FR2323393A1 - Germicidal gels contg. iodine - in which the gelling agent is a block copolymer of ethylene and propylene oxides - Google Patents

Germicidal gels contg. iodine - in which the gelling agent is a block copolymer of ethylene and propylene oxides

Info

Publication number
FR2323393A1
FR2323393A1 FR7528012A FR7528012A FR2323393A1 FR 2323393 A1 FR2323393 A1 FR 2323393A1 FR 7528012 A FR7528012 A FR 7528012A FR 7528012 A FR7528012 A FR 7528012A FR 2323393 A1 FR2323393 A1 FR 2323393A1
Authority
FR
France
Prior art keywords
iodine
germicidal
contg
gels
block copolymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7528012A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WEST LABORATORIES Inc
Original Assignee
WEST LABORATORIES Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WEST LABORATORIES Inc filed Critical WEST LABORATORIES Inc
Priority to FR7528012A priority Critical patent/FR2323393A1/en
Publication of FR2323393A1 publication Critical patent/FR2323393A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/18—Iodine; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/90—Block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)

Abstract

Germicidal compsns. in gel form contain iodine, a water soluble iodide to give an I:I2 ratio >0.25:1 and about 20-30 wt. % of a block copolymer of formula: HO(C2H4O)x(C3H6O)y(C2H4O)xH(I). The mol. wt. of the hydrophobic polypropylene fragment is 3500-4500 and the overall molecular wt. is 11000-12000. The compsns. are extremely stable and are liquid at low temps., which aids incorporation of the various components. At room temp. the gels are suitable for topical application. In an example, an ointment was prepd. contg. 25% Pluronic F-127 (RTM), 1.25% iodine, 0.60% NaI, 0.35% citric acid, 0.43% NaOH (46 degrees B), and 72.37% water.
FR7528012A 1975-09-12 1975-09-12 Germicidal gels contg. iodine - in which the gelling agent is a block copolymer of ethylene and propylene oxides Withdrawn FR2323393A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7528012A FR2323393A1 (en) 1975-09-12 1975-09-12 Germicidal gels contg. iodine - in which the gelling agent is a block copolymer of ethylene and propylene oxides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7528012A FR2323393A1 (en) 1975-09-12 1975-09-12 Germicidal gels contg. iodine - in which the gelling agent is a block copolymer of ethylene and propylene oxides

Publications (1)

Publication Number Publication Date
FR2323393A1 true FR2323393A1 (en) 1977-04-08

Family

ID=9159920

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7528012A Withdrawn FR2323393A1 (en) 1975-09-12 1975-09-12 Germicidal gels contg. iodine - in which the gelling agent is a block copolymer of ethylene and propylene oxides

Country Status (1)

Country Link
FR (1) FR2323393A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1981000207A1 (en) * 1979-07-11 1981-02-05 P Harrigan Pharmaceutical preparation
FR2465418A1 (en) * 1979-09-21 1981-03-27 West Agro Chemical Inc IODINE GERMICIDAL COMPOSITIONS WITH INCREASED STABILITY OF IODINE
EP0313684A1 (en) * 1982-09-30 1989-05-03 Geneco, Inc. Solution for eliminating intra-abdominal infections
EP0394881A2 (en) * 1989-04-24 1990-10-31 Becton, Dickinson and Company Radiation sterilizable antimicrobial ointment and process to manufacture

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1981000207A1 (en) * 1979-07-11 1981-02-05 P Harrigan Pharmaceutical preparation
FR2465418A1 (en) * 1979-09-21 1981-03-27 West Agro Chemical Inc IODINE GERMICIDAL COMPOSITIONS WITH INCREASED STABILITY OF IODINE
EP0313684A1 (en) * 1982-09-30 1989-05-03 Geneco, Inc. Solution for eliminating intra-abdominal infections
EP0394881A2 (en) * 1989-04-24 1990-10-31 Becton, Dickinson and Company Radiation sterilizable antimicrobial ointment and process to manufacture
EP0394881A3 (en) * 1989-04-24 1991-05-29 Becton, Dickinson and Company Radiation sterilizable antimicrobial ointment and process to manufacture

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