FR2403339A1 - 6-Halo-7-tert. amino-4-oxo-quinoline carboxylic acid derivs. - broad spectrum antibacterials and growth promoters for animals - Google Patents

6-Halo-7-tert. amino-4-oxo-quinoline carboxylic acid derivs. - broad spectrum antibacterials and growth promoters for animals

Info

Publication number
FR2403339A1
FR2403339A1 FR7825937A FR7825937A FR2403339A1 FR 2403339 A1 FR2403339 A1 FR 2403339A1 FR 7825937 A FR7825937 A FR 7825937A FR 7825937 A FR7825937 A FR 7825937A FR 2403339 A1 FR2403339 A1 FR 2403339A1
Authority
FR
France
Prior art keywords
substd
opt
halo
growth promoters
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7825937A
Other languages
French (fr)
Other versions
FR2403339B1 (en
Inventor
Marcel Pesson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoire Roger Bellon SA
Original Assignee
Laboratoire Roger Bellon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB39197/77A external-priority patent/GB1598915A/en
Application filed by Laboratoire Roger Bellon SA filed Critical Laboratoire Roger Bellon SA
Publication of FR2403339A1 publication Critical patent/FR2403339A1/en
Application granted granted Critical
Publication of FR2403339B1 publication Critical patent/FR2403339B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Quinoline derivs. of formula (Ie and their pharmaceutically acceptable acid addn. salts are new. R1 = lower alkyl (opt. substd. by aryl, OH or halo), vinyl or allyl. R2 and R3 are separately 1-5C (esp. 1-2C) alkyl, or together they complete pyrrolidino, piperidino (opt. substd. by OH), morpholino or piperazino opt. 4-substd. by R4(CH2)n. n = 0-3. R4 = H, OH (if n = 2 or 3), opt. substd. phenyl, benzyl, vinyl (if n = 1, 2 or 3), or lower acyl. X = F, Cl or Br). Cpds. (I) are prepd. e.g. by reacting the corresp. 7-chloro cpd. with HNR2R3. (I) are antibacterials useful in human and veterinary medicine and as growth promoters for adding to animal feed. They are more active with a broader spectrum of activity than known 6-H cpds., and are typically administered at 10-60 mg/kg/day.
FR7825937A 1977-09-20 1978-09-08 6-Halo-7-tert. amino-4-oxo-quinoline carboxylic acid derivs. - broad spectrum antibacterials and growth promoters for animals Granted FR2403339A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB39197/77A GB1598915A (en) 1977-09-20 1977-09-20 1,4-dihydro-quinoline-3-carboxylic acid derivatives process for their preparation and composition containing them
GB1298378 1978-04-03

Publications (2)

Publication Number Publication Date
FR2403339A1 true FR2403339A1 (en) 1979-04-13
FR2403339B1 FR2403339B1 (en) 1982-09-17

Family

ID=26249396

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7825937A Granted FR2403339A1 (en) 1977-09-20 1978-09-08 6-Halo-7-tert. amino-4-oxo-quinoline carboxylic acid derivs. - broad spectrum antibacterials and growth promoters for animals
FR8120346A Granted FR2498931A1 (en) 1977-09-20 1981-10-29 MEDICAMENT CONSISTING OF THE ACID ETHYL-1 FLUORO-6 PIPERAZINYL-7-OXO-4-DIHYDRO-1,4 QUINOLIN-3-CARBOXYLIC AND ITS SALTS OF ADDITION OF NON-TOXIC ACIDS PHARMACEUTICALLY ACCEPTABLE

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR8120346A Granted FR2498931A1 (en) 1977-09-20 1981-10-29 MEDICAMENT CONSISTING OF THE ACID ETHYL-1 FLUORO-6 PIPERAZINYL-7-OXO-4-DIHYDRO-1,4 QUINOLIN-3-CARBOXYLIC AND ITS SALTS OF ADDITION OF NON-TOXIC ACIDS PHARMACEUTICALLY ACCEPTABLE

Country Status (5)

Country Link
DE (1) DE2840910A1 (en)
ES (1) ES473486A1 (en)
FR (2) FR2403339A1 (en)
NL (1) NL190520C (en)
SE (1) SE444566B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0027752A1 (en) * 1979-09-28 1981-04-29 Société anonyme dite: LABORATOIRE ROGER BELLON Naphthyridine derivatives, processes for their preparation and pharmaceutical compositions containing them
FR2499990A1 (en) * 1981-02-19 1982-08-20 Kyorin Seiyaku Kk PROCESS FOR THE PREPARATION OF QUINOLEINECARBOXYLIC ACID DERIVATIVES, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE AS ANTIBACTERIAL AGENTS
WO2003002560A1 (en) * 2001-06-27 2003-01-09 Laboratorios Vita, S.A. New derivatives of oxazolidinones as antibacterial agents

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1979001144A1 (en) * 1978-05-30 1979-12-27 Fosroc International Ltd Anchoring cartridges
JPS5845426B2 (en) * 1978-09-29 1983-10-08 杏林製薬株式会社 Substituted quinoline carboxylic acid derivatives
DE3033157A1 (en) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-AMINO-1-CYCLOPROPYL-4-OXO-1,4-DIHYDRO-NAPHTHYRIDINE-3-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THE ANTIBACTERIAL AGENTS CONTAINING THEM
DE3306771A1 (en) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen CHINOLONIC CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THE ANTIBACTERIAL AGENTS CONTAINING THEM
DE3306772A1 (en) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen CHINOLONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THE ANTIBACTERIAL AGENTS CONTAINING THEM
DE3318145A1 (en) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-AMINO-1-CYCLOPROPYL-6,8-DIFLUOR-1,4-DIHYDRO-4-OXO-3-CHINOLINE CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS
NZ208470A (en) * 1983-07-18 1988-06-30 Abbott Lab 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives and antibacterial compositions containing such
EP0224121A3 (en) * 1985-11-19 1987-11-11 ROTTAPHARM S.p.A. 7-[4-amino-piperazinyl]- or 7-[4-chloro-piperazinyl]quinolinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing them
HU196218B (en) 1985-12-09 1988-10-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing quinoline carboxylic acid boric acid anhydrides
DE3713672A1 (en) * 1987-04-24 1988-11-17 Bayer Ag METHOD FOR PRODUCING PARENTERALLY AVAILABLE CHINOLONIC CARBONIC ACIDS
YU46099B (en) 1987-12-31 1992-12-21 Krka Tovarna Zdravil PROCESS FOR PREPARING 1-SUBSTITUTED 6-FLUORO-4-OXO-7- 1-PIPERAZINYL) -1
SI9200377A (en) 1992-12-11 1994-06-30 Krka Process for the preparation of 1-substituted 6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydroquinoline-3-carboxilic acid, novel intermediate used in this process and process for its preparation
KR20120025519A (en) 2009-05-15 2012-03-15 레드엑스 파마 리미티드 Redox drug derivatives
WO2013068948A1 (en) 2011-11-08 2013-05-16 Actelion Pharmaceuticals Ltd 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5049286A (en) * 1973-09-04 1975-05-01
BE863429A (en) * 1977-05-16 1978-05-16 Kyorin Seiyaku Kk QUINOLEIN-CARBOXYLIC ACID DERIVATIVES
JPS5365887A (en) * 1976-11-22 1978-06-12 Kyorin Seiyaku Kk Substituted quinoline*arboxylate and process for preparing same
FR2424919A1 (en) * 1978-05-03 1979-11-30 Kyorin Seiyaku Kk SUBSTITUTE QUINOLEINECARBOXYLIC ACID AND ITS DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4017622A (en) * 1972-12-18 1977-04-12 Dainippon Pharmaceutical Co., Ltd. Piperazine derivatives

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5049286A (en) * 1973-09-04 1975-05-01
JPS5365887A (en) * 1976-11-22 1978-06-12 Kyorin Seiyaku Kk Substituted quinoline*arboxylate and process for preparing same
BE863429A (en) * 1977-05-16 1978-05-16 Kyorin Seiyaku Kk QUINOLEIN-CARBOXYLIC ACID DERIVATIVES
FR2391210A1 (en) * 1977-05-16 1978-12-15 Kyorin Seiyaku Kk QUINOLEINECARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS
FR2424919A1 (en) * 1978-05-03 1979-11-30 Kyorin Seiyaku Kk SUBSTITUTE QUINOLEINECARBOXYLIC ACID AND ITS DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CA1976 *
CA1978 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0027752A1 (en) * 1979-09-28 1981-04-29 Société anonyme dite: LABORATOIRE ROGER BELLON Naphthyridine derivatives, processes for their preparation and pharmaceutical compositions containing them
FR2499990A1 (en) * 1981-02-19 1982-08-20 Kyorin Seiyaku Kk PROCESS FOR THE PREPARATION OF QUINOLEINECARBOXYLIC ACID DERIVATIVES, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE AS ANTIBACTERIAL AGENTS
WO2003002560A1 (en) * 2001-06-27 2003-01-09 Laboratorios Vita, S.A. New derivatives of oxazolidinones as antibacterial agents
ES2186550A1 (en) * 2001-06-27 2003-05-01 Vita Invest Sa Derivatives of oxazolidinones as antibacterial agents

Also Published As

Publication number Publication date
SE7809411L (en) 1979-03-21
SE444566B (en) 1986-04-21
FR2403339B1 (en) 1982-09-17
FR2498931B1 (en) 1984-02-10
ES473486A1 (en) 1979-11-01
NL190520C (en) 1994-04-05
NL190520B (en) 1993-11-01
NL7809591A (en) 1979-03-22
DE2840910A1 (en) 1979-04-05
FR2498931A1 (en) 1982-08-06

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Legal Events

Date Code Title Description
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0260, 920522

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0260, 780908

CL Concession to grant licences