FR2086041A1 - Piperazinedione derivs prepn - Google Patents

Piperazinedione derivs prepn

Info

Publication number
FR2086041A1
FR2086041A1 FR7021481A FR7021481A FR2086041A1 FR 2086041 A1 FR2086041 A1 FR 2086041A1 FR 7021481 A FR7021481 A FR 7021481A FR 7021481 A FR7021481 A FR 7021481A FR 2086041 A1 FR2086041 A1 FR 2086041A1
Authority
FR
France
Prior art keywords
piperazinedione
corresp
give
deriv
derivs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7021481A
Other languages
French (fr)
Other versions
FR2086041B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US833147A external-priority patent/US3560483A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of FR2086041A1 publication Critical patent/FR2086041A1/en
Application granted granted Critical
Publication of FR2086041B1 publication Critical patent/FR2086041B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Abstract

Piperazinedione derivs. prepn. New cpds. of formula:- (where R is H, lower alkyl or lower alkoxy and n is 2 or 4) are prepared by reacting the corresp. diphenyl-piperazinedione with (a) the appropriate disodium sulphide to give the corresp. dithia or tetrathia deriv. or (b) thiolacetic acid to give the corresp. 3,6-dithioacetate which is then reacted with (1) hydroxylaminine to give the 3,6-epidithia deriv. (2) hydrazine hydrate to give the corresp. epitetrathia deriv. Compds. are used in antifungal medicaments.
FR7021481A 1969-06-13 1970-06-11 Piperazinedione derivs prepn Granted FR2086041A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US833147A US3560483A (en) 1969-06-13 1969-06-13 1,4-dialkyl-3,6-diphenylepi(thio,dithia or tetrathia)-2,5-piperazinediones
US2852570A 1970-04-14 1970-04-14

Publications (2)

Publication Number Publication Date
FR2086041A1 true FR2086041A1 (en) 1971-12-31
FR2086041B1 FR2086041B1 (en) 1974-07-12

Family

ID=26703797

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7021481A Granted FR2086041A1 (en) 1969-06-13 1970-06-11 Piperazinedione derivs prepn

Country Status (4)

Country Link
BE (1) BE751879A (en)
DE (1) DE2029306A1 (en)
FR (1) FR2086041A1 (en)
NL (1) NL7008608A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728830A (en) * 1993-09-22 1998-03-17 Kyowa Hakko Kogyo Co., Ltd. Farnesyltransferase inhibitor

Also Published As

Publication number Publication date
FR2086041B1 (en) 1974-07-12
DE2029306A1 (en) 1970-12-17
BE751879A (en) 1970-12-14
NL7008608A (en) 1970-12-15

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Legal Events

Date Code Title Description
ST Notification of lapse