FR2430236A1 - Composition reductrice et procede pour la preparation de composes marques au technetium-99m, et substances radiopharmaceutiques contenant ces composes - Google Patents
Composition reductrice et procede pour la preparation de composes marques au technetium-99m, et substances radiopharmaceutiques contenant ces composesInfo
- Publication number
- FR2430236A1 FR2430236A1 FR7913264A FR7913264A FR2430236A1 FR 2430236 A1 FR2430236 A1 FR 2430236A1 FR 7913264 A FR7913264 A FR 7913264A FR 7913264 A FR7913264 A FR 7913264A FR 2430236 A1 FR2430236 A1 FR 2430236A1
- Authority
- FR
- France
- Prior art keywords
- technetium
- compounds
- reducing
- labeled
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G99/00—Subject matter not provided for in other groups of this subclass
- C01G99/006—Compounds containing, besides a metal not provided for elsewhere in this subclass, two or more other elements other than oxygen or hydrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
L'invention concerne des compositions destinées à réduire le technétium pour former des ligands marqués au technétium, qui comprennent un substrat acceptable du point de vue pharmacologique auquel est lié un complexe réducteur dont le potentiel d'oxydo-réduction est suffisant pour réduire le technétium à partir du degré d'oxydation + 7. Le complexe réducteur comprend de préférence un agent réducteur du technétium et un ligand chélateur correspondant. Des ligands marqués au technétium sont préparés par mélange de ces ligands avec un pertechnétate en présence du réducteur de l'invention, puis séparation du réducteur et du ligand marqué résultant. On peut préparer de la sorte des ligands marqués au technétium qui sont sensiblement dépourvus de l'agent réducteur utilisé dans leur préparation. Applications radiopharmaceutiques.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/909,385 US4272503A (en) | 1978-05-25 | 1978-05-25 | Reductant composition for technetium-99m and method for making technetium-99m labelled ligands |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2430236A1 true FR2430236A1 (fr) | 1980-02-01 |
FR2430236B1 FR2430236B1 (fr) | 1983-05-13 |
Family
ID=25427158
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7913264A Granted FR2430236A1 (fr) | 1978-05-25 | 1979-05-23 | Composition reductrice et procede pour la preparation de composes marques au technetium-99m, et substances radiopharmaceutiques contenant ces composes |
Country Status (10)
Country | Link |
---|---|
US (1) | US4272503A (fr) |
JP (2) | JPS54160305A (fr) |
BE (1) | BE876562A (fr) |
CA (1) | CA1111765A (fr) |
CH (1) | CH649924A5 (fr) |
DE (1) | DE2920770A1 (fr) |
FR (1) | FR2430236A1 (fr) |
GB (1) | GB2023327B (fr) |
NL (1) | NL7904059A (fr) |
SE (1) | SE7904316L (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4421735A (en) * | 1980-04-17 | 1983-12-20 | The Massachusetts General Hospital | Radiolabeled diagnostic compositions and method for making the same |
US4406876A (en) * | 1980-10-14 | 1983-09-27 | Research Foundation Of The State Univ. Of New York | Sulfur free small-particle production of technetium sulfur colloid |
NL8204108A (nl) * | 1981-10-27 | 1983-05-16 | Hybritech Inc | In beeld brengen van tumor met radioactief gemerkte monoclonale antilichamen. |
DE3237573A1 (de) * | 1982-10-09 | 1984-04-12 | Hoechst Ag, 6230 Frankfurt | Technetium-99m-tri- und tetraphosphonate zur szintigraphischen dastellung res-haltiger organe und der lymphgefaesse und verfahren zu deren herstellung |
US4574079A (en) * | 1983-05-27 | 1986-03-04 | Gavras Haralambos P | Radiolabeled angiotensin converting enzyme inhibitors for radiolabeling mammalian organ sites |
EP0163701A1 (fr) * | 1983-12-06 | 1985-12-11 | The Royal Melbourne Hospital | PREPARATION DE PRODUITS RADIOPHARMACEUTIQUES A BASE DE TECHNETIUM-99m/ |
USRE38435E1 (en) * | 1983-12-28 | 2004-02-24 | Daicel Chemical Industries, Ltd. | Separating agent |
US4707352A (en) * | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group |
US5164175A (en) * | 1986-12-10 | 1992-11-17 | Hoechst Aktiengesellschaft | Diagnostic aid containing an organ-specific substance labeled with technetium-99m |
US5059541A (en) * | 1988-04-29 | 1991-10-22 | Neorx Corporation | Minimal derivatization of proteins |
US5208007A (en) * | 1988-11-22 | 1993-05-04 | Board Of Regents Of The University Of Oklahoma | Isotopic tracer composition and method for making and using same |
US5808091A (en) * | 1991-10-29 | 1998-09-15 | Bracco International B.V. | Rhenium and technetium complexes containing a hypoxia localizing moiety |
JPH08508500A (ja) * | 1993-03-31 | 1996-09-10 | マリンクロット・メディカル・インコーポレイテッド | 非第一スズ還元剤を有する放射性薬剤 |
US5608110A (en) * | 1993-06-15 | 1997-03-04 | Bracco International B.V. | Heteroatom-bearing ligands and metal complexes thereof |
JP4293632B2 (ja) * | 1993-11-16 | 2009-07-08 | ブラッコ インターナショナル ベースローテン フェンノートシャップ | 固定化標識方法 |
US5774782A (en) * | 1996-05-22 | 1998-06-30 | Lockheed Martin Energy Systems, Inc. | Technetium-99m generator system |
US6783672B2 (en) * | 2001-01-18 | 2004-08-31 | Kemmons A. Tubbs | Integrated high throughput system for the mass spectrometry of biomolecules |
US7799526B2 (en) * | 2002-11-21 | 2010-09-21 | The University Of North Carolina At Chapel Hill | Phosphoprotein detection reagent and methods of making and using the same |
GB0804406D0 (en) * | 2008-03-10 | 2008-04-16 | Univ Zuerich | Metal complexes |
KR101752023B1 (ko) * | 2010-02-05 | 2017-06-28 | 나믹스 가부시끼가이샤 | 금속 도전성 페이스트용의 환원제 조성물 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2127809A1 (en) * | 1971-06-01 | 1972-12-14 | Kort, Waiter, Dr , 1000 Berlin | Radioactive technetium-iron complex - for scintigraphy of organs and blood vessels |
US3725295A (en) * | 1971-07-20 | 1973-04-03 | Atomic Energy Commission | Technetium labeling |
DE2419310A1 (de) * | 1973-04-23 | 1974-11-07 | Minnesota Mining & Mfg | Technetium-markierte komplexe, verfahren zu deren herstellung und deren anwendung |
DE2166643A1 (de) * | 1971-03-25 | 1975-01-30 | Minnesota Mining & Mfg | Verfahren zum radioaktiven kennzeichnen von pharmazeutisch unbedenklichen mikropartikeln |
FR2322586A1 (fr) * | 1975-09-02 | 1977-04-01 | Research Corp | Nouveaux chelates radiopharmaceutiques et procede de formation d'une image externe |
DE2543351A1 (de) * | 1975-09-29 | 1977-04-07 | Henkel & Cie Gmbh | Praeparate zur herstellung von 99m technetum-radiodiagnostika |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3784453A (en) * | 1970-12-16 | 1974-01-08 | H Dworkin | Process and apparatus for making radioactive labeled protein material |
US3873680A (en) * | 1972-08-30 | 1975-03-25 | Minnesota Mining & Mfg | Mercaptan and thioketal complexes of technetium 99M for diagnostic scanning |
-
1978
- 1978-05-25 US US05/909,385 patent/US4272503A/en not_active Expired - Lifetime
-
1979
- 1979-01-15 CA CA319,663A patent/CA1111765A/fr not_active Expired
- 1979-04-13 JP JP4522679A patent/JPS54160305A/ja active Pending
- 1979-05-16 SE SE7904316A patent/SE7904316L/xx not_active Application Discontinuation
- 1979-05-22 DE DE19792920770 patent/DE2920770A1/de not_active Ceased
- 1979-05-23 GB GB7917979A patent/GB2023327B/en not_active Expired
- 1979-05-23 NL NL7904059AA patent/NL7904059A/xx not_active Application Discontinuation
- 1979-05-23 FR FR7913264A patent/FR2430236A1/fr active Granted
- 1979-05-25 BE BE0/195405A patent/BE876562A/fr not_active IP Right Cessation
- 1979-05-25 CH CH4896/79A patent/CH649924A5/de not_active IP Right Cessation
-
1982
- 1982-10-15 JP JP57181234A patent/JPS58146514A/ja active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2166643A1 (de) * | 1971-03-25 | 1975-01-30 | Minnesota Mining & Mfg | Verfahren zum radioaktiven kennzeichnen von pharmazeutisch unbedenklichen mikropartikeln |
DE2127809A1 (en) * | 1971-06-01 | 1972-12-14 | Kort, Waiter, Dr , 1000 Berlin | Radioactive technetium-iron complex - for scintigraphy of organs and blood vessels |
US3725295A (en) * | 1971-07-20 | 1973-04-03 | Atomic Energy Commission | Technetium labeling |
DE2419310A1 (de) * | 1973-04-23 | 1974-11-07 | Minnesota Mining & Mfg | Technetium-markierte komplexe, verfahren zu deren herstellung und deren anwendung |
FR2322586A1 (fr) * | 1975-09-02 | 1977-04-01 | Research Corp | Nouveaux chelates radiopharmaceutiques et procede de formation d'une image externe |
DE2543351A1 (de) * | 1975-09-29 | 1977-04-07 | Henkel & Cie Gmbh | Praeparate zur herstellung von 99m technetum-radiodiagnostika |
Also Published As
Publication number | Publication date |
---|---|
DE2920770A1 (de) | 1979-11-29 |
FR2430236B1 (fr) | 1983-05-13 |
JPS54160305A (en) | 1979-12-19 |
NL7904059A (nl) | 1979-11-27 |
CA1111765A (fr) | 1981-11-03 |
GB2023327B (en) | 1982-08-25 |
JPS58146514A (ja) | 1983-09-01 |
GB2023327A (en) | 1979-12-28 |
SE7904316L (sv) | 1979-11-26 |
CH649924A5 (de) | 1985-06-28 |
US4272503A (en) | 1981-06-09 |
BE876562A (fr) | 1979-11-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property | ||
TP | Transmission of property | ||
ST | Notification of lapse |