FI943928A - (Bentsodioksaani-, bentsofuraani- tai bentsopyraani)-alkyyliamino)alkyylisubstituoituja guanidiineja selektiivisinä verisuonia supistavina aineina - Google Patents
(Bentsodioksaani-, bentsofuraani- tai bentsopyraani)-alkyyliamino)alkyylisubstituoituja guanidiineja selektiivisinä verisuonia supistavina aineina Download PDFInfo
- Publication number
- FI943928A FI943928A FI943928A FI943928A FI943928A FI 943928 A FI943928 A FI 943928A FI 943928 A FI943928 A FI 943928A FI 943928 A FI943928 A FI 943928A FI 943928 A FI943928 A FI 943928A
- Authority
- FI
- Finland
- Prior art keywords
- benzodioxane
- benzopyran
- benzofuran
- alkylamino
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Phenolic Resins Or Amino Resins (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84256092A | 1992-02-27 | 1992-02-27 | |
US84256092 | 1992-02-27 | ||
PCT/EP1993/000435 WO1993017017A1 (en) | 1992-02-27 | 1993-02-19 | [(benzodioxan, benzofuran or benzopyran)-alkylamino] alkyl substituted guanidines as selective vascoconstrictors |
EP9300435 | 1993-02-19 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI943928A0 FI943928A0 (fi) | 1994-08-26 |
FI943928A true FI943928A (fi) | 1994-08-26 |
FI109122B FI109122B (fi) | 2002-05-31 |
Family
ID=25287639
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI943928A FI109122B (fi) | 1992-02-27 | 1994-08-26 | Menetelmä verisuonia supistavana aineena käyttökelpoisten [(bentsodioksaani-, bentsofuraani- tai bentsopyraani)-alkyyliamino]alkyylisubstituoitujen guanidiinien valmistamiseksi ja välituote |
Country Status (37)
Country | Link |
---|---|
US (4) | US5541180A (fi) |
EP (1) | EP0639192B1 (fi) |
JP (1) | JP2779268B2 (fi) |
KR (1) | KR100190300B1 (fi) |
CN (1) | CN1038032C (fi) |
AP (1) | AP416A (fi) |
AT (1) | ATE138064T1 (fi) |
AU (1) | AU664237B2 (fi) |
BG (1) | BG62052B1 (fi) |
CA (1) | CA2117483C (fi) |
CZ (1) | CZ282092B6 (fi) |
DE (1) | DE69302687T2 (fi) |
DK (1) | DK0639192T3 (fi) |
EE (1) | EE03029B1 (fi) |
ES (1) | ES2087721T3 (fi) |
FI (1) | FI109122B (fi) |
GR (1) | GR3019927T3 (fi) |
HR (1) | HRP930235B1 (fi) |
HU (2) | HU222495B1 (fi) |
IL (1) | IL104868A (fi) |
LT (1) | LT3049B (fi) |
LV (1) | LV10715B (fi) |
MX (1) | MX9301053A (fi) |
MY (1) | MY110627A (fi) |
NO (1) | NO306255B1 (fi) |
NZ (1) | NZ249124A (fi) |
OA (1) | OA10095A (fi) |
PH (1) | PH31295A (fi) |
PL (1) | PL174736B1 (fi) |
RO (1) | RO115630B1 (fi) |
RU (1) | RU2121999C1 (fi) |
SG (1) | SG47763A1 (fi) |
SI (1) | SI9300097B (fi) |
SK (1) | SK280166B6 (fi) |
TW (1) | TW225531B (fi) |
WO (1) | WO1993017017A1 (fi) |
ZA (1) | ZA931404B (fi) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0714395B1 (en) * | 1993-08-19 | 1999-03-31 | Janssen Pharmaceutica N.V. | Vasoconstrictive substituted dihydropyranopyridines |
ES2212797T3 (es) * | 1993-08-19 | 2004-08-01 | Janssen Pharmaceutica N.V. | Derivados de dihidrobenzopirano vasoconstrictores. |
PH31437A (en) * | 1993-08-27 | 1998-11-03 | Janssen Pharmaceutica Nv | Tontophoretic delivery of an antimigrane drug. |
GB9318431D0 (en) * | 1993-09-06 | 1993-10-20 | Boots Co Plc | Therapeutic agents |
HRP950149A2 (en) * | 1994-04-13 | 1997-06-30 | Janssen Pharmaceutica Nv | Intranasal antimigrene composition |
US6054462A (en) * | 1994-04-13 | 2000-04-25 | Janssen Pharmaceutica, N.V. | Intranasal antimigraine compositions |
FR2724383B1 (fr) * | 1994-09-13 | 1996-10-18 | Synthelabo | Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique |
DE69524528T2 (de) * | 1994-10-14 | 2002-08-01 | Merck Patent Gmbh | ZNS wirksames (R)-(-)-2-[5-(4-Fluorophenyl)-3-pyridylmethylaminomethyl]chroman |
US5853383A (en) * | 1995-05-03 | 1998-12-29 | Alza Corporation | Preparation for formulations for electrotransport drug delivery |
KR19990021931A (ko) * | 1995-06-08 | 1999-03-25 | 디르크 반테 | 미세구형 전분의 항편두통 조성물 |
FR2752735B1 (fr) * | 1996-09-05 | 1998-10-02 | Synthelabo | Utilisation de derives de benzofurane pour obtenir un medicament destine au traitement de l'insuffisance veineuse et de l'ulcere veineux |
TW504510B (en) * | 1996-05-10 | 2002-10-01 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives |
US6133277A (en) | 1997-12-05 | 2000-10-17 | Janssen Pharmaceutica N.V. | (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties |
JP2003501427A (ja) * | 1999-06-02 | 2003-01-14 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | アミノアルキル置換(ベンゾジオキサン、ベンゾフランもしくはベンゾピラン)誘導体 |
UA73123C2 (en) | 1999-06-02 | 2005-06-15 | Janssen Pharmaceutica Nv | Derivatives of benzodioxane, benzofuran or benzopyran substituted by pyrolidinyl, piperidinyl or homopiperidinyl |
UA73981C2 (en) | 2000-03-10 | 2005-10-17 | Merck Patent Gmbh | (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit |
JO2352B1 (en) | 2000-06-22 | 2006-12-12 | جانسين فارماسيوتيكا ان. في | Compounds for the treatment of non-adaptation of the bottom of the uterus |
JO2654B1 (en) | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Multiple aryl caroxa amides are useful as lipid - lowering agents |
JO2409B1 (en) | 2000-11-21 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Second-phenyl carboxy amides are useful as lipid-lowering agents |
CA2427098A1 (en) * | 2000-11-29 | 2002-06-06 | John Mehnert Schaus | 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl)piperazine and pharmaceutically acceptable salts and solvates thereof and their use in the treatment of incontinence |
DK1379520T3 (da) * | 2001-02-23 | 2006-08-21 | Merck & Co Inc | N-substituerede ikke-aryl-heterocykliske NMDA/NR2B-antagonister |
DK1408964T3 (da) | 2001-07-26 | 2007-05-21 | Merck Patent Gmbh | Hidtil ukendt anvendelse af 2-5-(4-fluorphenyl)-3-pyridylmethylaminomethyl-chroman og fysiologisk acceptable salte deraf |
HUP0401910A3 (en) * | 2001-09-19 | 2011-02-28 | Merck Patent Gmbh | Novel use of substituted aminomethyl chromans and pharmaceutical compositions containing them |
KR20050092795A (ko) * | 2003-01-31 | 2005-09-22 | 짐머 오르쏘바이올로직스 인코포레이티드 | 수핵 조직을 함유하는 하이드로젤 조성물 |
EP1464335A3 (en) * | 2003-03-31 | 2007-05-09 | Taisho Pharmaceutical Co. Ltd. | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist |
CN101475528A (zh) * | 2003-03-31 | 2009-07-08 | 大正制药株式会社 | 新的喹啉、四氢喹唑啉和嘧啶衍生物以及与其应用有关的治疗方法 |
MY147767A (en) * | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
CA2637803A1 (en) * | 2006-01-18 | 2007-12-06 | Evolva Sa | Ppar modulators |
CN105061392B (zh) * | 2015-07-20 | 2017-07-18 | 上海现代哈森(商丘)药业有限公司 | 一种硫酸胍生合成方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL296841A (fi) * | 1962-08-20 | |||
FR1366479A (fr) * | 1962-08-20 | 1964-07-10 | Res Lab Dr C Janssen Nv | Procédé de production de nouveaux dérivés de la pipéridine et de leurs sels |
GB1411531A (en) * | 1972-10-24 | 1975-10-29 | Lafon Labor | Amino derivatives of 1,4-benzodioxan |
GR71865B (fi) * | 1978-03-20 | 1983-07-07 | Ciba Geigy | |
US4405922A (en) * | 1979-05-23 | 1983-09-20 | Hitachi Koki Company, Limited | Failure detection circuit for impact printers or the like |
US4405622A (en) * | 1980-10-16 | 1983-09-20 | Syntex (U.S.A.) Inc. | [1-(1,4-Benzodioxan-2-yl)-4-(4-aminopyrimidin-2-yl]piperazines useful as anti-depressants |
FR2524887A1 (fr) * | 1982-04-08 | 1983-10-14 | Bouchara Emile | Nouvelles cyanoguanidines, leur procede d'obtention et les compositions pharmaceutiques en renfermant |
CA1338012C (en) * | 1987-04-27 | 1996-01-30 | John Michael Mccall | Pharmaceutically active amines |
CA2011899A1 (en) * | 1989-03-13 | 1990-09-13 | Masaaki Toda | Benzopyran derivatives |
WO1994017017A1 (en) * | 1991-07-15 | 1994-08-04 | Exxon Research And Engineering Company | Benzene removal from gasoline boiling range streams |
DE4303657A1 (de) * | 1993-02-09 | 1994-08-11 | Bayer Ag | Neue Chinolon- und Naphthyridoncarbonsäurederivate |
-
1993
- 1993-02-02 SI SI9300097A patent/SI9300097B/sl unknown
- 1993-02-15 PH PH45728A patent/PH31295A/en unknown
- 1993-02-19 CZ CZ942020A patent/CZ282092B6/cs unknown
- 1993-02-19 SK SK1029-94A patent/SK280166B6/sk not_active IP Right Cessation
- 1993-02-19 CA CA002117483A patent/CA2117483C/en not_active Expired - Lifetime
- 1993-02-19 JP JP5514541A patent/JP2779268B2/ja not_active Expired - Lifetime
- 1993-02-19 DK DK93904017.6T patent/DK0639192T3/da active
- 1993-02-19 RU RU94041210A patent/RU2121999C1/ru active
- 1993-02-19 WO PCT/EP1993/000435 patent/WO1993017017A1/en active IP Right Grant
- 1993-02-19 NZ NZ249124A patent/NZ249124A/xx not_active IP Right Cessation
- 1993-02-19 US US08/256,995 patent/US5541180A/en not_active Expired - Lifetime
- 1993-02-19 EP EP93904017A patent/EP0639192B1/en not_active Expired - Lifetime
- 1993-02-19 RO RO94-01432A patent/RO115630B1/ro unknown
- 1993-02-19 HU HU9402464A patent/HU222495B1/hu active IP Right Grant
- 1993-02-19 PL PL93304902A patent/PL174736B1/pl unknown
- 1993-02-19 SG SG1996004264A patent/SG47763A1/en unknown
- 1993-02-19 AT AT93904017T patent/ATE138064T1/de active
- 1993-02-19 DE DE69302687T patent/DE69302687T2/de not_active Expired - Lifetime
- 1993-02-19 ES ES93904017T patent/ES2087721T3/es not_active Expired - Lifetime
- 1993-02-19 AU AU34991/93A patent/AU664237B2/en not_active Expired
- 1993-02-19 KR KR1019940702319A patent/KR100190300B1/ko not_active IP Right Cessation
- 1993-02-23 MY MYPI93000311A patent/MY110627A/en unknown
- 1993-02-24 TW TW082101304A patent/TW225531B/zh not_active IP Right Cessation
- 1993-02-25 MX MX9301053A patent/MX9301053A/es unknown
- 1993-02-25 HR HR07/842,560A patent/HRP930235B1/xx not_active IP Right Cessation
- 1993-02-26 LT LTIP367A patent/LT3049B/lt not_active IP Right Cessation
- 1993-02-26 CN CN93103671A patent/CN1038032C/zh not_active Expired - Lifetime
- 1993-02-26 LV LVP-93-149A patent/LV10715B/en unknown
- 1993-02-26 ZA ZA931404A patent/ZA931404B/xx unknown
- 1993-02-26 IL IL104868A patent/IL104868A/en not_active IP Right Cessation
- 1993-02-27 AP APAP/P/1993/000493A patent/AP416A/en active
-
1994
- 1994-06-24 BG BG98870A patent/BG62052B1/bg not_active Expired - Lifetime
- 1994-08-19 OA OA60555A patent/OA10095A/fr unknown
- 1994-08-26 FI FI943928A patent/FI109122B/fi not_active IP Right Cessation
- 1994-08-29 NO NO943186A patent/NO306255B1/no not_active IP Right Cessation
- 1994-11-21 EE EE9400432A patent/EE03029B1/xx unknown
-
1995
- 1995-06-21 HU HU95P/P00317P patent/HU211742A9/hu unknown
-
1996
- 1996-04-15 US US08/632,228 patent/US5688952A/en not_active Expired - Lifetime
- 1996-04-15 US US08/632,227 patent/US5607949A/en not_active Expired - Lifetime
- 1996-04-15 US US08/632,226 patent/US5624952A/en not_active Expired - Lifetime
- 1996-05-16 GR GR960401224T patent/GR3019927T3/el unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |