US7560107B2
(en)
|
1996-06-26 |
2009-07-14 |
Emory University |
Modified factor VIII
|
JP2005518181A
(en)
*
|
2001-01-12 |
2005-06-23 |
ジ・アメリカン・ナショナル・レッド・クロス |
Methods and compositions for reducing heparan sulfate proteoglycan-mediated clearance of factor VIII
|
CA2461443C
(en)
*
|
2001-10-05 |
2011-07-12 |
Emory University |
Nucleic acid and amino acid sequences encoding high-level expressor factor viii polypeptides and methods of use
|
MXPA04005079A
(en)
*
|
2001-11-30 |
2004-08-19 |
Univ Emory |
Factor viii c2 domain variants.
|
GB0207092D0
(en)
*
|
2002-03-26 |
2002-05-08 |
Sod Conseils Rech Applic |
Stable pharmaceutical composition containing factor VIII
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
US7485291B2
(en)
*
|
2003-06-03 |
2009-02-03 |
Cell Genesys, Inc. |
Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
|
US7709224B2
(en)
*
|
2003-06-03 |
2010-05-04 |
Biosante Pharmaceuticals, Inc. |
Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site
|
DE602004007924T2
(en)
*
|
2003-06-26 |
2008-04-10 |
Merck Patent Gmbh |
THROMBOPOIETINE PROTEINS WITH IMPROVED PROPERTIES
|
US20050059023A1
(en)
*
|
2003-09-16 |
2005-03-17 |
Cantor Thomas L. |
Methods and kits for monitoring resistance to therapeutic agents
|
US7211559B2
(en)
|
2003-10-31 |
2007-05-01 |
University Of Maryland, Baltimore |
Factor VIII compositions and methods
|
WO2005055930A2
(en)
*
|
2003-12-03 |
2005-06-23 |
University Of Rochester |
Recombinant factor viii having increased specific activity
|
PL1750733T3
(en)
*
|
2004-05-03 |
2014-05-30 |
Univ Emory |
METHOD OF ADMINISTERING PORCINE B-DOMAINLESS fVIII
|
WO2005123928A1
(en)
*
|
2004-06-08 |
2005-12-29 |
Battelle Memorial Institute |
Production of human coagulation factor viii from plant cells and whole plants
|
WO2006053299A2
(en)
*
|
2004-11-12 |
2006-05-18 |
Bayer Healthcare Llc |
Site-directed modification of fviii
|
US20100256062A1
(en)
|
2004-12-06 |
2010-10-07 |
Howard Tommy E |
Allelic Variants of Human Factor VIII
|
US7855279B2
(en)
|
2005-09-27 |
2010-12-21 |
Amunix Operating, Inc. |
Unstructured recombinant polymers and uses thereof
|
WO2007065691A2
(en)
|
2005-12-07 |
2007-06-14 |
Technische Universität München |
Small peptidic and peptido-mimetic affinity ligands for factor viii and factor viii-like proteins
|
EP1816201A1
(en)
|
2006-02-06 |
2007-08-08 |
CSL Behring GmbH |
Modified coagulation factor VIIa with extended half-life
|
PL2007885T3
(en)
*
|
2006-04-11 |
2010-12-31 |
Csl Behring Gmbh |
Method of increasing the in vivo recovery of therapeutic polypeptides
|
US7939632B2
(en)
*
|
2006-06-14 |
2011-05-10 |
Csl Behring Gmbh |
Proteolytically cleavable fusion proteins with high molar specific activity
|
WO2008077616A1
(en)
*
|
2006-12-22 |
2008-07-03 |
Csl Behring Gmbh |
Modified coagulation factors with prolonged in vivo half-life
|
EP1935430A1
(en)
*
|
2006-12-22 |
2008-06-25 |
CSL Behring GmbH |
Modified coagulation factors with prolonged in vivo half-life
|
FR2913020B1
(en)
*
|
2007-02-23 |
2012-11-23 |
Biomethodes |
NEW VIII FACTORS FOR THE TREATMENT OF TYPE A HEMOPHILS
|
EP1988101A1
(en)
*
|
2007-05-04 |
2008-11-05 |
Novo Nordisk A/S |
Improvement of factor VIII polypeptide titers in cell cultures
|
BRPI0818913A2
(en)
|
2007-11-01 |
2015-05-12 |
Univ Rochester |
Recombinant factor viii having high stability
|
EP2149603A1
(en)
|
2008-07-28 |
2010-02-03 |
DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH |
Factor IX variants with clotting activity in absence of their cofactor and their use for treating bleeding disorders
|
MX362028B
(en)
|
2009-02-03 |
2019-01-04 |
Amunix Pharmaceuticals Inc |
Extended recombinant polypeptides and compositions comprising same.
|
NZ597022A
(en)
|
2009-06-09 |
2014-05-30 |
Prolong Pharmaceuticals Llc |
Hemoglobin compositions
|
AU2010290077C1
(en)
|
2009-08-24 |
2015-12-03 |
Bioverativ Therapeutics Inc. |
Coagulation factor IX compositions and methods of making and using same
|
CA2780763A1
(en)
*
|
2009-11-13 |
2011-05-19 |
Puget Sound Blood Center |
Factor viii b cell epitope variants having reduced immunogenicity
|
ES2880038T3
(en)
|
2009-12-06 |
2021-11-23 |
Bioverativ Therapeutics Inc |
Chimeric and Hybrid Factor VIII-Fc Polypeptides and Methods of Using The Same
|
BR112012017483A2
(en)
*
|
2010-01-14 |
2019-09-24 |
Haplomics Inc |
prediction and reduction of alloimmunogenicity of protein therapeutics
|
WO2012006623A1
(en)
|
2010-07-09 |
2012-01-12 |
Biogen Idec Hemophilia Inc. |
Systems for factor viii processing and methods thereof
|
MX2013000301A
(en)
|
2010-07-09 |
2013-05-09 |
Biogen Idec Hemophilia Inc |
Chimeric clotting factors.
|
EP2635297B1
(en)
*
|
2010-11-05 |
2019-02-27 |
Baxalta GmbH |
A new variant of antihemophilic factor viii having increased specific activity
|
KR20140036144A
(en)
*
|
2011-01-05 |
2014-03-25 |
익스프레션 테라퍼틱스 엘엘씨 |
High yield suspension cell line, system, and method for making same
|
PL2717898T3
(en)
|
2011-06-10 |
2019-06-28 |
Bioverativ Therapeutics Inc. |
Pro-coagulant compounds and methods of use thereof
|
RS58578B1
(en)
|
2011-07-08 |
2019-05-31 |
Bioverativ Therapeutics Inc |
Factor viii chimeric and hybrid polypeptides, and methods of use thereof
|
US10656167B2
(en)
|
2011-07-25 |
2020-05-19 |
Bioverativ Therapeutics Inc. |
Assays to monitor bleeding disorders
|
CN102277379B
(en)
*
|
2011-08-18 |
2013-07-24 |
中国科学院遗传与发育生物学研究所 |
Expression vector for expressing coagulation factor VIII and application thereof
|
EP3453402B1
(en)
|
2012-01-12 |
2021-07-21 |
Bioverativ Therapeutics Inc. |
Reducing immunogenicity against factor viii in individuals undergoing factor viii therapy
|
BR112014017165B1
(en)
|
2012-01-12 |
2023-05-02 |
Bioverativ Therapeutics Inc |
CHIMERIC PROTEIN COMPRISING A FACTOR VIII PROTEIN, PHARMACEUTICAL COMPOSITION, AND USES THEREOF
|
ES2771208T3
(en)
|
2012-02-15 |
2020-07-06 |
Bioverativ Therapeutics Inc |
Factor VIII compositions and methods of preparation and use thereof
|
EP3549953A1
(en)
|
2012-02-15 |
2019-10-09 |
Bioverativ Therapeutics Inc. |
Recombinant factor viii proteins
|
EP2666782A1
(en)
*
|
2012-05-22 |
2013-11-27 |
Imnate Sarl |
Coagulation factor VIII with reduced immunogenicity.
|
CN104427995A
(en)
|
2012-06-08 |
2015-03-18 |
比奥根艾迪克Ma公司 |
Chimeric clotting factors
|
CA2875246A1
(en)
|
2012-06-08 |
2013-12-12 |
Biogen Idec Ma Inc. |
Procoagulant compounds
|
EP2870250B2
(en)
|
2012-07-06 |
2022-06-29 |
Bioverativ Therapeutics Inc. |
Cell line expressing single chain factor viii polypeptides and uses thereof
|
CN110054699A
(en)
|
2012-07-11 |
2019-07-26 |
比奥贝拉蒂治疗公司 |
Factor IX compound with XTEN and vWF ELISA albumen, and application thereof
|
EP2877202A4
(en)
|
2012-07-25 |
2016-06-01 |
Biogen Ma Inc |
Blood factor monitoring assay and uses thereof
|
EP2908847B1
(en)
|
2012-10-18 |
2022-03-30 |
Bioverativ Therapeutics Inc. |
Methods of using a fixed dose of a clotting factor
|
WO2014070953A1
(en)
|
2012-10-30 |
2014-05-08 |
Biogen Idec Ma Inc. |
Methods of Using FVIII Polypeptide
|
US10272163B2
(en)
|
2012-12-07 |
2019-04-30 |
The Regents Of The University Of California |
Factor VIII mutation repair and tolerance induction
|
ES2959747T3
(en)
|
2013-02-15 |
2024-02-28 |
Bioverativ Therapeutics Inc |
Optimized factor VIII gene
|
LT2968477T
(en)
|
2013-03-15 |
2020-03-10 |
Bioverativ Therapeutics Inc. |
Factor viii polypeptide formulations
|
AU2014228938B2
(en)
|
2013-03-15 |
2019-05-02 |
Bioverativ Therapeutics Inc. |
Factor IX polypeptide formulations
|
CN105392495A
(en)
|
2013-06-28 |
2016-03-09 |
比奥根Ma公司 |
Thrombin cleavable linker with xten and its uses thereof
|
US10947269B2
(en)
|
2013-08-08 |
2021-03-16 |
Bioverativ Therapeutics Inc. |
Purification of chimeric FVIII molecules
|
WO2015023891A2
(en)
|
2013-08-14 |
2015-02-19 |
Biogen Idec Ma Inc. |
Factor viii-xten fusions and uses thereof
|
EP3060242A1
(en)
|
2013-10-22 |
2016-08-31 |
DBV Technologies |
Method of treating haemophilia by inducing tolerance to blood factors
|
EP3065769A4
(en)
|
2013-11-08 |
2017-05-31 |
Biogen MA Inc. |
Procoagulant fusion compound
|
ES2967617T3
(en)
|
2013-12-06 |
2024-05-03 |
Bioverativ Therapeutics Inc |
Population pharmacokinetics tools and their uses
|
EP2881463A1
(en)
|
2013-12-09 |
2015-06-10 |
DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH |
Factor IX variants with clotting activity in absence of their cofactor and/or with increased F.IX clotting activity and their use for treating bleeding disorders
|
CN106456718A
(en)
|
2014-01-10 |
2017-02-22 |
比奥根Ma公司 |
Factor viii chimeric proteins and uses thereof
|
KR102382402B1
(en)
|
2014-02-04 |
2022-04-01 |
바이오젠 엠에이 인코포레이티드 |
Use of cation-exchange chromatography in the flow-through mode to enrich post-translational modifications
|
US20170051041A1
(en)
*
|
2014-02-19 |
2017-02-23 |
Kathleen Pratt |
Factor viii b cell epitope variants having reduced immunogenicity
|
EP3114138B1
(en)
|
2014-03-05 |
2021-11-17 |
Pfizer Inc. |
Improved muteins of clotting factor viii
|
MA40864A
(en)
|
2014-10-31 |
2017-09-05 |
Biogen Ma Inc |
HYPOTAURINE, GABA, BETA-ALANINE AND CHOLINE FOR THE REGULATION OF THE ACCUMULATION OF RESIDUAL BY-PRODUCTS IN MAMMAL CELL CULTURE PROCESSES
|
EA201890423A1
(en)
|
2015-08-03 |
2018-07-31 |
Биовератив Терапьютикс Инк. |
SLIGHT PROTEINS OF THE FACTOR IX, METHODS OF THEIR RECEPTION AND APPLICATION
|
PE20231949A1
(en)
*
|
2015-10-30 |
2023-12-05 |
Spark Therapeutics Inc |
VARIANTS OF FACTOR VIII REDUCED WITH CpG, COMPOSITIONS AND METHODS AND USES FOR THE TREATMENT OF HEMOSTASY DISORDERS
|
US10189889B2
(en)
|
2015-11-13 |
2019-01-29 |
Baxalta Incorporated |
Viral vectors encoding recombinant FVIII variants with increased expression for gene therapy of hemophilia A
|
TWI777175B
(en)
|
2015-11-13 |
2022-09-11 |
日商武田藥品工業股份有限公司 |
Viral vectors encoding recombinant fviii variants with increased expression for gene therapy of hemophilia a
|
LT3411478T
(en)
|
2016-02-01 |
2022-09-26 |
Bioverativ Therapeutics Inc. |
Optimized factor viii genes
|
CN109790529A
(en)
|
2016-06-24 |
2019-05-21 |
财团法人牧岩生命科学研究所 |
Chimeric protein and application thereof comprising FVIII the and vWF factor
|
BR112019011198A2
(en)
|
2016-12-02 |
2019-12-17 |
Bioverativ Therapeutics Inc |
methods of inducing immune tolerance to coagulation factors
|
BR112019011115A2
(en)
|
2016-12-02 |
2019-10-01 |
Bioverativ Therapeutics Inc |
methods for treating hemophilic arthropathy using chimeric clotting factors
|
US11633504B2
(en)
|
2017-05-09 |
2023-04-25 |
Emory University |
Nucleic acids encoding clotting factor variants and their use
|
TW201920255A
(en)
|
2017-08-09 |
2019-06-01 |
美商生物化學醫療公司 |
Nucleic acid molecules and uses thereof
|
WO2019152692A1
(en)
|
2018-02-01 |
2019-08-08 |
Bioverativ Therapeutics, Inc. |
Use of lentiviral vectors expressing factor viii
|
IL312315A
(en)
|
2018-04-04 |
2024-06-01 |
Sigilon Therapeutics Inc |
Implantable particles and related methods
|
JP2021523878A
(en)
|
2018-05-18 |
2021-09-09 |
バイオベラティブ セラピューティクス インコーポレイテッド |
How to treat hemophilia A
|
MX2021000582A
(en)
|
2018-07-16 |
2021-04-12 |
Baxalta Inc |
Gene therapy of hemophilia a using viral vectors encoding recombinant fviii variants with increased expression.
|
BR112021002017A2
(en)
|
2018-08-09 |
2021-05-11 |
Bioverativ Therapeutics Inc. |
nucleic acid molecules and their uses for non-viral gene therapy
|
UY38389A
(en)
|
2018-09-27 |
2020-04-30 |
Sigilon Therapeutics Inc |
IMPLANTABLE DEVICES FOR CELLULAR THERAPY AND RELATED METHODS
|
TW202039546A
(en)
|
2019-01-16 |
2020-11-01 |
美商巴克斯歐塔公司 |
Viral vectors encoding recombinant fviii variants with increased expression for gene therapy of hemophilia a
|
TW202115127A
(en)
|
2019-06-19 |
2021-04-16 |
美商百歐維拉提夫治療公司 |
Methods and compositions for treating hemophilia and low bone mineral density
|
WO2020257586A2
(en)
|
2019-06-20 |
2020-12-24 |
Baxalta Incorporated |
Method of treatment with viral-based gene therapy
|
JP2023506171A
(en)
|
2019-12-12 |
2023-02-15 |
武田薬品工業株式会社 |
Gene Therapy for Hemophilia A Using Viral Vectors Encoding Recombinant FVIII Variants with Increased Expression
|
TW202246505A
(en)
*
|
2021-03-05 |
2022-12-01 |
***聯邦商亞那拜恩有限公司 |
Codon-optimized nucleic acid that encodes coagulation factor ix protein, and use thereof
|
JP2024514307A
(en)
|
2021-03-31 |
2024-04-01 |
ヘモネティクス・コーポレーション |
Quality control formulations for blood coagulation measurement devices
|
CN117858895A
(en)
|
2021-06-14 |
2024-04-09 |
武田药品工业株式会社 |
Hemophilia a gene therapy using expression-enhanced viral vectors encoding recombinant FVIII variants
|
TW202323274A
(en)
|
2021-08-23 |
2023-06-16 |
美商百歐維拉提夫治療公司 |
Optimized factor viii genes
|
CN118019758A
(en)
|
2021-09-30 |
2024-05-10 |
比奥维拉迪维治疗股份有限公司 |
Nucleic acids encoding reduced immunogenicity factor VIII polypeptides
|
WO2024081309A1
(en)
|
2022-10-11 |
2024-04-18 |
Sigilon Therapeutics, Inc. |
Engineered cells and implantable elements for treatment of disease
|