GB1220623A - 0,4-dihydro-1-substituted-6,7-methylene-dioxy-4-oxo-3-quinoline carboxylic acid derivatives - Google Patents

0,4-dihydro-1-substituted-6,7-methylene-dioxy-4-oxo-3-quinoline carboxylic acid derivatives

Info

Publication number
GB1220623A
GB1220623A GB21907/68A GB2190768A GB1220623A GB 1220623 A GB1220623 A GB 1220623A GB 21907/68 A GB21907/68 A GB 21907/68A GB 2190768 A GB2190768 A GB 2190768A GB 1220623 A GB1220623 A GB 1220623A
Authority
GB
United Kingdom
Prior art keywords
substituted
dioxy
dihydro
oxo
methylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB21907/68A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Pharmaceutical Co filed Critical Warner Lambert Pharmaceutical Co
Publication of GB1220623A publication Critical patent/GB1220623A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1,220,623. 6,7 - Methylenedioxyquinoline derivatives. WARNER-LAMBERT PHARMACEUTICAL CO. 8 May, 1968 [18 May, 1967], No. 21907/68. Heading C2C. [Also in Division A5] The invention comprises compounds of formula wherein R is C 1-12 alkyl (possibly OH- or CO 2 H-substituted), C 2-12 alkenyl or C 3-8 cycloalkyl, and R 1 is NHOH, NHCOOR 2 , NHC 6 - H 4 OCH 3 or OCH 2 CH 2 N(R 2 ) 2 , where R 2 is C 1-12 alkyl. These compounds are prepared by reacting the acid chloride (above formula, R 1 Cl) with NH 2 OH, NH 2 COOR 2 , NH 2 C 6 H 4 - OCH 3 or HOCH 2 CH 2 N(R 2 ) 2 .
GB21907/68A 1967-05-18 1968-05-08 0,4-dihydro-1-substituted-6,7-methylene-dioxy-4-oxo-3-quinoline carboxylic acid derivatives Expired GB1220623A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63930467A 1967-05-18 1967-05-18

Publications (1)

Publication Number Publication Date
GB1220623A true GB1220623A (en) 1971-01-27

Family

ID=24563571

Family Applications (1)

Application Number Title Priority Date Filing Date
GB21907/68A Expired GB1220623A (en) 1967-05-18 1968-05-08 0,4-dihydro-1-substituted-6,7-methylene-dioxy-4-oxo-3-quinoline carboxylic acid derivatives

Country Status (6)

Country Link
US (1) US3524858A (en)
CA (1) CA918665A (en)
DE (1) DE1770447A1 (en)
FR (1) FR8415M (en)
GB (1) GB1220623A (en)
SE (1) SE342450B (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1194219B (en) * 1962-01-12 1965-06-03 Schaefer & Kind Armaturenfabri Quick-acting shut-off valve with a non-rising twist grip
US3966743A (en) * 1968-07-23 1976-06-29 Boehringer Mannheim G.M.B.H. Ortho fused cycloalkano-4-quinolone-3-carboxylic acid derivatives
US3907808A (en) * 1971-05-17 1975-09-23 Sterling Drug Inc 1,4-Dihydro-4-oxo-7-pyridyl-3-quinolinecarboxylic acid derivatives
US3755332A (en) * 1971-07-01 1973-08-28 Ciba Geigy Corp Substituted 4 indazolaminoquinolines
BE793524A (en) * 1971-12-30 1973-06-29 Riker Laboratories Inc BENZOQUINOLIZINE-CARBOXYLIC ACIDS AND THEIR DERIVATIVES
US4014877A (en) * 1972-11-02 1977-03-29 Riker Laboratories, Inc. Substituted benzo[ij]quinolizine-2-carboxylic acids and derivatives thereof
US3985882A (en) * 1972-11-02 1976-10-12 Riker Laboratories, Inc. Substituted benzo[ij]quinolinzine-2-carboxylic acids and derivatives thereof as bactericidal agents
US4001244A (en) * 1973-07-23 1977-01-04 G. D. Searle & Co. 1-aryl-3,4-dihydro-2(1h)-isoquinoline carbonyl chlorides
US3905982A (en) * 1973-07-23 1975-09-16 Searle & Co 1-Aryl-n-dialkylaminoalkyl-3,4-dihydro-2(1H)-isoquinolinecarboxamides and related compounds
FR2281761A1 (en) * 1974-08-13 1976-03-12 Roussel Uclaf NEW DERIVATIVES OF 3-QUINOLEINE CARBOXYLIC ACID, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS A MEDICINAL PRODUCT
US4192876A (en) * 1975-07-23 1980-03-11 Sandoz, Inc. 4-Hydroxy-3-nitro-quinoline-2(1H)-ones
JPS5324028A (en) * 1976-08-19 1978-03-06 Sumitomo Chem Co Ltd Systemic bactericide for plant
US4273930A (en) * 1977-06-20 1981-06-16 Sandoz, Inc. 4-Hydroxy-2-quinolinone-3-carboxylic acid esters
US4281131A (en) * 1977-06-20 1981-07-28 Sandoz, Inc. 4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof
US4284777A (en) * 1978-12-26 1981-08-18 E. I. Du Pont De Nemours And Company Antibacterials: 1-difluoromethyl-6,7-methylenedioxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and its esters
US4216324A (en) * 1978-12-26 1980-08-05 E. I. Du Pont De Nemours And Company 1-Difluoromethyl-6,7-methylenedioxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
IE52670B1 (en) * 1981-03-03 1988-01-20 Leo Ab Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation
FR2564832B1 (en) * 1984-05-23 1987-05-15 Panmedica Sa NOVEL N-ACYL DERIVATIVES OF AMINO ACIDS AND THEIR ESTERS, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM
EP0841927B1 (en) * 1995-08-02 2004-01-28 Darwin Discovery Limited Quinolones and their therapeutic use
EP0841929B1 (en) * 1995-08-02 2003-05-07 Darwin Discovery Limited Quinolones and their therapeutic use
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
NZ587551A (en) 2004-06-24 2012-01-12 Vertex Pharma 5-Amino-phenol derivatives such as 5-amino-2,4-di-tert-butyl-phenol
US8354427B2 (en) * 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
SI2502911T1 (en) * 2004-06-24 2017-07-31 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
RU2556984C2 (en) * 2004-06-24 2015-07-20 Вертекс Фармасьютикалз Инкорпорейтед Modulators of atp-binding cassette transporters
CN101374849A (en) * 2005-12-24 2009-02-25 沃泰克斯药物股份有限公司 Quinoline-4-ketones derivates as ABC transport protein regulation/control agent
SI3219705T1 (en) 2005-12-28 2020-08-31 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of the amorphous form of n-(2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl)-1,4-dihydro-4-oxoquinoline-3-carboxamide
RU2543714C2 (en) 2009-03-20 2015-03-10 Вертекс Фармасьютикалз Инкорпорейтед Method of obtaining modulators of cystic fibrousis transmembrane conductance regulator
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
BR112014021090B1 (en) 2012-02-27 2023-01-24 Vertex Pharmaceuticals Incorporated PHARMACEUTICAL COMPOSITION AND USE OF N-[2,4-BIS(1,1-DIMETHYLethyl)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE3-CARBOXAMIDE IN THE PREPARATION OF THE SAME
RU2749213C2 (en) 2014-10-07 2021-06-07 Вертекс Фармасьютикалз Инкорпорейтед Co-crystals of transmembrane conduction regulator modulators in cystic fibrosis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3172811A (en) * 1965-03-09 Quinolone proteus infection treatment
US2614121A (en) * 1946-03-01 1952-10-14 Charles C Price Process for making intermediates for producing basic compounds
GB1007590A (en) * 1962-04-09 1965-10-13 Norwich Pharma Co Lower alkyl esters of 6,7-di(lower)alkoxy-4-hydroxy-3-quinolinecarboxylic acid
GB1076828A (en) * 1963-12-12 1967-07-26 Warner Lambert Pharmaceutical Methylenedioxy quinoline derivatives
US3397208A (en) * 1965-02-24 1968-08-13 Norwich Pharma Co Method for preparing 4-hydroxy-6, 7-dialkoxy-3-carboalkoxyquinolines and novel 4-chloro-6, 7-dialkoxy-3-carboalkoxyquinolines useful therein

Also Published As

Publication number Publication date
SE342450B (en) 1972-02-07
DE1770447A1 (en) 1972-03-16
FR8415M (en) 1971-06-10
US3524858A (en) 1970-08-18
CA918665A (en) 1973-01-09

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