FR2070173A1 - Stabilized aqs pyrocatecholamine prepns - Google Patents

Stabilized aqs pyrocatecholamine prepns

Info

Publication number
FR2070173A1
FR2070173A1 FR7038663A FR7038663A FR2070173A1 FR 2070173 A1 FR2070173 A1 FR 2070173A1 FR 7038663 A FR7038663 A FR 7038663A FR 7038663 A FR7038663 A FR 7038663A FR 2070173 A1 FR2070173 A1 FR 2070173A1
Authority
FR
France
Prior art keywords
alkyl
pyrocatecholamine
prepns
aqs
stabilized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7038663A
Other languages
French (fr)
Other versions
FR2070173B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Alcon Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Laboratories Inc filed Critical Alcon Laboratories Inc
Publication of FR2070173A1 publication Critical patent/FR2070173A1/en
Application granted granted Critical
Publication of FR2070173B1 publication Critical patent/FR2070173B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The preparations contain ca 0.03-4 wt.% pyrocatecholamine (esp epinephrine) ca 0.05-4 wt.% boric acid, ca 0.05-3 wt.% ascorbic acid and ca 0.05-3 wt.% of a water-soluble pharmacologically tolerable thiol cpd of the formula HS-CHR1-COOR, HS-CHR2-CHR3-CO-R4, R5-CO-SH or HSCH2(CHOH)xCH2OH (where R and R5 are H or 1-4C alkyl, R1 is H, 1-3C alkyl or group HS-CH-COOR' in which R' is H or 1-4C alkyl, R2 is H or 1-3C alkyl, R3 is amino, acetamido or propionamido, R4 is OH, 1-3C alkoxy, NH2 or methyl-ethyl- or propylamino and x is 1-6). The preparations (which are particularly intended for treating open-angle glaucoma) have improved stability against oxidation.
FR7038663A 1969-10-29 1970-10-27 Stabilized aqs pyrocatecholamine prepns Granted FR2070173A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87235269A 1969-10-29 1969-10-29

Publications (2)

Publication Number Publication Date
FR2070173A1 true FR2070173A1 (en) 1971-09-10
FR2070173B1 FR2070173B1 (en) 1974-08-23

Family

ID=25359409

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7038663A Granted FR2070173A1 (en) 1969-10-29 1970-10-27 Stabilized aqs pyrocatecholamine prepns

Country Status (2)

Country Link
DE (1) DE2052991A1 (en)
FR (1) FR2070173A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1015663A (en) * 1972-06-16 1977-08-16 Bristol-Myers Canada Limited Ocular hypotensive compositions
NO142241C (en) * 1973-09-24 1980-07-30 Smith & Nephew Pharma PROCEDURE FOR PREPARING A STABLE, Aqueous SOLUTION FOR TOPICAL USE OF LIVING TISSUE
US4734438A (en) * 1983-04-26 1988-03-29 Macri Frank J Norepinephrine potentiated compositions and method of use
CA1217141A (en) * 1983-04-26 1987-01-27 Frank J. Macri Norepinephrine potentiated compositions and method of use
US4581376A (en) * 1983-04-26 1986-04-08 Macri Frank J Norepinephrine potentiated compositions and method of use
DE19756758C1 (en) * 1997-12-19 1999-08-05 Solvay Pharm Gmbh Stabilized pharmaceutical composition containing dopamine or dobutamine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1128705A (en) * 1966-01-18 1968-10-02 Canadian Patents Dev Dissolution of mucous secretions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1128705A (en) * 1966-01-18 1968-10-02 Canadian Patents Dev Dissolution of mucous secretions

Also Published As

Publication number Publication date
FR2070173B1 (en) 1974-08-23
DE2052991A1 (en) 1971-05-06

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Legal Events

Date Code Title Description
ST Notification of lapse