FI945829A - Preparation of human hemoglobin in transgenic pigs - Google Patents

Preparation of human hemoglobin in transgenic pigs Download PDF

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Publication number
FI945829A
FI945829A FI945829A FI945829A FI945829A FI 945829 A FI945829 A FI 945829A FI 945829 A FI945829 A FI 945829A FI 945829 A FI945829 A FI 945829A FI 945829 A FI945829 A FI 945829A
Authority
FI
Finland
Prior art keywords
preparation
human hemoglobin
transgenic pigs
pigs
transgenic
Prior art date
Application number
FI945829A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI945829A0 (en
Inventor
John S Logan
Steven H Holtzman
J Kevin O'donnell
Stephen H Pilder
Carl A Pinkert
Mark E Swanson
Hilary Keller
Ajay Sharma
Cynthia T Parsons
Ramesh Kumar
Steven P White
Original Assignee
Dnx Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dnx Corp filed Critical Dnx Corp
Publication of FI945829A0 publication Critical patent/FI945829A0/en
Publication of FI945829A publication Critical patent/FI945829A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FI945829A 1992-06-12 1994-12-12 Preparation of human hemoglobin in transgenic pigs FI945829A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US89764892A 1992-06-12 1992-06-12
US98789092A 1992-12-08 1992-12-08
US3089793A 1993-03-15 1993-03-15
PCT/US1993/005629 WO1993025071A1 (en) 1992-06-12 1993-06-11 Production of human hemoglobin in transgenic pigs

Publications (2)

Publication Number Publication Date
FI945829A0 FI945829A0 (en) 1994-12-12
FI945829A true FI945829A (en) 1995-02-10

Family

ID=27363743

Family Applications (1)

Application Number Title Priority Date Filing Date
FI945829A FI945829A (en) 1992-06-12 1994-12-12 Preparation of human hemoglobin in transgenic pigs

Country Status (7)

Country Link
EP (1) EP0655888A4 (en)
JP (1) JPH07507921A (en)
AU (1) AU687743B2 (en)
CA (1) CA2137911A1 (en)
FI (1) FI945829A (en)
NZ (1) NZ253642A (en)
WO (1) WO1993025071A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922854A (en) * 1991-06-14 1999-07-13 Kumar; Ramesh Purifying Human Hemogloblin from transgenic pig red cells and plasmids containing pig globin nucleic acids
US5821351A (en) * 1994-06-10 1998-10-13 Dnx Biotherapeutics Production of hemoglobin having a delta-like globin
EP0811072A1 (en) 1995-02-25 1997-12-10 Imperial Cancer Research Technology Limited Transgenic animals as model of psoriasis
US6022738A (en) * 1995-03-03 2000-02-08 Mount Sinai School Of Medicine Of The City University Of New York Vectors for expression of globin genes
US5741894A (en) * 1995-09-22 1998-04-21 Baxter International, Inc. Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form
US5861483A (en) 1996-04-03 1999-01-19 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof
JP4360915B2 (en) 2002-01-07 2009-11-11 ユーロスクリーン・ソシエテ・アノニム G protein-coupled receptor GPR43 ligand and use thereof
US20050227251A1 (en) 2003-10-23 2005-10-13 Robert Darnell Method of purifying RNA binding protein-RNA complexes
CN101189023B (en) 2005-03-31 2013-01-30 通用医疗公司 Monitoring and modulating hgf/hgfr activity
CA2665080C (en) 2005-10-01 2015-11-24 Charles Stout Regulatable fusion promoters
CN101886075B (en) * 2010-07-02 2011-12-21 东北农业大学 Porcine ROSA26 promoter and application thereof
GB201417042D0 (en) * 2014-09-29 2014-11-12 Fkd Therapies Oy Method
CA3090138A1 (en) 2018-02-02 2019-08-08 Bloodworks Antibody screens using transgenic antigen(s)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8711614D0 (en) * 1987-05-16 1987-06-24 Medical Res Council Proteins
AU6505690A (en) * 1989-09-26 1991-04-28 Richard R Behringer Erythroid-specific gene expression system
EP0590076A4 (en) * 1991-06-14 1997-02-12 Dnx Corp Production of human hemoglobin in transgenic pigs

Also Published As

Publication number Publication date
EP0655888A4 (en) 1997-06-11
AU4534393A (en) 1994-01-04
FI945829A0 (en) 1994-12-12
JPH07507921A (en) 1995-09-07
EP0655888A1 (en) 1995-06-07
CA2137911A1 (en) 1993-12-23
NZ253642A (en) 1996-10-28
AU687743B2 (en) 1998-03-05
WO1993025071A1 (en) 1993-12-23

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