FR2340950A1 - Esters du cefuroxime, leur procede de preparation et leur application en therapeutique - Google Patents
Esters du cefuroxime, leur procede de preparation et leur application en therapeutiqueInfo
- Publication number
- FR2340950A1 FR2340950A1 FR7704339A FR7704339A FR2340950A1 FR 2340950 A1 FR2340950 A1 FR 2340950A1 FR 7704339 A FR7704339 A FR 7704339A FR 7704339 A FR7704339 A FR 7704339A FR 2340950 A1 FR2340950 A1 FR 2340950A1
- Authority
- FR
- France
- Prior art keywords
- preparation process
- therapeutic application
- cefuroxime
- esters
- cefuroxime esters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB6009/76A GB1571683A (en) | 1976-02-16 | 1976-02-16 | Ester derivatives of cefuroxime |
GB2730276 | 1976-06-30 | ||
GB2730176 | 1976-06-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2340950A1 true FR2340950A1 (fr) | 1977-09-09 |
FR2340950B1 FR2340950B1 (fr) | 1980-02-01 |
Family
ID=27254745
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7704339A Granted FR2340950A1 (fr) | 1976-02-16 | 1977-02-16 | Esters du cefuroxime, leur procede de preparation et leur application en therapeutique |
Country Status (16)
Country | Link |
---|---|
US (1) | US4267320A (fr) |
JP (1) | JPS52100494A (fr) |
AT (1) | AT358727B (fr) |
AU (1) | AU514236B2 (fr) |
CA (1) | CA1094545A (fr) |
CH (2) | CH628901A5 (fr) |
CY (1) | CY1181A (fr) |
DE (1) | DE2706413C2 (fr) |
DK (1) | DK149062C (fr) |
FR (1) | FR2340950A1 (fr) |
HK (1) | HK17185A (fr) |
IL (1) | IL51450A (fr) |
KE (1) | KE3260A (fr) |
NL (2) | NL185209C (fr) |
SE (1) | SE431986B (fr) |
YU (1) | YU40977B (fr) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2387988A1 (fr) * | 1977-04-19 | 1978-11-17 | Glaxo Lab Ltd | Esters de cefuroxime, leur preparation et leur application therapeutique |
FR2531087A1 (fr) * | 1982-07-30 | 1984-02-03 | Glaxo Group Ltd | Nouvelle forme d'ester de cefuroxime, procede pour sa preparation et composition pharmaceutique la contenant |
FR2549837A1 (fr) * | 1983-07-29 | 1985-02-01 | Glaxo Group Ltd | Procede de preparation d'ester de 1-acetoxyethyle de cefuroxime |
FR2591597A1 (fr) * | 1985-09-30 | 1987-06-19 | Glaxo Group Ltd | Comprime pharmaceutique enrobe contenant de l'ester 1-acetoxyethylique de la cefuroxime et procede de preparation de celui-ci |
FR2631032A1 (fr) * | 1988-05-03 | 1989-11-10 | Glaxo Group Ltd | Procede de preparation de derives de cefuroxime et composes ainsi obtenus |
FR2631031A1 (fr) * | 1988-05-03 | 1989-11-10 | Glaxo Group Ltd | Procede de preparation de derives de cefuroxime et produits ainsi obtenus |
EP0757991A1 (fr) * | 1995-08-03 | 1997-02-12 | ACS DOBFAR S.p.A. | Forme cristalline de céfuroxime axétil biodisponible |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1093549A (fr) * | 1976-02-16 | 1981-01-13 | Michael Gregson | Traduction non-disponible |
GB1602736A (en) * | 1977-08-12 | 1981-11-18 | Glaxo Operations Ltd | A-acetoxyethyl esters of 3-carbamoyloxymethyl-7-(2-(fur-2-yl)-2-methoxyiminoacetamido)ceph-3-em-4-carboxylic acids |
JPS60190783A (ja) * | 1983-12-21 | 1985-09-28 | Sumitomo Seiyaku Kk | セフエム系化合物 |
GB8400024D0 (en) * | 1984-01-03 | 1984-02-08 | Glaxo Group Ltd | Cephalosporin antibiotics |
JPH0586375U (ja) * | 1991-07-11 | 1993-11-22 | 田中食品機械株式会社 | ゴルフ練習用マット |
JPH0541572U (ja) * | 1991-11-15 | 1993-06-08 | コナミ株式会社 | 遊戯機器用起伏形成装置 |
CN1111537C (zh) * | 1997-05-15 | 2003-06-18 | 第一制糖株式会社 | 高纯晶形头孢呋辛1-乙酰氧乙酯的制备方法 |
IN186539B (fr) * | 1997-09-29 | 2001-09-29 | Ranbaxy Lab Ltd | |
DK0937727T3 (da) * | 1998-02-20 | 2002-05-13 | Fako Ilaclari A S | Fremgangsmåde til fremstilling af opløseligt krystallinsk cefuroxim-axetil |
US6384213B1 (en) | 1998-10-23 | 2002-05-07 | Ranbaxy Laboratories Limited | Process for preparing a pure, pharmacopoeial grade amorphous form of cefuroxime axetil |
WO2000056286A1 (fr) | 1999-03-19 | 2000-09-28 | Ranbaxy Laboratories Limited | Procede de preparation d'une forme posologique orale biodisponible de cefuroxime axetil |
IN190831B (fr) | 1999-03-19 | 2003-08-23 | Ranbaxy Lab Ltd | |
CA2280925A1 (fr) | 1999-07-29 | 2001-01-29 | Bernard Charles Sherman | Cefuroxime axetil stabilise |
IN190849B (fr) | 2000-07-17 | 2003-08-23 | Ranbaxy Lab Ltd | |
AT411996B (de) * | 2000-09-11 | 2004-08-26 | Sandoz Ag | Verfahren zur herstellung von cefuroxim in der form seines n-butylammoniumsalzes |
WO2003010170A1 (fr) * | 2001-07-25 | 2003-02-06 | Lupin Limited | Procede ameliore de preparation de cefuroxime axetil |
ITMI20011763A1 (it) * | 2001-08-10 | 2003-02-10 | Antibioticos Spa | Processo di preparazione di cefuroxime axelite ad elevata purezza |
HRP20020924A2 (en) * | 2001-11-23 | 2003-10-31 | Glaxo Group Ltd | Pharmaceutical composition |
KR100552567B1 (ko) * | 2003-08-23 | 2006-02-15 | 한국유나이티드제약 주식회사 | 수분 흡수에 안정하고 빠르게 붕해되는 세푸록심 악세틸을포함하는 정제의 조성물 및 제조 방법 |
CN1295234C (zh) * | 2004-11-15 | 2007-01-17 | 中山大学 | 一种头孢呋辛酯非对映异构体的分离方法 |
DE102005019458A1 (de) | 2005-04-25 | 2006-10-26 | Grünenthal GmbH | Darreichungsform mit verbesserter Freisetzung von Cefuroximaxetil |
DE102006019619A1 (de) * | 2006-04-25 | 2007-10-31 | Grünenthal GmbH | Kristalline Modifikation von Cefuroximaxetil |
WO2013038323A1 (fr) | 2011-09-13 | 2013-03-21 | Unimark Remedies Ltd. | Compositions pharmaceutiques de céfuroxime axétil à goût masqué |
CN111732599A (zh) * | 2020-07-08 | 2020-10-02 | 江苏正大清江制药有限公司 | 一种合成头孢呋辛酯二聚体的方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1310642A (en) | 1970-11-09 | 1973-03-21 | Pfizer | Alpha-sulfo-and alpha-sulfoalkylacylcephalosporins |
US3870713A (en) * | 1970-12-07 | 1975-03-11 | Pfizer | Phosphono substituted alkylcephalosporins |
CA996929A (en) * | 1971-04-05 | 1976-09-14 | Kohzi Nakano | Acyloxyalkyl ester derivatives of penicillin |
US3974153A (en) * | 1971-05-14 | 1976-08-10 | Glaxo Laboratories Limited | 7-Hydrocarbonoxy imino-acetamido-3-carbamoyloxy methylceph-3-em-4 carboxylic acids |
BE794844A (fr) * | 1972-02-24 | 1973-08-01 | Pfizer | Alpha-carboxy-2-thienylmethylpenicilline et alpha-carboxy-2-thienylmethylcephalosporine,leurs esters et leurs sels |
PL98296B1 (pl) | 1973-02-07 | 1978-04-29 | Politechnika Gdanskapo | Sposob otrzymywania estrow acetoksymetylowych cefalosporyn |
US3962227A (en) * | 1973-02-23 | 1976-06-08 | Eli Lilly And Company | 3-halo cephalosporins |
AR207148A1 (es) * | 1974-05-02 | 1976-09-15 | Rhone Poulenc Ind | Procedimiento para la preparacion de un nuevo derivado de la cefalosporina |
-
1977
- 1977-02-11 CA CA271,637A patent/CA1094545A/fr not_active Expired
- 1977-02-15 AT AT100677A patent/AT358727B/de active Protection Beyond IP Right Term
- 1977-02-15 DK DK63877A patent/DK149062C/da not_active IP Right Cessation
- 1977-02-15 IL IL51450A patent/IL51450A/xx unknown
- 1977-02-15 CH CH187477A patent/CH628901A5/de not_active IP Right Cessation
- 1977-02-15 DE DE2706413A patent/DE2706413C2/de not_active Expired
- 1977-02-15 CY CY1181A patent/CY1181A/xx unknown
- 1977-02-15 AU AU22288/77A patent/AU514236B2/en not_active Expired
- 1977-02-15 NL NLAANVRAGE7701568,A patent/NL185209C/xx not_active IP Right Cessation
- 1977-02-15 YU YU411/77A patent/YU40977B/xx unknown
- 1977-02-15 SE SE7701668A patent/SE431986B/xx not_active IP Right Cessation
- 1977-02-15 JP JP1602077A patent/JPS52100494A/ja active Granted
- 1977-02-16 FR FR7704339A patent/FR2340950A1/fr active Granted
-
1979
- 1979-07-27 US US06/061,260 patent/US4267320A/en not_active Expired - Lifetime
-
1982
- 1982-03-05 CH CH137382A patent/CH634328A5/de not_active IP Right Cessation
-
1983
- 1983-02-05 KE KE3260A patent/KE3260A/xx unknown
-
1985
- 1985-03-14 HK HK171/85A patent/HK17185A/xx unknown
-
1993
- 1993-06-14 NL NL930073C patent/NL930073I2/nl unknown
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2387988A1 (fr) * | 1977-04-19 | 1978-11-17 | Glaxo Lab Ltd | Esters de cefuroxime, leur preparation et leur application therapeutique |
FR2531087A1 (fr) * | 1982-07-30 | 1984-02-03 | Glaxo Group Ltd | Nouvelle forme d'ester de cefuroxime, procede pour sa preparation et composition pharmaceutique la contenant |
EP0107276A2 (fr) * | 1982-07-30 | 1984-05-02 | Glaxo Group Limited | Forme d'ester de céfuroxime, procédé pour leur préparation et compositions les contenant |
EP0107276A3 (en) * | 1982-07-30 | 1985-03-06 | Glaxo Group Limited | Novel form of cefuroxime ester, process for its preparation and composition containing it |
FR2549837A1 (fr) * | 1983-07-29 | 1985-02-01 | Glaxo Group Ltd | Procede de preparation d'ester de 1-acetoxyethyle de cefuroxime |
FR2591597A1 (fr) * | 1985-09-30 | 1987-06-19 | Glaxo Group Ltd | Comprime pharmaceutique enrobe contenant de l'ester 1-acetoxyethylique de la cefuroxime et procede de preparation de celui-ci |
FR2631032A1 (fr) * | 1988-05-03 | 1989-11-10 | Glaxo Group Ltd | Procede de preparation de derives de cefuroxime et composes ainsi obtenus |
FR2631031A1 (fr) * | 1988-05-03 | 1989-11-10 | Glaxo Group Ltd | Procede de preparation de derives de cefuroxime et produits ainsi obtenus |
EP0757991A1 (fr) * | 1995-08-03 | 1997-02-12 | ACS DOBFAR S.p.A. | Forme cristalline de céfuroxime axétil biodisponible |
US5677443A (en) * | 1995-08-03 | 1997-10-14 | Acs Dobfar S.P.A. | Bioavailable crystalline form of cefuroxime axetil |
Also Published As
Publication number | Publication date |
---|---|
DK149062C (da) | 1986-06-16 |
IL51450A0 (en) | 1977-04-29 |
YU40977B (en) | 1986-10-31 |
YU41177A (en) | 1982-06-30 |
NL185209B (nl) | 1989-09-18 |
AU2228877A (en) | 1978-08-24 |
SE7701668L (sv) | 1977-08-17 |
JPS52100494A (en) | 1977-08-23 |
CH634328A5 (de) | 1983-01-31 |
DE2706413A1 (de) | 1977-08-18 |
CY1181A (en) | 1983-10-07 |
JPS633868B2 (fr) | 1988-01-26 |
DK149062B (da) | 1986-01-06 |
CH628901A5 (de) | 1982-03-31 |
IL51450A (en) | 1980-11-30 |
SE431986B (sv) | 1984-03-12 |
AT358727B (de) | 1980-09-25 |
NL7701568A (nl) | 1977-08-18 |
KE3260A (en) | 1983-03-25 |
DE2706413C2 (de) | 1986-08-28 |
US4267320A (en) | 1981-05-12 |
NL930073I1 (nl) | 1993-09-16 |
AU514236B2 (en) | 1981-01-29 |
NL930073I2 (nl) | 1993-11-01 |
NL185209C (nl) | 1990-02-16 |
HK17185A (en) | 1985-03-22 |
FR2340950B1 (fr) | 1980-02-01 |
CA1094545A (fr) | 1981-01-27 |
DK63877A (da) | 1977-08-17 |
ATA100677A (de) | 1980-02-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CC | Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990) |
Free format text: 92C0182, 920511 |
|
CB | Supplementary protection certificate (spc) granted (law of 25 june 1990) |
Free format text: 92C0182, 770216 |
|
CL | Concession to grant licences |