FR04C0021I2 - METHOD FOR ELIMINATING BILE SALTS IN A PATIENT AND ALKYLATED COMPOSITIONS FOR THIS PURPOSE - Google Patents

METHOD FOR ELIMINATING BILE SALTS IN A PATIENT AND ALKYLATED COMPOSITIONS FOR THIS PURPOSE

Info

Publication number
FR04C0021I2
FR04C0021I2 FR04C0021C FR04C0021C FR04C0021I2 FR 04C0021 I2 FR04C0021 I2 FR 04C0021I2 FR 04C0021 C FR04C0021 C FR 04C0021C FR 04C0021 C FR04C0021 C FR 04C0021C FR 04C0021 I2 FR04C0021 I2 FR 04C0021I2
Authority
FR
France
Prior art keywords
patient
bile salts
alkylated
eliminating
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR04C0021C
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Geltex Pharmaceuticals Inc
Original Assignee
Geltex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22980525&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR04C0021(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Geltex Pharmaceuticals Inc filed Critical Geltex Pharmaceuticals Inc
Publication of FR04C0021I1 publication Critical patent/FR04C0021I1/fr
Application granted granted Critical
Publication of FR04C0021I2 publication Critical patent/FR04C0021I2/en
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/60—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F26/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/02—Alkylation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/44—Preparation of metal salts or ammonium salts
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
    • C08L39/02—Homopolymers or copolymers of vinylamine
FR04C0021C 1994-06-10 2004-09-08 METHOD FOR ELIMINATING BILE SALTS IN A PATIENT AND ALKYLATED COMPOSITIONS FOR THIS PURPOSE Active FR04C0021I2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25843194A 1994-06-10 1994-06-10
PCT/US1995/007181 WO1995034585A1 (en) 1994-06-10 1995-06-05 Process for removing bile salts from a patient and alkylated compositions therefor

Publications (2)

Publication Number Publication Date
FR04C0021I1 FR04C0021I1 (en) 2007-10-26
FR04C0021I2 true FR04C0021I2 (en) 2008-05-16

Family

ID=22980525

Family Applications (1)

Application Number Title Priority Date Filing Date
FR04C0021C Active FR04C0021I2 (en) 1994-06-10 2004-09-08 METHOD FOR ELIMINATING BILE SALTS IN A PATIENT AND ALKYLATED COMPOSITIONS FOR THIS PURPOSE

Country Status (21)

Country Link
US (12) US5679717A (en)
EP (2) EP0909768A3 (en)
JP (1) JP3931217B2 (en)
KR (1) KR100271693B1 (en)
CN (1) CN1150217C (en)
AT (1) ATE184027T1 (en)
AU (1) AU698752C (en)
CA (1) CA2191478C (en)
DE (3) DE122004000034I1 (en)
DK (1) DK0764174T3 (en)
ES (1) ES2135743T3 (en)
FR (1) FR04C0021I2 (en)
GR (1) GR3031702T3 (en)
IL (2) IL114073A (en)
LU (1) LU91100I2 (en)
MX (1) MX9606171A (en)
NL (1) NL300159I2 (en)
NZ (1) NZ288076A (en)
RU (1) RU2160742C2 (en)
TW (1) TW474813B (en)
WO (1) WO1995034585A1 (en)

Families Citing this family (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5487888A (en) 1993-05-20 1996-01-30 Geltex, Inc. Iron-binding polymers for oral administration
US5929184A (en) * 1993-06-02 1999-07-27 Geltex Pharmaceuticals, Inc. Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants
US6129910A (en) * 1993-06-02 2000-10-10 Geltex Pharmaceuticals, Inc. Water-insoluble noncrosslinked bile acid sequestrants
US5607669A (en) * 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
TW474813B (en) * 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
US6203785B1 (en) 1996-12-30 2001-03-20 Geltex Pharmaceuticals, Inc. Poly(diallylamine)-based bile acid sequestrants
US5925379A (en) * 1997-03-27 1999-07-20 Geltex Pharmaceuticals, Inc. Interpenetrating polymer networks for sequestration of bile acids
US6423754B1 (en) * 1997-06-18 2002-07-23 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with polyallylamine polymers
US5985938A (en) * 1997-11-05 1999-11-16 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
US6083497A (en) * 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
US6566407B2 (en) 1997-11-05 2003-05-20 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
US6726905B1 (en) 1997-11-05 2004-04-27 Genzyme Corporation Poly (diallylamines)-based phosphate binders
US6264937B1 (en) 1998-01-09 2001-07-24 Geltex Pharmaceuticals, Inc. Fat-binding polymers
US6267952B1 (en) 1998-01-09 2001-07-31 Geltex Pharmaceuticals, Inc. Lipase inhibiting polymers
US6299868B1 (en) 1999-07-14 2001-10-09 Geltex Pharmaceuticals, Inc. Fat-binding polymers
US7048917B1 (en) 1998-01-09 2006-05-23 Genzyme Corporation Fat-binding polymers
US6294163B1 (en) 1998-10-02 2001-09-25 Geltex Pharmaceuticals, Inc. Polymers containing guanidinium groups as bile acid sequestrants
JP4749649B2 (en) * 1998-10-12 2011-08-17 中外製薬株式会社 Phosphate-binding polymer
TW568788B (en) * 1998-10-12 2004-01-01 Chugai Pharmaceutical Co Ltd Polymer combining with phosphoric acid and preparation containing the same
DE19850817A1 (en) 1998-11-04 2000-05-11 Basf Ag Modified cationic polymers, processes for their manufacture and their use in papermaking
US6271264B1 (en) * 1998-12-01 2001-08-07 Geltex Pharmaceuticals, Inc. Polymers containing spirobicyclic ammonium moieties as bile acid sequestrants
EP1175451B1 (en) 1999-04-16 2007-07-04 Abbott Laboratories Process for producing cross-linked polyallylamine hydrochloride
US6190649B1 (en) 1999-04-23 2001-02-20 Geltex Pharmaceuticals, Inc. Polyether-based bile acid sequestrants
EP1196181A1 (en) * 1999-07-14 2002-04-17 Geltex Pharmaceuticals, Inc. Fat-binding polymers, optionally combined with lipase inhibitors
US6180754B1 (en) 1999-09-03 2001-01-30 The Dow Chemical Company Process for producing cross-linked polyallylamine polymer
US6362266B1 (en) 1999-09-03 2002-03-26 The Dow Chemical Company Process for reducing cohesiveness of polyallylamine polymer gels during drying
US20020054903A1 (en) * 1999-10-19 2002-05-09 Joseph Tyler Direct compression polymer tablet core
US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
MXPA03000771A (en) * 2000-07-28 2003-06-04 Hoffmann La Roche New pharmaceutical composition.
CA2428800C (en) 2000-11-20 2011-09-13 Dow Global Technologies Inc. In vivo use of fluid absorbent polymers
US8263112B2 (en) * 2000-11-20 2012-09-11 Sorbent Therapeutics, Inc. In vivo use of water absorbent polymers
ES2349093T3 (en) 2000-11-28 2010-12-27 Mitsubishi Tanabe Pharma Corporation EXCRETION ACCELERATOR FOR AN ACUMULATIVE CHLORINE COMPOUND.
AT409630B (en) * 2000-12-13 2002-09-25 Dsm Fine Chem Austria Gmbh ALKYLATION OF N-BZW. CROSSLINKED POLYMERS CONTAINING AMINO OR AMMONIUM GROUPS
US6710162B2 (en) 2001-02-16 2004-03-23 Genzyme Corporation Method of drying a material having a cohesive phase
EP1923064B1 (en) 2001-04-18 2017-06-28 Genzyme Corporation Use of amine polymer for lowering serum glucose
WO2002085379A1 (en) * 2001-04-18 2002-10-31 Geltex Pharmaceuticals, Inc. Method for improving vascular access in patients with vascular shunts
AU2002252632B2 (en) * 2001-04-18 2004-09-23 Genzyme Corporation Low salt forms of polyallylamine
EP1379259A1 (en) * 2001-04-18 2004-01-14 Genzyme Corporation Methods of treating syndrome x with aliphatic polyamines
JP4499363B2 (en) * 2001-04-18 2010-07-07 ジェンザイム コーポレーション Method for reducing serum glucose
WO2002085380A1 (en) * 2001-04-18 2002-10-31 Geltex Pharmaceuticals, Inc. Method for treating gout and reducing serum uric acid
US7041280B2 (en) * 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
US7049345B2 (en) * 2001-06-29 2006-05-23 Genzyme Corporation Fat-binding polymers
US6600011B2 (en) 2001-10-09 2003-07-29 Genzyme Corporation Process for purification and drying of polymer hydrogels
AT414237B (en) * 2002-09-03 2006-10-15 Dsm Fine Chem Austria Gmbh Preparation of haloalkyl-ammonium salt, useful as alkylating agent, comprises reacting trimethylamine with dihaloalkane compound in presence of ethyl acetate, cooling the reaction mixture, filtering and drying the reaction mixture
AT411463B (en) 2002-09-03 2004-01-26 Dsm Fine Chem Austria Gmbh High yield production of alkylated nitrogen containing crosslinked polymer gels, e.g. epichlorohydrin crosslinked poly allylamine hydrochloride, comprises washing with methanol, sodium chloride and water
AU2003282867A1 (en) * 2002-10-22 2004-05-13 Genzyme Corporation Amine polymers for promoting bone formation
OA13174A (en) 2003-05-30 2006-12-13 Ranbaxy Lab Ltd Substituted pyrrole derivatives and their use as HMG-Co inhibitors.
US7459502B2 (en) * 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
US7335795B2 (en) * 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7767768B2 (en) * 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7385012B2 (en) * 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
US7608674B2 (en) * 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7449605B2 (en) * 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
JPWO2005092349A1 (en) 2004-03-26 2008-02-07 田辺三菱製薬株式会社 Insulin resistance improving agent
US8282960B2 (en) * 2004-03-30 2012-10-09 Relypsa, Inc. Ion binding compositions
US8192758B2 (en) * 2004-03-30 2012-06-05 Relypsa, Inc. Ion binding compositions
US7556799B2 (en) * 2004-03-30 2009-07-07 Relypsa, Inc. Ion binding polymers and uses thereof
US7854924B2 (en) 2004-03-30 2010-12-21 Relypsa, Inc. Methods and compositions for treatment of ion imbalances
KR101153035B1 (en) * 2004-03-30 2012-06-11 리립사, 인크. Ion binding compositions
US7429394B2 (en) * 2004-03-30 2008-09-30 Relypsa, Inc. Ion binding compositions
EP1778740A1 (en) * 2004-08-12 2007-05-02 VersaMatrix A/S Beaded and cross-linked poly(aminoalkylene) matrix and uses thereof
WO2006021218A1 (en) * 2004-08-27 2006-03-02 Versamatrix A/S Polyether polymer matrix
JP2008510860A (en) * 2004-08-27 2008-04-10 ヴァーサマトリックス・アクティーゼルスカブ High load functional resin
US20060177415A1 (en) * 2004-11-01 2006-08-10 Burke Steven K Once a day formulation for phosphate binders
US7985418B2 (en) 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
JP4547620B2 (en) * 2004-12-02 2010-09-22 日東紡績株式会社 Method for producing crosslinked allylamine polymers
MY144940A (en) * 2005-01-25 2011-11-30 Avantor Performance Mat Inc Chromatographic media
EP1869090A1 (en) * 2005-03-16 2007-12-26 Council Of Scientific And Industrial Research An improved process for the preparation of crosslinked polyallylamine polymer.
US8986669B2 (en) 2005-09-02 2015-03-24 Genzyme Corporation Method for removing phosphate and polymer used therefore
AR056499A1 (en) * 2005-09-06 2007-10-10 Serapis Farmaceuticals Ltd COMPOUNDS
DK1924246T3 (en) 2005-09-15 2016-01-18 Genzyme Corp PORTION LETTER DEFINITION OF amine polymers
BRPI0616604A2 (en) 2005-09-30 2012-12-25 Ilypsa Inc Method for Removing and Composition for Selectively Removing Potassium Ion from a Mammal's Gastrointestinal Tract, Method for Selectively Removing Potassium Ion from an Environment, Pharmaceutical Composition, Core-Wrap Particle, and, Uses of a Core-Wrap Particle and a pharmaceutical composition
WO2007038802A2 (en) * 2005-09-30 2007-04-05 Ilypsa, Inc. Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom
CA2627599A1 (en) 2005-11-08 2007-05-18 Ranbaxy Laboratories Limited Process for (3r,5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino)carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt
EP2016114A2 (en) * 2006-05-05 2009-01-21 Genzyme Corporation Amine condensation polymers as phosphate sequestrants
ES2398477T3 (en) 2006-06-16 2013-03-19 Mitsubishi Tanabe Pharma Corporation Agent for the prevention and / or treatment of glomerulopathy
FR2902799B1 (en) 2006-06-27 2012-10-26 Millipore Corp METHOD AND UNIT FOR PREPARING A SAMPLE FOR THE MICROBIOLOGICAL ANALYSIS OF A LIQUID
EP2041261A4 (en) * 2006-07-13 2012-07-04 Ass For Public Health Services Inoculation loop assembly
EP2049014A2 (en) * 2006-07-18 2009-04-22 Genzyme Corporation Amine dendrimers
EP2066293A2 (en) 2006-09-29 2009-06-10 Genzyme Corporation Amide dendrimer compositions
US8163799B2 (en) 2006-12-14 2012-04-24 Genzyme Corporation Amido-amine polymer compositions
US8163886B2 (en) 2006-12-21 2012-04-24 Emd Millipore Corporation Purification of proteins
US8569464B2 (en) 2006-12-21 2013-10-29 Emd Millipore Corporation Purification of proteins
US8362217B2 (en) 2006-12-21 2013-01-29 Emd Millipore Corporation Purification of proteins
WO2008103368A1 (en) * 2007-02-23 2008-08-28 Genzyme Corporation Amine polymer compositions
WO2008109095A1 (en) * 2007-03-08 2008-09-12 Genzyme Corporation Sulfone polymer compositions
US20100166696A1 (en) * 2007-04-27 2010-07-01 Dhal Pradeep K Amido-amine dendrimer compositions
EP2016947A1 (en) 2007-07-17 2009-01-21 Chemo Ibérica, S.A. Novel one step process for preparing cross-linked poly(allylamine) polymers
JP2011506449A (en) * 2007-12-14 2011-03-03 ジェンザイム コーポレーション Coating pharmaceutical composition
PA8807201A1 (en) * 2007-12-14 2009-07-23 Genzyme Corp PHARMACEUTICAL COMPOSITIONS
US8999702B2 (en) 2008-06-11 2015-04-07 Emd Millipore Corporation Stirred tank bioreactor
WO2009154747A1 (en) * 2008-06-20 2009-12-23 Genzyme Corporation Pharmaceutical compositions
DE102008030046A1 (en) 2008-06-25 2009-12-31 Ratiopharm Gmbh Preparation of tablets comprising polyallylamine polymer, useful for treating e.g. hyperphosphatemia, comprises mixing polyallylamine polymer and additives, compacting to slug, granulating the slug and compressing the granules into tablets
US20100104527A1 (en) * 2008-08-22 2010-04-29 Relypsa, Inc. Treating hyperkalemia with crosslinked cation exchange polymers of improved physical properties
KR102178208B1 (en) * 2008-08-22 2020-11-12 리립사, 인크. Crosslinked cation exchange polymers, compositions and use in treating hyperkalemia
WO2010022380A2 (en) 2008-08-22 2010-02-25 Relypsa, Inc. Linear polyol stabilized polyfluoroacrylate compositions
CA2735962A1 (en) * 2008-09-02 2010-04-15 Usv Limited Crosslinked polymers
US20120009242A1 (en) * 2008-11-03 2012-01-12 University Of Maryland, College Park Blood coagulation inducing polymer hydrogel
US8404784B2 (en) * 2008-12-03 2013-03-26 Navinta Llc Manufacturing process of making polymeric amine salts
CN102257122B (en) 2008-12-16 2015-07-29 Emd密理博公司 Stirred tank reactor and method
US8673272B2 (en) * 2009-07-27 2014-03-18 Isp Investments Inc. Ultraviolet-absorbing compounds
GB0915449D0 (en) * 2009-09-04 2009-10-07 Univ Robert Gordon Composition
BR112012021444A2 (en) 2010-02-24 2016-05-31 Relypsa Inc cross-linked amine polymer, pharmaceutical composition, method of lowering serum ldl cholesterol in an individual, methods for treating disease, removing bile salts from an individual, and for improving glycemic control in an individual, and process for preparing the polymer of amines.
CN102906159B (en) * 2010-02-24 2017-09-26 瑞立普萨公司 Amine polymer as bile acid sequestrant
WO2011146394A1 (en) * 2010-05-17 2011-11-24 Millipore Corporation Stimulus responsive polymers for the purification of biomolecules
TR201005327A2 (en) 2010-06-30 2012-01-23 Bi̇lgi̇ç Mahmut Synergistic pharmaceutical formulations.
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
BR112013010157B1 (en) 2010-11-08 2020-02-04 Albireo Ab ibat inhibitors, their uses, and pharmaceutical composition and combinations
SG190433A1 (en) 2010-11-08 2013-06-28 Albireo Ab A pharmaceutical combination comprising an ibat inhibitor and a bile acid binder
US20140243281A1 (en) 2011-10-28 2014-08-28 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
US20130123433A1 (en) 2011-11-14 2013-05-16 Formosa Laboratories, Inc. Method for preparing poly(allylamine) hydrochloride and derivatives therefrom
US10813946B2 (en) 2012-10-08 2020-10-27 Vifor (International) Ltd. Potassium binding polymers for treating hypertension and hyperkalemia
ES2471340B1 (en) 2012-12-21 2015-08-17 Laboratorios Rubió, S.A. Oral pharmaceutical composition for high dosage drugs
EP2970196B1 (en) * 2013-03-15 2020-11-25 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
CN103446179B (en) * 2013-05-14 2017-03-15 厦门绿洲安源投资管理有限公司 The application of the tree-shaped crosslinking polycation gel of the poly- fullerene of parents of binding chelating agent as phosphate, aliphatic acid and bile acid
HUE051198T2 (en) 2013-06-05 2021-03-01 Tricida Inc Proton-binding polymers for oral administration
US9475891B2 (en) 2013-09-19 2016-10-25 Navinta, Llc Process for the preparation of colesevelam hydrochloride
EP2875807B1 (en) 2013-11-20 2021-03-24 Sanovel Ilac Sanayi ve Ticaret A.S. Tablet formulation of colesevelam
ITMI20132132A1 (en) 2013-12-19 2015-06-20 Chemi Spa PROCESS FOR THE PREPARATION OF COLESEVELAM
JP2017517550A (en) 2014-06-13 2017-06-29 ユナイテッド セラピューティクス コーポレイション Treprostinil preparation
ES2857177T3 (en) 2014-12-10 2021-09-28 Tricida Inc Proton-binding polymers for oral administration
US20180015119A1 (en) 2015-02-23 2018-01-18 Amneal Pharmaceuticals Company Gmbh Process for granulating sevelamer carbonate
US20170114157A1 (en) 2015-10-21 2017-04-27 Saudi Arabian Oil Company Cationic polymers and porous materials
MA54925A (en) 2016-05-06 2021-12-22 Tricida Inc COMPOSITIONS FOR THE TREATMENT OF ACID-BASED DISORDERS
CN106008813B (en) * 2016-06-15 2017-11-14 新发药业有限公司 The method that polymerisation in solution prepares colesevelam hydrocholoride
US10563042B2 (en) 2016-12-14 2020-02-18 Ecolab Usa Inc. Quaternary cationic polymers
CN107232191B (en) * 2017-06-22 2021-05-18 华中师范大学 Perfluorobutyl modified polyethyleneimine macromolecular fluorine-containing surfactant, preparation thereof and application thereof in pesticide slow release
AU2018360867A1 (en) 2017-11-03 2020-04-30 Tricida, Inc. Compositions for and method of treating acid-base disorders
WO2019241056A1 (en) 2018-06-12 2019-12-19 Ecolab Usa Inc. Quaternary cationic surfactants and polymers for use as release and coating modifying agents in creping and tissue papers
CN112047854B (en) * 2020-10-20 2021-07-02 中国科学院长春应用化学研究所 Preparation method of N-vinyl alkyl amide

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE580490A (en) * 1958-07-15 1960-01-08 Merck & Co Inc Compositions and methods for lowering the cholesterol content of the blood
US3383281A (en) * 1961-09-22 1968-05-14 Merck & Co Inc Method for binding bile acids in vivo
US3308020A (en) * 1961-09-22 1967-03-07 Merck & Co Inc Compositions and method for binding bile acids in vivo including hypocholesteremics
US3288770A (en) * 1962-12-14 1966-11-29 Peninsular Chem Res Inc Water soluble quaternary ammonium polymers
BE756035A (en) * 1969-09-12 1971-03-11 Inveresk Res Int POLYMERS BRIDGES
US3803237A (en) * 1969-11-03 1974-04-09 Upjohn Co Reaction products of polyethylenepolyamines and chlorohydrins or epoxy containing compounds
NL7017227A (en) * 1969-12-27 1971-06-29
US3692895A (en) * 1970-09-08 1972-09-19 Norman A Nelson Method of reducing hypercholesteremia in humans employing a copolymer of polyethylenepolyamine and a bifunctional substance, such as epichlorohydria
US3980770A (en) * 1971-06-04 1976-09-14 Pharmacia Aktiebolag Polymerization products containing amino groups useful in serum cholesterol level control
AR206390A1 (en) 1973-02-05 1976-07-23 Rohm & Haas A MATRIX OF RETICULATED POLYMER RESIN AND PROCEDURE FOR ITS PREPARATION
US4217429A (en) * 1973-06-11 1980-08-12 Merck & Co., Inc. Poly-[(methylimino)trimethylene]
US4205064A (en) * 1973-06-11 1980-05-27 Merck & Co., Inc. Bile acid sequestering composition containing poly[{alkyl-(3-ammoniopropyl)imino}-trimethylenedihalides]
US4027009A (en) * 1973-06-11 1977-05-31 Merck & Co., Inc. Compositions and methods for depressing blood serum cholesterol
CS187563B1 (en) * 1974-02-08 1979-02-28 Petr Strop Method of preparation of the hydrophilic homogeneous or macroporous annexes
CS173201B1 (en) * 1974-02-13 1977-02-28
US4016209A (en) * 1975-04-23 1977-04-05 Merck & Co., Inc. 3-[N'-(3-Halopropyl)-N-'-methylamino]-N,N,N-trimethyl-1-propanaminium halide and acid addition salts thereof
US4101478A (en) * 1976-04-12 1978-07-18 Kostjuchenko Vladimir Mitrofan Synthetic rubber mix
US4071478A (en) * 1976-06-07 1978-01-31 Merck & Co., Inc. Controlled partially cross-linked 3,3-ionenes
FI67483C (en) * 1977-02-17 1985-04-10 Merck & Co Inc PROCEDURE FOR THE FRAMEWORK OF ETHCYCLE ADMINISTRATION OF PHARMACOLOGICAL PRODUCT AGAINST GALLSYRAK COMPLEX BILDANDE ADSORBATE PREPARATION
US4298715A (en) * 1978-03-01 1981-11-03 Monsanto Company Polyamine/epihalohydrin reaction products
JPS5566513A (en) * 1978-11-14 1980-05-20 Ono Pharmaceut Co Ltd Drug for arteriosclerosis comprising high polymer compound as active constituent
IT1106718B (en) * 1978-12-21 1985-11-18 Alfa Farmaceutici Spa PHARMACOLOGICALLY ACTIVE SALONIZED ANIONIC RESIN BASED COMPOSITIONS
EP0098884B1 (en) * 1982-01-18 1986-07-23 Mitsubishi Petrochemical Co., Ltd. Cholesterol lowering drug
JPS6090243A (en) * 1983-10-25 1985-05-21 Nitto Boseki Co Ltd Small spherical crosslinked monoallylamine polymer and its preparation
JPS60106803A (en) * 1983-11-14 1985-06-12 Nitto Boseki Co Ltd Production of allylurea polymer
EP0142962A3 (en) * 1983-11-14 1986-01-15 Nitto Boseki Co., Ltd. Process for producing poly (allylamine) derivatives
US4540760A (en) * 1984-01-11 1985-09-10 Nitto Boseki Co. Ltd. Process for producing polymers of monoallylamine
DE3572985D1 (en) * 1984-05-11 1989-10-19 Bristol Myers Co Novel bile sequestrant resin and uses
US4759923A (en) * 1987-06-25 1988-07-26 Hercules Incorporated Process for lowering serum cholesterol using poly(diallylmethylamine) derivatives
US5300566A (en) * 1988-04-15 1994-04-05 Air Products And Chemicals, Inc. Method for preparing poly(vinyl alcohol)-co-poly(vinylamine) via a two-phase process
DE3901527A1 (en) 1989-01-20 1990-07-26 Hoechst Ag ALKYLATED POLYETHYLENE IMIN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICINAL PRODUCTS AND PHARMACEUTICAL PREPARATIONS
US5236701A (en) * 1989-07-19 1993-08-17 Lowchol Scientific Inc. Ingestible hydrophilic polymeric amines useful for lowering blood cholesterol
GB8928278D0 (en) * 1989-12-14 1990-02-21 Smith Kline French Lab Compounds
GB9011332D0 (en) * 1990-05-21 1990-07-11 Smith Kline French Lab Compounds
IE914179A1 (en) * 1990-12-07 1992-06-17 Ici Plc Nitrogen derivatives
US5055197A (en) * 1991-04-05 1991-10-08 Rohm And Haas Company Process for removing residual monomers and oligemers from amine-containing polymers
US5142019A (en) * 1991-10-03 1992-08-25 Ppg Industries, Inc. Oligomers formed from reaction of acrylamidoglycolate alkyl ethers with β-hydroxyalkylamines
ATE159262T1 (en) * 1992-07-22 1997-11-15 Hoechst Ag POLYVINYLAMINE DERIVATIVES HAVING HYDROPHILIC CENTERS, METHOD FOR THE PRODUCTION THEREOF AND THE USE OF THE COMPOUNDS AS MEDICINAL PRODUCTS, ACTIVE CARRIERS AND FOOD ADDITIVES
DK0580079T3 (en) * 1992-07-22 1997-06-30 Hoechst Ag Cross-linked, nitrogen-containing vinyl copolymers, processes for their preparation and use of these compounds
JP3412842B2 (en) * 1992-07-28 2003-06-03 ミヨシ油脂株式会社 Metal collecting agent and method for producing the same
RU95107405A (en) * 1992-08-20 1997-02-10 Е. И. Дюпон Де Немур энд Компани (US) Cross-linked polymer ammonium salt, pharmaceutical composition, method for decreasing of cholesterol content in blood plasma, method for promotion of excretion of cholic acids
US5451397A (en) * 1992-12-21 1995-09-19 Rohm And Haas Company Bile acid sequestrant
US5607669A (en) 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
EP0706399A4 (en) * 1993-06-02 1998-08-12 Geltex Pharma Inc Compositions and process for removing bile salts
US5624963A (en) 1993-06-02 1997-04-29 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5703188A (en) 1993-06-02 1997-12-30 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5667775A (en) * 1993-08-11 1997-09-16 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5414068A (en) * 1994-01-24 1995-05-09 Rohm And Haas Company Crosslinked anion exchange particles and method for producing the particles
TW474813B (en) 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient

Also Published As

Publication number Publication date
WO1995034585A1 (en) 1995-12-21
ES2135743T3 (en) 1999-11-01
DE69511861T2 (en) 2000-02-10
JPH10501842A (en) 1998-02-17
US5679717A (en) 1997-10-21
FR04C0021I1 (en) 2007-10-26
AU698752B2 (en) 1998-11-05
US7101960B2 (en) 2006-09-05
US20040014899A1 (en) 2004-01-22
US5981693A (en) 1999-11-09
IL114073A0 (en) 1995-10-31
CA2191478A1 (en) 1995-12-21
NZ288076A (en) 1998-08-26
EP0909768A3 (en) 2001-01-17
EP0764174A1 (en) 1997-03-26
AU2699095A (en) 1996-01-05
US6433026B2 (en) 2002-08-13
JP3931217B2 (en) 2007-06-13
CA2191478C (en) 2007-10-16
CN1150217C (en) 2004-05-19
US6784254B2 (en) 2004-08-31
US5693675A (en) 1997-12-02
GR3031702T3 (en) 2000-02-29
EP0764174B1 (en) 1999-09-01
US7399821B2 (en) 2008-07-15
TW474813B (en) 2002-02-01
DE69511861D1 (en) 1999-10-07
LU91100I2 (en) 2004-11-08
US20010044519A1 (en) 2001-11-22
US20090155201A1 (en) 2009-06-18
DK0764174T3 (en) 2000-03-27
DE122004000034I2 (en) 2006-04-27
RU2160742C2 (en) 2000-12-20
US6066678A (en) 2000-05-23
US20020095002A1 (en) 2002-07-18
LU91100I9 (en) 2019-01-29
DE122004000034I1 (en) 2005-02-24
US6225355B1 (en) 2001-05-01
IL114073A (en) 2003-06-24
US5917007A (en) 1999-06-29
NL300159I2 (en) 2004-12-01
IL142419A0 (en) 2002-03-10
ATE184027T1 (en) 1999-09-15
US20050131161A1 (en) 2005-06-16
NL300159I1 (en) 2004-11-01
MX9606171A (en) 1998-07-31
AU698752C (en) 2002-08-08
CN1150435A (en) 1997-05-21
KR100271693B1 (en) 2000-11-15
US20070155950A1 (en) 2007-07-05
EP0909768A2 (en) 1999-04-21

Similar Documents

Publication Publication Date Title
FR04C0021I2 (en) METHOD FOR ELIMINATING BILE SALTS IN A PATIENT AND ALKYLATED COMPOSITIONS FOR THIS PURPOSE
EP0944552A4 (en) Method for removing toxic substances in water
GB9521826D0 (en) Method and composition for clarifying waste water
FR2726754B1 (en) DEVICE AND METHOD FOR EXAMINING VISUAL FUNCTIONS
ZA959552B (en) Method for use in casting technology
EE9700114A (en) Method and apparatus for waste water treatment
FR2723835B1 (en) METHOD FOR CREATING ANATOMICAL MODE DISPLAYS
EP0758234A4 (en) Method and composition for treating renal disease and failure
HU9501346D0 (en) Parts for supporting drinking water and method for treatment thereof
GB2305371B (en) Wear strip assembly for use in a waste water treatment facility
GB9708732D0 (en) Method for transferring waste
FR2757401B1 (en) METHOD FOR TRIGGERING OVULATION IN A MAMMAL
IL110020A (en) Apparatus and method for purifying waste water
HUP9601049A2 (en) Waste water treatment method
FR2722577B1 (en) METHOD AND DEVICE FOR DETERMINATION BY INTRODUCTION IN A REAGENT IN THE FORM OF PEBTS
ZA912113B (en) Method and composition for water treatment
GB9501400D0 (en) Method for treating water
FR2770094B1 (en) METHOD AND DEVICE FOR CREATING ARTIFICIAL SHEETS AND FLOWERS
AU3516993A (en) Method and device for treating water in a surface condenser
GB2285534B (en) Method for treating radioactive waste solution
AU3177399A (en) A method and a device for automatic circulation in waste water tank
AU2822695A (en) Method and apparatus for waste water treatment
GB9410262D0 (en) A method for treating waste water
GB2297500B (en) Waste water treatment plant and method for use therein
GB9608334D0 (en) Method for rapidly solidying water in a container