FI943928A - (Bentsodioksaani-, bentsofuraani- tai bentsopyraani)-alkyyliamino)alkyylisubstituoituja guanidiineja selektiivisinä verisuonia supistavina aineina - Google Patents

(Bentsodioksaani-, bentsofuraani- tai bentsopyraani)-alkyyliamino)alkyylisubstituoituja guanidiineja selektiivisinä verisuonia supistavina aineina Download PDF

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Publication number
FI943928A
FI943928A FI943928A FI943928A FI943928A FI 943928 A FI943928 A FI 943928A FI 943928 A FI943928 A FI 943928A FI 943928 A FI943928 A FI 943928A FI 943928 A FI943928 A FI 943928A
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FI
Finland
Prior art keywords
benzodioxane
benzopyran
benzofuran
alkylamino
alkyl
Prior art date
Application number
FI943928A
Other languages
English (en)
Swedish (sv)
Other versions
FI109122B (fi
FI943928A0 (fi
Inventor
Lommen Guy Rosalia Eugene Van
Bruyn Marcel Frans Leopold De
Walter Jacobus Joseph Janssens
Original Assignee
Janssen Pharmaceutica Nv
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Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of FI943928A0 publication Critical patent/FI943928A0/fi
Publication of FI943928A publication Critical patent/FI943928A/fi
Application granted granted Critical
Publication of FI109122B publication Critical patent/FI109122B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Phenolic Resins Or Amino Resins (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI943928A 1992-02-27 1994-08-26 Menetelmä verisuonia supistavana aineena käyttökelpoisten [(bentsodioksaani-, bentsofuraani- tai bentsopyraani)-alkyyliamino]alkyylisubstituoitujen guanidiinien valmistamiseksi ja välituote FI109122B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84256092A 1992-02-27 1992-02-27
US84256092 1992-02-27
PCT/EP1993/000435 WO1993017017A1 (en) 1992-02-27 1993-02-19 [(benzodioxan, benzofuran or benzopyran)-alkylamino] alkyl substituted guanidines as selective vascoconstrictors
EP9300435 1993-02-19

Publications (3)

Publication Number Publication Date
FI943928A0 FI943928A0 (fi) 1994-08-26
FI943928A true FI943928A (fi) 1994-08-26
FI109122B FI109122B (fi) 2002-05-31

Family

ID=25287639

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943928A FI109122B (fi) 1992-02-27 1994-08-26 Menetelmä verisuonia supistavana aineena käyttökelpoisten [(bentsodioksaani-, bentsofuraani- tai bentsopyraani)-alkyyliamino]alkyylisubstituoitujen guanidiinien valmistamiseksi ja välituote

Country Status (37)

Country Link
US (4) US5541180A (fi)
EP (1) EP0639192B1 (fi)
JP (1) JP2779268B2 (fi)
KR (1) KR100190300B1 (fi)
CN (1) CN1038032C (fi)
AP (1) AP416A (fi)
AT (1) ATE138064T1 (fi)
AU (1) AU664237B2 (fi)
BG (1) BG62052B1 (fi)
CA (1) CA2117483C (fi)
CZ (1) CZ282092B6 (fi)
DE (1) DE69302687T2 (fi)
DK (1) DK0639192T3 (fi)
EE (1) EE03029B1 (fi)
ES (1) ES2087721T3 (fi)
FI (1) FI109122B (fi)
GR (1) GR3019927T3 (fi)
HR (1) HRP930235B1 (fi)
HU (2) HU222495B1 (fi)
IL (1) IL104868A (fi)
LT (1) LT3049B (fi)
LV (1) LV10715B (fi)
MX (1) MX9301053A (fi)
MY (1) MY110627A (fi)
NO (1) NO306255B1 (fi)
NZ (1) NZ249124A (fi)
OA (1) OA10095A (fi)
PH (1) PH31295A (fi)
PL (1) PL174736B1 (fi)
RO (1) RO115630B1 (fi)
RU (1) RU2121999C1 (fi)
SG (1) SG47763A1 (fi)
SI (1) SI9300097B (fi)
SK (1) SK280166B6 (fi)
TW (1) TW225531B (fi)
WO (1) WO1993017017A1 (fi)
ZA (1) ZA931404B (fi)

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EP0714395B1 (en) * 1993-08-19 1999-03-31 Janssen Pharmaceutica N.V. Vasoconstrictive substituted dihydropyranopyridines
ES2212797T3 (es) * 1993-08-19 2004-08-01 Janssen Pharmaceutica N.V. Derivados de dihidrobenzopirano vasoconstrictores.
PH31437A (en) * 1993-08-27 1998-11-03 Janssen Pharmaceutica Nv Tontophoretic delivery of an antimigrane drug.
GB9318431D0 (en) * 1993-09-06 1993-10-20 Boots Co Plc Therapeutic agents
HRP950149A2 (en) * 1994-04-13 1997-06-30 Janssen Pharmaceutica Nv Intranasal antimigrene composition
US6054462A (en) * 1994-04-13 2000-04-25 Janssen Pharmaceutica, N.V. Intranasal antimigraine compositions
FR2724383B1 (fr) * 1994-09-13 1996-10-18 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique
DE69524528T2 (de) * 1994-10-14 2002-08-01 Merck Patent Gmbh ZNS wirksames (R)-(-)-2-[5-(4-Fluorophenyl)-3-pyridylmethylaminomethyl]chroman
US5853383A (en) * 1995-05-03 1998-12-29 Alza Corporation Preparation for formulations for electrotransport drug delivery
KR19990021931A (ko) * 1995-06-08 1999-03-25 디르크 반테 미세구형 전분의 항편두통 조성물
FR2752735B1 (fr) * 1996-09-05 1998-10-02 Synthelabo Utilisation de derives de benzofurane pour obtenir un medicament destine au traitement de l'insuffisance veineuse et de l'ulcere veineux
TW504510B (en) * 1996-05-10 2002-10-01 Janssen Pharmaceutica Nv 2,4-diaminopyrimidine derivatives
US6133277A (en) 1997-12-05 2000-10-17 Janssen Pharmaceutica N.V. (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
JP2003501427A (ja) * 1999-06-02 2003-01-14 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ アミノアルキル置換（ベンゾジオキサン、ベンゾフランもしくはベンゾピラン）誘導体
UA73123C2 (en) 1999-06-02 2005-06-15 Janssen Pharmaceutica Nv Derivatives of benzodioxane, benzofuran or benzopyran substituted by pyrolidinyl, piperidinyl or homopiperidinyl
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
JO2352B1 (en) 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus
JO2654B1 (en) 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2409B1 (en) 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents
CA2427098A1 (en) * 2000-11-29 2002-06-06 John Mehnert Schaus 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl)piperazine and pharmaceutically acceptable salts and solvates thereof and their use in the treatment of incontinence
DK1379520T3 (da) * 2001-02-23 2006-08-21 Merck & Co Inc N-substituerede ikke-aryl-heterocykliske NMDA/NR2B-antagonister
DK1408964T3 (da) 2001-07-26 2007-05-21 Merck Patent Gmbh Hidtil ukendt anvendelse af 2-5-(4-fluorphenyl)-3-pyridylmethylaminomethyl-chroman og fysiologisk acceptable salte deraf
HUP0401910A3 (en) * 2001-09-19 2011-02-28 Merck Patent Gmbh Novel use of substituted aminomethyl chromans and pharmaceutical compositions containing them
KR20050092795A (ko) * 2003-01-31 2005-09-22 짐머 오르쏘바이올로직스 인코포레이티드 수핵 조직을 함유하는 하이드로젤 조성물
EP1464335A3 (en) * 2003-03-31 2007-05-09 Taisho Pharmaceutical Co. Ltd. Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist
CN101475528A (zh) * 2003-03-31 2009-07-08 大正制药株式会社 新的喹啉、四氢喹唑啉和嘧啶衍生物以及与其应用有关的治疗方法
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
CA2637803A1 (en) * 2006-01-18 2007-12-06 Evolva Sa Ppar modulators
CN105061392B (zh) * 2015-07-20 2017-07-18 上海现代哈森（商丘）药业有限公司 一种硫酸胍生合成方法

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DE4303657A1 (de) * 1993-02-09 1994-08-11 Bayer Ag Neue Chinolon- und Naphthyridoncarbonsäurederivate

Also Published As

Publication number Publication date
US5607949A (en) 1997-03-04
NO943186L (no) 1994-08-29
DK0639192T3 (da) 1996-08-19
SI9300097B (en) 2001-12-31
SI9300097A (en) 1993-09-30
WO1993017017A1 (en) 1993-09-02
AP9300493A0 (en) 1993-04-30
EP0639192A1 (en) 1995-02-22
HU211742A9 (en) 1995-12-28
HUT71129A (en) 1995-11-28
FI109122B (fi) 2002-05-31
ATE138064T1 (de) 1996-06-15
US5688952A (en) 1997-11-18
ES2087721T3 (es) 1996-07-16
CN1038032C (zh) 1998-04-15
EP0639192B1 (en) 1996-05-15
RU94041210A (ru) 1996-07-10
CZ282092B6 (cs) 1997-05-14
NO306255B1 (no) 1999-10-11
FI943928A0 (fi) 1994-08-26
IL104868A0 (en) 1993-06-10
DE69302687D1 (de) 1996-06-20
AP416A (en) 1995-09-29
LV10715B (en) 1995-12-20
CA2117483C (en) 2001-01-09
EE03029B1 (et) 1997-08-15
MY110627A (en) 1998-09-30
PL174736B1 (pl) 1998-09-30
CA2117483A1 (en) 1993-09-02
CN1079470A (zh) 1993-12-15
SK102994A3 (en) 1995-07-11
OA10095A (en) 1996-12-18
HU9402464D0 (en) 1994-10-28
NO943186D0 (no) 1994-08-29
PH31295A (en) 1998-07-06
US5624952A (en) 1997-04-29
NZ249124A (en) 1995-08-28
IL104868A (en) 1998-01-04
RO115630B1 (ro) 2000-04-28
TW225531B (fi) 1994-06-21
GR3019927T3 (en) 1996-08-31
SG47763A1 (en) 1998-04-17
KR100190300B1 (ko) 1999-06-01
LTIP367A (lt) 1994-04-25
AU664237B2 (en) 1995-11-09
JPH07504408A (ja) 1995-05-18
HRP930235B1 (en) 1999-04-30
SK280166B6 (sk) 1999-09-10
BG98870A (bg) 1995-03-31
RU2121999C1 (ru) 1998-11-20
DE69302687T2 (de) 1996-11-14
CS202094A3 (en) 1995-01-18
HU222495B1 (hu) 2003-07-28
JP2779268B2 (ja) 1998-07-23
HRP930235A2 (en) 1997-10-31
US5541180A (en) 1996-07-30
BG62052B1 (bg) 1999-01-29
LV10715A (lv) 1995-06-20
AU3499193A (en) 1993-09-13
LT3049B (en) 1994-10-25
MX9301053A (es) 1994-03-31
ZA931404B (en) 1994-08-26

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