FR2266502A1 - N-(2-thenoyl)-cysteine and esters - with mucolytic activity, prepd. from cysteine (esters) and thenoyl chloride - Google Patents

N-(2-thenoyl)-cysteine and esters - with mucolytic activity, prepd. from cysteine (esters) and thenoyl chloride

Info

Publication number
FR2266502A1
FR2266502A1 FR7412290A FR7412290A FR2266502A1 FR 2266502 A1 FR2266502 A1 FR 2266502A1 FR 7412290 A FR7412290 A FR 7412290A FR 7412290 A FR7412290 A FR 7412290A FR 2266502 A1 FR2266502 A1 FR 2266502A1
Authority
FR
France
Prior art keywords
cysteine
esters
thenoyl
prepd
mucolytic activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7412290A
Other languages
French (fr)
Other versions
FR2266502B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SYNPHARM SA
Original Assignee
SYNPHARM SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SYNPHARM SA filed Critical SYNPHARM SA
Priority to FR7412290A priority Critical patent/FR2266502A1/en
Publication of FR2266502A1 publication Critical patent/FR2266502A1/en
Application granted granted Critical
Publication of FR2266502B1 publication Critical patent/FR2266502B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

N-(2-Thenoyl)-cysteine cpds. of formula (I) are new: (where R is H or 1-8C alkyl). Cpds. (I) have a mucolytic activity which is generally superior to that of L-cysteine (II) and N-acetyl-L-cysteine (III), while having better oxidn. stability than (II) and not having the undesirable side-effects of (III); cpds. (I) have very low toxicity; e.g. LD5o >3750 mg/kg (rat).
FR7412290A 1974-04-08 1974-04-08 N-(2-thenoyl)-cysteine and esters - with mucolytic activity, prepd. from cysteine (esters) and thenoyl chloride Granted FR2266502A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7412290A FR2266502A1 (en) 1974-04-08 1974-04-08 N-(2-thenoyl)-cysteine and esters - with mucolytic activity, prepd. from cysteine (esters) and thenoyl chloride

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7412290A FR2266502A1 (en) 1974-04-08 1974-04-08 N-(2-thenoyl)-cysteine and esters - with mucolytic activity, prepd. from cysteine (esters) and thenoyl chloride

Publications (2)

Publication Number Publication Date
FR2266502A1 true FR2266502A1 (en) 1975-10-31
FR2266502B1 FR2266502B1 (en) 1978-07-21

Family

ID=9137404

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7412290A Granted FR2266502A1 (en) 1974-04-08 1974-04-08 N-(2-thenoyl)-cysteine and esters - with mucolytic activity, prepd. from cysteine (esters) and thenoyl chloride

Country Status (1)

Country Link
FR (1) FR2266502A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2430945A2 (en) * 1978-07-12 1980-02-08 Chauvin Blache Lab Anti-bronchitic N-thenoyl derivs. of cysteine - for admin. orally or as aerosol sprays
DE2932186A1 (en) * 1978-08-10 1980-02-14 Robins Co Inc A H THIOPHENCARBOXAMIDO-ALKYLMERCAPTANE, MEDICINAL PRODUCTS, AND THEIR USE
US6974800B1 (en) 1999-05-03 2005-12-13 Astrazeneca Ab Formulations comprising an inhibitor of carboxypeptidase U and A thrombin inhibitor
US7071175B1 (en) 1999-05-03 2006-07-04 Astrazeneca Ab Pyridine mercapto carboxylic acids as carboxypeptidase U inhibitors

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2430945A2 (en) * 1978-07-12 1980-02-08 Chauvin Blache Lab Anti-bronchitic N-thenoyl derivs. of cysteine - for admin. orally or as aerosol sprays
DE2932186A1 (en) * 1978-08-10 1980-02-14 Robins Co Inc A H THIOPHENCARBOXAMIDO-ALKYLMERCAPTANE, MEDICINAL PRODUCTS, AND THEIR USE
FR2433019A1 (en) * 1978-08-10 1980-03-07 Robins Co Inc A H NOVEL THIOPHENECARBOXAMIDOALKYLMERCAPTANS, USEFUL IN PARTICULAR AS MUCOLYTICS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US6974800B1 (en) 1999-05-03 2005-12-13 Astrazeneca Ab Formulations comprising an inhibitor of carboxypeptidase U and A thrombin inhibitor
US7071175B1 (en) 1999-05-03 2006-07-04 Astrazeneca Ab Pyridine mercapto carboxylic acids as carboxypeptidase U inhibitors

Also Published As

Publication number Publication date
FR2266502B1 (en) 1978-07-21

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Legal Events

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TP Transmission of property
ST Notification of lapse