FR2027023A1 - Substd quinazoline derivs prepn cns depress - ants - Google Patents

Substd quinazoline derivs prepn cns depress - ants

Info

Publication number
FR2027023A1
FR2027023A1 FR6944372A FR6944372A FR2027023A1 FR 2027023 A1 FR2027023 A1 FR 2027023A1 FR 6944372 A FR6944372 A FR 6944372A FR 6944372 A FR6944372 A FR 6944372A FR 2027023 A1 FR2027023 A1 FR 2027023A1
Authority
FR
France
Prior art keywords
cns
substd
ants
depress
prepn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR6944372A
Other languages
French (fr)
Other versions
FR2027023B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Publication of FR2027023A1 publication Critical patent/FR2027023A1/en
Application granted granted Critical
Publication of FR2027023B1 publication Critical patent/FR2027023B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

Abstract

Substd. quinazoline derivs. prepn. CNS depressants. Compds of the general formula: (where R1 and R2 are H, halogen, R3 is lower alkyl, R4 is H, lower alkyl, (CH2)n-N(R3)2 or (CH2)n-COOR3, n being 1 or 2 and X is O or S) are prepd. by reacting the corresp. o-nitro compd. with the corresp. amine in acid medium in the presence of Sn or Zn, or catalytically to obtain a diamine and reacting this with carbonyl chloride or this carbonyl chloride in the presence of a 3 degrees amine. Compds. have CNS activity particularly as depressants.
FR6944372A 1968-12-24 1969-12-22 Substd quinazoline derivs prepn cns depress - ants Granted FR2027023A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2553768 1968-12-24

Publications (2)

Publication Number Publication Date
FR2027023A1 true FR2027023A1 (en) 1970-09-25
FR2027023B1 FR2027023B1 (en) 1973-07-13

Family

ID=11216999

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6944372A Granted FR2027023A1 (en) 1968-12-24 1969-12-22 Substd quinazoline derivs prepn cns depress - ants

Country Status (1)

Country Link
FR (1) FR2027023A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993004047A1 (en) * 1991-08-16 1993-03-04 Merck & Co., Inc. Quinazoline derivatives as inhibitors of hiv reverse transcriptase
EP0530994A1 (en) * 1991-08-16 1993-03-10 Merck & Co. Inc. Quinazoline derivatives as inhibitors of HIV reverse transcriptase
US5556860A (en) * 1993-05-26 1996-09-17 Sumitomo Pharmaceuticals Co., Ltd. Quinazolinone derivatives possessing calcium uptake inhibiting activity
EP1122253A1 (en) * 1998-10-16 2001-08-08 Sumitomo Pharmaceuticals Company, Limited Quinazolinone derivatives

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993004047A1 (en) * 1991-08-16 1993-03-04 Merck & Co., Inc. Quinazoline derivatives as inhibitors of hiv reverse transcriptase
EP0530994A1 (en) * 1991-08-16 1993-03-10 Merck & Co. Inc. Quinazoline derivatives as inhibitors of HIV reverse transcriptase
US5556860A (en) * 1993-05-26 1996-09-17 Sumitomo Pharmaceuticals Co., Ltd. Quinazolinone derivatives possessing calcium uptake inhibiting activity
EP1122253A1 (en) * 1998-10-16 2001-08-08 Sumitomo Pharmaceuticals Company, Limited Quinazolinone derivatives
EP1122253A4 (en) * 1998-10-16 2003-05-28 Sumitomo Pharma Quinazolinone derivatives
US6645971B1 (en) 1998-10-16 2003-11-11 Sumitomo Pharmaceuticals Company Limited Quinazolinone derivatives

Also Published As

Publication number Publication date
FR2027023B1 (en) 1973-07-13

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Legal Events

Date Code Title Description
ST Notification of lapse