FR2351112A1 - Prostaglandin derivs. - Google Patents

Prostaglandin derivs.

Info

Publication number
FR2351112A1
FR2351112A1 FR7714201A FR7714201A FR2351112A1 FR 2351112 A1 FR2351112 A1 FR 2351112A1 FR 7714201 A FR7714201 A FR 7714201A FR 7714201 A FR7714201 A FR 7714201A FR 2351112 A1 FR2351112 A1 FR 2351112A1
Authority
FR
France
Prior art keywords
cpds
healing
alpha
derivs
prostaglandin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7714201A
Other languages
French (fr)
Other versions
FR2351112B1 (en
Inventor
Salvador Moncada
Norman Whittake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/624,486 external-priority patent/US3984400A/en
Priority claimed from FR7631769A external-priority patent/FR2361871A1/en
Priority claimed from FR7710593A external-priority patent/FR2351111A1/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of FR2351112A1 publication Critical patent/FR2351112A1/en
Application granted granted Critical
Publication of FR2351112B1 publication Critical patent/FR2351112B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

(5Z)-5,6-Didehydro-9-deoxy-6,9 alpha-epoxyprostaglandin F1 alpha derivs. of formula (I) are novel cpds. In (I) R=H or a pharmacologically acceptable cation (esp. Na) and Z1, Z2=H or a blocking radical e.g. acyl or trialkylsilyl.(I) (R, Z1Z2=H) (known as prostacycline), and its salts is a useful intermediate for the synthesis of cpds. analogous to prostaglandins and has a strong antiaggreation effect on blood platelets, and is used in the prophylaxis and treatment of thromboses. Protacycline also inhibits and controls excessive gastric, secretion (avoiding or attenuating gastro-intestinal ulcers and lesions and accelerating their healing), is a vasodilator used particularly as an antihypertensive and favours the healing of wounds.The cpds. are usually administered parenterally (intravenously, sub-cutaneously or intramuscularly) in doses of 0.01-200 mg/kg, pref.0.01-10 mg/kg
FR7714201A 1975-10-21 1977-05-10 Prostaglandin derivs. Granted FR2351112A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US05/624,486 US3984400A (en) 1975-10-21 1975-10-21 11-Desoxy-16-aryl-ω-tetranorprostaglandins
FR7631769A FR2361871A1 (en) 1975-10-21 1976-10-21 Antihypertensive, antiulcer prostaglandins
FR7710593A FR2351111A1 (en) 1976-05-11 1977-04-07 2- (2B-ETHYNYL-CYCLOPENT-1A-YL) ACETALDEHYDES METHYLACETALS AND THEIR PREPARATION

Publications (2)

Publication Number Publication Date
FR2351112A1 true FR2351112A1 (en) 1977-12-09
FR2351112B1 FR2351112B1 (en) 1981-05-29

Family

ID=27250686

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7714201A Granted FR2351112A1 (en) 1975-10-21 1977-05-10 Prostaglandin derivs.

Country Status (1)

Country Link
FR (1) FR2351112A1 (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2359125A1 (en) * 1976-02-04 1978-02-17 Upjohn Co NEW PROSTAGLANDIN DERIVATIVES, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM
FR2378777A1 (en) * 1977-01-31 1978-08-25 Ono Pharmaceutical Co NEW ANALOGUES OF PROSTAGLANDINS
FR2401141A1 (en) * 1977-03-07 1979-03-23 Upjohn Co NEW HALOGEN DERIVATIVES OF PROSTAGLANDINS AND MEDICINES CONTAINING THEM
FR2401921A1 (en) * 1977-07-28 1979-03-30 Upjohn Co PROSTAGLANDINE DERIVATIVES
EP0001270A1 (en) * 1977-09-27 1979-04-04 Hoechst Aktiengesellschaft Analogues of prostacycline, methods for their preparation and their use in the treatment of circulatory diseases
EP0005768A1 (en) * 1978-05-17 1979-12-12 The Wellcome Foundation Limited Pharmaceutical formulations containing prostaglandin compounds and method for their preparation
EP0013955A1 (en) * 1979-01-25 1980-08-06 Hoechst Aktiengesellschaft Analogues of prostacyclin, their intermediates, a process for their preparation and medicaments containing them
EP0052204A1 (en) * 1980-11-13 1982-05-26 American Cyanamid Company Prostacyclin analogs of the 1 series and related analogs
FR2513639A1 (en) * 1981-09-25 1983-04-01 Squibb & Sons Inc NOVEL DIOXATRICYCLIC PROSTACYCLINS USEFUL AS CARDIOVASCULAR MEDICAMENTS AND NEW PRODUCTS USEFUL AS INTERMEDIATES FOR THEIR SYNTHESIS
EP0084775A1 (en) * 1982-01-21 1983-08-03 MERCK PATENT GmbH 13-Thia-prostacyclines
WO2013024051A1 (en) * 2011-08-12 2013-02-21 Ascendis Pharma A/S Sustained release composition of prostacyclin

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2359125A1 (en) * 1976-02-04 1978-02-17 Upjohn Co NEW PROSTAGLANDIN DERIVATIVES, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM
FR2362833A1 (en) * 1976-02-04 1978-03-24 Upjohn Co NEW PROSTAGLANDIN 5 DERIVATIVES, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM
FR2378777A1 (en) * 1977-01-31 1978-08-25 Ono Pharmaceutical Co NEW ANALOGUES OF PROSTAGLANDINS
FR2401141A1 (en) * 1977-03-07 1979-03-23 Upjohn Co NEW HALOGEN DERIVATIVES OF PROSTAGLANDINS AND MEDICINES CONTAINING THEM
FR2401139A2 (en) * 1977-03-07 1979-03-23 Upjohn Co NEW D5 DERIVATIVES OF PROSTAGLANDINS, THEIR PREPARATION PROCESS AND MEDICINAL PRODUCTS CONTAINING THEM
FR2401921A1 (en) * 1977-07-28 1979-03-30 Upjohn Co PROSTAGLANDINE DERIVATIVES
FR2401920A1 (en) * 1977-07-28 1979-03-30 Upjohn Co PROSTAGLANDINE DERIVATIVES
EP0001270A1 (en) * 1977-09-27 1979-04-04 Hoechst Aktiengesellschaft Analogues of prostacycline, methods for their preparation and their use in the treatment of circulatory diseases
EP0005768A1 (en) * 1978-05-17 1979-12-12 The Wellcome Foundation Limited Pharmaceutical formulations containing prostaglandin compounds and method for their preparation
FR2425856A1 (en) * 1978-05-17 1979-12-14 Wellcome Found PROSTAGLANDIN MEDICINAL PRODUCT
EP0013955A1 (en) * 1979-01-25 1980-08-06 Hoechst Aktiengesellschaft Analogues of prostacyclin, their intermediates, a process for their preparation and medicaments containing them
EP0052204A1 (en) * 1980-11-13 1982-05-26 American Cyanamid Company Prostacyclin analogs of the 1 series and related analogs
FR2513639A1 (en) * 1981-09-25 1983-04-01 Squibb & Sons Inc NOVEL DIOXATRICYCLIC PROSTACYCLINS USEFUL AS CARDIOVASCULAR MEDICAMENTS AND NEW PRODUCTS USEFUL AS INTERMEDIATES FOR THEIR SYNTHESIS
EP0084775A1 (en) * 1982-01-21 1983-08-03 MERCK PATENT GmbH 13-Thia-prostacyclines
WO2013024051A1 (en) * 2011-08-12 2013-02-21 Ascendis Pharma A/S Sustained release composition of prostacyclin
US9872864B2 (en) 2011-08-12 2018-01-23 Ascendis Pharma A/S Sustained release composition of prostacyclin

Also Published As

Publication number Publication date
FR2351112B1 (en) 1981-05-29

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