FI922645A0 - A-c-b-proinsulin, foerfarande foer framstaellning av detta och anvaendning av detta samt mellanprodukter foer anvaendning vid insulinframstaellning. - Google Patents

A-c-b-proinsulin, foerfarande foer framstaellning av detta och anvaendning av detta samt mellanprodukter foer anvaendning vid insulinframstaellning.

Info

Publication number
FI922645A0
FI922645A0 FI922645A FI922645A FI922645A0 FI 922645 A0 FI922645 A0 FI 922645A0 FI 922645 A FI922645 A FI 922645A FI 922645 A FI922645 A FI 922645A FI 922645 A0 FI922645 A0 FI 922645A0
Authority
FI
Finland
Prior art keywords
detta
insulin
anvaendning
proinsulin
foer
Prior art date
Application number
FI922645A
Other languages
English (en)
Other versions
FI922645A (fi
Inventor
Rama M Belagaje
Richard Dennis Dimarchi
Jr William Francis Heath
Harlan Beall Long
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI922645A0 publication Critical patent/FI922645A0/fi
Publication of FI922645A publication Critical patent/FI922645A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FI922645A 1991-06-11 1992-06-08 A-c-b-proinsulin, foerfarande foer framstaellning av detta och anvaendningav detta samt mellanprodukter foer anvaendning vid insulinframstaellning FI922645A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/715,183 US5304473A (en) 1991-06-11 1991-06-11 A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production

Publications (2)

Publication Number Publication Date
FI922645A0 true FI922645A0 (fi) 1992-06-08
FI922645A FI922645A (fi) 1992-12-12

Family

ID=24872995

Family Applications (1)

Application Number Title Priority Date Filing Date
FI922645A FI922645A (fi) 1991-06-11 1992-06-08 A-c-b-proinsulin, foerfarande foer framstaellning av detta och anvaendningav detta samt mellanprodukter foer anvaendning vid insulinframstaellning

Country Status (23)

Country Link
US (1) US5304473A (fi)
EP (1) EP0518587B1 (fi)
JP (1) JPH05255392A (fi)
KR (1) KR930000536A (fi)
CN (1) CN1068501A (fi)
AT (1) ATE166106T1 (fi)
AU (1) AU648670B2 (fi)
BR (1) BR9202180A (fi)
CA (1) CA2070503C (fi)
CZ (1) CZ171492A3 (fi)
DE (1) DE69225432T2 (fi)
DK (1) DK0518587T3 (fi)
ES (1) ES2116315T3 (fi)
FI (1) FI922645A (fi)
HU (1) HUT63193A (fi)
IE (1) IE921862A1 (fi)
IL (1) IL102107A0 (fi)
MX (1) MX9202726A (fi)
NO (1) NO922224L (fi)
NZ (1) NZ243089A (fi)
SK (1) SK171492A3 (fi)
YU (1) YU59392A (fi)
ZA (1) ZA924080B (fi)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378613A (en) * 1991-09-24 1995-01-03 Eli Lilly And Company Method for increased expression of low molecular weight recombinant polypeptides
US6348327B1 (en) * 1991-12-06 2002-02-19 Genentech, Inc. Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
CA2165781C (en) * 1993-06-21 2007-02-13 Tim Breece Process for producing relaxin
US5646242A (en) * 1994-11-17 1997-07-08 Eli Lilly And Company Selective acylation of epsilon-amino groups
US5665591A (en) * 1994-12-06 1997-09-09 Trustees Of Boston University Regulation of smooth muscle cell proliferation
KR0150565B1 (ko) * 1995-02-15 1998-08-17 김정재 유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법
US5576197A (en) * 1995-04-07 1996-11-19 Molecular Bio-Products Polymerase chain reaction container and methods of using the same
EP0741188A3 (en) * 1995-05-05 1999-07-14 Eli Lilly And Company Single chain insulin with high bioactivity
US5700904A (en) * 1995-06-07 1997-12-23 Eli Lilly And Company Preparation of an acylated protein powder
US5631347A (en) * 1995-06-07 1997-05-20 Eli Lilly And Company Reducing gelation of a fatty acid-acylated protein
GB9513967D0 (en) * 1995-07-08 1995-09-06 Univ Leicester Insulin
US5905140A (en) * 1996-07-11 1999-05-18 Novo Nordisk A/S, Novo Alle Selective acylation method
US7169889B1 (en) * 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US7378390B2 (en) * 1999-12-29 2008-05-27 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
US20050100991A1 (en) * 2001-04-12 2005-05-12 Human Genome Sciences, Inc. Albumin fusion proteins
EP1276756A4 (en) 2000-04-12 2004-06-09 Human Genome Sciences Inc ALBUMIN FUSION PROTEINS
US7790690B2 (en) 2000-10-11 2010-09-07 U.S. Department Of Veterans Affairs Glucose sensitive regulator of insulin transcription
CN1406131A (zh) * 2000-12-25 2003-03-26 株式会社资生堂 活化交感神经的香料组合物
US6867183B2 (en) * 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US7105314B2 (en) * 2001-04-02 2006-09-12 Novo Nordisk A/S Method for making human insulin precursors
CA2446739A1 (en) * 2001-05-25 2002-12-05 Human Genome Sciences, Inc. Chemokine beta-1 fusion proteins
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7196059B2 (en) * 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) * 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
ES2545090T3 (es) * 2001-12-21 2015-09-08 Human Genome Sciences, Inc. Proteínas de fusión de albúmina y GCSF
WO2003059934A2 (en) * 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin fusion proteins
WO2003105768A2 (en) * 2002-06-13 2003-12-24 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
US20050026826A1 (en) * 2003-01-17 2005-02-03 Margarethe Hoenig Feline proinsulin, insulin and constituent peptides
EP1594530A4 (en) 2003-01-22 2006-10-11 Human Genome Sciences Inc HYBRID PROTEINS OF ALBUMIN
EP1692168B1 (en) 2003-12-03 2011-07-20 Novo Nordisk A/S Single-chain insulin
NZ553263A (en) 2004-07-19 2010-06-25 Biocon Ltd Insulin-oligomer conjugates, formulations and uses thereof
US20090099095A1 (en) * 2007-05-16 2009-04-16 Peter Eriksson Novel neuroprotective peptide
WO2009050738A2 (en) * 2007-10-16 2009-04-23 Biocon Limited An orally administerable solid pharmaceutical composition and a process thereof
KR20140054009A (ko) * 2011-07-01 2014-05-08 바이엘 인텔렉쳐 프로퍼티 게엠베하 릴랙신 융합 폴리펩타이드 및 그의 용도
US9707276B2 (en) 2012-12-03 2017-07-18 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues
TW201605470A (zh) 2013-10-04 2016-02-16 默沙東藥廠 葡萄糖反應性胰島素結合物
CN108064173B (zh) 2014-11-21 2021-05-18 默沙东公司 胰岛素受体部分激动剂
WO2017040363A1 (en) 2015-09-02 2017-03-09 Merck Sharp & Dohme Corp. A process for obtaining insulin with correctly formed disulfide bonds
EP3448417A4 (en) 2016-04-26 2019-12-11 Merck Sharp & Dohme Corp. SOUND CONJUGATES OF INSULIN-INCRETIN
EP3463429A4 (en) 2016-05-24 2020-07-22 Merck Sharp & Dohme Corp. PARTIAL INSULIN RECEPTOR AGONISTS AND GLP-1 ANALOGUES
US10689430B2 (en) 2016-05-25 2020-06-23 Merck Sharp & Dohme Corp. Insulin receptor partial agonists
EP3272877A1 (en) 2016-07-18 2018-01-24 ETH Zurich B-cell-mimetic cells
WO2018015330A1 (en) 2016-07-18 2018-01-25 Eth Zurich B-cell-mimetic cells
AU2017322552B2 (en) * 2016-09-06 2021-12-02 Chemical & Biopharmaceutical Laboratories Of Patras S.A. Proinsulin derivatives
US11041009B2 (en) 2017-03-23 2021-06-22 Merck Sharp & Dohme Corp. Glucose responsive insulin comprising a tri-valent sugar cluster for treatment of diabetes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666884A (en) * 1984-04-10 1987-05-19 New England Deaconess Hospital Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls
AU641631B2 (en) * 1988-12-23 1993-09-30 Novo Nordisk A/S Human insulin analogues
NZ232375A (en) * 1989-02-09 1992-04-28 Lilly Co Eli Insulin analogues modified at b29
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser

Also Published As

Publication number Publication date
IE921862A1 (en) 1992-12-16
CA2070503A1 (en) 1992-12-12
AU648670B2 (en) 1994-04-28
ZA924080B (en) 1993-12-06
DE69225432T2 (de) 1998-10-01
IL102107A0 (en) 1993-01-14
DK0518587T3 (da) 1998-10-19
JPH05255392A (ja) 1993-10-05
HU9201915D0 (en) 1992-08-28
ATE166106T1 (de) 1998-05-15
DE69225432D1 (de) 1998-06-18
EP0518587A2 (en) 1992-12-16
CA2070503C (en) 1999-01-12
HUT63193A (en) 1993-07-28
CZ171492A3 (en) 1993-05-12
YU59392A (sh) 1994-11-15
SK171492A3 (en) 1995-04-12
AU1806992A (en) 1993-03-11
CN1068501A (zh) 1993-02-03
US5304473A (en) 1994-04-19
NO922224L (no) 1992-12-14
KR930000536A (ko) 1993-01-15
ES2116315T3 (es) 1998-07-16
FI922645A (fi) 1992-12-12
BR9202180A (pt) 1993-02-02
NZ243089A (en) 1994-01-26
EP0518587B1 (en) 1998-05-13
EP0518587A3 (en) 1993-12-01
MX9202726A (es) 1992-12-01
NO922224D0 (no) 1992-06-05

Similar Documents

Publication Publication Date Title
FI922645A (fi) A-c-b-proinsulin, foerfarande foer framstaellning av detta och anvaendningav detta samt mellanprodukter foer anvaendning vid insulinframstaellning
DE68927073D1 (de) Modifiziertes Baculovirus,Herstellung und Verwendung als Expressionsvektor
DE69027666D1 (de) Herstellung von biologischaktivem insulinähnlichem wachstumsfaktor i aus hochexpressions-wirtszellsystemen
EA199700329A1 (ru) Новый белок и способ его получения
DE58909125D1 (de) Verfahren zur Herstellung von Diorganodialkoxysilanen.
EP0271824A3 (en) Horse gamma interferon
NO921574D0 (no) Forbedring av utbyttet ved sekresjon av disulfidbrodannende proteine
NO923252D0 (no) Fosfoinositolglykan-peptid med insulinlignende virkning
NO167036C (no) Fremgangsmaate til fremstilling av insulinderivater
IE810709L (en) Chiral hydantoins
ATE198074T1 (de) Neue silylverbindungen und ihre verwendung
ATE381619T1 (de) Verfahren zur herstellung von rekombinantem insulin durch fusionsproteine
AU7542187A (en) Light inducible promoter
AU643773B2 (en) Growth hormone releasing factor analogs
DE69219242D1 (de) Muteine des menschlichen Parathormons und ihre Herstellung
HU9401821D0 (en) Ureins derived from alpha, omega-diamino-acids and process for producing them
DE59406704D1 (de) Verfahren zur Herstellung von gegebenenfalls 2-substituierten 5-Chlorimidazol-4-carbaldehyden
DE68919619D1 (de) DNA-Sequenz, beteiligt an der Regulation der Expression einer DNA-Sequenz, die einen Polypeptid-Precursor kodiert, Expressionsvektoren und Methode der periplasmatischen Herstellung des Polypeptides.
JPS6447780A (en) Ferroelectric liquid crystal compound, production thereof and liquid crystal composition thereof

Legal Events

Date Code Title Description
FD Application lapsed