FR2138285A1 - Crystalline, solid 3-beta-acetoxy-18-iodo pregnanes - as stable inter for pharmacologically active steroids - Google Patents

Crystalline, solid 3-beta-acetoxy-18-iodo pregnanes - as stable inter for pharmacologically active steroids

Info

Publication number
FR2138285A1
FR2138285A1 FR7118479A FR7118479A FR2138285A1 FR 2138285 A1 FR2138285 A1 FR 2138285A1 FR 7118479 A FR7118479 A FR 7118479A FR 7118479 A FR7118479 A FR 7118479A FR 2138285 A1 FR2138285 A1 FR 2138285A1
Authority
FR
France
Prior art keywords
acetoxy
beta
crystalline
pregnanes
iodo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7118479A
Other languages
French (fr)
Other versions
FR2138285B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Choay SA
Original Assignee
Choay SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Choay SA filed Critical Choay SA
Priority to FR7118479A priority Critical patent/FR2138285A1/en
Publication of FR2138285A1 publication Critical patent/FR2138285A1/en
Application granted granted Critical
Publication of FR2138285B1 publication Critical patent/FR2138285B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

Crystalline cpds. are of formula : (where R is -CO.Me or ). The cpds. are inters. for steroids such as holantogenin but have never been isolated as stable crystalline solids. 3 beta-Acetoxy-5 alpha-20-ol is treated with iodine in a solvent such as cyclohexane to give I(R = -CH.Me OH ) which in turn, is converted into I(R = -CO.Me) by oxidn. with CrO3 or Kiliani's reagent. These pure inters. may be used for prepg. high yields of steroids such as 18-hydroxyprogesterone, a known diuretic, without going via the 18,20-epoxy derivs. which give lower yields.
FR7118479A 1971-05-21 1971-05-21 Crystalline, solid 3-beta-acetoxy-18-iodo pregnanes - as stable inter for pharmacologically active steroids Granted FR2138285A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7118479A FR2138285A1 (en) 1971-05-21 1971-05-21 Crystalline, solid 3-beta-acetoxy-18-iodo pregnanes - as stable inter for pharmacologically active steroids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7118479A FR2138285A1 (en) 1971-05-21 1971-05-21 Crystalline, solid 3-beta-acetoxy-18-iodo pregnanes - as stable inter for pharmacologically active steroids

Publications (2)

Publication Number Publication Date
FR2138285A1 true FR2138285A1 (en) 1973-01-05
FR2138285B1 FR2138285B1 (en) 1973-05-25

Family

ID=9077423

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7118479A Granted FR2138285A1 (en) 1971-05-21 1971-05-21 Crystalline, solid 3-beta-acetoxy-18-iodo pregnanes - as stable inter for pharmacologically active steroids

Country Status (1)

Country Link
FR (1) FR2138285A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2283149A1 (en) * 1974-07-15 1976-03-26 Akzo Nv PROCESS FOR THE PREPARATION OF 11B-HYDROXY-18-ALKYL-STEROIDS OF THE OESTRANE SERIES

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2283149A1 (en) * 1974-07-15 1976-03-26 Akzo Nv PROCESS FOR THE PREPARATION OF 11B-HYDROXY-18-ALKYL-STEROIDS OF THE OESTRANE SERIES

Also Published As

Publication number Publication date
FR2138285B1 (en) 1973-05-25

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Legal Events

Date Code Title Description
ST Notification of lapse