FI922848A - Förfarande för framställning av terapeutiskt aktiva tetrahydropyrrolo[1,2-a]pyrazin-4-spiro-3'-pyrrolidinderivat - Google Patents

Förfarande för framställning av terapeutiskt aktiva tetrahydropyrrolo[1,2-a]pyrazin-4-spiro-3'-pyrrolidinderivat Download PDF

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Publication number
FI922848A
FI922848A FI922848A FI922848A FI922848A FI 922848 A FI922848 A FI 922848A FI 922848 A FI922848 A FI 922848A FI 922848 A FI922848 A FI 922848A FI 922848 A FI922848 A FI 922848A
Authority
FI
Finland
Prior art keywords
tetrahydropyrrolo
pyrazine
spiro
preparation
pyrrolidine derivatives
Prior art date
Application number
FI922848A
Other languages
English (en)
Finnish (fi)
Other versions
FI98066B (sv
FI98066C (sv
FI922848A0 (sv
Inventor
Toshiyuki Negoro
Makoto Murata
Shozo Ueda
Buichi Fujitani
Yoshiyuki Ono
Original Assignee
Dainippon Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co filed Critical Dainippon Pharmaceutical Co
Publication of FI922848A0 publication Critical patent/FI922848A0/sv
Publication of FI922848A publication Critical patent/FI922848A/sv
Publication of FI98066B publication Critical patent/FI98066B/sv
Application granted granted Critical
Publication of FI98066C publication Critical patent/FI98066C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
FI922848A 1991-06-26 1992-06-18 Förfarande för framställning av terapeutiskt aktiva tetrahydropyrrolo[1,2-a]pyrazin-4-spiro-3'-pyrrolidinderivat FI98066C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP18318591 1991-06-26
JP03183185 1991-06-26

Publications (4)

Publication Number Publication Date
FI922848A0 FI922848A0 (sv) 1992-06-18
FI922848A true FI922848A (sv) 1992-12-27
FI98066B FI98066B (sv) 1996-12-31
FI98066C FI98066C (sv) 1997-04-10

Family

ID=16131263

Family Applications (1)

Application Number Title Priority Date Filing Date
FI922848A FI98066C (sv) 1991-06-26 1992-06-18 Förfarande för framställning av terapeutiskt aktiva tetrahydropyrrolo[1,2-a]pyrazin-4-spiro-3'-pyrrolidinderivat

Country Status (21)

Country Link
US (1) US5258382A (sv)
EP (1) EP0520320B1 (sv)
JP (1) JP2516147B2 (sv)
KR (1) KR100241196B1 (sv)
CN (1) CN1034176C (sv)
AT (1) ATE157980T1 (sv)
AU (1) AU648901B2 (sv)
CA (1) CA2071273C (sv)
DE (1) DE69222096T2 (sv)
DK (1) DK0520320T3 (sv)
ES (1) ES2108717T3 (sv)
FI (1) FI98066C (sv)
GR (1) GR3024870T3 (sv)
HK (1) HK1001728A1 (sv)
HU (1) HU218214B (sv)
IE (1) IE921891A1 (sv)
MX (1) MX9203231A (sv)
NO (1) NO300637B1 (sv)
NZ (1) NZ243255A (sv)
TW (1) TW202450B (sv)
ZA (1) ZA924425B (sv)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3195455B2 (ja) * 1993-01-06 2001-08-06 ウェルファイド株式会社 キノリン−３−酢酸誘導体、その製造法と用途
JP3681082B2 (ja) * 1996-06-27 2005-08-10 住友ベークライト株式会社 イミド環含有エポキシ樹脂及びエポキシ樹脂組成物
AU9461898A (en) * 1997-10-20 1999-05-10 Dainippon Pharmaceutical Co. Ltd. Stable drug composition
KR100571614B1 (ko) 1997-10-20 2006-04-17 다이닛본 스미토모 세이야꾸 가부시끼가이샤 속용성 의약 조성물
JP2007246539A (ja) * 1997-10-20 2007-09-27 Dainippon Sumitomo Pharma Co Ltd 速溶性医薬組成物
WO2001034148A1 (fr) * 1999-11-11 2001-05-17 Kyorin Pharmaceutical Co., Ltd. Preparations solides pour administration orale
ATE319712T1 (de) 1999-12-21 2006-03-15 Mgi Gp Inc Hydantoin derivate, pharmazeutische zusammensetzungen und verfahren zu ihrer verwendung
US20060058310A1 (en) * 2002-11-14 2006-03-16 Yoshifumi Takenobu Remedies for vertebral canal stenosis
CA2656921A1 (en) * 2006-07-07 2008-01-10 Dainippon Sumitomo Pharma Co., Ltd. 3-hydrazino-2,5-dioxopyrrolidine-3-carboxylates and a process for preparing the same as well as a use of the same
EP2058300B1 (en) * 2006-08-31 2013-01-09 Dainippon Sumitomo Pharma Co., Ltd. Succinic acid diester derivative, process for production thereof, and use of the derivative in the production of pharmaceutical preparation
JP5149802B2 (ja) * 2006-09-20 2013-02-20 日産化学工業株式会社 光学活性コハク酸イミド化合物の製造法
JP5149803B2 (ja) * 2006-09-27 2013-02-20 大日本住友製薬株式会社 コハク酸イミド化合物の製造方法
JP5113070B2 (ja) * 2006-09-29 2013-01-09 大日本住友製薬株式会社 ２，５−ジオキソピロリジン−３−カルボキシレート類の製造方法
WO2008050847A1 (fr) 2006-10-25 2008-05-02 Dainippon Sumitomo Pharma Co., Ltd. Préparation granulaire non agglutinante
WO2008081860A1 (ja) * 2006-12-28 2008-07-10 Dainippon Sumitomo Pharma Co., Ltd. 光学活性コハク酸イミド誘導体およびその製造方法ならびにその使用
JPWO2008136527A1 (ja) * 2007-05-08 2010-07-29 大日本住友製薬株式会社 光学活性ジオキソピロリジン誘導体の精製方法
US20100222354A1 (en) * 2007-07-13 2010-09-02 Eisai R & D Management Co., Ltd. AMPA Receptor Antagonists and Aldose Reductase Inhibitors for Neuropathic Pain
JP2011026201A (ja) * 2007-10-17 2011-02-10 Mitsubishi Tanabe Pharma Corp 光学活性ピロリル−コハク酸イミド誘導体の立体選択的な製造方法
JP5697998B2 (ja) 2009-02-06 2015-04-08 大日本住友製薬株式会社 光学活性スクシンイミド誘導体の製造方法及びその中間体
US8900830B2 (en) 2010-07-29 2014-12-02 Sumitomo Dainippon Pharma Co., Ltd. Process for producing optically active succinimide derivatives
CN103391782A (zh) 2011-02-02 2013-11-13 公立大学法人名古屋市立大学 用于预防或治疗伴有眼内血管新生及/或眼内血管渗透性过高的疾病的药物
EP3192510B1 (en) * 2014-09-11 2022-01-05 Sumitomo Dainippon Pharma Co., Ltd. Ophthalmic suspension formulation
CN106928234A (zh) * 2017-02-07 2017-07-07 上海合全药业股份有限公司 （2‑苄基‑1,2,3,4‑四氢吡咯并[1,2‑a]吡嗪）‑4‑甲醇的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60142984A (ja) * 1983-12-28 1985-07-29 Kyorin Pharmaceut Co Ltd 新規なスピロピロリジン−２，５−ジオン誘導体およびその製造法
WO1986001107A1 (en) * 1984-08-14 1986-02-27 Pfizer Inc. Tetracyclic spiro-hydantoin aldose reductase inhibitors, compositions and methods of making
JPS63132889A (ja) * 1986-11-21 1988-06-04 Tanabe Seiyaku Co Ltd キナゾリノン誘導体
AU617541B2 (en) * 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors

Also Published As

Publication number Publication date
NO300637B1 (no) 1997-06-30
DK0520320T3 (da) 1997-10-13
FI98066B (sv) 1996-12-31
KR100241196B1 (ko) 2000-03-02
NO922512L (no) 1992-12-28
TW202450B (sv) 1993-03-21
ES2108717T3 (es) 1998-01-01
HU218214B (hu) 2000-06-28
MX9203231A (es) 1993-08-01
ATE157980T1 (de) 1997-09-15
AU648901B2 (en) 1994-05-05
CN1034176C (zh) 1997-03-05
JP2516147B2 (ja) 1996-07-10
AU1848392A (en) 1993-01-14
IE921891A1 (en) 1992-12-30
EP0520320A2 (en) 1992-12-30
FI98066C (sv) 1997-04-10
US5258382A (en) 1993-11-02
NZ243255A (en) 1994-03-25
GR3024870T3 (en) 1998-01-30
CN1068825A (zh) 1993-02-10
FI922848A0 (sv) 1992-06-18
DE69222096D1 (de) 1997-10-16
HU9202105D0 (en) 1992-10-28
KR930000519A (ko) 1993-01-15
CA2071273A1 (en) 1992-12-27
HK1001728A1 (en) 1998-07-03
EP0520320A3 (en) 1993-03-24
HUT63424A (en) 1993-08-30
CA2071273C (en) 2002-08-20
JPH05186472A (ja) 1993-07-27
DE69222096T2 (de) 1998-01-22
EP0520320B1 (en) 1997-09-10
ZA924425B (en) 1993-03-31
NO922512D0 (no) 1992-06-25

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Owner name: DAINIPPON SUMITOMO PHARMA CO., LTD.

Free format text: DAINIPPON SUMITOMO PHARMA CO., LTD.

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