698A Granted FR2440950A1 (fr) 1978-08-21 1980-02-07 Nouveaux 4-hydroxy-4h-2,3-dihydrobenzopyranne-4-carboxamides, utiles comme intermediaires chimiques
FR8002697A Granted FR2440949A1 (fr) 1978-08-21 1980-02-07 Nouveaux 4-hydroxy-4h-2,3-dihydrobenzopyranne-4-carboximidates, utiles comme intermediaires chimiques

Family Applications Before (2)

Application Number Title Priority Date Filing Date
FR7920969A Granted FR2442851A1 (fr) 1978-08-21 1979-08-20 Nouvelles spiro(4 h-2,3-dihydrovenzopyranne(4,5')oxazolidine)-2',4'-diones et medicament en contenant
FR8002698A Granted FR2440950A1 (fr) 1978-08-21 1980-02-07 Nouveaux 4-hydroxy-4h-2,3-dihydrobenzopyranne-4-carboxamides, utiles comme intermediaires chimiques

Country Status (34)

Country Link
US (1) US4200642A (fr)
JP (4) JPS6011914B2 (fr)
AR (1) AR225614A1 (fr)
AT (1) AT366689B (fr)
AU (1) AU535170B2 (fr)
BE (1) BE878311A (fr)
CA (1) CA1121361A (fr)
CH (1) CH639974A5 (fr)
CS (1) CS208129B2 (fr)
DD (1) DD146602A5 (fr)
DE (2) DE2953954C2 (fr)
DK (1) DK258479A (fr)
EG (1) EG14639A (fr)
ES (1) ES483511A1 (fr)
FI (1) FI65255C (fr)
FR (3) FR2442851A1 (fr)
GB (2) GB2028318B (fr)
GR (1) GR71913B (fr)
HU (1) HU179746B (fr)
IE (1) IE48932B1 (fr)
IL (1) IL58076A (fr)
IN (1) IN152416B (fr)
IT (1) IT1123536B (fr)
LU (1) LU81613A1 (fr)
NL (1) NL7906318A (fr)
NO (1) NO792699L (fr)
NZ (1) NZ191350A (fr)
PH (1) PH18091A (fr)
PL (1) PL130686B1 (fr)
PT (1) PT70086A (fr)
SE (1) SE447116B (fr)
SU (1) SU942597A3 (fr)
YU (1) YU41488B (fr)
ZA (1) ZA794379B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4329459A (en) * 1980-05-05 1982-05-11 The Upjohn Company Tetrahydrobenzopyran derivatives
SG56656G (en) * 1980-07-28 1987-03-27 Pfizer Hypoglycemic 5-substituted oxazolidine-2, 4-diones
US4367234A (en) * 1980-07-28 1983-01-04 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
ES515751A0 (es) * 1981-10-13 1983-10-16 Pfizer "un procedimiento por analogia para la preparacion de derivados de espiro-oxindol-oxazolidindiona".
US4438272A (en) 1982-04-15 1984-03-20 Alcon Laboratories, Inc. Spiro-(fluoren-9,4'-imidazolidine)-2',5'-diones
US4540700A (en) * 1982-04-15 1985-09-10 Alcon Laboratories, Inc. Treatment of diabetic complications with certain spiro-imidazolidine-diones
US4436745A (en) 1982-04-15 1984-03-13 Alcon Laboratories, Inc. Method of inhibiting aldose reductase activity
US4464385A (en) * 1982-04-15 1984-08-07 Alcon Laboratories, Inc. Treatment of diabetic complications with hydantoins
ZA832679B (en) * 1982-05-07 1983-12-28 Ici Plc Indoline derivatives
US4430337A (en) * 1982-06-23 1984-02-07 Pfizer Inc. Alicyclic substituted oxazolidine-2,4-diones having hypoglycemic activity
US4556670A (en) * 1982-12-06 1985-12-03 Pfizer Inc. Spiro-3-hetero-azolones for treatment of diabetic complications
US4464380A (en) * 1983-05-25 1984-08-07 Pfizer Inc. Imidazolidinedione derivatives
US4533667A (en) * 1983-05-25 1985-08-06 Pfizer Inc. Imidazolidinedione derivatives
DK277484A (da) * 1983-06-23 1984-12-24 Hoffmann La Roche Thiazolidinderivater
JPS61200991A (ja) * 1985-03-04 1986-09-05 Sanwa Kagaku Kenkyusho:Kk スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤
DE3522791C1 (en) * 1985-06-26 1987-01-02 Ferroplast Gmbh Positioning wall for lagging a cavity to be filled with a hardenable material in mining or tunnelling
WO1987004344A1 (fr) * 1986-01-17 1987-07-30 Pfizer Inc. Derives de l'acide hydroxyacetique pour le traitement de complications diabetiques
US5039672A (en) * 1990-04-05 1991-08-13 Pfizer Inc. Heterocyclic compounds as aldose reductase inhibitors
US5068332A (en) * 1990-10-12 1991-11-26 American Home Products Corporation Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
US5102886A (en) * 1990-10-12 1992-04-07 American Home Products Corporation 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
FR2707981B1 (fr) * 1993-07-20 1995-09-01 Adir Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
EP1194146B1 (fr) 1999-06-18 2006-07-19 Merck & Co., Inc. Derives d'arylthiazolidinedione et d'aryloxazolidinedione
EP1194147B1 (fr) 1999-06-18 2007-01-10 Merck & Co., Inc. Derives d'arylthiazolidinedione et d'aryloxazolidinedione
ITPI20060083A1 (it) * 2006-07-11 2008-01-12 Univ Pisa Derivati 2,2-dimetilcromanici 4-spiro-eterocicilici azotati (a 5 e 6 termini) n-sostituiti quali cardio-protettori nei confronti dell'insulto ischemico
USD775790S1 (en) * 2015-11-18 2017-01-10 Ginger Damon Motorcycle jacket
RU2020123382A (ru) 2017-12-21 2022-01-21 Эссити Хайджин Энд Хелт Актиеболаг Впитывающее изделие и способ изготовления впитывающего изделия
RU2748513C1 (ru) 2017-12-21 2021-05-26 Эссити Хайджин Энд Хелт Актиеболаг Впитывающее изделие и способ изготовления впитывающего изделия

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1204232B (de) * 1959-07-16 1965-11-04 Ncr Co Verfahren zur Herstellung von Derivaten von 3-Alkyl-3'-methyl-spiro[benzoxazolin-2, 2'-(2'H-1'-benzopyran)]
US3532744A (en) * 1967-07-28 1970-10-06 American Home Prod 1- and 2-amino substituted indane and tetralene carboxylic acids
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
CA1088945A (fr) * 1976-10-18 1980-11-04 Pfizer Limited Derives de l'hydantoine utilises comme agents therapeutiques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/68 *

Also Published As

Publication number Publication date
FR2442851B1 (fr) 1983-06-17
IN152416B (fr) 1984-01-07
SE447116B (sv) 1986-10-27
AR225614A1 (es) 1982-04-15
GR71913B (fr) 1983-08-16
JPS5946517B2 (ja) 1984-11-13
JPS55129288A (en) 1980-10-06
DD146602A5 (de) 1981-02-18
JPS6011914B2 (ja) 1985-03-28
JPS55129280A (en) 1980-10-06
CS208129B2 (en) 1981-08-31
CH639974A5 (fr) 1983-12-15
GB2028318B (en) 1982-08-04
FR2440950B1 (fr) 1981-06-12
AU535170B2 (en) 1984-03-08
SE7906949L (sv) 1980-02-22
FR2442851A1 (fr) 1980-06-27
YU41488B (en) 1987-08-31
IE791592L (en) 1980-02-21
JPS5943954B2 (ja) 1984-10-25
PH18091A (en) 1985-03-20
NZ191350A (en) 1984-04-27
IL58076A (en) 1982-07-30
NL7906318A (nl) 1980-02-25
BE878311A (fr) 1980-02-20
JPS55129279A (en) 1980-10-06
SU942597A3 (ru) 1982-07-07
GB2033904B (en) 1982-08-04
PT70086A (en) 1979-09-01
ATA560579A (de) 1981-09-15
LU81613A1 (fr) 1980-04-21
US4200642A (en) 1980-04-29
FI65255C (fi) 1984-04-10
ES483511A1 (es) 1980-09-01
IL58076A0 (en) 1979-12-30
EG14639A (en) 1985-03-31
PL217881A1 (fr) 1981-01-02
GB2028318A (en) 1980-03-05
JPS5528996A (en) 1980-02-29
PL130686B1 (en) 1984-08-31
YU199979A (en) 1983-06-30
FR2440949B1 (fr) 1981-06-12
ZA794379B (en) 1980-08-27
AU5009279A (en) 1980-02-28
DE2933441A1 (de) 1980-02-28
FI65255B (fi) 1983-12-30
CA1121361A (fr) 1982-04-06
DE2933441C2 (fr) 1987-04-23
IT7925182A0 (it) 1979-08-20
JPS6011915B2 (ja) 1985-03-28
FI792567A (fi) 1980-02-22
HU179746B (en) 1982-12-28
GB2033904A (en) 1980-05-29
IE48932B1 (en) 1985-06-26
NO792699L (no) 1980-02-22
IT1123536B (it) 1986-04-30
DE2953954A1 (fr) 1982-09-02
DE2953954C2 (fr) 1987-12-03
DK258479A (da) 1980-02-22
AT366689B (de) 1982-04-26
FR2440950A1 (fr) 1980-06-06

Similar Documents

Publication Publication Date Title
FR2440949A1 (fr) Nouveaux 4-hydroxy-4h-2,3-dihydrobenzopyranne-4-carboximidates, utiles comme intermediaires chimiques
FR2411179A1 (fr) Nouveaux derives de l'acide 2-(4-thio-2-oxoazetidine-1-yl)-3-methyl-crotonique et procedes pour leur preparation
GB1492362A (en) M-acyloxyphenyl-1,3-oxazolidenes and methods of synthesis thereof
KR860001058A (ko) 물성 향상제의 제조방법
JPS5640617A (en) Synthesis of fluorocarbonyl compound
FR2434392A1 (fr) Nouveau compose disulfure utile dans la chromatographie de covalence
BE900275A (fr) Azetidinones.
FR2452483A1 (fr) Derives d'alcenylphenylmaleimides, leurs dimeres lineaires et leur procede de preparation
ATE38979T1 (de) Herstellungsverfahren von fluorierten alkyl(methyl)acrylaten.
FR2436150A1 (fr) Derives de 3'',4''-diacyltylosine utiles comme medicaments
DK141786A (da) Fremgangsmaade til fremstilling af et mellemprodukt til brug ved fremstilling af 1-beta-methylcarbapenemantibiotika
FR2506313A1 (fr) Derives de l'acide n-acetylneuraminique et leur preparation
JPS5527147A (en) Preparation of carboxylic acid having aryl substituent
FR2380271A1 (fr) Acides halogene-benzofuranone-carboxyliques utiles comme intermediaires de synthese
FR2359111A1 (fr) Nouveaux derives d'acides phenoxyphenoxy-alcanecarboxyliques utiles comme herbicides
FR2448536A1 (fr) Nouveaux derives de 2-hydroxymethyl-pyrazine, et leur procede de preparation
ES455202A1 (es) Un procedimiento para la preparacion de una (vinilo 2, 2- disustituido)-y-butirolactona.
ES8304103A1 (es) Un procedimientpo para la preparacion de nuevos derivados de carbamoiloxiisoxazol.
ATE7292T1 (de) Verfahren zur herstellung von monochlormethylketonen.
FR2450819A1 (fr) Derives de quinoleine
FR2453171A1 (fr) Hemiacetals doubles cycliques d'enediol, compositions en contenant et procedes pour les preparer
EP0041661A3 (en) Preparation of intermediates of carbaprostacyclines
FR2414050A1 (fr) Nouveaux carbamates substitues, leur preparation et leur utilisation comme insecticides
ATE23158T1 (de) Hexahydrodioxopyrimidine, ihre herstellung und verwendung.
FR2377378A1 (fr) Nouvelles amidines

Legal Events

Date Code Title Description
ST Notification of lapse