FR2440358A1 - Nouveau derive de la phenylalanylvalylarginine, son procede de production et son utilisation pour mesurer l'activite d'enzymes - Google Patents

Nouveau derive de la phenylalanylvalylarginine, son procede de production et son utilisation pour mesurer l'activite d'enzymes

Info

Publication number
FR2440358A1
FR2440358A1 FR7926784A FR7926784A FR2440358A1 FR 2440358 A1 FR2440358 A1 FR 2440358A1 FR 7926784 A FR7926784 A FR 7926784A FR 7926784 A FR7926784 A FR 7926784A FR 2440358 A1 FR2440358 A1 FR 2440358A1
Authority
FR
France
Prior art keywords
derivative
enzymes
activity
measuring
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7926784A
Other languages
English (en)
Other versions
FR2440358B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Torii and Co Ltd
Original Assignee
Torii and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torii and Co Ltd filed Critical Torii and Co Ltd
Publication of FR2440358A1 publication Critical patent/FR2440358A1/fr
Application granted granted Critical
Publication of FR2440358B1 publication Critical patent/FR2440358B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • C12Q2334/30—Naphthol derivatives, e.g. alpha-naphthyl-esters, i.e. alpha-NE, beta-naphthyl-esters, i.e. beta-NE
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/802—Chromogenic or luminescent peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'INVENTION A POUR OBJET UN NOUVEAU DERIVE DE LA PHENYLALANYLVALYLARGININE, SON PROCEDE DE PRODUCTION ET SON PROCEDE POUR MESURER L'ACTIVITE D'ENZYMES. CE DERIVE DE PHENYLALANYLVALYLARGININE REPOND A LA FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE: R REPRESENTE L'HYDROGENE OU UN GROUPE BENZOYLE; ET R REPRESENTE UN GROUPE NAPHTYLE. CE DERIVE PEUT ETRE UTILISE COMME SUBSTRAT POUR DIVERSES ENZYMES TELLES QUE LA TRYPSINE, LA PLASMINE, LA KALLIKREINE, L'UROKINASE, LA C1-ESTERASE, ETC. AUSSI, L'ACTIVITE D'ENZYMES PEUT ETRE MESUREE EN UTILISANT CE DERIVE COMME SUBSTRAT.
FR7926784A 1978-10-30 1979-10-29 Nouveau derive de la phenylalanylvalylarginine, son procede de production et son utilisation pour mesurer l'activite d'enzymes Granted FR2440358A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13339578A JPS5559150A (en) 1978-10-30 1978-10-30 Aminoacid derivative

Publications (2)

Publication Number Publication Date
FR2440358A1 true FR2440358A1 (fr) 1980-05-30
FR2440358B1 FR2440358B1 (fr) 1983-11-10

Family

ID=15103739

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7926784A Granted FR2440358A1 (fr) 1978-10-30 1979-10-29 Nouveau derive de la phenylalanylvalylarginine, son procede de production et son utilisation pour mesurer l'activite d'enzymes

Country Status (5)

Country Link
US (1) US4308201A (fr)
JP (1) JPS5559150A (fr)
DE (1) DE2943580C2 (fr)
FR (1) FR2440358A1 (fr)
GB (1) GB2034325B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982000641A1 (fr) * 1980-08-25 1982-03-04 Ab Kabivitrum Substrats de peptides pour la determination de l'activite de proteases
JPS5753445A (en) * 1980-09-16 1982-03-30 Torii Yakuhin Kk Peptide compound
US4428874A (en) 1981-03-25 1984-01-31 Pentapharm A.G. Tripeptide derivatives
US4568636A (en) * 1981-03-25 1986-02-04 Pentapharm Ag Tripeptide derivatives
US4434096A (en) 1981-06-30 1984-02-28 E. I. Du Pont De Nemours And Company Substrates for the quantitative determination of proteolytic enzymes
JPS5925699A (ja) * 1982-08-03 1984-02-09 Torii Yakuhin Kk 酵素活性測定方法
DE3244030A1 (de) * 1982-11-27 1984-05-30 Behringwerke Ag, 3550 Marburg Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE380258B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser
SE380257B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser

Also Published As

Publication number Publication date
US4308201A (en) 1981-12-29
GB2034325B (en) 1982-12-15
JPS6126918B2 (fr) 1986-06-23
DE2943580A1 (de) 1980-05-14
DE2943580C2 (de) 1982-10-14
JPS5559150A (en) 1980-05-02
GB2034325A (en) 1980-06-04
FR2440358B1 (fr) 1983-11-10

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