FR2287912A1 - Sepharose type polysaccharides with amino-acid, pref glycine, gps - useful as non-specific immunity adjuvants for vaccines - Google Patents

Sepharose type polysaccharides with amino-acid, pref glycine, gps - useful as non-specific immunity adjuvants for vaccines

Info

Publication number
FR2287912A1
FR2287912A1 FR7434489A FR7434489A FR2287912A1 FR 2287912 A1 FR2287912 A1 FR 2287912A1 FR 7434489 A FR7434489 A FR 7434489A FR 7434489 A FR7434489 A FR 7434489A FR 2287912 A1 FR2287912 A1 FR 2287912A1
Authority
FR
France
Prior art keywords
gps
pref
galactopyranose
vaccines
polysaccharides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7434489A
Other languages
French (fr)
Inventor
Tam Nguyen-Dang
Maurice-Marie Janot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bpifrance Financement SA
Original Assignee
Agence National de Valorisation de la Recherche ANVAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agence National de Valorisation de la Recherche ANVAR filed Critical Agence National de Valorisation de la Recherche ANVAR
Priority to FR7434489A priority Critical patent/FR2287912A1/en
Publication of FR2287912A1 publication Critical patent/FR2287912A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0036—Galactans; Derivatives thereof
    • C08B37/0039—Agar; Agarose, i.e. D-galactose, 3,6-anhydro-D-galactose, methylated, sulfated, e.g. from the red algae Gelidium and Gracilaria; Agaropectin; Derivatives thereof, e.g. Sepharose, i.e. crosslinked agarose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Polysaccharides of the 'Sepharose' type having -NH-(CH2)n-COOH gps. (where n=1,2 or 3). The polysaccharides are esp. those having beta-D-galactopyranose gps. and 3,6-dianhydro-alpha-L-galactopyranose gps; the Beta-D-galactopyranose gps. are in corresponding pairs joined to each other in 1,3 posns. and the 3,6-dianhydro-alpha-L-galactopyranose gps. are also pref. in corresponding pairs joined 1,4. They are used as non-specific immunity adjuvants esp. for vaccines e.g. where the vaccine antigens have only weak immunogenic capacity. They may also be injected separately after administration of the vaccine. The polysaccharides have good stability and are free from toxicity and are injected as aqs. dispersions (sterilised at 120 degrees C) at doses of 50-5000 (pref. 500-1000) mg. per unit dose of vaccine, used for treatment of viral or bacterial disease.
FR7434489A 1974-10-14 1974-10-14 Sepharose type polysaccharides with amino-acid, pref glycine, gps - useful as non-specific immunity adjuvants for vaccines Withdrawn FR2287912A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7434489A FR2287912A1 (en) 1974-10-14 1974-10-14 Sepharose type polysaccharides with amino-acid, pref glycine, gps - useful as non-specific immunity adjuvants for vaccines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7434489A FR2287912A1 (en) 1974-10-14 1974-10-14 Sepharose type polysaccharides with amino-acid, pref glycine, gps - useful as non-specific immunity adjuvants for vaccines

Publications (1)

Publication Number Publication Date
FR2287912A1 true FR2287912A1 (en) 1976-05-14

Family

ID=9144063

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7434489A Withdrawn FR2287912A1 (en) 1974-10-14 1974-10-14 Sepharose type polysaccharides with amino-acid, pref glycine, gps - useful as non-specific immunity adjuvants for vaccines

Country Status (1)

Country Link
FR (1) FR2287912A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4466957A (en) * 1982-02-25 1984-08-21 American Home Products Corporation Vaccine adjuvants
EP0572354A2 (en) * 1992-05-28 1993-12-01 Aligena Ag Immobilized buffered gels and membranes of hydroxy groups containing polymers

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4466957A (en) * 1982-02-25 1984-08-21 American Home Products Corporation Vaccine adjuvants
EP0572354A2 (en) * 1992-05-28 1993-12-01 Aligena Ag Immobilized buffered gels and membranes of hydroxy groups containing polymers
EP0572354A3 (en) * 1992-05-28 1994-03-02 Aligena Ag
US5430099A (en) * 1992-05-28 1995-07-04 Aligena Ag Immobilized buffered gels and membranes of hydroxy groups containing polymers
US5597863A (en) * 1992-05-28 1997-01-28 Aligena Ag Immobilized buffered gels and membranes of hydroxy groups containing polymers
US5599506A (en) * 1992-05-28 1997-02-04 Aligena Ag Immobilized buffered gels and membranes of hydroxy groups containing polymers

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Legal Events

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