FR2376856A1 - POLYMORPHIC FORMS OF TICRYNAFENE, THEIR PREPARATION PROCESS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING - Google Patents

POLYMORPHIC FORMS OF TICRYNAFENE, THEIR PREPARATION PROCESS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING

Info

Publication number
FR2376856A1
FR2376856A1 FR7800007A FR7800007A FR2376856A1 FR 2376856 A1 FR2376856 A1 FR 2376856A1 FR 7800007 A FR7800007 A FR 7800007A FR 7800007 A FR7800007 A FR 7800007A FR 2376856 A1 FR2376856 A1 FR 2376856A1
Authority
FR
France
Prior art keywords
ticrynafene
pharmaceutical compositions
preparation process
compositions containing
polymorphic forms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7800007A
Other languages
French (fr)
Other versions
FR2376856B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
SmithKline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Corp filed Critical SmithKline Corp
Publication of FR2376856A1 publication Critical patent/FR2376856A1/en
Application granted granted Critical
Publication of FR2376856B1 publication Critical patent/FR2376856B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

4-(2-Thenoyl)-2,3-dichlorophenoxyacetic acid of the polymorphic modification B, characterised by an infrared spectrum having strong absorption bands at 1725 and 1418 cm<-1> and a very weak absorption band at 1180 cm<-1>, and a melting point, determined by differential thermoanalysis, of 152 DEG C. This modification B can be prepared by recrystallising the modification A either a) slowly or rapidly from non-polar solvents, or b) rapidly from hot chloroform or ethylene dichloride.
FR7800007A 1977-01-07 1978-01-02 POLYMORPHIC FORMS OF TICRYNAFENE, THEIR PREPARATION PROCESS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING Granted FR2376856A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB56277 1977-01-07

Publications (2)

Publication Number Publication Date
FR2376856A1 true FR2376856A1 (en) 1978-08-04
FR2376856B1 FR2376856B1 (en) 1981-01-23

Family

ID=9706556

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7800007A Granted FR2376856A1 (en) 1977-01-07 1978-01-02 POLYMORPHIC FORMS OF TICRYNAFENE, THEIR PREPARATION PROCESS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING

Country Status (18)

Country Link
JP (1) JPS5387349A (en)
AU (1) AU510569B2 (en)
BE (1) BE862688A (en)
CH (1) CH634066A5 (en)
DD (1) DD134096A5 (en)
DE (1) DE2800489A1 (en)
DK (1) DK565677A (en)
ES (1) ES465181A1 (en)
FR (1) FR2376856A1 (en)
GR (1) GR66062B (en)
IL (1) IL53651A0 (en)
IT (1) IT1089800B (en)
LU (1) LU78823A1 (en)
NL (1) NL7800213A (en)
PL (1) PL203865A1 (en)
PT (1) PT67416B (en)
SE (1) SE7714959L (en)
ZA (1) ZA777531B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996020939A1 (en) * 1995-01-04 1996-07-11 Ferrer Internacional, S.A. POLYMORPHS B AND C OF 1-[2,4-DICHLORO-β-[(7-CHLOROBENZO[b]THIEN-3-YL)METHOXY]PHENETYL]IMIDAZOLE MONONITRATE

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007064595A2 (en) * 2005-11-29 2007-06-07 Bausch & Lomb Incorporated Fluocinolone acetonide drug substance polymorphic interconversion

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2115042A2 (en) * 1970-11-25 1972-07-07 Cerpha 4-2-thienylketo-2,3-dichlorophenoxy acetic acid - prepn and purificn

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2115042A2 (en) * 1970-11-25 1972-07-07 Cerpha 4-2-thienylketo-2,3-dichlorophenoxy acetic acid - prepn and purificn

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996020939A1 (en) * 1995-01-04 1996-07-11 Ferrer Internacional, S.A. POLYMORPHS B AND C OF 1-[2,4-DICHLORO-β-[(7-CHLOROBENZO[b]THIEN-3-YL)METHOXY]PHENETYL]IMIDAZOLE MONONITRATE
AU691234B2 (en) * 1995-01-04 1998-05-14 Ferrer Internacional, S.A. Process for preparing polymorphs B and C of 1- 2,4-dichloro -beta- (7-chlorobenzo b thien-3-yl)methoxy phenethyl imidazole mononitrate
US5939555A (en) * 1995-01-04 1999-08-17 Ferrer Internacional, S.A. Polymorphs B and C of 1- 2,4-dichloro-β- (7-chlorobenzo b!thien-3-yl)methoxy!phenethyl!imidazole mononitrate

Also Published As

Publication number Publication date
PT67416B (en) 1979-05-22
IL53651A0 (en) 1978-03-10
ZA777531B (en) 1978-10-25
PL203865A1 (en) 1979-06-04
NL7800213A (en) 1978-07-11
AU3169877A (en) 1979-06-28
DK565677A (en) 1978-07-08
IT1089800B (en) 1985-06-18
ES465181A1 (en) 1979-01-01
JPS5387349A (en) 1978-08-01
PT67416A (en) 1978-01-01
SE7714959L (en) 1978-07-08
LU78823A1 (en) 1978-06-09
GR66062B (en) 1981-01-15
FR2376856B1 (en) 1981-01-23
DE2800489A1 (en) 1978-07-13
CH634066A5 (en) 1983-01-14
BE862688A (en) 1978-07-06
DD134096A5 (en) 1979-02-07
AU510569B2 (en) 1980-07-03

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Legal Events

Date Code Title Description
ST Notification of lapse