FR2395264A1 - NEW DERIVATIVES 1- (3- (3,4,5-TRIMETHOXYPHENOXY) -2-HYDROXYPROPYL) -4-ARYL-PIPERAZINIQUES, PROCESS FOR THEIR PREPARATION AND APPLICATION AS A MEDICINAL PRODUCT - Google Patents

NEW DERIVATIVES 1- (3- (3,4,5-TRIMETHOXYPHENOXY) -2-HYDROXYPROPYL) -4-ARYL-PIPERAZINIQUES, PROCESS FOR THEIR PREPARATION AND APPLICATION AS A MEDICINAL PRODUCT

Info

Publication number
FR2395264A1
FR2395264A1 FR7809675A FR7809675A FR2395264A1 FR 2395264 A1 FR2395264 A1 FR 2395264A1 FR 7809675 A FR7809675 A FR 7809675A FR 7809675 A FR7809675 A FR 7809675A FR 2395264 A1 FR2395264 A1 FR 2395264A1
Authority
FR
France
Prior art keywords
piperaziniques
trimethoxyphenoxy
hydroxypropyl
aryl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7809675A
Other languages
French (fr)
Other versions
FR2395264B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Deutsche Gold und Silber Scheideanstalt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH, Deutsche Gold und Silber Scheideanstalt filed Critical Degussa GmbH
Priority to IT48718/78A priority Critical patent/IT1202819B/en
Publication of FR2395264A1 publication Critical patent/FR2395264A1/en
Application granted granted Critical
Publication of FR2395264B1 publication Critical patent/FR2395264B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Ce sont les composés de la formule 1 et leurs sels, que l'on obtient par réaction d'un composé II avec un composé III, réduction éventuellement d'un ou deux groupes nitro en groupes amino et/ou acylation avec un acide ou dérivé d'acide correspondant au radical R1 . Ces substances ont une action axiolytique-antiagressive et un effet neuroleptique-tranquillisant. Indications : excitation, troubles psychoneurotiques.These are the compounds of formula 1 and their salts, which are obtained by reacting a compound II with a compound III, optionally reducing one or two nitro groups to amino groups and / or acylation with an acid or derivative of acid corresponding to the radical R1. These substances have an axiolytic-antiagressive action and a neuroleptic-tranquilizing effect. Indications: excitement, psychoneurotic disorders.

FR7809675A 1977-04-04 1978-03-31 NEW DERIVATIVES 1- (3- (3,4,5-TRIMETHOXYPHENOXY) -2-HYDROXYPROPYL) -4-ARYL-PIPERAZINIQUES, PROCESS FOR THEIR PREPARATION AND APPLICATION AS A MEDICINAL PRODUCT Granted FR2395264A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IT48718/78A IT1202819B (en) 1977-04-04 1978-04-03 REPLACED PIPERAZINE DERIVATIVES EQUIPPED WITH PHARMACOLOGICAL ACTIVITY, AND PROCEDURE FOR THEIR PRODUCTION

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB14100/77A GB1583372A (en) 1977-04-04 1977-04-04 1-(3-(3,4,5-trimethoxyphenoxy)-2-hydroxypropyl)-4-aryl piperazine derivatives

Publications (2)

Publication Number Publication Date
FR2395264A1 true FR2395264A1 (en) 1979-01-19
FR2395264B1 FR2395264B1 (en) 1980-03-07

Family

ID=10034980

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7809675A Granted FR2395264A1 (en) 1977-04-04 1978-03-31 NEW DERIVATIVES 1- (3- (3,4,5-TRIMETHOXYPHENOXY) -2-HYDROXYPROPYL) -4-ARYL-PIPERAZINIQUES, PROCESS FOR THEIR PREPARATION AND APPLICATION AS A MEDICINAL PRODUCT

Country Status (23)

Country Link
JP (1) JPS6038383B2 (en)
AR (1) AR222149A1 (en)
AT (1) AT360997B (en)
AU (1) AU516315B2 (en)
BE (1) BE865642A (en)
CA (1) CA1124718A (en)
CH (1) CH638795A5 (en)
CS (1) CS249503B2 (en)
DE (1) DE2814168A1 (en)
DK (1) DK145225C (en)
ES (1) ES468486A1 (en)
FI (1) FI69627C (en)
FR (1) FR2395264A1 (en)
GB (1) GB1583372A (en)
HU (1) HU179952B (en)
MX (1) MX6120E (en)
NL (1) NL7803540A (en)
NO (1) NO149209C (en)
PL (1) PL112249B1 (en)
SE (1) SE435507B (en)
SU (1) SU893133A3 (en)
YU (1) YU40513B (en)
ZA (1) ZA781889B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2428040A1 (en) * 1978-06-06 1980-01-04 Hoechst Ag Hypotensive and neuroleptic piperazine derivs. - which are pyridyl-piperazinyl-hydroxy-propoxy-acetanilide or indolinone cpds.
FR2488892A2 (en) * 1977-04-04 1982-02-26 Degussa NOVEL 1- (3- (3,4,5-TRIMETHOXYPHENOXY) -2-HYDROXYPROPYL) -4-ARYL-PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS A MEDICINAL PRODUCT

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4335126A (en) * 1977-03-10 1982-06-15 Degussa Aktiengesellschaft 1-[3-(3,4,5-Trimethoxyphenoxy)-2-hydroxy-propyl]-4-aryl-piperazine-derivatives having pharmaceutical activity
DE3023369A1 (en) * 1980-06-23 1982-01-14 Boehringer Mannheim Gmbh, 6800 Mannheim ARYLOXYPROPANOLAMINE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
FR2568878B1 (en) * 1984-08-07 1986-11-21 Cortial NOVEL (PHENYLPIPERAZINYLETHYLAMINE ETHOXY) -4 PHENOL DERIVATIVES, THEIR PREPARATION METHOD AND THEIR THERAPEUTIC APPLICATION

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2027036A1 (en) * 1968-12-24 1970-09-25 Hoffmann La Roche
FR2068051A5 (en) * 1969-11-26 1971-08-20 Robert Jean
FR2189044A1 (en) * 1972-06-17 1974-01-25 Sumitomo Chemical Co

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2235597A1 (en) * 1972-07-20 1974-01-31 Boehringer Mannheim Gmbh SINGLE SQUARE CLIP ON 3- (5,6,7,8TETRAHYDRONAPHTH-1-YL-OXY) -PROPYL SQUARE CLIP FOR -PIPERAZINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2027036A1 (en) * 1968-12-24 1970-09-25 Hoffmann La Roche
FR2068051A5 (en) * 1969-11-26 1971-08-20 Robert Jean
FR2189044A1 (en) * 1972-06-17 1974-01-25 Sumitomo Chemical Co

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2488892A2 (en) * 1977-04-04 1982-02-26 Degussa NOVEL 1- (3- (3,4,5-TRIMETHOXYPHENOXY) -2-HYDROXYPROPYL) -4-ARYL-PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS A MEDICINAL PRODUCT
FR2428040A1 (en) * 1978-06-06 1980-01-04 Hoechst Ag Hypotensive and neuroleptic piperazine derivs. - which are pyridyl-piperazinyl-hydroxy-propoxy-acetanilide or indolinone cpds.

Also Published As

Publication number Publication date
DK145225B (en) 1982-10-11
GB1583372A (en) 1981-01-28
HU179952B (en) 1983-01-28
CA1124718A (en) 1982-06-01
AU516315B2 (en) 1981-05-28
JPS6038383B2 (en) 1985-08-31
JPS53130682A (en) 1978-11-14
CH638795A5 (en) 1983-10-14
AR222149A1 (en) 1981-04-30
NO149209B (en) 1983-11-28
SE7803742L (en) 1978-10-05
BE865642A (en) 1978-10-03
CS249503B2 (en) 1987-03-12
DE2814168C2 (en) 1989-02-16
DK145225C (en) 1983-04-11
AT360997B (en) 1981-02-10
PL205745A1 (en) 1979-05-07
MX6120E (en) 1984-11-19
NL7803540A (en) 1978-10-06
DE2814168A1 (en) 1978-10-05
FI781009A (en) 1978-10-05
ATA233078A (en) 1980-07-15
YU76778A (en) 1982-10-31
AU3470378A (en) 1979-10-11
ES468486A1 (en) 1979-01-16
YU40513B (en) 1986-02-28
SE435507B (en) 1984-10-01
NO781159L (en) 1978-10-05
PL112249B1 (en) 1980-10-31
DK146678A (en) 1978-10-05
FR2395264B1 (en) 1980-03-07
ZA781889B (en) 1979-03-28
FI69627B (en) 1985-11-29
SU893133A3 (en) 1981-12-23
FI69627C (en) 1986-03-10
NO149209C (en) 1984-03-07

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