FR2416218A1 - Procede de preparation de n-(p-aminobenzoyl) glutamates de dialkyle - Google Patents
Procede de preparation de n-(p-aminobenzoyl) glutamates de dialkyleInfo
- Publication number
- FR2416218A1 FR2416218A1 FR7902346A FR7902346A FR2416218A1 FR 2416218 A1 FR2416218 A1 FR 2416218A1 FR 7902346 A FR7902346 A FR 7902346A FR 7902346 A FR7902346 A FR 7902346A FR 2416218 A1 FR2416218 A1 FR 2416218A1
- Authority
- FR
- France
- Prior art keywords
- aminobenzoyl
- glutamates
- dialkyl
- preparing
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Abstract
L'invention concerne la préparation de N-(p-aminobenzoyl)-glutamates de dialkyle de formule générale :
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/875,051 US4136101A (en) | 1978-02-03 | 1978-02-03 | Process for preparing dialkyl (p-aminobenzoyl) glutamates |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2416218A1 true FR2416218A1 (fr) | 1979-08-31 |
Family
ID=25365117
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7902346A Withdrawn FR2416218A1 (fr) | 1978-02-03 | 1979-01-30 | Procede de preparation de n-(p-aminobenzoyl) glutamates de dialkyle |
Country Status (8)
Country | Link |
---|---|
US (1) | US4136101A (fr) |
JP (1) | JPS54115337A (fr) |
AU (1) | AU4230878A (fr) |
BE (1) | BE873895A (fr) |
DE (1) | DE2900326A1 (fr) |
FR (1) | FR2416218A1 (fr) |
GB (1) | GB2013659A (fr) |
NL (1) | NL7812587A (fr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5101814A (en) * | 1989-08-11 | 1992-04-07 | Palti Yoram Prof | System for monitoring and controlling blood glucose |
US5190041A (en) * | 1989-08-11 | 1993-03-02 | Palti Yoram Prof | System for monitoring and controlling blood glucose |
US5166149A (en) * | 1989-09-08 | 1992-11-24 | Chemex Pharmaceuticals, Inc. | Methotrexate compositions and methods of treatment using same |
US5066828A (en) * | 1990-04-12 | 1991-11-19 | Merrell Dow Pharmaceuticals Inc. | Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases |
US5382582A (en) * | 1993-03-26 | 1995-01-17 | Chan; Carcy L. | Methotrexate analogs and methods of using same |
US5698556A (en) * | 1995-06-07 | 1997-12-16 | Chan; Carcy L. | Methotrexate analogs and methods of using same |
EP2002846B1 (fr) | 1996-12-06 | 2017-01-25 | Amgen Inc. | Thérapie combinée utilisant un inhibiteur IL-1 pour traiter les maladies liées au IL-1 |
JP2006517191A (ja) * | 2002-12-30 | 2006-07-20 | アムジエン・インコーポレーテツド | 共刺激因子を用いた併用療法 |
US6921667B2 (en) | 2003-03-07 | 2005-07-26 | Prometheus Laboratories, Inc. | Methods for direct detection of individual methotrexate metabolites |
US7582282B2 (en) | 2003-08-29 | 2009-09-01 | Prometheus Laboratories Inc. | Methods for optimizing clinical responsiveness to methotrexate therapy using metabolite profiling and pharmacogenetics |
US20080312201A1 (en) * | 2004-09-10 | 2008-12-18 | Patrick Fogarty | Reduced Toxicity Methotrexate Formulations and Methods for Using the Same |
US20060286571A1 (en) | 2005-04-28 | 2006-12-21 | Prometheus Laboratories, Inc. | Methods of predicting methotrexate efficacy and toxicity |
ES2473665T3 (es) | 2005-11-28 | 2014-07-07 | Verrow Pharmaceuticals, Inc. | Composiciones útiles para reducir la nefrotoxicidad y los métodos de uso de las mismas |
EP2265274B1 (fr) | 2008-03-03 | 2018-11-21 | Tosk, Inc. | Adjuvants pour réduire la toxicité du méthotrexate, et procédés d'utilisation |
US9261509B2 (en) | 2010-09-13 | 2016-02-16 | Thierry Dervieux | Methods for monitoring methotrexate therapy |
JP5785622B2 (ja) | 2010-12-03 | 2015-09-30 | コチャク ファルマ イラチュ ヴェキミャ サン.アー.シェーKocak Farma Ilac Ve Kimya San.A.S | その構造内にグルタミン酸部分を有する葉酸拮抗薬の新規な製造方法 |
TR201113223A2 (tr) | 2011-12-29 | 2012-06-21 | Koçak Farma İlaç Ve Ki̇mya Sanayi̇ A. Ş. | Pemetrekset disodyum hazırlanmasına yönelik tek basamaklı işlem. |
CN113735735A (zh) * | 2021-03-03 | 2021-12-03 | 浙江致新医药科技有限公司 | 一种甲氨化反应的制备方法 |
CN113461689B (zh) * | 2021-06-30 | 2023-03-31 | 浙江浙北药业有限公司 | 一种甲氨蝶呤化合物的制备方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3892801A (en) * | 1974-09-11 | 1975-07-01 | American Cyanamid Co | Method for preparing alkali salts of p-methylaminobenzoylglutamic acid |
-
1978
- 1978-02-03 US US05/875,051 patent/US4136101A/en not_active Expired - Lifetime
- 1978-12-07 AU AU42308/78A patent/AU4230878A/en active Pending
- 1978-12-27 NL NL7812587A patent/NL7812587A/xx not_active Application Discontinuation
-
1979
- 1979-01-05 DE DE19792900326 patent/DE2900326A1/de not_active Withdrawn
- 1979-01-09 GB GB7900821A patent/GB2013659A/en not_active Withdrawn
- 1979-01-30 FR FR7902346A patent/FR2416218A1/fr not_active Withdrawn
- 1979-02-02 BE BE0/193234A patent/BE873895A/fr unknown
- 1979-02-03 JP JP1099779A patent/JPS54115337A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
NL7812587A (nl) | 1979-08-07 |
BE873895A (fr) | 1979-08-02 |
DE2900326A1 (de) | 1979-08-09 |
GB2013659A (en) | 1979-08-15 |
US4136101A (en) | 1979-01-23 |
AU4230878A (en) | 1979-08-09 |
JPS54115337A (en) | 1979-09-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |