FI971234A - Imidatsolijohdannainen - Google Patents

Imidatsolijohdannainen Download PDF

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Publication number
FI971234A
FI971234A FI971234A FI971234A FI971234A FI 971234 A FI971234 A FI 971234A FI 971234 A FI971234 A FI 971234A FI 971234 A FI971234 A FI 971234A FI 971234 A FI971234 A FI 971234A
Authority
FI
Finland
Prior art keywords
alkyl
halogeno
formula
imidazole
hydrogen
Prior art date
Application number
FI971234A
Other languages
English (en)
Swedish (sv)
Other versions
FI971234A0 (fi
Inventor
Hirohiko Sugimoto
Tamio Fujiwara
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of FI971234A0 publication Critical patent/FI971234A0/fi
Publication of FI971234A publication Critical patent/FI971234A/fi

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Dental Preparations (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI971234A 1994-09-26 1997-03-25 Imidatsolijohdannainen FI971234A (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP25749094 1994-09-26
JP8469095 1995-03-15
JP22720595 1995-08-12
PCT/JP1995/001936 WO1996010019A1 (fr) 1994-09-26 1995-09-25 Derive imidazole

Publications (2)

Publication Number Publication Date
FI971234A0 FI971234A0 (fi) 1997-03-25
FI971234A true FI971234A (fi) 1997-05-23

Family

ID=27304632

Family Applications (1)

Application Number Title Priority Date Filing Date
FI971234A FI971234A (fi) 1994-09-26 1997-03-25 Imidatsolijohdannainen

Country Status (20)

Country Link
US (2) US5910506A (fi)
EP (1) EP0786455B1 (fi)
JP (1) JP3155009B2 (fi)
KR (1) KR100387157B1 (fi)
CN (1) CN1093535C (fi)
AT (1) ATE255564T1 (fi)
BR (1) BR9509024A (fi)
CA (1) CA2200316C (fi)
DE (1) DE69532245T2 (fi)
DK (1) DK0786455T3 (fi)
ES (1) ES2211917T3 (fi)
FI (1) FI971234A (fi)
HU (1) HUT77357A (fi)
MX (1) MX9702030A (fi)
NO (1) NO308739B1 (fi)
PL (1) PL183931B1 (fi)
PT (1) PT786455E (fi)
RU (1) RU2157368C2 (fi)
TW (1) TW401404B (fi)
WO (1) WO1996010019A1 (fi)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997035843A1 (fr) * 1996-03-28 1997-10-02 Shionogi & Co., Ltd. Derives d'imidazole absorbables par la lymphe
AU712071B2 (en) * 1996-04-04 1999-10-28 Shionogi & Co., Ltd. Anti-HIV composition containing imidazole derivatives
KR100399463B1 (ko) * 1996-12-26 2003-09-29 시오노기세이야쿠가부시키가이샤 이미다졸 유도체의 제조 방법
ATE261944T1 (de) * 1996-12-26 2004-04-15 Shionogi & Co Verfahren zur herstellung von carbamoylsubstituierten imidazolderivaten
TWI232214B (en) * 1998-04-16 2005-05-11 Shionogi & Co Preparation of aryl sulfenyl halide
WO2000061109A1 (fr) 1999-04-12 2000-10-19 Shionogi & Co., Ltd. Procede de production de composition medicamenteuse renfermant un compose medicamenteux hydrophobe basique
GB0016787D0 (en) 2000-07-07 2000-08-30 Pfizer Ltd Compounds useful in therapy
KR100567706B1 (ko) 2001-01-31 2006-04-05 워너-램버트 캄파니 엘엘씨 알코올의 카르바모일화 방법
JP2004519477A (ja) * 2001-02-23 2004-07-02 カー・イュー・ルーベン・リサーチ・アンド・ディベロップメント Hiv抑制n−アミノイミダゾール誘導体
DE60219292T2 (de) 2001-04-10 2008-04-10 Pfizer Inc. Pyrazolderivate zur behandlung von hiv
GB0113524D0 (en) 2001-06-04 2001-07-25 Hoffmann La Roche Pyrazole derivatives
EA008775B1 (ru) 2002-04-26 2007-08-31 Джилид Сайэнс, Инк. Ингибиторы протеазы вич для лечения инфекции вич и фармацевтическая композиция
TW200423930A (en) 2003-02-18 2004-11-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitors
JP4485520B2 (ja) 2003-03-24 2010-06-23 エフ.ホフマン−ラ ロシュ アーゲー 逆転写酵素阻害剤としてのベンジル−ピリダジノン類
DK1628685T3 (da) 2003-04-25 2011-03-21 Gilead Sciences Inc Antivirale phosphonatanaloge
US7300924B2 (en) 2003-04-25 2007-11-27 Gilead Sciences, Inc. Anti-infective phosphonate analogs
WO2005002626A2 (en) 2003-04-25 2005-01-13 Gilead Sciences, Inc. Therapeutic phosphonate compounds
WO2004096287A2 (en) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
US7470724B2 (en) 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
US7452901B2 (en) 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
JP2006524710A (ja) 2003-04-25 2006-11-02 ギリアード サイエンシーズ, インコーポレイテッド キナーゼインヒビターホスホネート抱合体
US7407965B2 (en) 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
US7432261B2 (en) 2003-04-25 2008-10-07 Gilead Sciences, Inc. Anti-inflammatory phosphonate compounds
WO2005016912A1 (en) * 2003-08-19 2005-02-24 Pfizer Inc. An efficient microbial preparation of capravirine metabolites m4 and m5
WO2005044308A1 (en) 2003-10-24 2005-05-19 Gilead Sciences, Inc. Phosphonate analogs of antimetabolites
WO2005044279A1 (en) 2003-10-24 2005-05-19 Gilead Sciences, Inc. Purine nucleoside phosphonate conjugates
JP2007508843A (ja) 2003-10-24 2007-04-12 ギリアード サイエンシーズ, インコーポレイテッド 治療用化合物の同定のための方法および組成物
MXPA06006899A (es) 2003-12-22 2006-09-04 Gilead Sciences Inc Derivados de carbovir y abacavir 4'-sustituidos asi como compuestos relacionados con actividad antiviral de virus de inmunodeficiencia humana y virus de la hepatitis c.
US20080132549A1 (en) * 2004-04-14 2008-06-05 Pfizer Inc. Sulphur-Linked Imidazone Compounds for the Treatment of Hiv/Aids
US7871991B2 (en) 2004-07-27 2011-01-18 Gilead Sciences, Inc. Phosphonate analogs of HIV inhibitor compounds
CN1993333B (zh) 2004-08-04 2012-08-01 大正制药株式会社 ***衍生物
CA2592909A1 (en) * 2005-01-06 2006-07-13 Pfizer Limited Imidazole derivatives as enzyme reverse transcriptase modulators
NZ568285A (en) * 2005-12-01 2011-08-26 Hoffmann La Roche 2,4,5-triphenyl imidazoline derivatives as inhibitors of the interaction between P53 and MDM2 proteins for use as anticancer agents
US8022091B2 (en) 2006-02-03 2011-09-20 Taisho Pharmaceutical Co., Ltd. Triazole derivative
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US7649098B2 (en) * 2006-02-24 2010-01-19 Lexicon Pharmaceuticals, Inc. Imidazole-based compounds, compositions comprising them and methods of their use
US7994205B2 (en) * 2006-03-31 2011-08-09 Takeda Pharmaceutical Company Limited Aryl-or heteroaryl-sulfonyl compounds as acid secretion inhibitors
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WO2009017219A1 (ja) 2007-08-01 2009-02-05 Taisho Pharmaceutical Co., Ltd. S1p1結合阻害物質
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ES2526649T3 (es) 2007-12-21 2015-01-14 F. Hoffmann-La Roche Ag Compuestos heterocíclicos antivíricos
MX2011000306A (es) 2008-07-08 2011-03-15 Gilead Sciences Inc Sales de compuestos inhibidores de hiv.
JP2012517479A (ja) * 2009-02-12 2012-08-02 エグゼリクシス, インコーポレイテッド 糖尿病および肥満の処置においてtgr5アゴニストとして使用するためのトリアゾールおよびイミダゾール誘導体
CA2756086A1 (en) 2009-03-26 2010-09-30 Takeda Pharmaceutical Company Limited Pyrazole compound
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EP2716632A1 (en) 2012-10-05 2014-04-09 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses
EP2716639A1 (en) 2012-10-05 2014-04-09 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses
GB201602934D0 (en) 2016-02-19 2016-04-06 Cancer Res Inst Royal Compounds
EP3381905A1 (en) * 2017-03-30 2018-10-03 Institut National de la Sante et de la Recherche Medicale (INSERM) Novel antiviral compounds
EP3960740B1 (en) 2017-08-01 2023-11-15 Gilead Sciences, Inc. Crystalline forms of ethyl ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl)-l-alaninate (gs-9131) vanillate for treating viral infections

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63150266A (ja) * 1986-12-12 1988-06-22 Mitsui Petrochem Ind Ltd ベンジルイミダゾ−ル誘導体
JPH0283373A (ja) * 1988-05-19 1990-03-23 Nippon Soda Co Ltd 5員環の複素環化合物及びその製造方法
IL98319A (en) * 1990-07-05 1997-04-15 Roussel Uclaf Sulphurous derivatives of imidazole, their preparation process, and pharmaceutical compositions containing them
TW235963B (fi) * 1992-01-16 1994-12-11 Shionogi & Co
DE10230797C2 (de) * 2001-07-16 2003-09-25 Dieter Reif Befestigungsklammer zur Verbindung von Holzbauteilen

Also Published As

Publication number Publication date
PT786455E (pt) 2004-02-27
CN1158609A (zh) 1997-09-03
DE69532245T2 (de) 2004-09-16
EP0786455A1 (en) 1997-07-30
CA2200316A1 (en) 1996-04-04
US6147097A (en) 2000-11-14
EP0786455B1 (en) 2003-12-03
NO971306L (no) 1997-05-21
AU4788896A (en) 1996-04-19
DE69532245D1 (en) 2004-01-15
PL183931B1 (pl) 2002-08-30
AU706095B2 (en) 1999-06-10
ES2211917T3 (es) 2004-07-16
EP0786455A4 (en) 1998-12-30
US5910506A (en) 1999-06-08
DK0786455T3 (da) 2004-03-29
WO1996010019A1 (fr) 1996-04-04
HUT77357A (hu) 1998-03-30
JP3155009B2 (ja) 2001-04-09
BR9509024A (pt) 1997-09-30
RU2157368C2 (ru) 2000-10-10
CA2200316C (en) 2004-09-21
KR100387157B1 (ko) 2003-09-29
FI971234A0 (fi) 1997-03-25
NO971306D0 (no) 1997-03-20
TW401404B (en) 2000-08-11
CN1093535C (zh) 2002-10-30
NO308739B1 (no) 2000-10-23
KR970706260A (ko) 1997-11-03
PL320009A1 (en) 1997-09-01
ATE255564T1 (de) 2003-12-15
MX9702030A (es) 1997-06-28

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