FR2421610A1 - Pellicule medicamenteuse a base d'une substance active a action anti angineuse telle que la nitroglycerine ou l'isosorbide dimitrate - Google Patents
Pellicule medicamenteuse a base d'une substance active a action anti angineuse telle que la nitroglycerine ou l'isosorbide dimitrateInfo
- Publication number
- FR2421610A1 FR2421610A1 FR7908827A FR7908827A FR2421610A1 FR 2421610 A1 FR2421610 A1 FR 2421610A1 FR 7908827 A FR7908827 A FR 7908827A FR 7908827 A FR7908827 A FR 7908827A FR 2421610 A1 FR2421610 A1 FR 2421610A1
- Authority
- FR
- France
- Prior art keywords
- active substance
- action
- dimitrate
- anginous
- nitroglycerin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne la médecine. La pellicule antiangineuse faisant l'objet de l'invention est caractérisée notamment en ce qu'elle se présente sous forme d'une plaque ou lame de 0,1 à 1,5 mm d'épaisseur composée d'un excipient biologiquement soluble et résorbable constitué par un homopolymère d'amide acrylique ou de vinylpyrrolidone, ou un copolymère de ceux-ci avec un acrylate, ce copolymère comprenant 99 à 70 % en poids d'amide acrylique et de vinylpyrrolidone pour 1 à 30 % en poids d'acrylate d'une masse moléculaire de 50 000 à 1 000 000, et d'une substance active à action antiangineuse. La figure 1 montre notamment à titre de comparaison, la variation DELTA SI % en fonction du temps de l'index systolique en % par rapport à la valeur initiale, dans le cas de la pellicule conforme à l'invention et dans celui d'un médicament connu. Les pellicules en question exercent une action prolongée, permettent une haute précision de dosage de la substance active et sont douées d'une bonne stabilité au stockage.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU782605039A SU806037A1 (ru) | 1978-04-06 | 1978-04-06 | Антиангинальное средство |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2421610A1 true FR2421610A1 (fr) | 1979-11-02 |
FR2421610B1 FR2421610B1 (fr) | 1982-11-12 |
Family
ID=20759951
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7908827A Granted FR2421610A1 (fr) | 1978-04-06 | 1979-04-06 | Pellicule medicamenteuse a base d'une substance active a action anti angineuse telle que la nitroglycerine ou l'isosorbide dimitrate |
Country Status (6)
Country | Link |
---|---|
JP (1) | JPS6024763B2 (fr) |
CA (1) | CA1127082A (fr) |
DE (1) | DE2913752A1 (fr) |
FR (1) | FR2421610A1 (fr) |
GB (2) | GB2078771B (fr) |
SU (1) | SU806037A1 (fr) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0054279A2 (fr) * | 1980-12-16 | 1982-06-23 | Forest Laboratories, Inc. | Composition à libération retardée de nitroglycérine et sa méthode de préparation |
EP0072251A2 (fr) * | 1981-08-10 | 1983-02-16 | LecTec Corporation | Pansement amélioré contenant un médicament |
EP0108218A2 (fr) * | 1982-10-08 | 1984-05-16 | Verex Laboratories, Inc. | Forme de dosage orale solide à libération constante de composés pharmaceutiques très solubles dans l'eau |
FR2542998A1 (fr) * | 1983-03-24 | 1984-09-28 | Rhone Poulenc Sante | Nouvelle forme transdermale du dinitrate d'isosorbide |
US5204109A (en) * | 1989-12-28 | 1993-04-20 | Nitto Denko Corporation | Percutaneous gel preparation |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4291015A (en) * | 1979-08-14 | 1981-09-22 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing a vasodilator |
JPS57116011A (en) * | 1981-01-08 | 1982-07-19 | Nitto Electric Ind Co Ltd | Pharmaceutical preparation |
CA1218604A (fr) * | 1981-07-08 | 1987-03-03 | Alec D. Keith | Vehicules de trinitroglycerol a decharge temporisee, et leurs domaines d'emploi |
SU1011126A1 (ru) * | 1981-07-14 | 1983-04-15 | Всесоюзный научно-исследовательский и испытательный институт медицинской техники | Средство дл лечени сахарного диабета |
US4482533A (en) * | 1982-01-11 | 1984-11-13 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing propranolol |
US4693887A (en) * | 1983-09-15 | 1987-09-15 | The Kendall Company | Microphase separated hydrogels for controlled release of bioactive materials |
JPS6066759A (ja) * | 1983-09-21 | 1985-04-16 | 日東電工株式会社 | 医薬製剤 |
JPS60148471A (ja) * | 1983-12-27 | 1985-08-05 | マンヴイル サービス コーポレーション | 王冠支持式キヤリヤ |
US5364628A (en) * | 1985-05-31 | 1994-11-15 | Sandoz Ltd. | Pharmaceutical compositions |
JPS61280423A (ja) * | 1985-06-05 | 1986-12-11 | Kiyuukiyuu Yakuhin Kogyo Kk | 口腔内粘膜貼付剤 |
US4764378A (en) * | 1986-02-10 | 1988-08-16 | Zetachron, Inc. | Buccal drug dosage form |
DE3823395A1 (de) * | 1988-07-09 | 1990-03-15 | Holzapfel Boeving Partner Werb | Mit einem wirkstoff getraenktes tuch |
DE69007886T2 (de) * | 1989-07-21 | 1994-11-17 | Izhak Blank | Östradiol enthaltende Mittel und Verfahren zur topischen Anwendung. |
US5232703A (en) * | 1989-07-21 | 1993-08-03 | Izhak Blank | Estradiol compositions and methods for topical application |
EP1888025B1 (fr) * | 2005-06-08 | 2020-08-12 | Basf Corporation | Composition de porteur de medicament du procede de formation de film a partir de cette composition |
BR112015003733A2 (pt) * | 2012-08-23 | 2017-07-04 | Cardiolynx Ag | composições de liberação estendida de um nitrato de aminoalquila |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE859931C (de) * | 1944-05-24 | 1952-12-18 | Roehm & Haas G M B H | Galenische Praeparate |
FR2213779A1 (fr) * | 1973-01-13 | 1974-08-09 | Byk Gulden Lomberg Chem Fab | |
FR2285896A1 (fr) * | 1974-09-24 | 1976-04-23 | Nippon Kayaku Kk | Preparation pharmaceutique destinee a l'administration dans la cavite buccale |
FR2326933A1 (fr) * | 1975-10-10 | 1977-05-06 | Squibb & Sons Inc | Comprime a liberation controlee de medicament |
DE2634004A1 (de) * | 1976-07-29 | 1978-02-02 | Bernhard Dr Lippold | Verfahren zur beschleunigung der aufloesung und verbesserung der loeslichkeit von schlechtloeslichen zur oralen verabreichung bestimmten arzneistoffen |
-
1978
- 1978-04-06 SU SU782605039A patent/SU806037A1/ru active
-
1979
- 1979-04-05 DE DE19792913752 patent/DE2913752A1/de not_active Ceased
- 1979-04-05 CA CA324,996A patent/CA1127082A/fr not_active Expired
- 1979-04-06 GB GB8120761A patent/GB2078771B/en not_active Expired
- 1979-04-06 FR FR7908827A patent/FR2421610A1/fr active Granted
- 1979-04-06 GB GB7912104A patent/GB2021610B/en not_active Expired
- 1979-04-06 JP JP54041172A patent/JPS6024763B2/ja not_active Expired
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE859931C (de) * | 1944-05-24 | 1952-12-18 | Roehm & Haas G M B H | Galenische Praeparate |
FR2213779A1 (fr) * | 1973-01-13 | 1974-08-09 | Byk Gulden Lomberg Chem Fab | |
FR2285896A1 (fr) * | 1974-09-24 | 1976-04-23 | Nippon Kayaku Kk | Preparation pharmaceutique destinee a l'administration dans la cavite buccale |
FR2326933A1 (fr) * | 1975-10-10 | 1977-05-06 | Squibb & Sons Inc | Comprime a liberation controlee de medicament |
DE2634004A1 (de) * | 1976-07-29 | 1978-02-02 | Bernhard Dr Lippold | Verfahren zur beschleunigung der aufloesung und verbesserung der loeslichkeit von schlechtloeslichen zur oralen verabreichung bestimmten arzneistoffen |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0054279A2 (fr) * | 1980-12-16 | 1982-06-23 | Forest Laboratories, Inc. | Composition à libération retardée de nitroglycérine et sa méthode de préparation |
EP0054279A3 (en) * | 1980-12-16 | 1982-09-22 | Forest Laboratories, Inc. | Composition with sustained release of nitroglycerine, and method of preparing it |
EP0072251A2 (fr) * | 1981-08-10 | 1983-02-16 | LecTec Corporation | Pansement amélioré contenant un médicament |
EP0072251A3 (en) * | 1981-08-10 | 1984-02-01 | Lectec Corporation | Improved bandage containing a medicament |
EP0108218A2 (fr) * | 1982-10-08 | 1984-05-16 | Verex Laboratories, Inc. | Forme de dosage orale solide à libération constante de composés pharmaceutiques très solubles dans l'eau |
EP0108218A3 (fr) * | 1982-10-08 | 1984-11-28 | Verex Laboratories, Inc. | Forme de dosage orale solide à libération constante de composés pharmaceutiques très solubles dans l'eau |
FR2542998A1 (fr) * | 1983-03-24 | 1984-09-28 | Rhone Poulenc Sante | Nouvelle forme transdermale du dinitrate d'isosorbide |
EP0123585A2 (fr) * | 1983-03-24 | 1984-10-31 | Rhone-Poulenc Sante | Nouvelle forme transdermale de médicaments |
EP0123585A3 (en) * | 1983-03-24 | 1985-10-02 | Rhone-Poulenc Sante | Transdermal drug form |
US4746509A (en) * | 1983-03-24 | 1988-05-24 | Rhone-Poulenc Sante | Transdermal medicament |
US5204109A (en) * | 1989-12-28 | 1993-04-20 | Nitto Denko Corporation | Percutaneous gel preparation |
Also Published As
Publication number | Publication date |
---|---|
JPS54154511A (en) | 1979-12-05 |
SU806037A1 (ru) | 1981-02-23 |
FR2421610B1 (fr) | 1982-11-12 |
JPS6024763B2 (ja) | 1985-06-14 |
GB2021610A (en) | 1979-12-05 |
GB2078771B (en) | 1983-03-09 |
GB2078771A (en) | 1982-01-13 |
CA1127082A (fr) | 1982-07-06 |
GB2021610B (en) | 1982-10-20 |
DE2913752A1 (de) | 1979-12-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |