FR13C0037I1 - Solvat acetonique du dimethoxy docetaxel et son procede de preparation - Google Patents

Solvat acetonique du dimethoxy docetaxel et son procede de preparation

Info

Publication number: FR13C0037I1
Authority: FR; France
Prior art keywords: preparation process; dimethoxy docetaxel; acetonic; solvate; acetonic solvate
Prior art date: 2003-09-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Aventis Pharma SA

Original Assignee

Aventis Pharma SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-09-19

Filing date

2013-07-04

Publication date

2013-09-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34224354&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR13C0037(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2013-07-04 Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA

2013-09-08 Publication of FR13C0037I1 publication Critical patent/FR13C0037I1/fr

2015-11-20 Application granted granted Critical

2015-11-20 Publication of FR13C0037I2 publication Critical patent/FR13C0037I2/fr

Status Active legal-status Critical Current

Links

ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 title 1
229960003668 docetaxel Drugs 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
239000012453 solvate Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Oncology (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cephalosporin Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

FR13C0037C 2003-09-19 2013-07-04 Solvat acetonique du dimethoxy docetaxel et son procede de preparation Active FR13C0037I2 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0311016A FR2859996B1 (fr)	2003-09-19	2003-09-19	Solvat acetonique du dimethoxy docetaxel et son procede de preparation
PCT/FR2004/002344 WO2005028462A1 (fr)	2003-09-19	2004-09-16	Solvat acetonique du dimethoxy docetaxel et son procede de preparation

Publications (2)

Publication Number	Publication Date
FR13C0037I1 true FR13C0037I1 (fr)	2013-09-08
FR13C0037I2 FR13C0037I2 (fr)	2015-11-20

Family

ID=34224354

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
FR0311016A Expired - Lifetime FR2859996B1 (fr)	2003-09-19	2003-09-19	Solvat acetonique du dimethoxy docetaxel et son procede de preparation
FR13C0037C Active FR13C0037I2 (fr)	2003-09-19	2013-07-04	Solvat acetonique du dimethoxy docetaxel et son procede de preparation

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
FR0311016A Expired - Lifetime FR2859996B1 (fr)	2003-09-19	2003-09-19	Solvat acetonique du dimethoxy docetaxel et son procede de preparation

Country Status (38)

Country	Link
US (1)	US7241907B2 (fr)
EP (1)	EP1667986B1 (fr)
JP (1)	JP5010279B2 (fr)
KR (1)	KR101123588B1 (fr)
CN (1)	CN100429207C (fr)
AR (1)	AR045667A1 (fr)
AU (1)	AU2004274212B2 (fr)
BE (1)	BE2013C036I2 (fr)
BR (1)	BRPI0414492A8 (fr)
CA (1)	CA2539309A1 (fr)
CR (1)	CR8292A (fr)
CY (2)	CY1114575T1 (fr)
DK (1)	DK1667986T3 (fr)
ES (1)	ES2403149T4 (fr)
FR (2)	FR2859996B1 (fr)
HK (1)	HK1093340A1 (fr)
HR (1)	HRP20130322T1 (fr)
HU (1)	HUS1300025I1 (fr)
IL (1)	IL174240A (fr)
LU (1)	LU92172I2 (fr)
MA (1)	MA28045A1 (fr)
ME (2)	MEP11708A (fr)
MX (1)	MXPA06002639A (fr)
MY (1)	MY136668A (fr)
NO (2)	NO335997B1 (fr)
NZ (1)	NZ545835A (fr)
PA (1)	PA8612401A1 (fr)
PE (1)	PE20050870A1 (fr)
PL (1)	PL1667986T3 (fr)
PT (1)	PT1667986E (fr)
RS (2)	RS54614B1 (fr)
RU (1)	RU2342373C2 (fr)
SI (1)	SI1667986T1 (fr)
TN (1)	TNSN06086A1 (fr)
TW (1)	TWI382022B (fr)
UA (1)	UA87115C2 (fr)
WO (1)	WO2005028462A1 (fr)
ZA (1)	ZA200602255B (fr)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2009533330A (ja) *	2006-03-21	2009-09-17	ドクターレディズラボラトリーズリミテッド	ドセタキセルの多形体およびプロセス
US7855591B2 (en) *	2006-06-07	2010-12-21	Atmel Corporation	Method and system for providing a charge pump very low voltage applications
US7652522B2 (en) *	2006-09-05	2010-01-26	Atmel Corporation	High efficiency low cost bi-directional charge pump circuit for very low voltage applications
JP2010516625A (ja)	2007-01-24	2010-05-20	インサートセラピューティクス，インコーポレイテッド	制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート
AU2013205442B2 (en) *	2008-01-17	2016-05-12	Aventis Pharma S.A.	Crystalline forms of dimethoxy docetaxel and methods for preparing same
FR2926551A1 (fr) *	2008-01-17	2009-07-24	Aventis Pharma Sa	Formes cristallines du dimethoxy docetaxel et leurs procedes de preparation
EP2331140B1 (fr)	2008-08-11	2018-07-04	Nektar Therapeutics	Conjugués d'alcanoate polymère à multiples bras
FR2945211A1 (fr) *	2009-05-06	2010-11-12	Sanofi Aventis	Combinaison antitumorale comprenant la cabazitaxel et la capecitabine
AU2015200149B2 (en) *	2009-10-29	2016-12-01	Aventis Pharma S.A.	Novel antitumoral use of cabazitaxel
WO2011051894A1 (fr)	2009-10-29	2011-05-05	Aventis Pharma S.A.	Nouvelle utilisation antitumorale du cabazitaxel
CA2708489A1 (fr) *	2009-10-29	2011-04-29	Aventis Pharma S.A.	Utilisation de cabazitaxel et de prednisone ou de prednisolone pour traiter le cancer de la prostate
WO2012088445A1 (fr)	2010-12-22	2012-06-28	Nektar Therapeutics	Conjugués promédicaments polymères à plusieurs bras de composés à base de cabazitaxel
US20130331443A1 (en)	2010-12-22	2013-12-12	Nektar Therapeutics	Multi-arm polymeric prodrug conjugates of taxane-based compounds
EA023950B1 (ru)	2011-04-12	2016-07-29	Тева Фармасьютикалз Интернэшнл Гмбх	Твердофазные формы кабазитаксела и способы их получения
WO2013024495A1 (fr) *	2011-08-18	2013-02-21	Dr. Reddys Laboratories Limited	Formulations pharmaceutiques de cabazitaxel
TWI526437B (zh) *	2011-09-09	2016-03-21	台灣神隆股份有限公司	卡巴他賽之結晶型
US8722900B2 (en)	2011-10-31	2014-05-13	Scinopharm Taiwan, Ltd.	Process for cabazitaxel, and intermediates thereof
CN103874692A (zh)	2011-11-01	2014-06-18	费森尤斯卡比肿瘤学有限公司	卡巴他赛的无定形形式和用于其制备的方法
CN104011035A (zh)	2011-11-28	2014-08-27	费森尤斯卡比肿瘤学有限公司	卡巴他赛的晶型和用于制备其的方法
EP2791122B1 (fr)	2011-12-13	2019-01-23	Aventis Pharma S.A.	Forme cristalline du cabazitaxel et son procédé de préparation
US9403785B2 (en)	2012-01-03	2016-08-02	Shilpa Medicare Limited	Process for preparing amorphous cabazitaxel
BR112014019675A2 (pt) *	2012-02-10	2017-07-11	Aventis Pharma Sa	usos pediátricos de cabazitaxel
CN104220431A (zh)	2012-03-08	2014-12-17	伊瓦克斯国际有限责任公司	卡巴他赛的固态形式及其制备方法
CN102675257B (zh) *	2012-05-10	2014-07-02	上海金和生物技术有限公司	一种卡巴他赛晶体及其制备方法
CN102746258B (zh) *	2012-07-25	2015-02-04	重庆泰濠制药有限公司	卡巴他赛的结晶形式及其制备方法
CN104583189A (zh)	2012-07-31	2015-04-29	永信药品工业股份有限公司	非晶型的卡巴利他索
EP2884963B1 (fr)	2012-08-15	2017-12-27	Yung Shin Pharm. Ind. Co. Ltd.	Formulation pharmaceutique stable de cabazitaxel
CN103664836B (zh) *	2012-09-20	2016-04-20	齐鲁制药有限公司	7β,10β-二甲氧基多西紫杉醇氘代丙酮合物的晶型A及其制备方法
WO2014055493A1 (fr)	2012-10-02	2014-04-10	Cerulean Pharma Inc.	Procédés et systèmes s'appliquant à la précipitation de polymères et à la génération de particules
CN103804323A (zh) *	2012-11-14	2014-05-21	上海希迈医药科技有限公司	一种卡巴他赛溶剂化物及其制备方法和应用
CN103058960B (zh) *	2012-12-12	2014-12-10	江苏奥赛康药业股份有限公司	卡巴他赛多晶型形式及其制备方法
EP2743264A1 (fr)	2012-12-13	2014-06-18	INDENA S.p.A.	Nouvelle forme cristalline de cabazitaxel, procédé de préparation et ses compositions pharmaceutiques
CN103910698B (zh) *	2012-12-30	2016-01-20	上海医药工业研究院	卡巴他赛丙酮合物及其结晶
CN103910696B (zh) *	2012-12-30	2016-01-20	上海医药工业研究院	卡巴他赛异丙醚合物及其结晶
EP2777691A1 (fr)	2013-03-14	2014-09-17	Pharmachemie B.V.	Taxoïde - purification des excipients liquides
EP2815749A1 (fr)	2013-06-20	2014-12-24	IP Gesellschaft für Management mbH	Forme solide de 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione ayant un réseau de diffraction de rayons X spécifique
WO2015000165A1 (fr) *	2013-07-04	2015-01-08	北京新天宇科技开发有限公司	Produit de transformation stable du mono-acétonate de dimethoxy docetaxel et ses formes cristallines, et leurs procédés de préparation
CN104277014A (zh) *	2013-07-04	2015-01-14	北京新天宇科技开发有限公司	二甲氧基多西紫杉醇一丙酮化物的稳定转化物及其结晶形式、以及它们的制备方法
EP2865675A1 (fr)	2013-10-23	2015-04-29	INDENA S.p.A.	Forme cristalline anhydre de Cabazitaxel, procédé de préparation et ses compositions pharmaceutiques
EP2865674A1 (fr)	2013-10-23	2015-04-29	INDENA S.p.A.	Formes dissoutes cristallines de Cabazitaxel
CN103601704B (zh) *	2013-11-22	2015-05-06	石家庄智恒医药科技有限公司	无定形卡巴他赛的制备
ES2904505T3 (es)	2015-01-12	2022-04-05	Emcure Pharmaceuticals Ltd	Formulación líquida de cabazitaxel
ES2817331T3 (es)	2015-02-17	2021-04-07	Univ Erasmus Med Ct Rotterdam	Uso del cabazitaxel en el tratamiento del cáncer de próstata
EP3093014A1 (fr) *	2015-05-13	2016-11-16	Aventis Pharma S.A.	Cabazitaxel et son utilisation pour le traitement du cancer
US10188626B2 (en)	2015-11-03	2019-01-29	Cipla Limited	Stabilized cabazitaxel formulations
KR20230117467A (ko)	2016-11-29	2023-08-08	피티씨 테라퓨틱스 엠피, 인크.	세피아프테린의 다형체 및 그의 염
US11130760B2 (en)	2016-11-29	2021-09-28	Ptc Therapeutics Mp, Inc.	Polymorphic form of sepiapterin
WO2019046849A1 (fr)	2017-09-01	2019-03-07	Censa Pharmaceuticals Inc.	Composition pharmaceutique comprenant de la sépiaptérine et ses utilisations
MX2020012979A (es)	2018-05-30	2021-04-29	Ptc Therapeutics Mp Inc	Métodos para aumentar la exposición al plasma de sepiapterina.
WO2020249507A1 (fr)	2019-06-11	2020-12-17	Indena S.P.A.	Forme cristalline anhydre du cabazitaxel, procédé pour sa préparation et compositions pharmaceutiques la contenant
EP3808345A1 (fr)	2019-10-15	2021-04-21	Sanofi Mature IP	Cabazitaxel chez des patients atteints d'un cprcm précédemment traités avec du docétaxel et qui ont résisté à un traitement antérieur impliquant un agent inhibiteur ciblé de la signalisation d'androgène
EP3797834A1 (fr)	2019-09-25	2021-03-31	Sanofi Mature IP	Cabazitaxel chez des patients atteints d'un cprcm précédemment traités avec du docétaxel et qui ont résisté à un traitement antérieur impliquant un agent inhibiteur ciblé de la signalisation d'androgène

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5766635A (en) *	1991-06-28	1998-06-16	Rhone-Poulenc Rorer S.A.	Process for preparing nanoparticles
MA23823A1 (fr) *	1995-03-27	1996-10-01	Aventis Pharma Sa	Nouveaux taxoides, leur preparation et les compositions qui les contiennent
FR2745814B1 (fr) *	1996-03-06	1998-04-03	Rhone Poulenc Rorer Sa	Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2771092B1 (fr)	1997-11-18	1999-12-17	Rhone Poulenc Rorer Sa	Procede de preparation de derives de la classe des taxoides
EP0982027A1 (fr) *	1998-08-17	2000-03-01	Aventis Pharma S.A.	Dérivés taxoides pour traiter les proliférations cellulaires anormales du cerveau
US6346543B1 (en) *	1998-08-17	2002-02-12	Aventis Pharma S.A.	Use of a taxoid to treat abnormal cell proliferation in the brain
US6136989A (en) *	1998-12-30	2000-10-24	Phytogen Life Sciences, Incorporated	Method for high yield and large scale extraction of paclitaxel from paclitaxel-containing material
US5969165A (en) *	1999-01-07	1999-10-19	508037 (Nb) Inc.	Isolation and purification of paclitaxel and other related taxanes by industrial preparative low pressure chromatography on a polymeric resin column
ES2211550T3 (es) *	1999-05-17	2004-07-16	Bristol-Myers Squibb Company	Nuevas condiciones de reaccion para la escision de eteres de sililo en la preparacion de paclitaxel (taxol(r)) y analogos de paclitaxel.
US7410980B2 (en) *	2001-11-29	2008-08-12	Daiichi Pharmaceutical Co., Ltd.	Crystals of taxane derivative and process for their production

2003
- 2003-09-19 FR FR0311016A patent/FR2859996B1/fr not_active Expired - Lifetime
2004
- 2004-08-19 PE PE2004000799A patent/PE20050870A1/es not_active Application Discontinuation
- 2004-09-16 WO PCT/FR2004/002344 patent/WO2005028462A1/fr active Application Filing
- 2004-09-16 CA CA002539309A patent/CA2539309A1/fr not_active Abandoned
- 2004-09-16 AU AU2004274212A patent/AU2004274212B2/en active Active
- 2004-09-16 KR KR1020067005396A patent/KR101123588B1/ko active IP Right Grant
- 2004-09-16 ME MEP-117/08A patent/MEP11708A/xx unknown
- 2004-09-16 PA PA20048612401A patent/PA8612401A1/es unknown
- 2004-09-16 SI SI200432016T patent/SI1667986T1/sl unknown
- 2004-09-16 DK DK04787385.6T patent/DK1667986T3/da active
- 2004-09-16 ES ES04787385T patent/ES2403149T4/es active Active
- 2004-09-16 UA UAA200604360A patent/UA87115C2/ru unknown
- 2004-09-16 NZ NZ545835A patent/NZ545835A/en not_active IP Right Cessation
- 2004-09-16 BR BRPI0414492A patent/BRPI0414492A8/pt not_active Application Discontinuation
- 2004-09-16 RU RU2006113122/04A patent/RU2342373C2/ru active Protection Beyond IP Right Term
- 2004-09-16 PL PL04787385T patent/PL1667986T3/pl unknown
- 2004-09-16 EP EP04787385A patent/EP1667986B1/fr active Active
- 2004-09-16 JP JP2006526663A patent/JP5010279B2/ja active Active
- 2004-09-16 MX MXPA06002639A patent/MXPA06002639A/es active IP Right Grant
- 2004-09-16 ME MEP-2008-117A patent/ME00054B/me unknown
- 2004-09-16 PT PT4787385T patent/PT1667986E/pt unknown
- 2004-09-16 CN CNB200480026128XA patent/CN100429207C/zh active Active
- 2004-09-16 RS RS20060189A patent/RS54614B1/en unknown
- 2004-09-16 AR ARP040103329A patent/AR045667A1/es not_active Application Discontinuation
- 2004-09-16 RS YUP-2006/0189A patent/RS20060189A/sr unknown
- 2004-09-17 TW TW093128097A patent/TWI382022B/zh active
- 2004-09-17 MY MYPI20043787A patent/MY136668A/en unknown
- 2004-09-17 US US10/944,254 patent/US7241907B2/en active Active
2006
- 2006-03-09 IL IL174240A patent/IL174240A/en active IP Right Grant
- 2006-03-15 CR CR8292A patent/CR8292A/es unknown
- 2006-03-17 MA MA28881A patent/MA28045A1/fr unknown
- 2006-03-17 TN TNP2006000086A patent/TNSN06086A1/en unknown
- 2006-03-17 ZA ZA200602255A patent/ZA200602255B/en unknown
- 2006-04-19 NO NO20061714A patent/NO335997B1/no active Protection Beyond IP Right Term
- 2006-12-28 HK HK06114182.3A patent/HK1093340A1/xx not_active IP Right Cessation
2013
- 2013-03-20 LU LU92172C patent/LU92172I2/fr unknown
- 2013-04-10 HR HRP20130322TT patent/HRP20130322T1/hr unknown
- 2013-04-16 CY CY20131100313T patent/CY1114575T1/el unknown
- 2013-05-13 CY CY2013016C patent/CY2013016I1/el unknown
- 2013-06-07 HU HUS1300025C patent/HUS1300025I1/hu unknown
- 2013-06-13 BE BE2013C036C patent/BE2013C036I2/fr unknown
- 2013-07-04 FR FR13C0037C patent/FR13C0037I2/fr active Active
2015
- 2015-04-22 NO NO2015013C patent/NO2015013I1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
AR045667A1 (es)	2005-11-02
ES2403149T4 (es)	2013-06-24
LU92172I9 (fr)	2019-01-03
JP5010279B2 (ja)	2012-08-29
CR8292A (es)	2008-10-15
CY1114575T1 (el)	2016-10-05
AU2004274212A1 (en)	2005-03-31
IL174240A (en)	2010-12-30
FR13C0037I2 (fr)	2015-11-20
US7241907B2 (en)	2007-07-10
PT1667986E (pt)	2013-04-24
MA28045A1 (fr)	2006-07-03
CN1849311A (zh)	2006-10-18
RU2006113122A (ru)	2006-08-27
EP1667986B1 (fr)	2013-01-16
NO2015013I2 (no)	2015-04-22
TWI382022B (zh)	2013-01-11
CY2013016I2 (el)	2018-01-10
DK1667986T3 (da)	2013-05-06
SI1667986T1 (sl)	2013-05-31
WO2005028462A1 (fr)	2005-03-31
RU2342373C2 (ru)	2008-12-27
JP2007505866A (ja)	2007-03-15
BRPI0414492A (pt)	2006-11-14
MXPA06002639A (es)	2006-06-05
UA87115C2 (ru)	2009-06-25
MY136668A (en)	2008-11-28
FR2859996A1 (fr)	2005-03-25
TNSN06086A1 (en)	2007-10-03
CA2539309A1 (fr)	2005-03-31
AU2004274212B2 (en)	2010-03-04
BE2013C036I2 (fr)	2023-12-14
ES2403149T3 (es)	2013-05-14
CN100429207C (zh)	2008-10-29
HK1093340A1 (en)	2007-03-02
TW200524891A (en)	2005-08-01
PL1667986T3 (pl)	2013-06-28
KR20060072147A (ko)	2006-06-27
US20050065138A1 (en)	2005-03-24
ZA200602255B (en)	2007-07-25
CY2013016I1 (el)	2018-01-10
HUS1300025I1 (hu)	2016-08-29
MEP11708A (en)	2010-06-10
PE20050870A1 (es)	2005-11-21
EP1667986A1 (fr)	2006-06-14
NZ545835A (en)	2009-10-30
BRPI0414492A8 (pt)	2019-01-15
NO335997B1 (no)	2015-04-20
IL174240A0 (en)	2006-08-01
KR101123588B1 (ko)	2012-03-22
LU92172I2 (fr)	2013-05-21
NO20061714L (no)	2006-04-19
PA8612401A1 (es)	2005-08-04
HRP20130322T1 (en)	2013-07-31
RS20060189A (en)	2008-06-05
FR2859996B1 (fr)	2006-02-03
RS54614B1 (en)	2016-08-31
NO2015013I1 (no)	2015-05-04
ME00054B (me)	2011-02-10

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