GB1220623A - 0,4-dihydro-1-substituted-6,7-methylene-dioxy-4-oxo-3-quinoline carboxylic acid derivatives - Google Patents
0,4-dihydro-1-substituted-6,7-methylene-dioxy-4-oxo-3-quinoline carboxylic acid derivativesInfo
- Publication number
- GB1220623A GB1220623A GB21907/68A GB2190768A GB1220623A GB 1220623 A GB1220623 A GB 1220623A GB 21907/68 A GB21907/68 A GB 21907/68A GB 2190768 A GB2190768 A GB 2190768A GB 1220623 A GB1220623 A GB 1220623A
- Authority
- GB
- United Kingdom
- Prior art keywords
- substituted
- dioxy
- dihydro
- oxo
- methylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1,220,623. 6,7 - Methylenedioxyquinoline derivatives. WARNER-LAMBERT PHARMACEUTICAL CO. 8 May, 1968 [18 May, 1967], No. 21907/68. Heading C2C. [Also in Division A5] The invention comprises compounds of formula wherein R is C 1-12 alkyl (possibly OH- or CO 2 H-substituted), C 2-12 alkenyl or C 3-8 cycloalkyl, and R 1 is NHOH, NHCOOR 2 , NHC 6 - H 4 OCH 3 or OCH 2 CH 2 N(R 2 ) 2 , where R 2 is C 1-12 alkyl. These compounds are prepared by reacting the acid chloride (above formula, R 1 Cl) with NH 2 OH, NH 2 COOR 2 , NH 2 C 6 H 4 - OCH 3 or HOCH 2 CH 2 N(R 2 ) 2 .
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63930467A | 1967-05-18 | 1967-05-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1220623A true GB1220623A (en) | 1971-01-27 |
Family
ID=24563571
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB21907/68A Expired GB1220623A (en) | 1967-05-18 | 1968-05-08 | 0,4-dihydro-1-substituted-6,7-methylene-dioxy-4-oxo-3-quinoline carboxylic acid derivatives |
Country Status (6)
Country | Link |
---|---|
US (1) | US3524858A (en) |
CA (1) | CA918665A (en) |
DE (1) | DE1770447A1 (en) |
FR (1) | FR8415M (en) |
GB (1) | GB1220623A (en) |
SE (1) | SE342450B (en) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1194219B (en) * | 1962-01-12 | 1965-06-03 | Schaefer & Kind Armaturenfabri | Quick-acting shut-off valve with a non-rising twist grip |
US3966743A (en) * | 1968-07-23 | 1976-06-29 | Boehringer Mannheim G.M.B.H. | Ortho fused cycloalkano-4-quinolone-3-carboxylic acid derivatives |
US3907808A (en) * | 1971-05-17 | 1975-09-23 | Sterling Drug Inc | 1,4-Dihydro-4-oxo-7-pyridyl-3-quinolinecarboxylic acid derivatives |
US3755332A (en) * | 1971-07-01 | 1973-08-28 | Ciba Geigy Corp | Substituted 4 indazolaminoquinolines |
BE793524A (en) * | 1971-12-30 | 1973-06-29 | Riker Laboratories Inc | BENZOQUINOLIZINE-CARBOXYLIC ACIDS AND THEIR DERIVATIVES |
US4014877A (en) * | 1972-11-02 | 1977-03-29 | Riker Laboratories, Inc. | Substituted benzo[ij]quinolizine-2-carboxylic acids and derivatives thereof |
US3985882A (en) * | 1972-11-02 | 1976-10-12 | Riker Laboratories, Inc. | Substituted benzo[ij]quinolinzine-2-carboxylic acids and derivatives thereof as bactericidal agents |
US4001244A (en) * | 1973-07-23 | 1977-01-04 | G. D. Searle & Co. | 1-aryl-3,4-dihydro-2(1h)-isoquinoline carbonyl chlorides |
US3905982A (en) * | 1973-07-23 | 1975-09-16 | Searle & Co | 1-Aryl-n-dialkylaminoalkyl-3,4-dihydro-2(1H)-isoquinolinecarboxamides and related compounds |
FR2281761A1 (en) * | 1974-08-13 | 1976-03-12 | Roussel Uclaf | NEW DERIVATIVES OF 3-QUINOLEINE CARBOXYLIC ACID, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS A MEDICINAL PRODUCT |
US4192876A (en) * | 1975-07-23 | 1980-03-11 | Sandoz, Inc. | 4-Hydroxy-3-nitro-quinoline-2(1H)-ones |
JPS5324028A (en) * | 1976-08-19 | 1978-03-06 | Sumitomo Chem Co Ltd | Systemic bactericide for plant |
US4273930A (en) * | 1977-06-20 | 1981-06-16 | Sandoz, Inc. | 4-Hydroxy-2-quinolinone-3-carboxylic acid esters |
US4281131A (en) * | 1977-06-20 | 1981-07-28 | Sandoz, Inc. | 4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof |
US4284777A (en) * | 1978-12-26 | 1981-08-18 | E. I. Du Pont De Nemours And Company | Antibacterials: 1-difluoromethyl-6,7-methylenedioxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and its esters |
US4216324A (en) * | 1978-12-26 | 1980-08-05 | E. I. Du Pont De Nemours And Company | 1-Difluoromethyl-6,7-methylenedioxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid |
IE52670B1 (en) * | 1981-03-03 | 1988-01-20 | Leo Ab | Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation |
FR2564832B1 (en) * | 1984-05-23 | 1987-05-15 | Panmedica Sa | NOVEL N-ACYL DERIVATIVES OF AMINO ACIDS AND THEIR ESTERS, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM |
EP0841927B1 (en) * | 1995-08-02 | 2004-01-28 | Darwin Discovery Limited | Quinolones and their therapeutic use |
EP0841929B1 (en) * | 1995-08-02 | 2003-05-07 | Darwin Discovery Limited | Quinolones and their therapeutic use |
US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
NZ587551A (en) | 2004-06-24 | 2012-01-12 | Vertex Pharma | 5-Amino-phenol derivatives such as 5-amino-2,4-di-tert-butyl-phenol |
US8354427B2 (en) * | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
SI2502911T1 (en) * | 2004-06-24 | 2017-07-31 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
RU2556984C2 (en) * | 2004-06-24 | 2015-07-20 | Вертекс Фармасьютикалз Инкорпорейтед | Modulators of atp-binding cassette transporters |
CN101374849A (en) * | 2005-12-24 | 2009-02-25 | 沃泰克斯药物股份有限公司 | Quinoline-4-ketones derivates as ABC transport protein regulation/control agent |
SI3219705T1 (en) | 2005-12-28 | 2020-08-31 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of the amorphous form of n-(2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl)-1,4-dihydro-4-oxoquinoline-3-carboxamide |
RU2543714C2 (en) | 2009-03-20 | 2015-03-10 | Вертекс Фармасьютикалз Инкорпорейтед | Method of obtaining modulators of cystic fibrousis transmembrane conductance regulator |
US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
BR112014021090B1 (en) | 2012-02-27 | 2023-01-24 | Vertex Pharmaceuticals Incorporated | PHARMACEUTICAL COMPOSITION AND USE OF N-[2,4-BIS(1,1-DIMETHYLethyl)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE3-CARBOXAMIDE IN THE PREPARATION OF THE SAME |
RU2749213C2 (en) | 2014-10-07 | 2021-06-07 | Вертекс Фармасьютикалз Инкорпорейтед | Co-crystals of transmembrane conduction regulator modulators in cystic fibrosis |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3172811A (en) * | 1965-03-09 | Quinolone proteus infection treatment | ||
US2614121A (en) * | 1946-03-01 | 1952-10-14 | Charles C Price | Process for making intermediates for producing basic compounds |
GB1007590A (en) * | 1962-04-09 | 1965-10-13 | Norwich Pharma Co | Lower alkyl esters of 6,7-di(lower)alkoxy-4-hydroxy-3-quinolinecarboxylic acid |
GB1076828A (en) * | 1963-12-12 | 1967-07-26 | Warner Lambert Pharmaceutical | Methylenedioxy quinoline derivatives |
US3397208A (en) * | 1965-02-24 | 1968-08-13 | Norwich Pharma Co | Method for preparing 4-hydroxy-6, 7-dialkoxy-3-carboalkoxyquinolines and novel 4-chloro-6, 7-dialkoxy-3-carboalkoxyquinolines useful therein |
-
1967
- 1967-05-18 US US639304A patent/US3524858A/en not_active Expired - Lifetime
-
1968
- 1968-05-08 GB GB21907/68A patent/GB1220623A/en not_active Expired
- 1968-05-17 DE DE19681770447 patent/DE1770447A1/en active Pending
- 1968-05-17 FR FR152381A patent/FR8415M/fr not_active Expired
- 1968-05-17 SE SE6739/68A patent/SE342450B/xx unknown
- 1968-05-17 CA CA020366A patent/CA918665A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
SE342450B (en) | 1972-02-07 |
DE1770447A1 (en) | 1972-03-16 |
FR8415M (en) | 1971-06-10 |
US3524858A (en) | 1970-08-18 |
CA918665A (en) | 1973-01-09 |
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