FR2135221A1 - Doxorubicin 14-esters prepn - by treating 14-bromodaunomycin with a salt of the corresp acid - Google Patents
Doxorubicin 14-esters prepn - by treating 14-bromodaunomycin with a salt of the corresp acidInfo
- Publication number
- FR2135221A1 FR2135221A1 FR7215548A FR7215548A FR2135221A1 FR 2135221 A1 FR2135221 A1 FR 2135221A1 FR 7215548 A FR7215548 A FR 7215548A FR 7215548 A FR7215548 A FR 7215548A FR 2135221 A1 FR2135221 A1 FR 2135221A1
- Authority
- FR
- France
- Prior art keywords
- acid
- salt
- acids
- bromodaunomycin
- doxorubicin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Doxorubicin 14-esters of a mono- or dicarboxylic aliphatic, aromatic, cycloaliphatic, araliphatic or heterocyclic acid (1-20C) opt. substd. by halogen, OH, alkyl, alkoxy, NH2, NO2; mono- or dialkyl substd. alkyl- or arylcarbonic acids; carbamic acids, alkylcarbamic acids, and sulphonic acids; also their acid-addn. salts. They are prepd. by treating 14-bromodaunomycin or a salt with a salt of the required acid with an alkali metal, an alkaline earth metal or a quaternary ammonium gp., opt. alkylated. The reaction medium is pref. an inert polar solvent, e.g. acetone.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2403071 | 1971-05-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2135221A1 true FR2135221A1 (en) | 1972-12-15 |
FR2135221B1 FR2135221B1 (en) | 1978-03-03 |
Family
ID=11211575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7215548A Granted FR2135221A1 (en) | 1971-05-04 | 1972-05-02 | Doxorubicin 14-esters prepn - by treating 14-bromodaunomycin with a salt of the corresp acid |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2135221A1 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2361417A1 (en) * | 1976-08-12 | 1978-03-10 | Farmaceutici Italia | NEW ADRIAMYCINE DERIVATIVES AND METHOD FOR PREPARING THEM |
US4299822A (en) * | 1980-06-09 | 1981-11-10 | Sidney Farber Cancer Institute, Inc. | N-Trifluoroacetyladriamycin-14-O-hemiglutarate and -hemiadipate and therapeutic compositions containing same |
EP0424899A2 (en) * | 1989-10-25 | 1991-05-02 | Dong-A Pharm. Co., Ltd. | Novel anthracycline glycoside derivatives and preparing method thereof |
EP0746336A4 (en) * | 1991-08-05 | 1996-07-26 | Igen Inc | Prodrugs activated by targeted catalytic proteins |
US6258360B1 (en) | 1989-05-04 | 2001-07-10 | Igen International, Inc. | Prodrugs activated by targeted catalytic proteins |
US6702705B1 (en) | 1988-05-04 | 2004-03-09 | Igen International, Inc. | Prodrugs activated by targeted catalytic proteins |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2007443A1 (en) * | 1968-04-12 | 1970-01-09 | Farmaceutici Italia |
-
1972
- 1972-05-02 FR FR7215548A patent/FR2135221A1/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2007443A1 (en) * | 1968-04-12 | 1970-01-09 | Farmaceutici Italia |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2361417A1 (en) * | 1976-08-12 | 1978-03-10 | Farmaceutici Italia | NEW ADRIAMYCINE DERIVATIVES AND METHOD FOR PREPARING THEM |
US4299822A (en) * | 1980-06-09 | 1981-11-10 | Sidney Farber Cancer Institute, Inc. | N-Trifluoroacetyladriamycin-14-O-hemiglutarate and -hemiadipate and therapeutic compositions containing same |
US6702705B1 (en) | 1988-05-04 | 2004-03-09 | Igen International, Inc. | Prodrugs activated by targeted catalytic proteins |
US6258360B1 (en) | 1989-05-04 | 2001-07-10 | Igen International, Inc. | Prodrugs activated by targeted catalytic proteins |
EP0424899A2 (en) * | 1989-10-25 | 1991-05-02 | Dong-A Pharm. Co., Ltd. | Novel anthracycline glycoside derivatives and preparing method thereof |
EP0424899A3 (en) * | 1989-10-25 | 1991-09-18 | Dong-A Pharm. Co., Ltd. | Novel anthracycline glycoside derivatives and preparing method thereof |
EP0746336A4 (en) * | 1991-08-05 | 1996-07-26 | Igen Inc | Prodrugs activated by targeted catalytic proteins |
EP0746336A1 (en) * | 1991-08-05 | 1996-12-11 | Igen, Inc. | Prodrugs activated by targeted catalytic proteins |
Also Published As
Publication number | Publication date |
---|---|
FR2135221B1 (en) | 1978-03-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property |