FR2361395A1 - Derives de la xanthine par substitution basique - Google Patents

Derives de la xanthine par substitution basique

Info

Publication number
FR2361395A1
FR2361395A1 FR7708949A FR7708949A FR2361395A1 FR 2361395 A1 FR2361395 A1 FR 2361395A1 FR 7708949 A FR7708949 A FR 7708949A FR 7708949 A FR7708949 A FR 7708949A FR 2361395 A1 FR2361395 A1 FR 2361395A1
Authority
FR
France
Prior art keywords
groups
carbon atoms
group
alk
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7708949A
Other languages
English (en)
Other versions
FR2361395B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Deutsche Gold und Silber Scheideanstalt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH, Deutsche Gold und Silber Scheideanstalt filed Critical Degussa GmbH
Publication of FR2361395A1 publication Critical patent/FR2361395A1/fr
Application granted granted Critical
Publication of FR2361395B1 publication Critical patent/FR2361395B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Ces composés sont représentés par la formule générale I : T-Alk-NH-CH2 -C(OH)-CH 2 -O-Ar I et ils sont préparés entre autres par réaction du composé II, T-Alk-Z II, sur un composé III, X-CH2 -CH(OH)-CH2 -O-Ar III. Ils sont utiles pour le traitement des maladies suivantes : tachyarythmie, angine de poitrine, troubles fonctionnels cardiaques vegétatifs, hypertension artérielle, notamment essentielle, syndrome cardiaque hypercinétique, phéochromocytome. T = radicaltheophyllinyle-(7) ou théobrominyle-(1). Alk = groupe alcoylène droit ou ramifié à 2-5 atomes de carbone, qui peut être également substitué par un groupe hydroxy. Ar = radical aromatique mono ou bicyclique condensé, carbocyclique ou hétérocyclique, non substitué ou substitué par des groupes alcoyle de 1-6 atomes de carbone, des groupes alcényle à 2-6 atomes de carbone, des groupes alcinyle à 2-6 atomes de carbone, des groupes hydroxy, des groupes acyloxy à 1-6 atomes de carbone, des groupes alcoxy à 1-6 atomes de carbone, des groupes alcénoxy à 2-6 atomes de carbone, des radicaux phényle, des atomes d'halogène, des groupes amino, des groupes acyle à 2-6 atomes de carbone, des groupes aminocarbonyle, des groupes uréide, des groupes acylamine à 1-6 atomes de carbone, des groupes cycloalcoyle à 3-8 atomes de carbone ou des groupes cycloalcényle à 4-8 atomes de carbone, le radical hétérocyclique étant constitué dans tous les cas par des noyaux simples à 5 ou 6 chaînons; Z et X sont differents et représentent chacun, soit un groupe amino ou un groupe amino protégé, soit un groupe hydroxy qui est estérifié par un acide organique ou inorganique et peut constituer, dans sa forme non estérifice, un noyau d'oxyde d'éthylène avec un second groupe voisin.
FR7708949A 1976-04-15 1977-03-25 Derives de la xanthine par substitution basique Granted FR2361395A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB15547/76A GB1527543A (en) 1976-04-15 1976-04-15 Basically substituted xanthine derivatives

Publications (2)

Publication Number Publication Date
FR2361395A1 true FR2361395A1 (fr) 1978-03-10
FR2361395B1 FR2361395B1 (fr) 1981-02-13

Family

ID=10061083

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7708949A Granted FR2361395A1 (fr) 1976-04-15 1977-03-25 Derives de la xanthine par substitution basique

Country Status (28)

Country Link
US (1) US4144340A (fr)
JP (1) JPS52128396A (fr)
AR (1) AR217426A1 (fr)
AT (1) AT350070B (fr)
AU (1) AU511983B2 (fr)
BE (1) BE853571A (fr)
CA (1) CA1078379A (fr)
CH (1) CH631454A5 (fr)
CS (1) CS196357B2 (fr)
DE (1) DE2716210A1 (fr)
DK (1) DK141051B (fr)
ES (2) ES457783A1 (fr)
FI (1) FI61900C (fr)
FR (1) FR2361395A1 (fr)
GB (1) GB1527543A (fr)
GR (1) GR63643B (fr)
IN (1) IN145872B (fr)
IT (1) IT1143568B (fr)
MX (1) MX5064E (fr)
NL (1) NL7704087A (fr)
NO (1) NO148291C (fr)
NZ (1) NZ183859A (fr)
PL (1) PL106083B1 (fr)
PT (1) PT66442B (fr)
RO (1) RO72835A (fr)
SE (1) SE431335B (fr)
SU (1) SU668604A3 (fr)
ZA (1) ZA772294B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2935062A1 (de) * 1978-09-06 1980-03-20 Degussa Substituierte aminoalkylguanidine, deren herstellung und arzneimittel
EP0022321A1 (fr) * 1979-07-10 1981-01-14 Beecham Group Plc Dérivés de benzène, leur préparation et utilisation dans des compositions pharmaceutiques
DE2929596A1 (de) * 1979-07-21 1981-02-05 Hoechst Ag Verfahren zur herstellung von oxoalkyl-xanthinen
CH655658B (fr) * 1980-09-18 1986-05-15
US4364922A (en) * 1980-10-14 1982-12-21 University Of Virginia Alumni Patents Foundation Adenosine antagonists in the treatment and diagnosis of A-V node conduction disturbances
US4406903A (en) * 1981-01-21 1983-09-27 John Wyeth And Brother Limited Xanthine derivatives useful as antidepressives
US5817662A (en) * 1992-11-09 1998-10-06 Cell Therapeutics, Inc. Substituted amino alkyl compounds
US6103730A (en) * 1994-03-24 2000-08-15 Cell Therapeutics, Inc. Amine substituted compounds
US5801182A (en) * 1994-03-24 1998-09-01 Cell Therapeutics, Inc. Amine substituted compounds
US5807861A (en) * 1994-03-24 1998-09-15 Cell Therapeutics, Inc. Amine substituted xanthinyl compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT308139B (de) * 1970-07-27 1973-06-25 Degussa Verfahren zur Herstellung von neuen basisch substituierten Alkyltheophyllinen, ihren Isomeren und Säureadditionssalzen
AT313916B (de) * 1971-10-28 1974-03-11 Degussa Verfahren zur Herstellung von neuen basisch substituierten Theophyllinen und deren Säureadditionssalzen
AT311995B (de) * 1971-09-06 1973-12-10 Degussa Verfahren zur Herstellung von neuen basisch substituierten Alkyltheophyllinen
DE2308826C3 (de) * 1973-02-22 1980-03-27 Ludwig Merckle Kg Chem. Pharm. Fabrik, 7902 Blaubeuren Phenoxyalkancarbonsäureester von Oxyalkyltheophyllinen, Verfahren zu ihrer Herstellung und Arzneimittel

Also Published As

Publication number Publication date
SE431335B (sv) 1984-01-30
PT66442A (pt) 1977-05-01
NO771301L (no) 1977-10-18
CA1078379A (fr) 1980-05-27
PL106083B1 (pl) 1979-11-30
ATA262677A (de) 1978-10-15
DK141051C (fr) 1980-06-16
DK141051B (da) 1979-12-31
DE2716210A1 (de) 1977-11-03
CH631454A5 (de) 1982-08-13
AU511983B2 (en) 1980-09-18
RO72835A (fr) 1983-08-03
NZ183859A (en) 1979-03-28
US4144340A (en) 1979-03-13
FI771187A (fr) 1977-10-16
FI61900C (fi) 1982-10-11
SE7704319L (sv) 1977-11-28
RO72835B (ro) 1983-07-30
FR2361395B1 (fr) 1981-02-13
DK166677A (fr) 1977-10-16
AR217426A1 (es) 1980-03-31
ZA772294B (en) 1978-03-29
BE853571A (nl) 1977-10-14
JPS52128396A (en) 1977-10-27
CS196357B2 (en) 1980-03-31
AU2425677A (en) 1978-10-19
SU668604A3 (ru) 1979-06-15
FI61900B (fi) 1982-06-30
ES457783A1 (es) 1978-03-01
NO148291C (no) 1983-09-14
IT1143568B (it) 1986-10-22
NL7704087A (nl) 1977-10-18
ES457784A1 (es) 1978-03-01
AT350070B (de) 1979-05-10
IN145872B (fr) 1979-01-06
GR63643B (en) 1979-11-28
GB1527543A (en) 1978-10-04
MX5064E (es) 1983-03-09
PT66442B (pt) 1978-09-22
NO148291B (no) 1983-06-06

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