FR2389605A1 - - Google Patents

Info

Publication number
FR2389605A1
FR2389605A1 FR7812998A FR7812998A FR2389605A1 FR 2389605 A1 FR2389605 A1 FR 2389605A1 FR 7812998 A FR7812998 A FR 7812998A FR 7812998 A FR7812998 A FR 7812998A FR 2389605 A1 FR2389605 A1 FR 2389605A1
Authority
FR
France
Prior art keywords
compounds
formula
invention correspond
correspond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7812998A
Other languages
English (en)
Other versions
FR2389605B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of FR2389605A1 publication Critical patent/FR2389605A1/fr
Application granted granted Critical
Publication of FR2389605B1 publication Critical patent/FR2389605B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Les composés de l'invention répondent à la formule :
FR7812998A 1977-05-02 1978-05-02 Expired FR2389605B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/792,616 US4069223A (en) 1977-05-02 1977-05-02 4-Aminomethyl-1-(3,3,3-triarylpropyl)-4-arylpiperidine and derivatives thereof

Publications (2)

Publication Number Publication Date
FR2389605A1 true FR2389605A1 (fr) 1978-12-01
FR2389605B1 FR2389605B1 (fr) 1981-07-17

Family

ID=25157505

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7812998A Expired FR2389605B1 (fr) 1977-05-02 1978-05-02

Country Status (10)

Country Link
US (1) US4069223A (fr)
JP (1) JPS549281A (fr)
AU (1) AU520250B2 (fr)
CA (1) CA1105465A (fr)
DE (1) DE2819210A1 (fr)
FR (1) FR2389605B1 (fr)
GB (1) GB1581923A (fr)
NL (1) NL7804725A (fr)
SE (1) SE7805011L (fr)
ZA (1) ZA782514B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53125944U (fr) * 1977-12-22 1978-10-06
US4173641A (en) * 1978-05-15 1979-11-06 Pfizer Inc. Di-O-n-alkyl glycerol derivatives as immune stimulants
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US5849761A (en) * 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US5849762A (en) * 1997-07-14 1998-12-15 Adolor Corporation Peripherally acting anti-pruritic opiates
US6353004B1 (en) 1997-07-14 2002-03-05 Adolor Coporation Peripherally acting anti-pruritic opiates
US20030158220A1 (en) * 1997-11-03 2003-08-21 Foss Joseph F. Use of methylnaltrexone and related compounds to treat chronic opioid use side effects
MXPA03009353A (es) * 2001-04-12 2004-02-12 Pharmacopeia Inc Aril y biaril piperidinas utilizadas como antagonistas de mch.
PT1615646E (pt) 2003-04-08 2015-02-12 Progenics Pharm Inc Formulações farmacêuticas com metilnaltrexona
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
EP1749528A1 (fr) 2005-08-05 2007-02-07 Pharma C S.A. Combinaisons pharmaceutiques comprenant un agoniste de l'opioide mu et un inhibiteur de la production de monoxide d'azote
TW200817048A (en) * 2006-09-08 2008-04-16 Wyeth Corp Dry powder compound formulations and uses thereof
ES2570374T3 (es) * 2007-03-29 2016-05-18 Progenics Pharm Inc Antagonistas del receptor opioide periférico y usos de los mismos
PT2139890E (pt) * 2007-03-29 2014-09-03 Wyeth Llc Antagonistas do receptor opióide periférico e respectivas utilizações
MX351611B (es) 2007-03-29 2017-10-20 Wyeth Llc Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas.
WO2009099411A1 (fr) 2008-02-06 2009-08-13 Progenics Pharmaceuticals, Inc. Préparation et utilisation de (r),(r)-2,2'-bis-méthylnaltrexone
CA2676881C (fr) 2008-09-30 2017-04-25 Wyeth Antagonistes de recepteurs opioides peripheriques, et leurs utilisations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1125112A (en) 1966-01-07 1968-08-28 Science Union & Cie New derivatives of diazabicyclo-decane and process for preparing them
US3998832A (en) * 1975-04-16 1976-12-21 G. D. Searle & Co. Anti-diarrheal compounds

Also Published As

Publication number Publication date
AU520250B2 (en) 1982-01-21
AU3562278A (en) 1979-11-08
SE7805011L (sv) 1978-11-03
FR2389605B1 (fr) 1981-07-17
GB1581923A (en) 1980-12-31
CA1105465A (fr) 1981-07-21
DE2819210A1 (de) 1979-02-08
ZA782514B (en) 1979-06-27
US4069223A (en) 1978-01-17
NL7804725A (nl) 1978-11-06
JPS549281A (en) 1979-01-24

Similar Documents

Publication Publication Date Title
FR2453145A1 (fr)
FR2389605A1 (fr)
FR2383171A1 (fr) Derives de thiopropanoylaminoacides utiles comme hypotenseurs
FR2383929A1 (fr) 1-hydroxy 2, 3, 4, 5-tetrahydro-1h-3-benzazepines substituees
FR2367741A1 (fr) Nouveaux mercaptoacylamino-acides
FR2377392A1 (fr) Nouveaux medicaments derives de la meta-trifluoromethyl-phenylpiperazine
FR2390537A1 (fr) Melanges d'azureurs optiques derivant du stilbene
FR2381762A1 (fr) Dibenzodiazepines utilisables comme antischizophreniques
FR2389623A1 (fr)
FR2384745A1 (fr) Derives de la somatostatine et leur preparation
FR2372165A1 (fr)
FR2366276A1 (fr) Aza-13 prostaglandines
FR2394514A1 (fr) Nouvel acide cyclohexanecarboxylique et ses derives
FR2394550A1 (fr) Nouveaux derives d'acides imidazoledicarboxylique et leur utilisation comme antibiotiques
FR2389597A1 (fr)
FR2389608A1 (fr)
FR2361351A1 (fr) Intermediaires de preparation d'homologues de somatostatine
FR2369276A1 (fr) Nouve
FR2389615A1 (fr)
FR2367761A1 (fr) Derives piperidylideniques de benzo-xanthenes,
FR2387215A1 (fr) 4-alcoylthio-2-trifluoromethylalcanesulfonanilides et leurs derives
FR2446284A1 (fr) Tetrahydro-benzo(c)quinoleine-9(8h)ones
FR2382431A1 (fr) Nouvelles 2-hydroxy-propylamines, leur preparation et leur utilisation comme agents tensio-actifs
FR2445838A1 (fr) Nouveaux 1a,3b-dihydroxy-5-steroides
FR2378519A1 (fr)

Legal Events

Date Code Title Description
ST Notification of lapse