FI943084A - Uusia sulfonyyliaminopyrimidiinejä - Google Patents

Uusia sulfonyyliaminopyrimidiinejä Download PDF

Info

Publication number: FI943084A
Authority: FI; Finland
Prior art keywords: sulfonylaminopyrimidines; new; prophylaxis; medicines; compounds
Prior art date: 1993-06-28

Application number

FI943084A

Other languages

English (en)

Swedish (sv)

Other versions

FI112944B (fi

FI943084A0 (fi

Inventor

Volker Breu

Kaspar Burri

Jean-Marie Cassal

Martine Clozel

Georges Hirth

Bernd-Michael Loeffler

Marcel Mueller

Werner Neidhart

Henri Ramuz

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-28

Filing date

1994-06-27

Publication date

1994-12-29

1994-06-27 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1994-06-27 Publication of FI943084A0 publication Critical patent/FI943084A0/fi

1994-12-29 Publication of FI943084A publication Critical patent/FI943084A/fi

2004-02-13 Application granted granted Critical

2004-02-13 Publication of FI112944B publication Critical patent/FI112944B/fi

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/69—Benzenesulfonamido-pyrimidines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Compositions Of Macromolecular Compounds (AREA)
Pyridine Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

FI943084A 1993-06-28 1994-06-27 Menetelmä uusien terapeuttisesti käyttökelpoisten sulfonyyliaminopyrimidiinijohdannaisten valmistamiseksi FI112944B (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH192493		1993-06-28
CH192493		1993-06-28

Publications (3)

Publication Number	Publication Date
FI943084A0 FI943084A0 (fi)	1994-06-27
FI943084A true FI943084A (fi)	1994-12-29
FI112944B FI112944B (fi)	2004-02-13

Family

ID=4221780

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI943084A FI112944B (fi)	1993-06-28	1994-06-27	Menetelmä uusien terapeuttisesti käyttökelpoisten sulfonyyliaminopyrimidiinijohdannaisten valmistamiseksi

Country Status (41)

Country	Link
US (1)	US5541186A (fi)
EP (1)	EP0633259B1 (fi)
JP (1)	JP2545200B2 (fi)
KR (1)	KR100338905B1 (fi)
CN (1)	CN1050839C (fi)
AT (1)	ATE175669T1 (fi)
AU (1)	AU678467B2 (fi)
BG (1)	BG61691B1 (fi)
BR (2)	BR9402558A (fi)
CA (1)	CA2125730C (fi)
CO (1)	CO4230230A1 (fi)
CZ (1)	CZ287184B6 (fi)
DE (1)	DE59407626D1 (fi)
DK (1)	DK0633259T3 (fi)
EC (1)	ECSP941111A (fi)
ES (1)	ES2127850T3 (fi)
FI (1)	FI112944B (fi)
GR (1)	GR3029874T3 (fi)
HR (1)	HRP940370B1 (fi)
HU (2)	HUT67636A (fi)
IL (1)	IL110089A (fi)
IS (1)	IS4185A (fi)
LT (1)	LT3723B (fi)
LV (1)	LV11175B (fi)
MY (1)	MY110871A (fi)
NO (1)	NO306403B1 (fi)
NZ (1)	NZ260842A (fi)
PE (1)	PE56794A1 (fi)
PH (1)	PH30688A (fi)
PL (2)	PL177031B1 (fi)
RO (1)	RO114325B1 (fi)
RU (1)	RU2142457C1 (fi)
SG (1)	SG43888A1 (fi)
SI (1)	SI0633259T1 (fi)
SK (1)	SK280736B6 (fi)
SV (1)	SV1994000028A (fi)
TW (1)	TW394761B (fi)
UA (1)	UA40578C2 (fi)
UY (1)	UY23797A1 (fi)
YU (1)	YU40794A (fi)
ZA (1)	ZA944434B (fi)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5514696A (en) *	1992-05-06	1996-05-07	Bristol-Myers Squibb Co.	Phenyl sulfonamide endothelin antagonists
US6063911A (en) *	1993-12-01	2000-05-16	Marine Polymer Technologies, Inc.	Methods and compositions for treatment of cell proliferative disorders
US6743783B1 (en) *	1993-12-01	2004-06-01	Marine Polymer Technologies, Inc.	Pharmaceutical compositions comprising poly-β-1→4-N-acetylglucosamine
US5612359A (en) *	1994-08-26	1997-03-18	Bristol-Myers Squibb Company	Substituted biphenyl isoxazole sulfonamides
US6268369B1 (en)	1994-11-16	2001-07-31	Synaptic Pharmaceutical Corporation	5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
KR970706823A (ko)	1994-11-16	1997-12-01	멀닉스 캐슬린 피.	디히드로피리미딘과 그 사용법(dihydropyrimidines and uses thereof)
CA2162630C (en) *	1994-11-25	2007-05-01	Volker Breu	Sulfonamides
TW313568B (fi) *	1994-12-20	1997-08-21	Hoffmann La Roche
ATE238285T1 (de) *	1994-12-28	2003-05-15	Kowa Co	Pyrimidin-derivate
US5780473A (en) *	1995-02-06	1998-07-14	Bristol-Myers Squibb Company	Substituted biphenyl sulfonamide endothelin antagonists
US5760038A (en) *	1995-02-06	1998-06-02	Bristol-Myers Squibb Company	Substituted biphenyl sulfonamide endothelin antagonists
US5573762A (en)	1995-04-24	1996-11-12	Genentech, Inc.	Use of leukemia inhibitory factor specific antibodies and endothelin antagonists for treatment of cardiac hypertrophy
US5739333A (en) *	1995-05-16	1998-04-14	Tanabe Seiyaku Co., Ltd.	Sulfonamide derivative and process for preparing the same
US5846990A (en) *	1995-07-24	1998-12-08	Bristol-Myers Squibb Co.	Substituted biphenyl isoxazole sulfonamides
KR100453097B1 (ko) *	1995-09-06	2004-12-31	코와 가부시키가이샤	피리미딘유도체
JPH09124620A (ja)	1995-10-11	1997-05-13	Bristol Myers Squibb Co	置換ビフェニルスルホンアミドエンドセリン拮抗剤
CZ260596A3 (en) *	1995-10-12	1997-12-17	Hoffmann La Roche	Sulfonamide derivative, process of its preparation and pharmaceutical composition containing thereof
US6228861B1 (en)	1995-11-16	2001-05-08	Synaptic Pharmaceutical Corporation	Dihydropyrimidines and uses thereof
TW414792B (en) *	1995-12-20	2000-12-11	Yamanouchi Pharma Co Ltd	An arylethensulfonamide derivative having endothelin receptor antagonistic effect and its pharmaceutical composition
US5856507A (en) *	1997-01-21	1999-01-05	Bristol-Myers Squibb Co.	Methods for the preparation of biphenyl isoxazole sulfonamides
HUP0002351A3 (en)	1996-02-20	2001-10-29	Bristol Myers Squibb Co	Methods for the preparation of biphenyl isoxazole sulfonamides, intermediates and process for preparing them
US5939446A (en) *	1996-04-09	1999-08-17	Bristol-Myers Squibb Co.	Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists
US6172066B1 (en)	1996-05-16	2001-01-09	Synaptic Pharmaceutical Corporation	Dihydropyrimidines and uses thereof
US6245773B1 (en)	1996-05-16	2001-06-12	Synaptic Pharmaceutical Corporation	5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
CA2265972A1 (en) *	1996-09-16	1998-03-26	Philip D. Acott	Use of igf-i for the treatment of polycystic kidney disease and related indications
AU6187898A (en) *	1997-01-30	1998-08-25	Bristol-Myers Squibb Company	Method for preventing or treating low renin hypertension by administering an endothelin antagonist
TW536540B (en) *	1997-01-30	2003-06-11	Bristol Myers Squibb Co	Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
US6680323B2 (en)	1998-12-23	2004-01-20	Synaptic Pharmaceutical Corporation	Dihydropyrimidines and uses thereof
US6274585B1 (en)	1998-12-23	2001-08-14	Synaptic Pharmaceutical Corporation	Dihydropyrimidines and uses thereof
US7566452B1 (en)	1999-05-04	2009-07-28	New York University	Cancer treatment with endothelin receptor antagonists
CA2315614C (en) *	1999-07-29	2004-11-02	Pfizer Inc.	Pyrazoles
AU2001265871A1 (en) *	2000-04-25	2001-11-07	Actelion Pharmaceuticals Ltd	Substituted sulfonylaminopyrimidines
US6720324B2 (en)	2000-07-05	2004-04-13	Synaptic Pharmaceutical Corporation	Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof
MY140724A (en)	2000-07-21	2010-01-15	Actelion Pharmaceuticals Ltd	Novel arylethene-sulfonamides
US6670362B2 (en)	2000-09-20	2003-12-30	Pfizer Inc.	Pyridazine endothelin antagonists
ATE446289T1 (de)	2000-09-25	2009-11-15	Actelion Pharmaceuticals Ltd	Arylalkanen-sulfonamiden mit endothelin- antagonistischer aktivität
US6639082B2 (en)	2000-10-17	2003-10-28	Bristol-Myers Squibb Company	Methods for the preparation of biphenyl isoxazole sulfonamides
KR100374326B1 (ko) *	2000-11-29	2003-03-03	한국과학기술연구원	6-히드록시-1, 3-디옥신-4-온 고리를 가진인간면역결핍바이러스 프로테아제 억제 화합물 및 그의제조방법
CN100432070C (zh)	2000-12-18	2008-11-12	埃科特莱茵药品有限公司	新颖的磺酰胺类化合物及其作为内皮素受体拮抗剂的应用
WO2002083650A1 (en) *	2001-04-11	2002-10-24	Actelion Pharmaceuticals Ltd	Novel sulfonylamino-pyrimidines
CA2784937A1 (en) *	2002-05-24	2003-12-04	Millennium Pharmaceuticals, Inc.	Ccr9 inhibitors and methods of use thereof
AU2011218661B2 (en) *	2002-05-24	2012-07-05	Millennium Pharmaceuticals, Inc.	CCR9 inhibitors and methods of use thereof
US7741519B2 (en) *	2007-04-23	2010-06-22	Chemocentryx, Inc.	Bis-aryl sulfonamides
US7227035B2 (en) *	2002-11-18	2007-06-05	Chemocentryx	Bis-aryl sulfonamides
EP1798223B2 (en) *	2002-11-18	2014-07-30	ChemoCentryx, Inc.	Aryl sulfonamides
US7420055B2 (en) *	2002-11-18	2008-09-02	Chemocentryx, Inc.	Aryl sulfonamides
CA2507334C (en)	2002-12-02	2013-05-07	Actelion Pharmaceuticals Ltd.	Pyrimidine-sulfamides and their use as endothelian receptor antagonist
DE102004027119A1 (de)	2003-06-06	2004-12-30	Schott Ag	UV-Strahlung absorbierendes Glas mit geringer Absorption im sichtbaren Bereich, ein Verfahren zu seiner Herstellung sowie dessen Verwendung
CN1930135B (zh) *	2004-03-05	2011-12-28	弗·哈夫曼-拉罗切有限公司	作为p2x3和p2x2/3拮抗剂的二氨基嘧啶
JP4926943B2 (ja) *	2004-04-13	2012-05-09	シンタファーマシューティカルズコーポレーション	Ｉｌ−１２産生を阻害する二塩
CN1972918B (zh) *	2004-06-28	2010-10-13	霍夫曼-拉罗奇有限公司	嘧啶衍生物
KR100847203B1 (ko) *	2004-06-28	2008-07-17	에프. 호프만-라 로슈 아게	피리미딘 유도체
TW200628467A (en)	2004-11-11	2006-08-16	Actelion Pharmaceuticals Ltd	Novel sulfamides
WO2007025900A1 (en) *	2005-09-01	2007-03-08	F. Hoffmann-La Roche Ag	Diaminopyrimidines as p2x3 and p3x2/3 modulators
CN101296907B (zh) *	2005-09-01	2013-03-27	弗·哈夫曼-拉罗切有限公司	作为p2x3和p2x2/3调节剂的二氨基嘧啶类
WO2007025901A1 (en)	2005-09-01	2007-03-08	F. Hoffmann-La Roche Ag	Diaminopyrimidines as p2x3 and p2x2/3 modulators
MX2008011844A (es) *	2006-03-13	2008-10-02	Encysive Pharmaceuticals Inc	Formulaciones de sitaxsentano de sodio.
MX2008011842A (es) *	2006-03-13	2008-10-02	Encysive Pharmaceuticals Inc	Procedimientos y composiciones para el tratamiento de insuficiencia cardiaca diastolica.
US20080026061A1 (en) *	2006-06-22	2008-01-31	Reichwein John F	Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide
AR062501A1 (es)	2006-08-29	2008-11-12	Actelion Pharmaceuticals Ltd	Composiciones terapeuticas
ES2552842T3 (es)	2007-02-19	2015-12-02	Marine Polymer Technologies, Inc.	Composiciones hemostáticas y regímenes terapéuticos
MX2010001837A (es)	2007-08-17	2010-03-10	Actelion Pharmaceuticals Ltd	Derivados de 4-pirimidinasulfamida.
JP2013523898A (ja)	2010-04-15	2013-06-17	マリンポリマーテクノロジーズ，インコーポレーテッド	ポリ−ｎ−アセチルグルコサミンナノファイバーの抗菌性の適用
CN107362171A (zh)	2011-04-15	2017-11-21	海洋聚合物技术公司	用聚‑n‑乙酰基葡糖胺纳米纤维治疗疾病
RU2604060C1 (ru) *	2015-10-06	2016-12-10	федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургская государственная химико-фармацевтическая академия" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФА Минздрава России)	Способ получения 2,5-дизамещенных 6-гидроксипиримидин-4(3н)-онов
MD3433234T2 (ro)	2016-03-22	2022-02-28	Merck Sharp & Dohme	Modulatori alosterici ai receptorilor nicotinici de acetilcolină
RU2643356C2 (ru) *	2016-06-22	2018-02-01	федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации	Новое n-арилсульфамидное производное о-бензоиламинобензойной кислоты, обладающее анксиолитической, актопротекторной и антидепрессивной активностью

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3663598D1 (en)	1985-07-24	1989-06-29	Siemens Ag	Nuclear-fuel assembly
TW270116B (fi) *	1991-04-25	1996-02-11	Hoffmann La Roche
RU2086544C1 (ru) *	1991-06-13	1997-08-10	Хоффманн-Ля Рош АГ	Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
TW287160B (fi) *	1992-12-10	1996-10-01	Hoffmann La Roche

1994
- 1994-06-08 TW TW083105221A patent/TW394761B/zh not_active IP Right Cessation
- 1994-06-13 CA CA002125730A patent/CA2125730C/en not_active Expired - Fee Related
- 1994-06-16 DE DE59407626T patent/DE59407626D1/de not_active Expired - Lifetime
- 1994-06-16 EP EP94109257A patent/EP0633259B1/de not_active Expired - Lifetime
- 1994-06-16 SI SI9430236T patent/SI0633259T1/xx unknown
- 1994-06-16 AT AT94109257T patent/ATE175669T1/de active
- 1994-06-16 DK DK94109257T patent/DK0633259T3/da active
- 1994-06-16 SG SG1996004116A patent/SG43888A1/en unknown
- 1994-06-16 ES ES94109257T patent/ES2127850T3/es not_active Expired - Lifetime
- 1994-06-21 ZA ZA944434A patent/ZA944434B/xx unknown
- 1994-06-22 IL IL11008994A patent/IL110089A/xx not_active IP Right Cessation
- 1994-06-24 IS IS4185A patent/IS4185A/is unknown
- 1994-06-24 HR HR01924/93-6A patent/HRP940370B1/xx not_active IP Right Cessation
- 1994-06-24 HU HU9401907A patent/HUT67636A/hu unknown
- 1994-06-24 NZ NZ260842A patent/NZ260842A/en unknown
- 1994-06-24 AU AU65948/94A patent/AU678467B2/en not_active Ceased
- 1994-06-27 UA UA94005281A patent/UA40578C2/uk unknown
- 1994-06-27 PL PL94323036A patent/PL177031B1/pl unknown
- 1994-06-27 CZ CZ19941573A patent/CZ287184B6/cs not_active IP Right Cessation
- 1994-06-27 NO NO942428A patent/NO306403B1/no unknown
- 1994-06-27 BG BG98880A patent/BG61691B1/bg unknown
- 1994-06-27 EC EC1994001111A patent/ECSP941111A/es unknown
- 1994-06-27 UY UY23797A patent/UY23797A1/es not_active IP Right Cessation
- 1994-06-27 KR KR1019940014774A patent/KR100338905B1/ko not_active IP Right Cessation
- 1994-06-27 MY MYPI94001661A patent/MY110871A/en unknown
- 1994-06-27 BR BR9402558A patent/BR9402558A/pt not_active Application Discontinuation
- 1994-06-27 YU YU40794A patent/YU40794A/sh unknown
- 1994-06-27 LT LTIP1979A patent/LT3723B/lt not_active IP Right Cessation
- 1994-06-27 PL PL94304007A patent/PL175771B1/pl unknown
- 1994-06-27 US US08/266,072 patent/US5541186A/en not_active Expired - Lifetime
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- 1994-06-27 LV LVP-94-131A patent/LV11175B/lv unknown
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- 1994-06-27 CO CO94027814A patent/CO4230230A1/es unknown
- 1994-06-27 CN CN94106574A patent/CN1050839C/zh not_active Expired - Fee Related
- 1994-06-27 FI FI943084A patent/FI112944B/fi not_active IP Right Cessation
- 1994-06-27 RU RU94022258/04A patent/RU2142457C1/ru not_active IP Right Cessation
- 1994-06-28 JP JP6146003A patent/JP2545200B2/ja not_active Expired - Fee Related
- 1994-06-28 SK SK779-94A patent/SK280736B6/sk unknown
- 1994-06-28 RO RO94-01112A patent/RO114325B1/ro unknown
- 1994-06-28 SV SV1994B00028A patent/SV1994000028A/es not_active Application Discontinuation
1995
- 1995-06-21 HU HU95P/P00298P patent/HU211533A9/hu unknown
1996
- 1996-12-05 BR BR1100089-9A patent/BR1100089A/pt active IP Right Grant
1999
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Also Published As

Publication number	Publication date
JP2545200B2 (ja)	1996-10-16
PL175771B1 (pl)	1999-02-26
CN1106007A (zh)	1995-08-02
LT3723B (en)	1996-02-26
SG43888A1 (en)	1997-11-14
EP0633259A1 (de)	1995-01-11
PH30688A (en)	1997-09-16
HU9401907D0 (en)	1994-09-28
UY23797A1 (es)	1994-12-16
YU40794A (sh)	1997-07-31
ES2127850T3 (es)	1999-05-01
LV11175A (lv)	1996-04-20
AU678467B2 (en)	1997-05-29
CN1050839C (zh)	2000-03-29
TW394761B (en)	2000-06-21
BG98880A (bg)	1995-05-31
AU6594894A (en)	1995-01-05
HUT67636A (en)	1995-04-28
US5541186A (en)	1996-07-30
IS4185A (is)	1994-12-29
HRP940370A2 (en)	1996-12-31
UA40578C2 (uk)	2001-08-15
IL110089A0 (en)	1994-10-07
KR950000676A (ko)	1995-01-03
SK77994A3 (en)	1995-03-08
PL177031B1 (pl)	1999-09-30
LTIP1979A (en)	1995-01-31
PE56794A1 (es)	1995-02-07
ECSP941111A (es)	1994-11-16
CA2125730C (en)	2005-10-18
JPH0717972A (ja)	1995-01-20
BR1100089A (pt)	2000-03-14
DK0633259T3 (da)	1999-09-06
BR9402558A (pt)	1995-03-28
RO114325B1 (ro)	1999-03-30
EP0633259B1 (de)	1999-01-13
LV11175B (en)	1996-06-20
NO942428L (no)	1994-12-29
RU2142457C1 (ru)	1999-12-10
NZ260842A (en)	1996-05-28
SI0633259T1 (en)	1999-06-30
SV1994000028A (es)	1995-04-19
IL110089A (en)	2000-08-31
MY110871A (en)	1999-05-31
NO942428D0 (no)	1994-06-27
FI112944B (fi)	2004-02-13
CO4230230A1 (es)	1995-10-19
HRP940370B1 (en)	1999-12-31
DE59407626D1 (de)	1999-02-25
ATE175669T1 (de)	1999-01-15
RU94022258A (ru)	1996-04-20
SK280736B6 (sk)	2000-07-11
BG61691B1 (bg)	1998-03-31
CA2125730A1 (en)	1994-12-29
GR3029874T3 (en)	1999-07-30
NO306403B1 (no)	1999-11-01
ZA944434B (en)	1995-01-03
FI943084A0 (fi)	1994-06-27
CZ157394A3 (en)	1995-01-18
HU211533A9 (en)	1995-12-28
PL304007A1 (en)	1995-01-09
KR100338905B1 (ko)	2002-11-13
CZ287184B6 (en)	2000-10-11

Legal Events

Date	Code	Title	Description
2014-01-15	MM	Patent lapsed

Publication	Publication Date	Title
FI943084A0 (fi)	1994-06-27	Uusia sulfonyyliaminopyrimidiinejä
ATE167476T1 (de)	1998-07-15	Substituierte 2-phenyl-3-methocypropensäurenester als fungizide mittel.
DK0601386T3 (da)	2003-05-26	Sulfonamider
DK348189D0 (da)	1989-07-13	Kondenserede heterocyckliske forbindelser
KR910700089A (ko)	1991-03-13	히드로클로로플루오로프로판의 공비 조성물 또는 공비형 조성물
IT1270975B (it)	1997-05-26	Composti piperidin-triazinici atti all'impiego come stabilizzanti allaluce, al calore e alla ossidazione per materiali organici
IT1263892B (it)	1996-09-05	Composti piperidin-triazinici atti all'impiego come stabilizzanti per materiali organici
ATE207480T1 (de)	2001-11-15	Substituierte aminoalkylaminopyridine
DK0552631T3 (da)	1998-05-11	Alfa-Aryl-alfa-hydroxy-beta-imidazolinyl-propionsyreamider
NO305556B1 (no)	1999-06-21	Tiokarbamoylforbindelser og anvendelse derav samt middel for beskyttelse av tekniske materialer
IT1262952B (it)	1996-07-23	Tetraalchilpiperidine, loro preparazione e loro impiego come stabilizzanti alla luce. (caso 153-5502)